ORCID Profile
0000-0002-5567-7399
Current Organisation
University Of Strathclyde
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Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6FD90013E
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6CS90028C
Abstract: Guest editors Matthew Baker and Karen Faulds introduce the Fundamental Developments in Clinical Infrared and Raman Spectroscopy issue of Chemical Society Reviews
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6FD90014C
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1AN00726B
Abstract: Duplex SERS-based lateral flow testing for C. diff bacterial infection using new biomarker, SlpA, and ToxB within 20 minutes.
Publisher: American Chemical Society (ACS)
Date: 03-09-2019
Publisher: Springer Science and Business Media LLC
Date: 15-05-2017
DOI: 10.1038/S41536-017-0014-3
Abstract: The field of regenerative medicine spans a wide area of the biomedical landscape—from single cell culture in laboratories to human whole-organ transplantation. To ensure that research is transferrable from bench to bedside, it is critical that we are able to assess regenerative processes in cells, tissues, organs and patients at a biochemical level. Regeneration relies on a large number of biological factors, which can be perturbed using conventional bioanalytical techniques. A versatile, non-invasive, non-destructive technique for biochemical analysis would be invaluable for the study of regeneration and Raman spectroscopy is a potential solution. Raman spectroscopy is an analytical method by which chemical data are obtained through the inelastic scattering of light. Since its discovery in the 1920s, physicists and chemists have used Raman scattering to investigate the chemical composition of a vast range of both liquid and solid materials. However, only in the last two decades has this form of spectroscopy been employed in biomedical research. Particularly relevant to regenerative medicine are recent studies illustrating its ability to characterise and discriminate between healthy and disease states in cells, tissue biopsies and in patients. This review will briefly outline the principles behind Raman spectroscopy and its variants, describe key ex les of its applications to biomedicine, and consider areas of regenerative medicine that would benefit from this non-invasive bioanalytical tool.
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2AN00703G
Abstract: SERS for antibiotic resistance diagnosis.
Publisher: American Chemical Society (ACS)
Date: 06-01-2016
DOI: 10.1021/ACS.ANALCHEM.5B02776
Abstract: A significant advantage of using surface enhanced Raman scattering (SERS) for DNA detection is the capability to detect multiple analytes simultaneously within the one s le. However, as the analytes approach the metallic surface required for SERS, they become more concentrated and previous studies have suggested that different dye labels will have different affinities for the metal surface. Here, the interaction of single stranded DNA labeled with either fluorescein (FAM) or tetramethylrhodamine (TAMRA) with a metal surface, using spermine induced aggregated silver nanoparticles as the SERS substrate, is investigated by analyzing the labels separately and in mixtures. Comparison studies were also undertaken using the dyes in their free isothiocyanate forms, fluorescein isothiocyanate (F-ITC) and tetramethylrhodamine isothiocyanate (TR-ITC). When the two dyes are premixed prior to the addition of nanoparticles, TAMRA exerts a strong masking effect over FAM due to a stronger affinity for the metal surface. When parameters such as order of analyte addition, analysis time, and analyte concentration are investigated, the masking effect of TAMRA is still observed but the extent changes depending on the experimental parameters. By using bootstrap estimation of changes in SERS peak intensity, a greater insight has been achieved into the surface affinity of the two dyes as well as how they interact with each other. It has been shown that the order of addition of the analytes is important and that specific dye related interactions occur, which could greatly affect the observed SERS spectra. SERS has been used successfully for the simultaneous detection of several analytes however, this work has highlighted the significant factors that must be taken into consideration when planning a multiple analyte assay.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Karen Faulds.