ORCID Profile
0000-0002-8757-8256
Current Organisations
Brigham and Women's Hospital
,
Chengdu University
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Publisher: Elsevier BV
Date: 05-2016
Publisher: Springer Science and Business Media LLC
Date: 09-06-2021
DOI: 10.1038/S41467-021-23595-X
Abstract: In brown adipose tissue, thermogenesis is suppressed by thioesterase superfamily member 1 (Them1), a long chain fatty acyl-CoA thioesterase. Them1 is highly upregulated by cold ambient temperature, where it reduces fatty acid availability and limits thermogenesis. Here, we show that Them1 regulates metabolism by undergoing conformational changes in response to β-adrenergic stimulation that alter Them1 intracellular distribution. Them1 forms metabolically active puncta near lipid droplets and mitochondria. Upon stimulation, Them1 is phosphorylated at the N-terminus, inhibiting puncta formation and activity and resulting in a diffuse intracellular localization. We show by correlative light and electron microscopy that Them1 puncta are biomolecular condensates that are inhibited by phosphorylation. Thus, Them1 forms intracellular biomolecular condensates that limit fatty acid oxidation and suppress thermogenesis. During a period of energy demand, the condensates are disrupted by phosphorylation to allow for maximal thermogenesis. The stimulus-coupled reorganization of Them1 provides fine-tuning of thermogenesis and energy expenditure.
Publisher: American Chemical Society (ACS)
Date: 10-04-2020
Publisher: Elsevier BV
Date: 12-2021
Publisher: Springer Science and Business Media LLC
Date: 08-12-2015
Publisher: Elsevier BV
Date: 12-2015
Publisher: Society of Exploration Geophysicists
Date: 11-2017
Abstract: Calibration of 3C vertical seismic profile (VSP) data is an exciting challenge because the orientation of the tool is random when only seismic data are considered. We have augmented the sensor package on the VSP tool with micro-electro-mechanical system (MEMS) inertial sensors and applied a gesture measuring method to determine the tool orientation and calibration. This technique can quickly produce high precision, orientation, and angle information when integrated with the seismometer. The augmented sensor package consists of a low-cost triaxial MEMS gyroscope, an electronic compass, and an accelerometer. The technique to process the gesture information is based on the OpenGL software for 3D modeling. We have tested this approach on a large number of field data sets and it appeared to be faster and more reliable than other approaches.
Publisher: Elsevier BV
Date: 2018
No related grants have been discovered for Jérémie Courtois.