ORCID Profile
0000-0002-7191-2002
Current Organisations
Northumbria University
,
Ocean University of China
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7RA12063J
Abstract: Three epipolythiodioxopiperazines with two new ones were isolated from a marine-derived fungus, and all of them exhibited extensive cytotoxicity.
Publisher: MDPI AG
Date: 22-09-2022
DOI: 10.3390/MD20100593
Abstract: Chemical investigation of the psychrophilic fungus Pseudogymnoascus sp. HDN17-933 derived from Antarctica led to the discovery of six new tetrapeptides psegymamides A–F (1–6), whose planar structures were elucidated by extensive NMR and MS spectrometric analyses. Structurally, psegymamides D–F (4–6) possess unique backbones bearing a tetrahydropyridoindoles unit, which make them the first ex les discovered in naturally occurring peptides. The absolute configurations of structures were unambiguously determined using solid-phase total synthesis assisted by Marfey’s method, and all compounds were evaluated for their inhibition of human (h) nicotinic acetylcholine receptor subtypes. Compound 2 showed significant inhibitory activity. A preliminary structure–activity relationship investigation revealed that the tryptophan residue and the C-terminal with methoxy group were important to the inhibitory activity. Further, the high binding affinity of compound 2 to hα4β2 was explained by molecular docking studies.
Publisher: Wiley
Date: 02-2010
Publisher: Wiley
Date: 27-05-2015
Publisher: American Chemical Society (ACS)
Date: 10-06-2020
Publisher: Informa UK Limited
Date: 09-2009
Location: United Kingdom of Great Britain and Northern Ireland
Location: United States of America
No related grants have been discovered for Dehai Li.