ORCID Profile
0000-0003-1909-1873
Current Organisations
UNIVERSIDAD NACIONAL MAYOR DE SAN MARCOS
,
Universidad Peruana Cayetano Heredia
,
San Marcos University
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Publisher: Public Library of Science (PLoS)
Date: 10-06-2014
Publisher: Public Library of Science (PLoS)
Date: 10-02-2016
Publisher: Elsevier BV
Date: 08-2013
Publisher: Elsevier BV
Date: 2014
Publisher: Wiley
Date: 03-02-2015
DOI: 10.1111/TMI.12456
Publisher: Public Library of Science (PLoS)
Date: 16-03-2015
Publisher: Public Library of Science (PLoS)
Date: 23-12-2015
Publisher: Elsevier BV
Date: 12-2012
DOI: 10.1016/J.VACCINE.2012.10.057
Abstract: Recombinant antigens cloned from the oncosphere life cycle stage of the cestode parasite Taenia solium (T. solium) have been proven to be effective as vaccines for protecting pigs against infections with T. solium. Previous studies have defined three different host protective oncosphere antigens, TSOL18, TSOL16 and TSOL45. In this study, we evaluated the potential for combining the antigens TSOL16 and TSOL18 as a practical vaccine. Firstly, in a laboratory trial, we compared the immunogenicity of the combined antigens (TSOL16/18) versus the immunogenicity of the antigens separately. Secondly, in a field trial, we tested the ability of the TSOL16/18 vaccine to induce detectable antibody responses in animals living under environmental stress and traditionally reared in areas where T. solium cysticercosis is endemic and finally, we characterised the immune response of the study population. Pigs of 8-16 weeks of age were vaccinated with 200 μg each of TSOL16 and TSOL18, plus 5mg of Quil-A. Specific total IgG, IgG(1) and IgG(2) antibody responses induced by TSOL16 and TSOL18 were determined with ELISA. The immunogenicity of both antigens was retained in the combined TSOL16/18 vaccine. The combined vaccine TSOL16/18 induced detectable specific anti-TSOL18 antibody responses in 100% (113/113) and specific anti-TSOL16 in 99% (112/113) of the vaccinated animals measured at 2 weeks following the booster vaccination. From the two IgG antibody subtypes analysed we found there was stronger response to IgG(2).
Publisher: Wiley
Date: 03-03-2006
DOI: 10.1111/J.1365-3024.2006.00820.X
Abstract: Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species.
Publisher: American Society of Parasitologists
Date: 04-2006
DOI: 10.1645/GE-619R.1
Publisher: Elsevier BV
Date: 09-2012
Publisher: Public Library of Science (PLoS)
Date: 11-12-2015
Publisher: Public Library of Science (PLoS)
Date: 17-07-2012
Publisher: Public Library of Science (PLoS)
Date: 26-07-2016
Publisher: Elsevier BV
Date: 06-2012
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Armando Gonzalez.