ORCID Profile
0000-0002-9675-4063
Current Organisation
Universidade de São Paulo Hospital das Clínicas
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Publisher: Springer Science and Business Media LLC
Date: 06-07-2017
Publisher: Wiley
Date: 06-11-2022
DOI: 10.1111/JPI.12838
Abstract: The increasing number of people living with human immunodeficiency virus, HIV, (PLWH) have an elevated incidence of risk for noncommunicable comorbidities, the aetiology of which remains incompletely understood. While sleep disturbances are often reported in PLWH, it is unknown to what extent they relate to changes in the circadian and/or sleep homeostatic processes. We studied the relationship between sleep characteristics, circadian phase, and HIV status in older adults from the HAALSI (Health and Ageing in Africa: a Longitudinal Study of an INDEPTH Community in South Africa) subs le of the Agincourt Health and Demographic Surveillance System in South Africa ( n = 187, 36 human immunodeficiency virus positive [HIV+], age: 66.7 ± 11.5 years, range 45—93 years), where HIV prevalence is high and (in contrast to the global north) does not associate significantly with potentially confounding behavioural differences. In participants with valid actigraphy data ( n = 172), regression analyses adjusted for age and sex indicated that HIV+ participants had slightly later sleep onset ( β = .16, p = .039), earlier sleep offset times ( β = −.16, p = .049) and shorter total sleep times ( β = −.20, p = .009) compared to the HIV negative (HIV−) participants. In a subset of participants ( n = 51, 11 HIV+), we observed a later dim light melatonin onset (DLMO) in HIV+ (21:16 ± 01:47) than in HIV− (20:06 ± 00:58) participants ( p = .006). This substantial difference remained when adjusted for age and sex ( β = 1.21 p = .006). In 36 participants (6 HIV+) with DLMO and actigraphy data, median phase angle of entrainment was −6 min in the HIV+ group and +1 h 25 min in the HIV− group. DLMO time correlated with sleep offset ( ρ = 0.47, p = .005) but not sleep onset ( ρ = −0.086, p = .623). Collectively, our data suggest that the sleep phase occurred earlier than what would be biologically optimal among the HIV+ participants. This is the first report of a mistimed circadian phase in PLWH, which has important potential implications for their health and well‐being, especially given the well‐established relationships between circadian asynchrony and sleep deprivation with poorer health outcomes.
Publisher: Hindawi Limited
Date: 2013
DOI: 10.1155/2013/971841
Abstract: An increase in the prevalence of obesity in people with spinal cord injury can contribute to low-grade chronic inflammation and increase the risk of infection in this population. A decrease in sympathetic activity contributes to immunosuppression due to the lower activation of immune cells in the blood. The effects of physical exercise on inflammatory parameters in in iduals with spinal cord injury have not been well described. We conducted a review of the literature published from 1974 to 2012. This review explored the relationships between low-grade inflammation, spinal cord injury, and exercise to discuss a novel mechanism that might explain the beneficial effects of exercise involving an increase in catecholamines and cytokines in people with spinal cord injury.
Publisher: Elsevier BV
Date: 03-2017
DOI: 10.1016/J.BBI.2016.12.027
Abstract: Sleep generally regulates immune functions in a supportive manner and can affect parameters that are directly involved in the rejection process. The first objective was to assess whether sleep deprivation (SD) or sleep restriction (SR) affects the allograft rejection process in mice. The second objective was to investigate whether the rejection process itself modulates the sleep pattern of allografted mice. Adult BALB/c and C57BL/6J male mice were used as the donors and recipients, respectively, except for the syngeneic group (ISOTX), which received skin from mice of the same strain (C57BL/6J). The recipients were randomly assigned to either one of two control groups - TX (allogenic) or ISOTX (syngeneic) - which underwent stereotaxic surgery to enable sleep recording prior to the allograft but were not sleep deprived one of two paradoxical sleep deprived groups - SDTX and TXSD - which underwent 72h of continuous SD either before or after the allograft respectively, and one of two sleep restricted groups - SRTX and TXSR - which underwent 21h of SD and 3h of sleep for 15days either before or after the allograft respectively. The skin allograft was inspected daily to determine the survival time, expected as 8.0±0.4days in this transplant model under no treatment. The sleep pattern was controlled throughout the rejection process in the SD and SR groups. Draining lymph nodes, spleen, blood and skin grafts were harvested on the 5th day after transplantation for evaluation of the immune parameters related to allograft rejection. In the control groups, we observed a reduction in paradoxical sleep throughout the entire allograft rejection process. Acute and chronic experimental sleep loss in the SD and SR groups produced marked alterations in the immune response. Both SD and SR prolonged allograft survival compared to the non-sleep-deprived group. There were reductions in the following parameters involved in the allograft rejection under sleep loss: CD4 We provide, as far as we are aware, the first evidence in vivo that the immune response can alter the normal sleep pattern, and that sleep loss can conversely affect the immune response related to graft rejection.
Publisher: Hindawi Limited
Date: 15-04-2014
DOI: 10.1155/2014/246342
Abstract: Objective . The objective of this study was to correlate metabolic and hormonal parameters before and after 8, 16, and 24 weeks (wk) of moderate aerobic training in in iduals with chronic primary insomnia. Method. Four male and sixteen female volunteers (adults, sedentary, and healthy) performed exercise training for 24 weeks. Blood and Pittsburgh Sleep Quality Index (PSQI) was obtained at baseline, 8, 16, and 24 wk of training. Results. PSQI scores decreased after 8, 16, and 24 wk of training regarding baseline values. Indeed, total sleep time (TST) increased after 16 and 24 wk of exercise training regarding baseline values. The correlations were analyzed using the delta ( Δ ) values ( Δ 1 = 8 wk less baseline Δ 2 = 16 wk less baseline Δ 3 = 24 wk less baseline). We have observed a negative correlation for Δ 1 between TST and cortisol, a positive correlation for Δ 3 between TST and growth hormone, a negative correlation for Δ 1 between TST and VLDL, a negative correlation for Δ 1 between TST and triacylglycerols, and a negative correlation for Δ 1 and Δ 2 between TST and thyroid-stimulating hormone. Conclusion. The exercise training improved the sleep quality of patients with chronic primary insomnia.
Location: Brazil
Location: Brazil
No related grants have been discovered for Francieli S Ruiz.