ORCID Profile
0000-0002-6058-3549
Current Organisations
University of Adelaide Roseworthy Campus
,
University of Adelaide
,
South Australian Health and Medical Research Institute Limited
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Publisher: BMJ
Date: 04-2022
DOI: 10.1136/BMJOPEN-2020-045908
Abstract: Transient ischaemic attack (TIA) may be a warning sign of stroke and difficult to differentiate from minor stroke and TIA-mimics. Urgent evaluation and diagnosis is important as treating TIA early can prevent subsequent strokes. Recent improvements in mass spectrometer technology allow quantification of hundreds of plasma proteins and lipids, yielding large datasets that would benefit from different approaches including machine learning. Using plasma protein, lipid and radiological biomarkers, our study will develop predictive algorithms to distinguish TIA from minor stroke (positive control) and TIA-mimics (negative control). Analysis including machine learning employs more sophisticated modelling, allowing non-linear interactions, adapting to datasets and enabling development of multiple specialised test-panels for identification and differentiation. Patients attending the Emergency Department, Stroke Ward or TIA Clinic at the Royal Adelaide Hospital with TIA, minor stroke or TIA-like symptoms will be recruited consecutively by staff-alert for this prospective cohort study. Advanced neuroimaging will be performed for each participant, with images assessed independently by up to three expert neurologists. Venous blood s les will be collected within 48 hours of symptom onset. Plasma proteomic and lipid analysis will use advanced mass spectrometry (MS) techniques. Principal component analysis and hierarchical cluster analysis will be performed using MS software. Output files will be analysed for relative biomarker quantitative differences between the three groups. Differences will be assessed by linear regression, one-way analysis of variance, Kruskal-Wallis H-test, χ 2 test or Fisher’s exact test. Machine learning methods will also be applied including deep learning using neural networks. Patients will provide written informed consent to participate in this grant-funded study. The Central Adelaide Local Health Network Human Research Ethics Committee approved this study (HREC/18/CALHN/384 R20180618). Findings will be disseminated through peer-reviewed publication and conferences data will be managed according to our Data Management Plan (DMP2020-00062).
Publisher: Wiley
Date: 30-05-2021
DOI: 10.1111/AVJ.13079
Abstract: Tongue‐ties (TTs) are used to aid control and aim to conservatively treat upper airway disorders in racehorses. However, welfare concerns have led to their use being banned in other equestrian disciplines. In the United Kingdom, TTs have been reported to be used in approximately 5% of starts. The frequency of their use elsewhere is unknown. The objectives of this retrospective single cohort study were to estimate the frequency of TT use within the Australian Thoroughbred (TB) racing industry, and to describe usage patterns. Data of all Australian TB horse races from 2010 to 2013 calendar years were collected by accessing the Racing Information Services Australia database. Frequency of TT use was calculated, and usage patterns were explored at the start, horse and trainer levels. Between 2010 and 2013, there were a total of 728,678 starts from 62,377 horses prepared by 4927 trainers and that raced on 1453 race dates across 402 venues. Tongue‐ties were used in 21.4% of starts however, frequency varied according to location, race, trainer and horse. At the horse level, 32.2% wore a TT at least once and 7.6% wore it at every race on record. At the trainer level, 71.3% used TTs in at least one of their horses but only 1.4% used them systematically. The present study concludes that TT use in Australian TB racehorses, during the period 2010–2013, was common and considerably higher than previously reported in the United Kingdom. Most Australian trainers use the device and appear to adapt its usage according to in idual horse and race factors.
Publisher: Wiley
Date: 06-10-2021
DOI: 10.1111/EVJ.13511
Abstract: Standing flank laparotomy can be an alternative to ventral midline laparotomy in horses with colic. Standing flank laparotomy avoids general anaesthesia, provides excellent access to some regions of the abdominopelvic cavity and costs less than ventral midline laparotomy. To report a series of cases of peritoneal and intestinal diseases other than SC diseases managed with standing flank laparotomy. Retrospective case series. Records from equids with colic subjected to standing flank laparotomy at five hospitals (2003‐2020) were reviewed. Descriptive data analysis was performed. Thirty horses (sixteen survived to discharge), six ponies (four survived) and one donkey (euthanised) were subjected to standing flank laparotomy via the left flank (n = 31), right flank (n = 2) or both flanks (n = 4). The primary disease affected the peritoneum (0/5 survived), SI (5/9 survived) and caecum and/or LC (15/23 survived). Enterotomy was performed in four animals (all survived). Partial typhlectomy was performed in one horse (euthanised). Resection‐anastomosis of the SI or LC was performed in three animals (one survived). Three animals had intraoperative complications that negatively affected the outcome: Two ponies had intolerance to abdominopelvic exploration one mare had spontaneous exteriorisation of a long segment of the SI leading to a large tear in the mesentery. In seven cases, severe/extensive lesions found during standing flank laparotomy warranted immediate euthanasia. The survival rate was 54%. All owners were satisfied with the decision to perform standing flank laparotomy. The retrospective design, lack of a control group, small number of cases and lack of standardised protocols between hospitals. Although ventral midline laparotomy is the standard of care for horses with colic, standing flank laparotomy is a viable approach for some types of colic. Systemic administration of analgesics may not produce sufficient peritoneal analgesia, which can lead to intolerance to abdominopelvic exploration during standing flank laparotomy in horses with colic and may negatively affect the outcome.
Location: United States of America
Location: Australia
No related grants have been discovered for Erik Noschka.