ORCID Profile
0000-0002-1155-5728
Current Organisation
Hong Kong University of Science and Technology
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Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2BM00705C
Abstract: To overcome the endosomal barrier, we attached a fusogenic peptide (L17E) onto peptide self-assembled disks, which mimicked the functional subunits of the virus capsid and improved transfection efficiency.
Publisher: American Chemical Society (ACS)
Date: 25-10-2017
Abstract: The catalytic performance of Pd-based catalysts has long been hindered by surface contamination, particle agglomeration, and lack of rational structural design. Here we report a simple adsorption method for rapid synthesis (∼90 s) of structure-optimized Pd alloy supported on nitrogen-doped carbon without the use of surfactants or extra reducing agents. The material shows much lower overpotential than 30 wt % Pd/C and 40 wt % Pt/C catalysts while exhibiting excellent durability (80 h). Moreover, unveiled by the density functional theory (DFT) calculation results, the underlying reason for the outstanding performance is that the PdMnCo alloy yridinic nitrogen-doped carbon interfaces weaken the hydrogen-adsorption energy on the catalyst and thus optimize the Gibbs free energy of the intermediate state (ΔG
Publisher: Wiley
Date: 06-10-2021
Abstract: Aromatic residues are widely used as building blocks for driving self‐assemblies in natural and designer biomaterials. The noncovalent interactions involving aromatic rings determine proteins’ structure and biofunction. Here, we studied the effects of changes in the proximity of the aromatic rings in a self‐assembling peptide for modulating interactions involving the aromatic residues. By changing the distance between the aromatic ring and peptide backbone and replacing the side chain with a sulfur atom, we altered the nanostructures and gene transfection efficiency of peptide‐DNA co‐assemblies. This study demonstrates the significance of subtle alterations in aromatic interactions and facilitates deeper understanding of the aromatic‐involving interactions.
Publisher: American Chemical Society (ACS)
Date: 21-06-2022
Abstract: Broadening the applicable tools for mRNA delivery provides more flexibility in research and those proven effective and safe can potentially be translated for clinical use. We report here a 27-amino acid peptide sequence mimicking the viral capsid protein, termed pepMAX, capable of co-assembling with mRNA into 100-150 nm nanostructures for efficient transfection of multiple cell lines. The mRNA loading and N/P ratio have been systematically optimized for each cell line. In HeLa, HEK293, and SKNMC, the transfection attained (>80%) is comparable with that of commercially available vectors Lipofectamine MessengerMAX
Publisher: American Chemical Society (ACS)
Date: 22-01-2018
Abstract: Phothermal therapy has received increasing attention in recent years as a potentially effective way to treat cancer. In pursuit of a more biocompatible photothermal agent, we utilize biosafe materials including ellagic acid (EA), polyvinylpyrrolidone (PVP), and iron element as building blocks, and we successfully fabricate a homogeneous nanosized Fe-EA framework for the first time by a facile method. As expected, the novel nanoagent exhibits no obvious cytotoxicity and good hemocompatibility in vitro and in vivo. The microenvironment responsiveness to both pH and hydrogen peroxide makes the NPs biodegradable in tumor tissues, and the framework should be easily cleared by the body. Photothermal potentials of the nanoparticles are demonstrated with relevant features of strong NIR light absorption, moderately effective photothermal conversion efficiency, and good photothermal stability. The in vivo photothermal therapy also achieved effective tumor ablation with no apparent toxicity. On the other hand, it also exhibits T2 MR imaging ability originated from ferric ions. Our work highlights the promise of the Fe-EA framework for imaging-guided photothermal therapy.
Publisher: MDPI AG
Date: 09-07-2019
DOI: 10.3390/LIFE9030059
Abstract: The discovery of the genetic roots of various human diseases has motivated the exploration of different exogenous nucleic acids as therapeutic agents to treat these genetic disorders (inherited or acquired). However, the physicochemical properties of nucleic acids render them liable to degradation and also restrict their cellular entrance and gene translation/inhibition at the correct cellular location. Therefore, gene condensation rotection and guided intracellular trafficking are necessary for exogenous nucleic acids to function inside cells. Diversified cationic formulation materials, including natural and synthetic lipids, polymers, and proteins eptides, have been developed to facilitate the intracellular transportation of exogenous nucleic acids. The chemical properties of different formulation materials determine their special features for nucleic acid delivery, so understanding the property–function correlation of the formulation materials will inspire the development of next-generation gene delivery carriers. Therefore, in this review, we focus on the chemical properties of different types of formulation materials and discuss how these formulation materials function as protectors and cellular pathfinders for nucleic acids, bringing them to their destination by overcoming different cellular barriers.
Publisher: Elsevier BV
Date: 06-2022
Publisher: American Chemical Society (ACS)
Date: 23-08-2018
Publisher: American Chemical Society (ACS)
Date: 17-02-2023
No related grants have been discovered for Ruilu Feng.