ORCID Profile
0000-0003-4769-441X
Current Organisations
University of Oxford, Wadham College
,
University of Oxford
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Publisher: Oxford University Press (OUP)
Date: 24-04-2019
DOI: 10.1104/PP.18.01458
Publisher: Wiley
Date: 09-03-2017
DOI: 10.1111/NPH.14519
Publisher: Springer Science and Business Media LLC
Date: 05-2019
DOI: 10.1038/S41586-019-1203-6
Abstract: Complex multicellular organisms evolved on Earth in an oxygen-rich atmosphere
Publisher: Proceedings of the National Academy of Sciences
Date: 31-08-2020
Abstract: The plant cysteine oxidases (PCOs) have been identified as oxygen-sensing enzymes in plants, controlling hypoxia-dependent processes, including adaptive responses to flooding. As such, they are potential targets for engineering plants with enhanced flood tolerance. To approach this in a rational manner requires an understanding of how PCO structure relates to their ability to trigger hypoxic adaptation. We report the structures of two PCOs from Arabidopsis and show that the effects of mutagenesis of key amino acids at their active site are seen both in vitro and, importantly, in planta. This work provides a platform for further efforts to manipulate PCO structure and function to improve the ability of crops to withstand future climate extremes.
Publisher: American Association for the Advancement of Science (AAAS)
Date: 05-07-2019
Abstract: The ability to sense and respond to changes in oxygen levels is critical for most forms of life. To date, mechanistic studies of this process in mammals have focused on the oxygen-sensitive stability of a transcription factor called hypoxia-inducible factor. Masson et al. discovered an enzymatic oxygen sensor in humans that is functionally identical to plant cysteine oxidases, enzymes that control responses to hypoxia in plants. The human and plant enzymes convert the N-terminal cysteine in substrate proteins to cysteine sulfinic acid, a modification that ultimately targets the proteins for degradation. Oxygen sensing is impaired in many human diseases, and further study of the human enzyme could help in the development of strategies for therapeutic intervention. Science , this issue p. 65
Location: United Kingdom of Great Britain and Northern Ireland
Location: Italy
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Francesco Licausi.