ORCID Profile
0000-0002-8826-681X
Current Organisation
Augusta University
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Publisher: SAGE Publications
Date: 2022
DOI: 10.1177/14799731221121670
Abstract: The roles of physical activity (PA) and exercise within the management of cystic fibrosis (CF) are recognised by their inclusion in numerous standards of care and treatment guidelines. However, information is brief, and both PA and exercise as multi-faceted behaviours require extensive stakeholder input when developing and promoting such guidelines. On 30 th June and 1 st July 2021, 39 stakeholders from 11 countries, including researchers, healthcare professionals and patients participated in a virtual conference to agree an evidence-based and informed expert consensus about PA and exercise for people with CF. This consensus presents the agreement across six themes: (i) patient and system centred outcomes, (ii) health benefits, iii) measurement, (iv) prescription, (v) clinical considerations, and (vi) future directions. The consensus was achieved by a stepwise process, involving: (i) written evidence-based synopses (ii) peer critique of synopses (iii) oral presentation to consensus group and peer challenge of revised synopses and (iv) anonymous voting on final proposed synopses for adoption to the consensus statement. The final consensus document includes 24 statements which surpassed the consensus threshold ( % agreement) out of 30 proposed statements. This consensus can be used to support health promotion by relevant stakeholders for people with CF.
Publisher: American Thoracic Society
Date: 02-2018
Publisher: American Physiological Society
Date: 2011
DOI: 10.1152/AJPHEART.00471.2010
Abstract: Endothelial dysfunction is now considered an important early event in the development of atherosclerosis, which precedes gross morphological signs and clinical symptoms. The assessment of flow-mediated dilation (FMD) was introduced almost 20 years ago as a noninvasive approach to examine vasodilator function in vivo. FMD is widely believed to reflect endothelium-dependent and largely nitric oxide-mediated arterial function and has been used as a surrogate marker of vascular health. This noninvasive technique has been used to compare groups of subjects and to evaluate the impact of interventions within in iduals. Despite its widespread adoption, there is considerable variability between studies with respect to the protocols applied, methods of analysis, and interpretation of results. Moreover, differences in methodological approaches have important impacts on the response magnitude, can result in spurious data interpretation, and limit the comparability of outcomes between studies. This review results from a collegial discussion between physiologists with the purpose of developing considered guidelines. The contributors represent several distinct research groups that have independently worked to advance the evidence base for improvement of the technical approaches to FMD measurement and analysis. The outcome is a series of recommendations on the basis of review and critical appraisal of recent physiological studies, pertaining to the most appropriate methods to assess FMD in humans.
Publisher: American Physiological Society
Date: 02-2011
No related grants have been discovered for Ryan Harris.