ORCID Profile
0000-0002-0824-7716
Current Organisations
CSIRO Clayton
,
CSIRO
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Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0NJ03425H
Abstract: Docetaxel (DTX) is a widely used chemotherapy drug that is associated with numerous side effects and limited bioavailability. We show synthetic copolymer conjugates of docetaxel with drug loading up to 20% and assess their efficacy in MCF-7 cells.
Publisher: Wiley
Date: 11-06-2020
Publisher: American Association for the Advancement of Science (AAAS)
Date: 03-01-2020
Abstract: We report expansion-tolerant architectures in ultrahigh-loading sulfur cathodes inspired by particle agglomeration theories.
Publisher: Elsevier BV
Date: 04-2022
DOI: 10.1016/J.ACTBIO.2022.02.002
Abstract: The invaluable health, economic and social impacts of vaccination are hard to exaggerate. The ability to stabilize vaccines is urgently required for their equitable distribution without the dependence on the 'cold-chain' logistics. Herein, for the first time we report biomimetic-mineralization of live-viral vaccines using metal-organic frameworks (MOFs) to enhance their storage stability from days to months. Applying ZIF-8 and aluminium fumarate (Alfum), the Newcastle Disease Virus (NDV) V4 strain and Influenza A WSN strain were encapsulated with remarkable retention of their viral titre. The ZIF-8@NDV, ZIF-8@WSN and Alfum@WSN composites were validated for live-virus recovery using a tissue culture infectious dose (TCID
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1TC00407G
Abstract: Combining the MOF biomimetic mineralisation of enzymes with electrochemical sensing, an ultra-stable proof-of-concept biosensor with a clinically relevant wide linear range of 1–10 mM glucose and a detection limit of 0.05 mM is fabricated.
Publisher: Wiley
Date: 06-2023
Abstract: A zeolitic imidazolate framework (ZIF‐8) containing two enzymes that form a cascade biocatalyst has been integrated with 3D structures that are fabricated through a two‐photon polymerization using direct laser writing lithography. Glucose oxidase (GOx) and horseradish peroxidase (HRP) are encapsulated by the biomimetic self‐assembly process of ZIF‐8 to form the GOx/HRP/ZIF‐8 composite which grows in situ on the surface of microprinted carbon‐coated hexagonal substrates (cHS). The GOx/HRP/ZIF‐8/cHS film is applied to glucose detection through enzymatic oxidation of glucose to gluconic acid, forming H 2 O 2 , in the presence of GOx and the subsequent reduction of H 2 O 2 to water in the presence of HRP and Amplex Red. This reaction is monitored using fluorimetry as the oxidation of Amplex Red with H 2 O 2 catalyzed by HRP forms red‐emitting resorufin. The GOx/HRP/ZIF‐8/cHS film responds to glucose concentrations with a linear range of 10–200 µ m , which correlates to the salivary glucose level in healthy humans. The GOx/HRP/ZIF‐8/cHS film shows more than eight times and 13 times enhanced activity than GOx/HRP/cHS (without ZIF‐8) and GOx/HRP/ZIF‐8 on a non‐3D patterned substrate, respectively. The GOx/HRP/ZIF‐8/cHS film retains more than 80% or 100% of its initial activity after being stored for over 2 months at ≤24 or 4 °C, respectively.
Publisher: Wiley
Date: 19-09-2022
Publisher: Wiley
Date: 04-08-2022
Abstract: Per‐ and polyfluoroalkyl substances (PFAS) are a group of recalcitrant molecules that have been used since the 1940s in a variety of applications. They are now linked to a host of negative health outcomes and are extremely resistant to degradation under environmental conditions. Currently, membrane technologies or adsorbents are used to remediate contaminated water. These techniques are either inefficient at capturing smaller PFAS molecules, have high energy demands, or result in concentrated waste that must be incinerated at high temperatures. This Review focuses on what role metal‐organic frameworks (MOFs) may play in addressing the PFAS problem. Specifically, how the unique properties of MOFs such as their well‐defined pore sizes, ultra‐high internal surface area, and tunable surface chemistry may be a sustainable solution for PFAS contamination.
Location: Australia
No related grants have been discovered for Ruhani Singh.