ORCID Profile
0000-0002-4546-2976
Current Organisation
Federal University of Ceara
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Publisher: Springer Science and Business Media LLC
Date: 20-11-2019
DOI: 10.1038/S41598-019-53533-3
Abstract: C ylobacter species infections have been associated with malnutrition and intestinal inflammation among children in low-resource settings. However, it remains unclear whether that association is specific to C ylobacter jejuni/coli . The aim of this study was to assess the association between both all C ylobacter species infections and C ylobacter jejuni/coli infections on growth and enteric inflammation in children aged 1–24 months. We analyzed data from 1715 children followed from birth until 24 months of age in the MAL-ED birth cohort study, including detection of C ylobacter species by enzyme immunoassay and C ylobacter jejuni/coli by quantitative PCR in stool s les. Myeloperoxidase (MPO) concentration in stool, used as a quantitative index of enteric inflammation, was measured. The incidence rate per 100 child-months of infections with C ylobacter jejuni/coli and C ylobacter species during 1–24 month follow up were 17.7 and 29.6 respectively. Female sex of child, shorter duration of exclusive breastfeeding, lower maternal age, mother having less than 3 living children, maternal educational level of years, lack of routine treatment of drinking water, and unimproved sanitation were associated with C ylobacter jejuni/coli infection. The cumulative burden of both C ylobacter jejuni/coli infections and C ylobacter species were associated with poor growth and increased intestinal inflammation.
Publisher: Elsevier BV
Date: 10-2017
Publisher: Elsevier BV
Date: 05-2021
Publisher: Cold Spring Harbor Laboratory
Date: 24-01-2022
DOI: 10.1101/2022.01.23.22269711
Abstract: We adopted the reverse transcriptase - loop mediated isothermal lification (RT-LAMP) to detect SARS-Cov-2 in patient s les. Two primer sets for genes N and Orf1ab were designed to detect SARS-CoV-2, and one primer set was designed to detect the human gene Actin . We collected prospective 138 nasopharyngeal swabs, 70 oropharyngeal swabs, 69 saliva, and 68 mouth saline wash s les from patients suspected to have severe acute respiratory syndrome (SARS) caused by SARS-CoV-2 to test the RT-LAMP in comparison with the golden standard technique RT-qPCR. Accuracy of diagnosis using both primers, N5 and Orf9, was evaluated. Sensitivity and specificity for diagnosis was 96% (95% CI 87-99) and 85% (95% CI 76-91) in 138 s les, respectively. Accurate diagnosis results were obtained only in nasopharyngeal swab processed via extraction kit. Accurate and rapid diagnosis could aid COVID-19 pandemic management by identifying, isolating, and treating patients rapidly. New nucleic acid lification test for the diagnosis of SARS-CoV-2 using the RT-LAMP N5 primer set showed mutations in strains of interest, such as the gamma strain (P.1) of SARS-CoV-2 When evaluated in combination N5 and Orf9 primer sets maintained high sensitivity and specificity
Publisher: Wiley
Date: 20-05-2022
DOI: 10.1002/JMV.27842
Abstract: We adopted the reverse‐transcriptase‐loop‐mediated isothermal lification (RT‐LAMP) to detect severe acute respiratory syndrome coronavirus 2 (SARS‐Cov‐2) in patient s les. Two primer sets for genes N and Orf1ab were designed to detect SARS‐CoV‐2, and one primer set was designed to detect the human gene Actin . We collected prospective 138 nasopharyngeal swabs, 70 oropharyngeal swabs, 69 salivae, and 68 mouth saline wash s les from patients suspected to have severe acute respiratory syndrome (SARS) caused by SARS‐CoV‐2 to test the RT‐LAMP in comparison with the gold standard technique reverse‐transcription quantitative polymerase chain reaction (RT‐qPCR). The accuracy of diagnosis using both primers, N5 and Orf9, was evaluated. Sensitivity and specificity for diagnosis were 96% (95% confidence interval [CI]: 87–99) and 85% (95% CI: 76–91) in 138 s les, respectively. Accurate diagnosis results were obtained only in nasopharyngeal swabs processed via extraction kit. Accurate and rapid diagnosis could aid coronavirus disease 2019 (COVID‐19) pandemic management by identifying, isolating, and treating patients rapidly.
No related grants have been discovered for Alexandre Havt.