ORCID Profile
0000-0002-6884-1362
Current Organisations
RMIT University City Campus
,
Bond University
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Publisher: Emerald
Date: 06-05-2014
DOI: 10.1108/EJIM-06-2013-0051
Abstract: – Innovation education has been identified as a key contributor to enhancing the innovative behavior of in iduals, organizations and economies yet very little literature exists on the development and assessment of innovation education programs (IEPs). This is particularly so in the higher education and vocational education domains. The purpose of this paper is to bridge the gap in the literature, by proposing a conceptual framework of a multi-dimensional IEP. – The paper employs a transparent and reproducible procedure and critical appraisal of the literature coupled with emergent inquiry and case study implementation of a leading international IEP. – The study provides a framework by which innovation education facilitators may develop and evaluate their IEPs. The proposed framework provides a thematic appreciation of the multi-dimensional relationships between components. – Limited within the context of this case study, geographical context and scant literature on IEPs and reproducible procedure. – The study provides a conceptual innovation education framework, based upon a successful international innovation management program.
Publisher: Routledge
Date: 17-01-2019
Publisher: Walter de Gruyter GmbH
Date: 2010
DOI: 10.1515/JPM.2010.026
Abstract: Although premature infants are increasingly surviving the neonatal period, up to one-third develop bronchopulmonary dysplasia (BPD). Despite evidence that bacterial colonization of the neonatal respiratory tract by certain bacteria may be a risk factor in BPD development, little is known about the role these bacteria play. The aim of this study was to investigate the use of culture-independent molecular profiling methodologies to identify potential etiological agents in neonatal airway secretions. This study used terminal restriction fragment length polymorphism (T-RFLP) and clone sequence analyses to characterize bacterial species in endo-tracheal (ET) aspirates from eight intubated pre-term infants. A wide range of different bacteria was identified in the s les. Forty-seven T-RF band lengths were resolved in the s le set, with a range of 0-15 separate species in each patient. Clone sequence analyses confirmed the identity of in idual species detected by T-RFLP. We speculate that the identification of known opportunistic pathogens including S. aureus, Enterobacter sp., Moraxella catarrhalis, Pseudomonas aeruginosa and Streptococcus sp., within the airways of pre-term infants, might be causally related to the subsequent development of BPD. Further, we suggest that culture-independent techniques, such as T-RFLP, hold important potential for the characterization of neonatal conditions, such as BPD.
Publisher: Elsevier BV
Date: 07-2019
Publisher: American Society for Microbiology
Date: 12-2013
DOI: 10.1128/JCM.02164-13
Abstract: Primary ciliary dyskinesia (PCD) is a genetic disease characterized by abnormalities in ciliary function, leading to compromised airway clearance and chronic bacterial infection of the upper and lower airways. The compositions of these infections and the relationships between their characteristics and disease presentation are poorly defined. We describe here the first systematic culture-independent evaluation of lower airway bacteriology in PCD. Thirty-three airway s les (26 from sputum, 7 from bronchoalveolar lavage [BAL] fluid) were collected from 24 PCD patients aged 4 to 73 years. 16S rRNA quantitative PCR and pyrosequencing were used to determine the bacterial loads and community compositions of the s les. Bacterial loads, which ranged from 1.3 × 10 4 to 5.2 × 10 9 CFU/ml, were positively correlated with age ( P = 0.002) but not lung function. An analysis of ∼7,000 16S rRNA sequences per s le identified bacterial species belonging to 128 genera. The concurrently collected paired s les showed high bacterial community similarity. The mean relative abundance of the dominant genera was 64.5% (standard deviation [SD], 24.5), including taxa reported through standard diagnostic microbiology (members of the genera Pseudomonas , Haemophilus , and Streptococcus ) and those requiring specific ex vivo growth conditions (members of the genera Prevotella and Porphyromonas ). The significant correlations observed included a positive relationship between Pseudomonas aeruginosa relative abundance and age and a negative relationship between P. aeruginosa relative abundance and lung function. Members of the genus Ralstonia were also found to contribute substantially to the bacterial communities in a number of patients. Follow-up s les from a subset of patients revealed high levels of bacterial community temporal stability. The detailed microbiological characterization presented here provides a basis for the reassessment of the clinical management of PCD airway infections.
Publisher: Springer Science and Business Media LLC
Date: 05-05-2013
Publisher: Inderscience Publishers
Date: 2004
Publisher: Elsevier BV
Date: 09-2011
Publisher: Wiley
Date: 25-01-2012
Publisher: American Society for Microbiology
Date: 31-12-2012
Abstract: Recent studies have greatly extended our understanding of the microbiota present in and on the human body. Here, advanced sequencing strategies have provided unprecedented analytical power. The important implications that the emerging data have for human health emphasize the need to intensify research in this area (D. A. Relman, Nature 486:194-195, 2012). It is already clear from these studies that the microbiotas characterized in different body locations of healthy in iduals are both complex and erse (The Human Microbiome Project Consortium, Nature 486:215-221). These studies also provide a point of contrast for investigations that aim to characterize the microbiota present in disease conditions. In this regard, Madan et al. (mBio 3(4):e00251-12, 2012) monitored the development over time of microbiota in the oropharynges and feces of neonates with cystic fibrosis and explored the potential for interactions between these complex microbial systems.
Publisher: Emerald
Date: 07-01-2022
Abstract: The purpose of this practitioner paper is to explore whether the principles of Design Thinking and the Lean Startup could be employed in developing a disruptive model for delivering educational programs within higher education in a way that attempts to eliminate the multitude of problems facing this industry, while simultaneously adhering to the principles of frugal innovation and meeting relevant sustainability goals. The authors followed a design thinking approach, employing tools such as empathy mapping, customer journey, value proposition and semi-structured interviews to obtain a deep level of understanding of the problems educators and students within the context of entrepreneurship education are facing. Throughout the process they drew on the practice of emergent inquiry and customer co-creation to help guide decision making. The authors successfully derived a conceptual solution in the form of a Minimum Viable Product of which the features were tested against the multitude of user needs and requirements. It was possible to demonstrate how the solution meets all nine of the requirements for frugal innovations while simultaneously adhering to applicable sustainability principles. The proposed solution offers a potential opportunity to first-movers in chosen academic disciplines to become leaders in online education. Even in an industry such as higher education there is a dire need for frugality and finding sustainable solutions for educators and students in both developed and developing markets. With this paper the authors succeed in presenting innovative combinations of digital artefacts, platforms and infrastructure to arrive at a novel crowd-sourced solution that is unique in its design.
Publisher: World Scientific Pub Co Pte Lt
Date: 25-07-2019
DOI: 10.1142/S1363919619500506
Abstract: This paper draws on survey data to clarify whether small high-technology firms benefit most from adopting greater numbers of new product development (NPD) tools to support NPD projects, or from using tools more thoroughly. This is an important issue given that small firms adopt NPD tools despite facing acute resource limitations and using informal processes. Prior studies of the performance impact of NPD tools have focused on large firms, and very few have assessed the performance impact of using NPD tools to higher levels of thoroughness.The paper covers tools across functional/technical and management/marketing aspects of NPD, and measures performance in process, product and market. We found that increasing the number of tools adopted did not measurably improve performance, in contrast to prior findings in larger firms. Instead, we found that firms obtained meaningfully improved NPD performance from using tools at higher average levels of thoroughness. Higher average thoroughness produced statistically significant performance benefits across seven of our nine performance measures. Our findings imply that small firms should emphasize selective but thorough and well-designed implementation of NPD tools.
Publisher: Elsevier BV
Date: 08-2010
Publisher: BMJ
Date: 15-06-2012
Publisher: Informa UK Limited
Date: 2010
DOI: 10.5172/SER.17.2.193
Publisher: Cambridge University Press (CUP)
Date: 05-06-2013
DOI: 10.1017/S0950268813001362
Abstract: The incidence, morbidity, and mortality associated with Clostridium difficile gastrointestinal infections has increased greatly over recent years, reaching epidemic proportions a trend due, in part, to the emergence of hypervirulent and antibiotic-resistant strains. The need to identify alternative, non-antibiotic, treatment strategies is therefore urgent. The ability of bacteria in faecal matter transplanted from healthy in iduals to displace pathogen populations is well recognized. Further, there is growing evidence that such faecal microbiota transplantation can be of benefit in a wide range of conditions associated with gut dysbiosis. Recent technical advances have greatly increased our ability to understand the processes that underpin the beneficial changes in bacterial community composition, as well as to characterize their extent and duration. However, while much of the research into faecal microbiota transplantation focuses currently on achieving clinical efficacy, the potential for such therapies to contribute to the transmission of infective agents also requires careful consideration.
Publisher: MDPI AG
Date: 05-06-2020
DOI: 10.3390/SU12114612
Abstract: The COVID-19 pandemic has not only had a significant and catastrophic effect on business and economies globally, but has identified the external and internal enablement of new venture creation. This paper aims to provide entrepreneurship insights, implementations and dynamics to demonstrate the role of entrepreneurship in times of such adversity within an Australian context. We provide emergent enquiry narratives from leading Australian scholars, identifying entrepreneurial initiatives as a catalyst to new venture creation and growth. Narratives include insights associated with the entrepreneurial mindset, the multidimensional effects of resilience and entrepreneurship, entrepreneurship education, entrepreneurship enablers and the entrepreneurial ecosystem. Opportunities for further research are identified, particularly regarding context and empirical outcomes. We postulate that entrepreneurship may well be the unsung hero during the current COVID-19 economic crisis.
Publisher: Elsevier BV
Date: 12-2011
Publisher: American Society for Microbiology
Date: 2011
DOI: 10.1128/JCM.01650-10
Abstract: The aim of this study was to determine whether geographical differences impact the composition of bacterial communities present in the airways of cystic fibrosis (CF) patients attending CF centers in the United States or United Kingdom. Thirty-eight patients were matched on the basis of clinical parameters into 19 pairs comprised of one U.S. and one United Kingdom patient. Analysis was performed to determine what, if any, bacterial correlates could be identified. Two culture-independent strategies were used: terminal restriction fragment length polymorphism (T-RFLP) profiling and 16S rRNA clone sequencing. Overall, 73 different terminal restriction fragment lengths were detected, ranging from 2 to 10 for U.S. and 2 to 15 for United Kingdom patients. The statistical analysis of T-RFLP data indicated that patient pairing was successful and revealed substantial transatlantic similarities in the bacterial communities. A small number of bands was present in the vast majority of patients in both locations, indicating that these are species common to the CF lung. Clone sequence analysis also revealed that a number of species not traditionally associated with the CF lung were present in both s le groups. The species number per s le was similar, but differences in species presence were observed between s le groups. Cluster analysis revealed geographical differences in bacterial presence and relative species abundance. Overall, the U.S. s les showed tighter clustering with each other compared to that of United Kingdom s les, which may reflect the lower ersity detected in the U.S. s le group. The impact of cross-infection and biogeography is considered, and the implications for treating CF lung infections also are discussed.
Publisher: Informa UK Limited
Date: 03-2011
DOI: 10.1586/ERM.10.117
Publisher: World Scientific Pub Co Pte Lt
Date: 06-2012
DOI: 10.1142/S1363919612400014
Abstract: Despite the attention it gives to innovation tools, the product innovation literature does not address the behavioural motivation behind practitioners' adoption of particular tools, or relate this to new venture development. This paper focuses on technology-based new ventures executing their first projects and presents insights into how their innovation tool adoption evolves over time. The paper synthesises case study findings into a hierarchy of tool adoption states encapsulating how new venture teams started with an exclusive focus on effectiveness, and over time progressively attended to problem solving, efficiency, and finally resource management. They often progressed to the next state only in response to costly mistakes and delays, whereas the experienced team in our comparison well-established firm operated within all four states from project initiation. Knowledge of this hierarchy of tool adoption states could help new venture teams to optimise the time they invest in product innovation tools.
Publisher: Expert Projects
Date: 06-03-2019
DOI: 10.33788/RCIS.64.5
Abstract: As they grow, companies that were once characterised as agile, innovative and entrepreneurial, tend to become bureaucratic and slow to respond to changes in their environments. In order to stay competitive and build competitive advantage, managers realise that they have to rejuvenate the entrepreneurial spirit and innovate on a sustainable basis, yet this remains a significant challenge for them. Our corporate entrepreneurship and innovation course for post-graduate studentscultivates and understanding of entrepreneurship and innovation in the context of established business. Its unique design, which follows a logical progression of data collection in real-life participating organizations through secondary and primary research, assures in-depth understanding of the factors that shape the current organizational profiles. Students, working in teams, draw on this data and entrepreneurship and innovation theory to develop practical corporate entrepreneurship development plans which they present to their ‘clients’. These plans reflect leadership orientation represented by entrepreneurial visions and strategies, as well as contextualised factors for control in the form of innovation processes and tools. Finally, teams recommend a range of tactics that foster supportive environments for entrepreneurship and innovation. In the process of doing so, students are themselves transformed from being traditional managers to becoming entrepreneurial managers.
Publisher: Routledge
Date: 17-01-2019
Publisher: Oxford University Press (OUP)
Date: 26-04-2013
DOI: 10.1093/CID/CIT270
Publisher: Routledge
Date: 17-01-2019
Publisher: Routledge
Date: 17-01-2019
Publisher: World Scientific Pub Co Pte Lt
Date: 06-2016
DOI: 10.1142/S1363919616400089
Abstract: Recognising the greater variety and sophistication of product innovation strategies to target existing and previously untapped markets, the author presents an extended version of the Ansoff product-market expansion grid that highlights the different approaches for developed world and emerging markets. The proposed model consists of seven distinct categories of growth options and depicts alternative strategic possibilities within each category, where appropriate. Categories that are new to the matrix include resource-constrained innovation, necessity innovation and reverse innovation. Necessity innovation is a new concept and a special case of user-innovation, defined as innovation by resource-constrained consumers in emerging markets to serve their own unmet needs. Utilising recent industry ex les from a variety of media, the author demonstrates the traits of each strategic approach to grow revenue streams through product-market innovation.
Publisher: Springer International Publishing
Date: 2021
Publisher: Public Library of Science (PLoS)
Date: 25-09-2013
Publisher: Springer Science and Business Media LLC
Date: 29-11-2012
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2016
Publisher: World Scientific Pub Co Pte Lt
Date: 31-05-2013
DOI: 10.1142/S1363919613400124
Abstract: In this paper, we present a qualitative, interview-based study of the processes small technology-based firms go through when they adopt tools and adapt them for use. By extracting 59 instances of tool internalisation across five firms, we derived a coding scheme combining existing and emergent forms of tool bricolage. The four types are reconstruction, reinterpretation, evolution, and customisation. We articulate ex les of each type. Our findings reinforce the variability of any given tool once enacted in practice, contrary to implied expectations in some innovation tools literature that tool application is a straightforward mechanical process. In the small firms in our study, we found reinterpretation is the most prevalent form of tool adaptation. This type of tool use is prone to being superficial and failing to gain the benefits available from a more carefully customised or reconstructed tool. We also report on the different ways in which practitioners gain awareness of new tools.
Publisher: SAGE Publications
Date: 07-2011
DOI: 10.2500/AJRA.2011.25.3628
Abstract: Chronic rhinosinusitis (CRS) with or without polyps is a common chronic upper airway condition of multifactorial origin. Fundamental to effective treatment of any infection is the ability to accurately characterize the underlying cause. Many studies have shown that only a small fraction of the total range of bacterial species present in CRS is detected through conventional culture-dependent techniques. Consequently, culture data are often unrepresentative of the true ersity of the microbial community within the s le. These drawbacks, along with the length of time required to complete the analysis, strongly support the development of alternative means of assessing which bacterial species are present. As such, molecular microbiological approaches that assess the content of clinical s les in a culture-independent manner could significantly enhance the range and quality of data obtained routinely from such s les. We aimed to characterize the bacterial ersity present in tissue and mucus s les taken from the CRS setting using molecular nonculture-dependent techniques. Through 16S ribosomal RNA (rRNA) gene clone sequencing and terminal restriction fragment length polymorphism (T-RFLP) analysis, the bacteria present in 70 clinical s les from 43 CRS patients undergoing endoscopic sinus surgery were characterized. Bacterial T-RFLP profiles were generated for 70 of 73 s les and a total of 48 separate bands were detected. Species belonging to 34 genera were identified as present by clone sequence analysis. Of the species detected, those within the genera Pseudomonas, Citrobacter, Haemophilus, Propionibacterium, Staphylococcus, and Streptococcus were found numerically dominant, with Pseudomonas aeruginosa the most frequently detected species. This study has validated the use of the culture-independent technique T-RFLP in sinonasal s les. Preliminary characterization of the microbial ersity in CRS suggests a complex range of common and novel bacterial species within the upper airway in CRS, providing further evidence for the polymicrobial etiology of CRS.
Publisher: Springer Science and Business Media LLC
Date: 09-12-2010
Publisher: AOSIS
Date: 07-12-2013
Abstract: The research aims to identify key success criteria for innovations by enterprises targeting the bottom of the pyramid. Innovation, social entrepreneurship and the bottom of the economic pyramid are defined in the light of academic literature and their varied criteria are explored. The two different academic opinions on fortune or opportunity existing in the BOP markets are also contrasted. The research philosophy is based on realism and the research methodology selected is inductive. The data have been collected through secondary sources using case study strategy to present four cases of innovations by social or corporate enterprises at the BOP. The case studies have been chosen from a variable range in terms of BOP countries, social enterprises and multinational companies, for-profit or not-for-profit organisations, and product or business model innovations. Success criteria identified from case studies in the light of academic literature include going beyond selling to the poor, considering BOP groups as producers and BOP engagement. A conceptual framework has been developed from identified criteria and further recommendations for empirically testing the framework to turn it into a model have been provided.
Publisher: Routledge
Date: 17-01-2019
Publisher: BMJ
Date: 06-04-2013
Publisher: David Publishing Company
Date: 28-01-2013
Publisher: World Scientific Pub Co Pte Ltd
Date: 05-2022
DOI: 10.1142/S1363919622500311
Abstract: Despite half a century’s extensive scholarly research in the decision-making process of in iduals around the adoption of new innovations, innovation practitioners are still not able to capitalise sufficiently on the existing knowledge base to successfully commercialise new products. Evidence of this stems from consumers’ continued rejection of new offerings at alarming rates. This makes the marketing of innovation, with a focus on influencing consumers’ decision-making process, one of the most challenging corporate challenges for new product managers. To address this gap, this paper sequentially applies a systematic literature review (SLR), followed by extensive descriptive and bibliometric analyses, to reveal and assess the current state of knowledge in this field. Furthermore, the analysis identifies six prominent future research paths that could fill identified gaps in knowledge. Using the results of the bibliometric section, practitioners can pinpoint specific research areas of interest, enabling them to access and utilise findings from past studies more effectively.
Publisher: Wiley
Date: 06-2008
Publisher: BMJ
Date: 19-11-2012
Publisher: Elsevier BV
Date: 06-2013
Publisher: Elsevier BV
Date: 05-2013
Location: South Africa
No related grants have been discovered for Gerrit Anton de Waal.