ORCID Profile
0000-0003-1094-9853
Current Organisations
Victoria Department of Health and Human Services Division of Health
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Self employed
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Publisher: American Physical Society (APS)
Date: 25-05-2022
Publisher: Elsevier BV
Date: 04-1974
Publisher: Elsevier BV
Date: 12-2017
Publisher: Elsevier BV
Date: 05-1984
DOI: 10.1016/0002-9343(84)90266-3
Abstract: Although many host defenses, including physical barriers, phagocytic cells, and humoral elements, normally protect the central nervous system from microbial pathogens, a variety of extrinsic factors may compromise these defenses and put patients at risk of acquiring central nervous system infection. These risk factors include: (1) communication of the cerebrospinal fluid space with integumentary surfaces (2) communication of the cerebrospinal fluid space with other body spaces through shunts (3) suppurative foci contiguous to the central nervous system (4) hematogenous spread of infectious agents (5) new acquisition of infectious agents with a propensity for causing central nervous system infection and (6) administration of certain antimicrobial or immunosuppressive drugs. Recognition that these factors are present and therefore that the patient is at risk allows monitoring for and prompt response to signs and symptoms of central nervous system infection.
Publisher: Wiley
Date: 07-2009
DOI: 10.1111/J.1445-5994.2009.01933.X
Abstract: Acute Q fever in pregnancy is uncommon, but is probably underrecognized. It results in a significant risk of adverse pregnancy outcome and also predisposes to the development of chronic Q fever in the mother. Here, we review the clinical features, epidemiology, treatment and follow-up of acute Q fever in pregnancy. The potential for transmission of Coxiella to the neonate and birthing suite staff will also be highlighted.
Publisher: Microbiology Society
Date: 09-2012
Abstract: Lodderomyces elongisporus has been recently identified in the literature as an infrequent human bloodstream isolate, commonly mistaken for a non-albicans Candida. A case of Lodderomyces endocarditis in an intravenous drug user is described. To our knowledge, this report highlights the first documented case of Lodderomyces as a cause of endocarditis and summarizes the susceptibility patterns in the reported literature. All isolates reported so far have fluconazole MICs of ≤0.25 µg ml(-1).
Publisher: IOP Publishing
Date: 05-2022
DOI: 10.1088/1748-0221/17/05/P05009
Abstract: The centrality of heavy-ion collisions is directly related to the created medium in these interactions. A procedure to determine the centrality of collisions with the LHCb detector is implemented for lead-lead collisions at √ s NN = 5 TeV and lead-neon fixed-target collisions at √ s NN = 69 GeV. The energy deposits in the electromagnetic calorimeter are used to determine and define the centrality classes. The correspondence between the number of participants and the centrality for the lead-lead collisions is in good agreement with the correspondence found in other experiments, and the centrality measurements for the lead-neon collisions presented here are performed for the first time in fixed-target collisions at the LHC.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 13-04-2016
Abstract: A twenty-eight-year-old woman underwent decompressive laminectomy and placement of an interlaminar stabilizer due to L4/L5 disc herniation. Thirteen days later she developed a fever unresponsive to meropenem and vancomycin, along with signs of meningitis. A Mycoplasma hominis epidural abscess was identified. She had no preoperative risk factors for extragenital M. hominis infection, but had had a urinary catheter inserted intraoperatively. M. hominis postoperative surgical site infection is a rarely identified complication of spinal surgery. Seeding from the genitourinary tract is the most likely source.
Publisher: American Physical Society (APS)
Date: 21-04-2022
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 02-2001
Publisher: Springer Science and Business Media LLC
Date: 07-2022
Abstract: A data s le collected with the LHCb detector corresponding to an integrated luminosity of 9 fb − 1 is used to measure eleven CP violation observables in B ± → Dh ± decays, where h is either a kaon or a pion. The neutral D meson decay is reconstructed in the three-body final states: K ± π ∓ π 0 π + π − π 0 K + K − π 0 and the suppressed π ± K ∓ π 0 combination. The mode where a large CP asymmetry is expected, B ± → [ π ± K ∓ π 0 ] D K ± , is observed with a significance greater than seven standard deviations. The ratio of the partial width of this mode relative to that of the favoured mode, B ± → [ K ± π ∓ π 0 ] D K ± , is R ADS( K ) = (1 . 27 ± 0 . 16 ± 0 . 02) × 10 − 2 . Evidence for a large CP asymmetry is also seen: A ADS( K ) = −0 . 38 ± 0 . 12 ± 0 . 02. Constraints on the CKM angle γ are calculated from the eleven reported observables.
Publisher: Springer Science and Business Media LLC
Date: 2022
Abstract: The production cross-section of the χ c 1 (3872) state relative to the ψ (2 S ) meson is measured using proton-proton collision data collected with the LHCb experiment at centre-of-mass energies of $$ \\sqrt{s} $$ s = 8 and 13 TeV, corresponding to integrated luminosities of 2.0 and 5.4 fb − 1 , respectively. The two mesons are reconstructed in the J/ψπ + π − final state. The ratios of the prompt and nonprompt χ c 1 (3872) to ψ (2 S ) production cross-sections are measured as a function of transverse momentum, p T , and rapidity, y , of the χ c 1 (3872) and ψ (2 S ) states, in the kinematic range 4 p T 20 GeV/ c and 2 . 0 y 4 . 5. The prompt ratio is found to increase with p T , independently of y . For the prompt component, the double ratio of the χ c 1 (3872) and ψ (2 S ) production cross-sections between 13 and 8 TeV is observed to be consistent with unity, independent of p T and centre-of-mass energy.
Publisher: Elsevier BV
Date: 03-2016
DOI: 10.1016/J.IJANTIMICAG.2015.12.009
Abstract: It is uncertain whether flucloxacillin achieves therapeutic concentrations against meticillin-sensitive Staphylococcus aureus (MSSA) in cerebrospinal fluid (CSF). In this study, plasma and CSF concentrations of flucloxacillin and vancomycin in an adult patient were compared. Unlike vancomycin, the flucloxacillin CSF level was not therapeutic. Flucloxacillin monotherapy should be used with caution for MSSA central nervous system infection in adults.
Publisher: Elsevier BV
Date: 10-2016
DOI: 10.1016/J.JCJO.2016.05.013
Abstract: To describe the clinical features and risk factors of and optimal antifungal therapy for Purpureocillium lilacinum keratitis. Retrospective case series in a quaternary referral hospital setting. Comprehensive chart review of patients diagnosed with P. lilacinum keratitis in the past 10 years. Four patients were identified. All were aged 60 years or greater, with none having prior ocular trauma. Two had significant potential environmental exposure risks, and 3 were using systemic immunosuppressants for scleritis. All cases received empirical treatment that included topical corticosteroids. Three were treated with combined oral, topical, and intracameral voriconazole, but developed endophthalmitis necessitating surgery with poor outcomes, including enucleation in 2. One case received combined oral and topical voriconazole with terbinafine, and maintained visual acuity without the need for surgery. All P. lilacinum isolates were susceptible to voriconazole. P. lilacinum keratitis is rare, with the major risk factor being immunosuppression. There may be no history of ocular trauma. Microbiological diagnosis and antifungal susceptibility testing is essential. Combination synergistic antifungal therapy with topical voriconazole and oral terbinafine, with addition of systemic voriconazole if needed, results in the best outcome.
Publisher: BMJ
Date: 04-01-2017
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 05-1995
Publisher: BMJ
Date: 12-2020
Abstract: Melioidosis is caused by the tropical soil pathogen Burkholderia pseudomallei . Infection, usually in the form of pneumonia, disproportionately affects people with a risk factor for immune dysregulation and mortality remains high even with treatment. Climate change and increasing rates of diabetes render the populations of endemic areas increasingly vulnerable to the disease, which is emerging as a serious global health threat. We present here a case of a 68-year-old man from northern Australia with sepsis and osteoarticular melioidosis of the hip, and explore the links between diabetes mellitus and melioidosis, particularly with respect to musculoskeletal infection.
Publisher: American Physical Society (APS)
Date: 07-02-2022
Publisher: Therapeutic Guidelines Limited
Date: 02-2006
Publisher: BMJ
Date: 10-02-2017
Publisher: Wiley
Date: 09-2011
DOI: 10.1111/J.1445-5994.2011.02546.X
Abstract: We report the case of a 56-year-old man with the rare autoimmune pathologies of alternating hypothyroidism and hyperthyroidism due to thyroid-stimulating hormone receptor antibodies, and rheumatoid arthritis as manifestations of a human immunodeficiency virus-related immune reconstitution inflammatory syndrome. The patient also developed overt progression of a pre-existing skin malignancy that may also be related. This case highlights immune reconstitution syndrome as an important differential diagnosis following antiretroviral therapy commencement, and that a high index of suspicion should be maintained for this rare but important cluster of conditions. Furthermore, the patient's genetic predisposition to autoimmunity provides helpful insights into the pathogenesis of these disorders.
Publisher: Wiley
Date: 15-07-2018
DOI: 10.1111/CEO.13346
Abstract: Fungal keratitis is a rare but sight-threatening ocular infection. The epidemiology varies with geography, in particular climate and demography. We present descriptive epidemiology of fungal keratitis in Queensland, a large, geographically heterogenous Australian state. Descriptive ecological study. Queensland residents in the period 1996 to January 2016. We searched the state-wide pathology database for positive fungal cultures from corneal scrapings, aqueous humour, vitreous humour or contact lens specimens. Data were analysed by age, sex, climate and location. Cumulative incidence rates were estimated. Episodes of fungal keratitis, from which the abovementioned positive fungal cultures were assumed to originate. Two hundred and twenty-one episodes of fungal keratitis in 215 Queensland residents were identified (140 males and 75 females). The median age was 48 years and the modal age range was 25-50 years. Seasonal variation was seen in tropical Queensland. Fusarium (33%) and Aspergillus (13%) were the commonest pathogens. The cumulative incidence per 100 000 population was 4.7, but was significantly higher in rural/regional (5.4) and tropical Queensland (7.9). In Queensland, fungal keratitis occurs most frequently in males under 50 with increased case identification associated with the hot dry season in tropical Queensland. The sex and age distribution may reflect increased environmental exposure to fungi related to occupation. The higher cumulative incidence in tropical Queensland is in keeping with the rates observed in other tropical regions of the world. Knowledge of the epidemiology of the condition is essential in formulating empirical antifungal regimens in suspected fungal keratitis.
Publisher: Oxford University Press (OUP)
Date: 17-12-2011
DOI: 10.1093/CID/CIQ050
Publisher: IOP Publishing
Date: 02-2022
DOI: 10.1088/1748-0221/17/02/P02028
Abstract: The identification of charm jets is achieved at LHCb for data collected in 2015–2018 using a method based on the properties of displaced vertices reconstructed and matched with jets. The performance of this method is determined using a dijet calibration dataset recorded by the LHCb detector and selected such that the jets are unbiased in quantities used in the tagging algorithm. The charm-tagging efficiency is reported as a function of the transverse momentum of the jet. The measured efficiencies are compared to those obtained from simulation and found to be in good agreement.
Publisher: American Medical Association (AMA)
Date: 28-08-1996
Publisher: Oxford University Press (OUP)
Date: 10-2004
DOI: 10.1093/JAC/DKH403
Publisher: BMJ
Date: 08-2021
Abstract: A 29-year-old gravida 2 para 1 woman presented at 29 weeks gestation with fevers, back pain, thrombocytopenia and hepatitis. PCR testing of blood s les detected Coxiella burnetii and paired serology later confirmed the diagnosis of acute Q fever in pregnancy. The patient was treated empirically with oral clarithromycin and experienced a symptomatic and biochemical improvement. Therapy was changed to oral trimethoprim/sulphamethoxazole but was complicated by a delayed cutaneous reaction, prompting recommencement of clarithromycin. Therapy continued until delivery of a healthy girl at 39 weeks and 3 days. Q fever in pregnancy is likely under-reported and is associated with the development of chronic infection and obstetric complications. Treatment with clarithromycin is an alternative to trimethoprim/sulphamethoxazole in the setting of drug intolerance.
Publisher: American Physical Society (APS)
Date: 23-03-2022
Publisher: BMJ
Date: 17-09-2015
Publisher: Springer Science and Business Media LLC
Date: 03-2022
Abstract: The multihadron decays $$ {\\Lambda}_b^0 $$ Λ b 0 → D + pπ−π− and $$ {\\Lambda}_b^0 $$ Λ b 0 → D * + pπ−π− are observed in data corresponding to an integrated luminosity of 3 fb − 1 , collected in proton-proton collisions at centre-of-mass energies of 7 and 8 TeV by the LHCb detector. Using the decay $$ {\\Lambda}_b^0 $$ Λ b 0 → $$ {\\Lambda}_c^{+} $$ Λ c + π + π − π − as a normalisation channel, the ratio of branching fractions is measured to be $$ \\frac{\\mathcal{B}\\left({\\Lambda}_b^0\\to {D}^{+}p{\\pi}^{-}{\\pi}^{-}\\right)}{\\mathcal{B}\\left({\\Lambda}_b^0\\to {\\Lambda}_c^0{\\pi}^{+}{\\pi}^{-}{\\pi}^{-}\\right)}\\times \\frac{\\mathcal{B}\\left({D}^{+}\\to {K}^{-}{\\pi}^{+}{\\pi}^{+}\\right)}{\\mathcal{B}\\left({\\Lambda}_c^0\\to {pK}^{-}{\\pi}^{-}\\right)}=\\left(5.35\\pm 0.21\\pm 0.16\\right)\\%, $$ B Λ b 0 → D + p π − π − B Λ b 0 → Λ c 0 π + π − π − × B D + → K − π + π + B Λ c 0 → pK − π − = 5.35 ± 0.21 ± 0.16 % , where the first uncertainty is statistical and the second systematic. The ratio of branching fractions for the $$ {\\Lambda}_b^0 $$ Λ b 0 → D *+ pπ − π − and $$ {\\Lambda}_b^0 $$ Λ b 0 → D + pπ − π − decays is found to be $$ \\frac{\\mathcal{B}\\left({\\Lambda}_b^0\\to {D}^{\\ast +}p{\\pi}^{-}{\\pi}^{-}\\right)}{\\mathcal{B}\\left({\\Lambda}_b^0\\to {D}^{+}p{\\pi}^{-}{\\pi}^{-}\\right)}\\times \\left(\\mathcal{B}\\left({D}^{\\ast +}\\to {D}^{+}{\\pi}^0\\right)+\\mathcal{B}\\left({D}^{\\ast +}\\to {D}^{+}\\gamma \\right)\\right)=\\left(61.3\\pm 4.3\\pm 4.0\\right)\\%. $$ B Λ b 0 → D ∗ + p π − π − B Λ b 0 → D + p π − π − × B D ∗ + → D + π 0 + B D ∗ + → D + γ = 61.3 ± 4.3 ± 4.0 % .
Publisher: Wiley
Date: 12-1995
DOI: 10.1111/J.1749-6632.1995.TB17384.X-I1
Abstract: We have demonstrated that in aged mice, the titer of serum antibody induced against tetanus toxoid correlates with resistance to local paralysis caused by injection of tetanus toxin. Only mice immunized shortly after oral dosing with DHEAS demonstrated high serum antibody titers and complete protection from paralysis. These results became the basis for initiating proof-of-principle studies in human volunteers above age 65 using a licensed influenza vaccine and tetanus toxoid in two independent studies. The use of an oral delivery form of DHEAS before influenza vaccination was associated with a demonstrable increase in the number of in iduals with a fourfold increase in HAI titers following vaccination. The overall mean increase in HAI titers was highest in the DHEAS-treated group. The use of DHEAS in the immunization of elderly subjects against tetanus toxoid, while unable to enhance the responses, was not a detriment to antibody response. We conclude that further studies will justify the use of DHEAS as an adjuvant for antigens that represent primary responses in the elderly.
Publisher: Springer Science and Business Media LLC
Date: 1986
DOI: 10.2165/00003495-198600312-00001
Abstract: Despite the availability of effective antimicrobial agents and aggressive public health programmes, gonococcal infections, including salpingitis, remain a major worldwide problem resulting in significant rates of morbidity and infertility. Using an experimental model of gonococcal-infected human fallopian tubes in organ culture which are examined by light microscopy and scanning and transmission electron microscopy, basic pathogenic interactions between the gonococcus and the fallopian tube have been elucidated. The major steps in the pathogenic process include attachment, damage and invasion. Attachment appears to result from interaction of gonococcal pili with the tips of microvilli of non-ciliated cells of the fallopian tube mucosa. After gonococcal attachment occurs, fallopian tube damage is evident with loss of ciliary activity and sloughing of ciliated cells. The 2 compounds most likely to be mediators of this damage appear to be gonococcal lipopolysaccharide, which is released from the surface of the organism in the form of outer membrane blebs, as well as monomeric units of peptidoglycan, which are elaborated by the organism. Gonococcal attachment and perhaps elaboration of some molecule appear to initiate phagocytosis by non-ciliated epithelial cells. Gonococci are transported to the base of the non-ciliated cells and are released into the subepithelial space. This may lead to local disease (salpingitis) or disseminated disease (dermatitis-arthritis). Understanding the molecular mechanisms by which gonococci attach to, damage or invade the fallopian tube mucosa may result in identification of ways of preventing gonococcal infections and their sequelae.
Publisher: American Physical Society (APS)
Date: 03-03-2022
Publisher: Springer Science and Business Media LLC
Date: 2022
Abstract: The differential cross-section of prompt inclusive production of long-lived charged particles in proton-proton collisions is measured using a data s le recorded by the LHCb experiment at a centre-of-mass energy of $$ \\sqrt{s} $$ s = 13 TeV. The data s le, collected with an unbiased trigger, corresponds to an integrated luminosity of 5 . 4 nb − 1 . The differential cross-section is measured as a function of transverse momentum and pseudorapidity in the ranges p T ∈ [80 , 10 000) MeV /c and η ∈ [2 . 0 , 4 . 8) and is determined separately for positively and negatively charged particles. The results are compared with predictions from various hadronic-interaction models.
Publisher: Microbiology Society
Date: 2013
Abstract: Acute myopericarditis in the developed world is ascribed predominantly to viral infections. Enteroviruses and adenoviruses are commonly implicated but are not routinely tested for, as the condition is self-limiting and has a good prognosis. However, we recently encountered two cases of acute myopericarditis associated with concomitant Streptococcus pyogenes [group A Streptococcus (GAS)] pharyngotonsillitis. A microbiological aetiology was pursued because of the severity of the upper respiratory tract infection and associated systemic illness rather than to explain the myopericarditis per se. We report these two cases and review the literature of this potentially under-recognized condition. In the absence of features of rheumatic fever, we hypothesize a toxin-mediated process as opposed to an immune-mediated one. We suggest that perhaps all patients with myopericarditis be assessed for GAS pharyngitis.
Publisher: Wiley
Date: 07-2008
Publisher: Informa UK Limited
Date: 10-2012
Publisher: Informa UK Limited
Date: 2008
DOI: 10.1080/00365540701756953
Abstract: In order to assess the efficacy of 70% ethanol locks in addition to antibiotic therapy to treat tunnelled central venous catheter-associated bloodstream infections, a pilot study of 19 patients was performed prospectively using ethanol locks for 5 d in addition to antibiotic therapy to treat tunnelled central venous catheter-associated bacteraemia. 12 patients had mono-microbial infections and 7 had polymicrobial isolates. 17 of 19 patients completed ethanol lock therapy. 15 of 17 patients completing ethanol lock therapy had no recurrence of the original organism and retained their catheter for a median of 36 and an average of 47 d following initiation of ethanol lock therapy. These results demonstrate the safety and potential efficacy of this technique against a broad range of potentially virulent organisms. The intervention was acceptable to both staff and patients with no significant side-effects. These preliminary results from our prospective pilot study suggest that ethanol lock therapy is safe and easily integrated into clinical practice, and may have utility in treating central venous catheter-associated infections, avoiding removal of catheters in patients requiring long-term venous access.
Publisher: Cambridge University Press (CUP)
Date: 04-2010
DOI: 10.1086/651312
Abstract: In the midst of an outbreak, carbapenem-resistant Acinetobacter baumannii was grown from s les of multiple environmental sites in an intensive care unit. A commercial oxidizing disinfectant (potassium peroxomonosulphate 50%, sodium alkyl benzene sulphonate 15%, and sulphamic acid 5%) was introduced throughout the intensive care unit, and its use coincided with cessation of the outbreak.
Publisher: Wiley
Date: 1993
Abstract: To define the effects of incomplete Freund's adjuvant (ICFA) on subsequent arthritis induced by complete Freund's adjuvant (CFA) and type II collagen (CII) in DA and Lewis rats. ICFA was injected into DA and Lewis rats before CFA or CII injection. DA rats previously injected with ICFA had significantly less severe arthritis induced by CFA compared with those not receiving ICFA pretreatment (P < 0.01). ICFA had no significant impact on CFA-induced arthritis in Lewis rats or on CII-induced arthritis in DA rats. The injection of ICFA alone specifically suppresses subsequent CFA-induced arthritis in DA rats, but not in Lewis rats.
Publisher: Springer Science and Business Media LLC
Date: 02-2000
Abstract: Deep-seated Candida infections are challenging to diagnose by noninvasive means, and new modalities are needed to improve the yield of such investigations. Reported here is a case of Candida tropicalis vertebral osteomyelitis complicating epidural catheterisation in a diabetic patient with complicated abdominal sepsis. The diagnosis was supported by detection of increased D-arabinitol/L-arabinitol ratios in urine s les, and failure of medical management was indicated by elevated D-arabinitol/L-arabinitol ratios, which later decreased to baseline with successful surgical debridement and prolonged antifungal therapy.
Publisher: Elsevier BV
Date: 09-2018
DOI: 10.1016/J.IJID.2018.07.005
Abstract: To investigate the epidemiology, clinical characteristics and outcomes of those with hepatitis delta virus (HDV) infection in Queensland, Australia. Retrospective cohort study of in iduals tested for HDV between 1997 and 2016 in the public healthcare system in Queensland. 179 in iduals recorded positive HDV serology between 1997 and 2016, with a total of 4407 in iduals undergoing testing (seroprevalence 4.1%). The majority of HDV positive in iduals were male and were born overseas. Those born in Africa had a higher risk ratio (RR) for HDV infection (RR, 1.55 95% CI, 1.14-2.09) being born in Asia was associated with a relatively lower risk of HDV infection (RR, 0.36 95% CI, 0.27-0.58). Positive hepatitis C virus (HCV) serology was significantly associated with positive HDV serology (RR, 2.98 95% CI, 2.36-3.78). Of the HDV positive in iduals born in Australia, the majority were HCV positive (69.8%). HDV positive in iduals were less likely to be Hepatitis B e antigen (HBeAg) positive (RR, 0.64 95% CI, 0.45-0.93) and recorded lower hepatitis B virus (HBV) viral loads. Positive HDV serology was associated with increased risk of liver cirrhosis (RR, 2.3 95% CI 1.73-3.07) and liver transplantation (RR, 1.93 CI 1.31-2.85). Only 8% of HDV positive in iduals underwent HDV treatment. In Queensland, HDV seropositivity is associated with overseas birth, particularly in Africa. HDV infection is associated with decreased HBV viraemia and more advanced liver disease.
Publisher: Oxford University Press (OUP)
Date: 02-1996
Publisher: Elsevier BV
Date: 11-1996
DOI: 10.1016/S0002-9610(96)00248-6
Abstract: Proteasome 26S subunit, ATPase 2 (PSMC2) is a recently identified gene which is potentially associated with human carcinogenesis. However, the effects of PSMC2 on oral squamous cell carcinoma (OSCC) is still unclear. Here, we investigated PSMC2 expression in OSCC tissues and explored its effects on the biological behaviors of OSCC cells. PSMC2 expression was evaluated by immunohistochemistry in a tissue microarray containing 60 OSCC tissues and 9 normal tissues. PSMC2 was knocked down through lentivirus infection in OSCC cell lines. MTT, colony formation, flow cytometry, transwell, and scratch assays were performed to detect effects of PSMC2 knockdown on phenotypes of OSCC cells. Human apoptosis antibody array was used to screen potential downstream of PSMC2 in OSCC. Finally, the effects of PSMC2 knockdown on tumor growth were assessed in a tumor xenograft model using BALB/c nude mice. PSMC2 expression was significantly upregulated in OSCC tissues compared with normal tissues and correlated with poor prognosis. PSMC2 knockdown significantly suppressed cell proliferation, migration, but promoted apoptosis of OSCC cells. Additionally, we confirmed that PSMC2 knockdown can increase the expression of pro-apoptotic proteins. Furthermore, we found that PSMC2 knockdown downregulated expression of p100, p-Akt, CDK6, and upregulated of MAPK9. Xenograft experiments revealed that PSMC2 knockdown can suppress OSCC tumor growth and promote apoptosis. This study demonstrated that PSMC2 plays a critical role in OSCC progression through affecting pro-apoptotic protein expression and apoptosis pathways. It indicated that targeting PSMC2 might be a promising strategy for OSCC treatment.
Publisher: Wiley
Date: 10-2002
Publisher: BMJ
Date: 18-09-2012
Publisher: Elsevier BV
Date: 03-2022
Publisher: Oxford University Press (OUP)
Date: 03-1996
Abstract: An epidemiologic investigation was done after 3 patients contracted Ochrobactrum anthropi meningitis at one hospital in October 1994. Neurosurgical patients with pericardial tissue implants were at greater risk of infection than other neurosurgical patients (3/14 vs. 0/566 P<.001). Cultures of implants removed from 2 case-patients, an implant at implantation, a nonimplanted pericardial tissue, and an unwrapped but unopened bottle of Hank's balanced salt solution (HBSS) grew O. anthropi. Patient and tissue isolates had identical genotypes the isolate from the HBSS bottle had a unique genotype. Culture s les from an unopened HBSS bottle and from pericardial tissue grew Pseudomonas stutzeri of the same genotype however, no P. stutzeri infections were detected. The investigation documented intrinsic P. stutzeri contamination of HBSS. O. anthropi contamination of tissues occurred during processing, possibly due to extrinsic contamination of HBSS. Active surveillance is needed to detect infection in patients receiving transplanted tissues, and rigorous infection control practice are necessary during tissue harvesting and processing to ensure sterility.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 2011
Publisher: Informa UK Limited
Date: 2006
DOI: 10.1080/00365540500333996
Abstract: Atypical presentations of cryptococcal infection have been described as manifestations of immune reconstitution in HIV-infected patients following introduction of antiretroviral therapy. We describe a patient presenting with cryptococcal meningitis as an immune reconstitution reaction 10 weeks after initiation of anti-retroviral therapy. Subclinical CSF cryptococcal infection was demonstrated and the serum cryptococcal antigen was negative.
Publisher: Wiley
Date: 12-2009
Publisher: American Physical Society (APS)
Date: 03-06-2022
Publisher: Oxford University Press (OUP)
Date: 03-1999
Publisher: Springer Science and Business Media LLC
Date: 2022
Abstract: The W boson mass is measured using proton-proton collision data at $$ \\sqrt{s} $$ s = 13 TeV corresponding to an integrated luminosity of 1.7 fb − 1 recorded during 2016 by the LHCb experiment. With a simultaneous fit of the muon q T distribution of a s le of W → μν decays and the ϕ * distribution of a s le of Z → μμ decays the W boson mass is determined to be $$ {m}_w=80354\\pm {23}_{\\mathrm{stat}}\\pm {10}_{\\mathrm{exp}}\\pm {17}_{\\mathrm{theory}}\\pm {9}_{\\mathrm{PDF}}\\mathrm{MeV}, $$ m w = 80354 ± 23 stat ± 10 exp ± 17 theory ± 9 PDF MeV , where uncertainties correspond to contributions from statistical, experimental systematic, theoretical and parton distribution function sources. This is an average of results based on three recent global parton distribution function sets. The measurement agrees well with the prediction of the global electroweak fit and with previous measurements.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 08-1998
DOI: 10.1097/00002030-199812000-00011
Abstract: To describe two cases of cryptococcal meningitis and one re-exacerbation of Cryptococcus-associated meningitis occurring in temporal association with commencement of highly active antiretroviral therapy (HAART) in patients with advanced HIV infection (CD4 cells 2-4 log10 reduction) HIV viral loads (two out of three patients), and (iii) prominent inflammatory changes in cerebrospinal fluid (white blood cells > 10 x 10(6)/l) at diagnosis (two out of three patients). Our report suggests that in patients with advanced HIV infection, partial immune restitution induced by HAART can precipitate onset of clinically apparent meningitis in those patients with latent cryptococcal central nervous system infection or with residual cryptococcal antigen present in the cerebrospinal fluid.
Publisher: Wiley
Date: 03-2002
Publisher: Oxford University Press (OUP)
Date: 07-1992
Abstract: Pseudomonas pseudomallei, which causes melioidosis, is most commonly associated with pulmonary infection. We describe seven patients who developed a neurological syndrome as the predominant manifestation of melioidosis: this syndrome was characterized by peripheral motor weakness (mimicking Guillain-Barré syndrome), brain-stem encephalitis, aseptic meningitis, and respiratory failure. Neurological melioidosis occurred in the absence of demonstrable foci of infection in the central nervous system (CNS) in five of six patients whose cerebrospinal fluid was available for culture. Computed tomography and magnetic resonance imaging of the brain and spinal cord of these patients were not suggestive of pyogenic infection, although the latter procedure detected brain-stem encephalitis. Autopsy findings in one case confirmed brain-stem encephalitis without evidence of direct bacterial infection. The clinical presentation of neurological melioidosis includes features of an exotoxin-induced neurological syndrome, with profound neurological disease occurring in the absence of apparent direct infection of the CNS. This syndrome appears to be a newly recognized clinical presentation of melioidosis.
Publisher: Annual Reviews
Date: 10-1987
DOI: 10.1146/ANNUREV.MI.41.100187.001451
Abstract: Herpes simplex virus 1 (HSV-1) viral glycoproteins gD (carboxyl terminus), gE, gK, and gM, the membrane protein UL20, and membrane-associated protein UL11 play important roles in cytoplasmic virion envelopment and egress from infected cells. We showed previously that a recombinant virus carrying a deletion of the carboxyl-terminal 29 amino acids of gD (gDΔct) and the entire gE gene (ΔgE) did not exhibit substantial defects in cytoplasmic virion envelopment and egress (H. C. Lee et al., J. Virol. 83:6115-6124, 2009). The recombinant virus ΔgM2, engineered not to express gM, produced a 3- to 4-fold decrease in viral titers and a 50% reduction in average plaque sizes in comparison to the HSV-1(F) parental virus. The recombinant virus containing all three mutations, gDΔct-ΔgM2-ΔgE, replicated approximately 1 log unit less efficiently than the HSV-1(F) parental virus and produced viral plaques which were on average one-third the size of those of HSV-1(F). The recombinant virus ΔUL11-ΔgM2, engineered not to express either UL11 or gM, replicated more than 1 log unit less efficiently and produced significantly smaller plaques than UL11-null or gM-null viruses alone, in agreement with the results of Leege et al. (T. Leege et al., J. Virol. 83:896-907, 2009). Analyses of particle-to-PFU ratios, relative plaque size, and kinetics of virus growth and ultrastructural visualization of glycoprotein-deficient mutant and wild-type virions indicate that gDΔct, gE, and gM function in a cooperative but not redundant manner in infectious virion morphogenesis. Overall, comparisons of single, double, and triple mutant viruses generated in the same HSV-1(F) genetic background indicated that lack of either UL20 or gK expression caused the most severe defects in cytoplasmic envelopment, egress, and infectious virus production, followed by the double deletion of UL11 and gM.
Publisher: Elsevier BV
Date: 06-1996
DOI: 10.1016/0735-1097(96)00055-1
Abstract: The objectives of this study were to test prospectively for an association between Chlamydia and atherosclerosis by comparing the incidence of the pathogen found within atherosclerotic plaques in patients undergoing directional coronary atherectomy with a variety of control specimens and comparing the clinical features between the groups. Previous work has suggested an association between Chlamydia pneumoniae infection and coronary atherosclerosis, based on the demonstration of increased serologic titers and the detection of bacteria within atherosclerotic tissue, but this association has not yet been regarded as established. Coronary specimens from 90 symptomatic patients undergoing coronary atherectomy were tested for the presence of Chlamydia species using direct immunofluorescence. Control specimens from 24 subjects without atherosclerosis (12 normal coronary specimens and 12 coronary specimens from cardiac transplant recipients with subsequent transplant-induced coronary disease) were also examined. Coronary atherectomy specimens were definitely positive in 66 (73%) and equivocally positive in 5 (6%), resulting in 79% of specimens showing evidence for the presence of Chlamydia species within the atherosclerotic tissue. In contrast, only 1 (4%) of 24 nonatherosclerotic coronary specimens showed any evidence of Chlamydia. The statistical significance of this difference is a p value < 0.001. Transmission electron microscopy was used to confirm the presence of appropriate organisms in three of five positive specimens. No clinical factors except the presence of a primary nonrestenotic lesion (odds ratio 3.0, p = 0.057) predicted the presence of Chlamydia. This high incidence of Chlamydia only in coronary arteries diseased by atherosclerosis suggests an etiologic role for Chlamydia infection in the development of coronary atherosclerosis that should be further studied.
Publisher: American Society for Microbiology
Date: 06-2017
DOI: 10.1128/AAC.01988-16
Abstract: It is uncertain, given the lack of recent data and the inconclusive nature of previous data, whether ethambutol is cleared by hemodialysis using contemporary dialyzers. We measured serum ethambutol concentrations before, during, and 1 h after hemodialysis in a 75-year-old Caucasian man receiving ethambutol for disseminated Bacille Calmette-Guérin infection. There was a mean 41% decrease in serum ethambutol concentration during dialysis, confirming the hemodialyzability of ethambutol and the utility of drug monitoring in ensuring safety.
Publisher: American Physical Society (APS)
Date: 07-04-2022
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 07-2001
Publisher: American Physical Society (APS)
Date: 25-01-2022
Publisher: Informa UK Limited
Date: 1998
DOI: 10.1080/00365549850161269
Abstract: Disseminated Mycobacterium avium complex (MAC) infection presenting as a painful lytic femur lesion with associated fever, night sweats and weight loss occurred in a 45-y-old woman with apparent normal immune function. Surgical drainage and 24 months of medical therapy resulted in a cure.
Publisher: Oxford University Press (OUP)
Date: 04-1993
Abstract: This study sought to establish whether administration of dehydroepiandrosterone (DHEA) or its sulfate derivative to aged mice could effectively correct the immunosenescent phenotype. Supplemental DHEA sulfate and topical DHEA fully corrected the age-associated dysregulated production of T cell lymphokines by cells from all of the different lymphoid organs tested. Either DHEA or DHEA sulfate supplementation promoted enhanced antibody responses against recombinant hepatitis B surface antigen (rHBsAg) by the aged recipients when incorporated directly into the vaccine. When DHEA was provided either topically or was incorporated directly into vaccine, vigorous primary and secondary antibody responses were detected in the aged mice given a single administration of DHEA, regardless of the mode of administration. It was also established that DHEA treatment could enhance specific antibody responses to rHBsAg in aged animals that had previously not been effectively immunized by conventional vaccination procedures.
Location: Australia
No related grants have been discovered for Marion Woods.