ORCID Profile
0000-0001-5180-6870
Current Organisation
LEO Pharma
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: American Chemical Society (ACS)
Date: 04-2021
Publisher: Elsevier BV
Date: 2014
DOI: 10.1016/J.MEATSCI.2013.08.025
Abstract: The effects of diacylglycerols (DAG), pork back fat and sunflower oil on water and fat mobility in fermented sausages were studied with (1)H NMR relaxometry. The added fat affected the physicochemical parameters weight loss, water activity, moisture content and moisture content on a defatted-dry-matter basis of reduced-fat non-acid fermented sausages. The weight losses were the lowest in sausages prepared with DAG and sunflower oil, which resulted in higher water activity compared to sausages prepared with back fat. The relaxation times related to fat mobility differed between fat types and increased in the order: control<DAG<back fat<sunflower oil. The differences in fat mobility were ascribed to differences in the fat distribution caused by deviations in the physicochemical properties of the fat types.
Publisher: Portland Press Ltd.
Date: 24-07-2019
DOI: 10.1042/BJ20141243
Abstract: Class 1 cytokine receptors regulate essential biological processes through complex intracellular signalling networks. However, the structural platform for understanding their functions is currently incomplete as structure–function studies of the intracellular domains (ICDs) are critically lacking. The present study provides the first comprehensive structural characterization of any cytokine receptor ICD and demonstrates that the human prolactin (PRL) receptor (PRLR) and growth hormone receptor (GHR) ICDs are intrinsically disordered throughout their entire lengths. We show that they interact specifically with hallmark lipids of the inner plasma membrane leaflet through conserved motifs resembling immuno receptor tyrosine-based activation motifs (ITAMs). However, contrary to the observations made for ITAMs, lipid association of the PRLR and GHR ICDs was shown to be unaccompanied by changes in transient secondary structure and independent of tyrosine phosphorylation. The results of the present study provide a new structural platform for studying class 1 cytokine receptors and may implicate the membrane as an active component regulating intracellular signalling.
Publisher: Springer Science and Business Media LLC
Date: 11-03-2015
Publisher: Elsevier BV
Date: 03-2019
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Flemming Hofmann Larsen.