ORCID Profile
0000-0002-2562-0447
Current Organisation
KU Leuven
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Publisher: Cold Spring Harbor Laboratory
Date: 19-10-2023
Publisher: Elsevier BV
Date: 05-2019
DOI: 10.1016/J.JAD.2019.03.055
Abstract: Gray matter volume decrease, white matter vascular pathology and amyloid accumulation are age-related brain changes that have been related to the pathogenesis of late life depression (LLD). Furthermore, lower hippoc al volume and more white matter hyperintensities (WMH) may contribute to poor response to electroconvulsive therapy (ECT) in severely depressed older adults. We hypothesized that the accumulation of age-related brain changes negatively affects outcome following ECT in LLD. 34 elderly patients with severe LLD were treated twice weekly with ECT until remission. All had both 3T structural magnetic resonance imaging (MRI) and β-amyloid positron emission tomography (PET) imaging using 18F-flutemetamol at baseline. MADRS and MMSE were obtained weekly which included 1 week prior to ECT (T0), after the sixth ECT (T1), and one week (T2) after the last ECT as well as at four weeks (T3) and 6 months (T4) after the last ECT. We conducted a multiple logistic regression analysis and a survival analysis with neuroimaging measures as predictors, and response, remission and relapse as outcome variable. We did not find any association between baseline hippoc al volume, white matter hyperintensity volume and total amyloid load and response or remission at 1 and 4 weeks post ECT, nor with relapse at week 4. The present exploratory study was conducted at a single center academic hospital, the s le size was small, the focus was on hippoc al volume and the predictive effect of structural and molecular changes associated with aging were used. Our study shows no evidence of relationship between response to ECT and age-related structural or molecular brain changes, implying that ECT can be applied effectively in depressed patients irrespective of accumulating age-related brain changes.
Publisher: Cold Spring Harbor Laboratory
Date: 20-06-2023
DOI: 10.1101/2023.06.13.23290806
Abstract: Accurate presurgical brain mapping enables preoperative risk assessment and intraoperative guidance. This work investigated whether constrained spherical deconvolution (CSD) methods were more accurate than diffusion tensor imaging (DTI)-based methods for presurgical white matter mapping using intraoperative direct electrical stimulation (DES) as the ground truth. Five different tractography methods were compared (3 DTI-based and 2 CSD-based) in 22 preoperative neurosurgical patients. The corticospinal tract (CST, N=20) and arcuate fasciculus (AF, N=7) bundles were reconstructed, then minimum distances between tractograms and DES coordinates were compared between tractography methods. Receiver-operating characteristic (ROC) curves were used for both bundles. For the CST, binary agreement, linear modeling, and posthoc testing were used to compare tractography methods while correcting for relative lesion and bundle volumes. Distance measures between 154 positive (functional response, pDES) and negative (no response, nDES) coordinates, and 134 tractograms resulted in 860 data points. Higher agreement was found between pDES coordinates and CSD-based compared to DTI-based tractograms. ROC curves showed overall higher sensitivity at shorter distance cutoffs for CSD (8.5 mm) compared to DTI (14.5 mm). CSD-based CST tractograms showed significantly higher agreement with pDES, which was confirmed by linear modeling and posthoc tests (PFWE 0.05). CSD-based CST tractograms were more accurate than DTI-based ones when validated using DES-based assessment of motor and sensory function. This demonstrates the potential benefits of structural mapping using CSD in clinical practice. CSD-based tractograms of the CST are more sensitive than DTI-based tractograms when validated against sensory-motor DES mapping. This also demonstrated the feasibility of fully-automated CSD-based tractography for presurgical planning of the CST. Presurgical white matter mapping using probabilistic CSD tractography is more accurate and sensitive than manual DTI FACT or automated probabilistic DTI tractography. This study included 22 patients with DES data, which was used as the ground truth. Distance in mm between tractograms and DES data resulted in 860 datapoints, 685 of which belonged to the CST and were used for linear modeling, DTI = diffusion tensor imaging, CSD = constrained spherical deconvolution, TCK = tractogram/tractography, FWE = family-wise error rate, AUC = area under the curve
Publisher: Wiley
Date: 13-08-2023
DOI: 10.1002/MDS.29570
Abstract: To investigate whether mild motor signs (MMS) in old age correlate with synaptic density in the brain. Normal aging is associated with a decline in movement quality and quantity, commonly termed “mild parkinsonian signs” or more recently MMS. Whether MMS stem from global brain aging or pathology within motor circuits remains unresolved. The synaptic vesicle glycoprotein 2A positron emission tomography (PET) ligand 11 C‐UCB‐J allows the investigation of brain‐motor associations at the synaptic level in vivo. Fifty‐eight healthy older adults (≥50 years) were included from two monocentric control cohorts. Brain magnetic resonance imaging and 11 C‐UCB‐J PET data were available in 54 participants. 11 C‐UCB‐J PET binding was quantified by standardized uptake value ratio (SUVR) values in grey matter (GM) volumes of interest (VOIs): caudate, putamen, globus pallidus, substantia nigra, thalamus, cerebellum, and the frontal, parietal, temporal, and occipital cortex. Multiple linear regression analyses were performed with Movement Disorder Society‐Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) part III score measuring MMS as the dependent variable and mean SUVR values in each VOI as the independent variable with age, Fazekas score (white matter lesion [WML] load), VOI and cohort as covariates. Participants (68 ± 7.5 years 52% female) had an average MDS‐UPDRS part III score of 3.3 ± 2.8. The MDS‐UPDRS part III score was inversely associated with synaptic density, independently of WML load or GM volume, in the caudate, substantia nigra, thalamus, cerebellum, and parietal, occipital, temporal cortex. Cohen's f 2 showed moderate effect sizes for subcortical (range, 0.30–0.35), cortical (0.28–0.35) and cerebellar VOIs (0.31). MMS in healthy aging are associated with lower synaptic density throughout the brain. © 2023 International Parkinson and Movement Disorder Society.
No related grants have been discovered for Kristof Vansteelandt.