ORCID Profile
0000-0002-1861-1737
Current Organisations
Swiss Tropical and Public Health Institute
,
Universiteit Utrecht
,
Klinikum der Johann Wolfgang Goethe-Universität Frankfurt Zentrum der Chirurgie
,
Klinikum der Johann Wolfgang Goethe-Universität Frankfurt
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Publications
“Race for the Surface”: Eukaryotic Cells Can Win
Publisher: American Chemical Society (ACS)
Date: 16-08-2016
Abstract: With an aging population and the consequent increasing use of medical implants, managing the possible infections arising from implant surgery remains a global challenge. Here, we demonstrate for the first time that a precise nanotopology provides an effective intervention in bacterial cocolonization enabling the proliferation of eukaryotic cells on a substratum surface, preinfected by both live Gram-negative, Pseudomonas aeruginosa, and Gram-positive, Staphylococcus aureus, pathogenic bacteria. The topology of the model black silicon (bSi) substratum not only favors the proliferation of eukaryotic cells but is biocompatible, not triggering an inflammatory response in the host. The attachment behavior and development of filopodia when COS-7 fibroblast cells are placed in contact with the bSi surface are demonstrated in the dynamic study, which is based on the use of real-time sequential confocal imaging. Bactericidal nanotopology may enhance the prospect for further development of inherently responsive antibacterial nanomaterials for bionic applications such as prosthetics and implants.
Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces
Publisher: MDPI AG
Date: 14-04-2018
DOI: 10.3390/MA11040605
Health in the 2030 Agenda for Sustainable Development: from framework to action, transforming challenges into opportunities
Publisher: International Global Health Society
Date: 25-08-2019
Adsorption of Human Plasma Albumin and Fibronectin onto Nanostructured Black Silicon Surfaces
Publisher: American Chemical Society (ACS)
Date: 10-10-2016
DOI: 10.1021/ACS.LANGMUIR.6B02601
Abstract: The protein adsorption of two human plasma proteins-albumin (Alb) and fibronectin (Fn)-onto synthetic nanostructured bactericidal material-black silicon (bSi) surfaces (that contain an array of nanopillars) and silicon wafer (nonstructured) surfaces-was investigated. The adsorption behavior of Alb and Fn onto two types of substrata was studied using a combination of complementary analytical techniques. A two-step Alb adsorption mechanism onto the bSi surface has been proposed. At low bulk concentrations (below 40 μg/mL), the Alb preferentially adsorbed at the base of the nanopillars. At higher bulk concentrations, the Alb adsorbed on the top of the nanopillars. In the case of Fn, the protein preferentially adsorbed on the top of the nanopillars, irrespective of its bulk concentration.
Related Organisations
Klinikum Der Johann Wolfgang Goethe-Universität Frankfurt Zentrum Der Chirurgie
Location: Germany
Klinikum Der Johann Wolfgang Goethe-Universität Frankfurt
Location: Germany
Related Funding Activities
No related grants have been discovered for Samuel Fuhrimann.