ORCID Profile
0000-0002-9920-4358
Current Organisation
Tehran University of Medical Sciences
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Publisher: Walter de Gruyter GmbH
Date: 03-2009
DOI: 10.2478/V10007-009-0008-9
Abstract: [ 61 Cu]diacetyl- bis (N 4 -methylthiosemicarbazone) ([ 61 Cu] ATSM) was prepared using in house-made diacetyl- bis (N 4 -methylthiosemicarbazone) (ATSM) ligand and [ 61 Cu]CuCl 2 produced via the nat Zn(p, x) 61 Cu (180 μA proton irradiation, 22 MeV, 3.2 h) and purified by a ion chromatography method. [ 61 Cu]ATSM radiochemical purity was %, as shown by HPLC and RTLC methods. [ 61 Cu]ATSM was administered into normal and tumor bearing rodents for up to 210 minutes, followed by biodistribution and co-incidence imaging studies. Significant tumor/non-tumor accumulation was observed either by animal sacrification or imaging. [ 61 Cu]ATSM is a positron emission tomography (PET) radiotracer for tumor hypoxia imaging.
Publisher: Informa UK Limited
Date: 02-07-2020
Publisher: Springer Science and Business Media LLC
Date: 03-2009
Publisher: Walter de Gruyter GmbH
Date: 07-2008
Abstract: β-1–24-corticotrophin was successively labeled with [ 67 Ga]-gallium chloride after residulation with freshly prepared cyclic DTPA-dianhydride. The best results of the conjugation were obtained by the addition of 1 ml of a β-1–24-corticotrophin pharmaceutical solution (1 mg/mL, pH=6.5) to a glass tube pre-coated with DTPA-dianhydride (0.01 mg) at 25 °C with continuous mild stirring for 30 min. Radio-thin layer chromatography showed an overall radiochemical purity of % at optimized conditions after labeling. HPLC showed a radiochemical purity more than 95% (specific activity =300–500 MBq/mg, labeling efficiency 77%). The stability of the radioconjugate was tested in presence of human serum at 37 °C. Preliminary in vivo studies in normal rats were performed to determine the biodistribution of the radioimmunoconjugate up to 30 min. Lungs showed to have the major tracer uptake which is consistent with the natural distribution of ACTH receptors in human body. Pretreatment of animals with cold peptide following labeled compound administration reduced lung uptake at least 10 and 3 times after 15 and 30 min, respectively, as well as significant decrease in adrenal uptake after 15 min. These data support the specific receptor binding of the radiolabeled compound. This tracer can be used in detection of ACTH receptor in lung and adrenal malignancies.
Publisher: Springer Science and Business Media LLC
Date: 03-06-2008
Publisher: MDPI AG
Date: 2009
Publisher: Springer Science and Business Media LLC
Date: 07-2006
Publisher: MDPI AG
Date: 2008
Publisher: Walter de Gruyter GmbH
Date: 2010
Location: Iran (Islamic Republic of)
Location: Iran (Islamic Republic of)
No related grants have been discovered for Mehdi Akhlaghi.