ORCID Profile
0000-0001-8977-8131
Current Organisation
Universidade Federal de Minas Gerais
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Publisher: Wiley
Date: 21-07-2022
DOI: 10.1111/DMCN.15345
Abstract: To identify the standardized assessment scales for people with muscular dystrophy and investigate the quality/level of evidence of their measurement properties. A systematic review of patient‐reported outcome measures was conducted on the MEDLINE, Embase, AMED, DiTA, and PsycINFO databases in August 2020. We included psychometric studies that investigated the validity, reliability, and responsiveness of instruments assessing activity and participation for muscular dystrophy of any type (Duchenne, Becker, limb‐girdle, facioscapulohumeral, congenital, and myotonic) or age. Two independent reviewers selected the studies, extracted data, and evaluated the instruments' quality and level of evidence following the COnsensus‐based Standards for the selection of health status Measurement INstruments (COSMIN) checklist. The study followed the Preferred Reporting Items for Systematic reviews and Meta‐Analysis (PRISMA) 2020 guidelines. The searches identified 6675 references a total of 46 studies with 28 condition‐specific or general instruments were included. The measurement properties of most instruments had sufficient (68.8%) or indeterminate (25.7%) results according to COSMIN. The quality of evidence of the measurement properties was moderate (23.8%) or low (22.6%) according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). There is a lack of high‐quality instruments whose psychometric properties are adequately measured. The highest quality instrument is the Muscular Dystrophy Functional Rating Scale. The Motor Function Measure (general instrument), Duchenne Muscular Dystrophy Upper‐limb Patient‐reported Outcome Measure, North Star Ambulatory Assessment, and Myotonic Dystrophy Type 1 Activity and Participation Scale for Clinical Use (specific) are also recommended. There are 28 available instruments for activity and participation of people with muscular dystrophy. The evidence quality is moderate or low because of imprecision and indirectness. The Muscular Dystrophy Functional Rating Scale is the highest quality instrument. The Motor Function Measure is the second most recommended instrument. The Duchenne Muscular Dystrophy Upper‐limb Patient‐reported Outcome Measure, North Star Ambulatory Assessment, and Myotonic Dystrophy Type 1 Activity and Participation Scale for Clinical Use are also recommended.
Publisher: American Physiological Society
Date: 2019
DOI: 10.1152/JAPPLPHYSIOL.00406.2018
Abstract: This study aims to investigate the cardiorespiratory responses to different vibration frequencies to characterize the intensity of exercise, as well as to compare the effect of two types of squatting exercises (static and dynamic) on the whole body vibration (WBV) exercise in in iduals with chronic obstructive pulmonary disease (COPD). Twenty-six subjects were ided and paired into healthy and COPD groups that performed static squatting associated with WBV (frequencies: 30, 35, and 40 Hz litude: 2 mm) and dynamic squatting associated with WBV (frequency: 35 Hz litude 2 mm) on a vertical vibration platform. Oxygen consumption (V̇o 2 ), heart rate (HR), minute ventilation (V̇e), ratio of minute ventilation to oxygen production (V̇e/V̇o 2 ), ratio of minute ventilation to carbon dioxide production (V̇e/V̇co 2 ), oxygen saturation (SpO 2 ), and rating of perceived exertion were measured. For both groups, there was a decrease in V̇e/V̇o 2 and V̇e/V̇co 2 ratios during static and dynamic squats, as well as an increase in other cardiorespiratory parameters, and no significant difference existed between them. There was an effect of the type of squat on the HR variation the values in the static squat were higher than those of the dynamic squat in both groups. There was a significant difference with a reduction in SpO 2 at 40 Hz frequency when compared with 30 Hz in the COPD group. The other variables behaved similarly between the frequencies. The WBV exercise, regardless of the frequencies used, represented a mild effort that promoted cardiorespiratory response in COPD, with greater responses in the static squat and no adverse effect. NEW & NOTEWORTHY This study showed that an acute session of light exercise of whole body vibration (WBV) can increase the cardiorespiratory responses in patients with chronic obstructive pulmonary disease (COPD), reaching values similar to that of the control group. The results might contribute, therefore, to the elaboration of exercise protocols with WBV for the treatment of patients with COPD during rehabilitation. Thus, future studies referring to training on the vibratory platform could use these exercise parameters and demonstrate possible long-term benefits.
Publisher: Springer Science and Business Media LLC
Date: 20-08-2020
DOI: 10.1186/S12887-020-02279-3
Abstract: Gross motor development curves for children with Cerebral Palsy (CP), grouped by Gross Motor Function Classification System (GMFCS) levels, help health care professionals and parents to understand children’s motor function prognosis. Although these curves are widely used in Brazil to guide clinical decision-making, they were developed with Canadian children with CP. Little is known about how these patterns evolve in children and adolescents with CP in low-income countries like Brazil. The PARTICIPA BRAZIL aims to: (i) to identify and draw a profile of functioning and disability of Brazilian children and adolescents with CP by classifying them, for descriptive purposes, with all five valid and reliable functional classifications systems (gross motor function, manual ability, communication function, visual and eating and drinking abilities) (ii) to create longitudinal trajectories capturing the mobility capacity of Brazilian children and adolescents with CP for each level of the GMFCS (iii) to document longitudinal trajectories in the performance of activities and participation of Brazilian children and adolescents with CP across two functional classification systems: GMFCS and MACS (Manual Abilities Classification System) (iv) to document longitudinal trajectories of neuromusculoskeletal and movement-related functions and exercise tolerance functions of Brazilian children and adolescents with CP for each level of the GMFCS and (v) to explore interrelationships among all ICF framework components and the five functional classification systems in Brazilian children and adolescents with CP. We propose a multi-center, longitudinal, prospective cohort study with 750 Brazilian children and adolescents with CP from across the country. Participants will be classified according to five functional classification systems. Contextual factors, activity and participation, and body functions will be evaluated longitudinally and prospectively for four years. Nonlinear mixed-effects models for each of the five GMFCS and MACS levels will be created using test scores over time to create prognosis curves. To explore the interrelationships among ICF components, a multiple linear regression will be performed. The findings from this study will describe the level and nature of activities and levels of participation of children and youth with CP in Brazil. This will support evidence-based public policies to improve care to this population from childhood to adulthood, based on their prognosis.
Publisher: Elsevier BV
Date: 07-2018
Publisher: Elsevier BV
Date: 05-2018
Publisher: Elsevier BV
Date: 09-2020
Publisher: Wiley
Date: 02-10-2021
DOI: 10.1111/DMCN.15067
Abstract: To identify and assess published studies concerning physical therapy in Brazilian children and adolescents with cerebral palsy (CP) using the International Classification of Functioning, Disability and Health (ICF) framework. Articles in English and Portuguese published until October 2020, with no date restrictions, were searched in several different databases. Study characteristics, journal metrics, s le characteristics, and ICF domains explored intervention components and outcomes were extracted. Studies were classified according to the Oxford Centre for Evidence‐Based Medicine hierarchy levels to characterize the evidence. Ninety‐four studies were included. Spastic CP with fewer limitations in gross motor abilities was the most reported 67% of the studies had low levels of evidence and were published in journals without an impact factor. The three most frequent interventions were neurodevelopmental treatment, suit therapy, and transcranial direct current stimulation. Intervention components explored body functions and structures (73.4%), activity (59.6%), environment (2.1%). They did not explore participation (0%). The outcomes investigated addressed activity (79.8%), body functions and structures (67.0%), and participation (1.1%), but not environment (0%). Studies of physical therapy for Brazilian children and adolescents with CP focused on reducing impairments and activity limitations. Studies with higher levels of evidence and an expanded focus on participation and environmental factors are necessary.
Publisher: BMJ
Date: 16-10-2019
DOI: 10.1136/EMERMED-2017-207384
Abstract: To describe senior paediatric emergency clinician perspectives on the optimal frequency of and preferred modalities for practising critical paediatric procedures. Multicentre multicountry cross-sectional survey of senior paediatric emergency clinicians working in 96 EDs affiliated with the Pediatric Emergency Research Network. 1332/2446 (54%) clinicians provided information on suggested frequency of practice and preferred learning modalities for 18 critical procedures. Yearly practice was recommended for six procedures (bag valve mask ventilation, cardiopulmonary resuscitation (CPR), endotracheal intubation, laryngeal mask airway insertion, defibrillation/direct current (DC) cardioversion and intraosseous needle insertion) by at least 80% of respondents. 16 procedures were recommended for yearly practice by at least 50% of respondents. Two procedures (venous cutdown and ED thoracotomy) had yearly practice recommended by % of respondents. Simulation was the preferred learning modality for CPR, bag valve mask ventilation, DC cardioversion and transcutaneous pacing. Practice in alternative clinical settings (eg, the operating room) was the preferred learning modality for endotracheal intubation and laryngeal mask insertion. Use of models/mannequins for isolated procedural training was the preferred learning modality for all other invasive procedures. Free-text responses suggested the utility of cadaver labs and animal labs for more invasive procedures (thoracotomy, intercostal catheter insertion, open surgical airways, venous cutdown and pericardiocentesis). Paediatric ED clinicians suggest that most paediatric critical procedures should be practised at least annually. The preferred learning modality depends on the skill practised alternative clinical settings are thought to be most useful for standard airway manoeuvres, while simulation-based experiential learning is applicable for most other procedures.
Publisher: Escola Bahiana de Medicina e Saude Publica
Date: 26-05-2021
DOI: 10.17267/2238-2704RPF.V11I2.3779
Abstract: INTRODUÇÃO: Crianças com transtornos do neurodesenvolvimento apresentam uma variedade de condições que, em geral, possuem comprometimento da função cognitiva, bem como limitações para realizar atividades motoras grossas e finas decorrentes do déficit de equilíbrio e da coordenação motora. OBJETIVO: O presente estudo teve por objetivo verificar se a função cognitiva está associada e pode predizer desfechos do desenvolvimento motor grosso em crianças com transtornos do neurodesenvolvimento entre 5 e 10 anos de idade. MATERIAIS E MÉTODOS: Foi realizado um estudo transversal exploratório com 24 crianças com transtornos do neurodesenvolvimento, entre 5-10 anos de idade, capazes de deambular independente. Para avaliar a função cognitiva e as habilidades motoras grossas das crianças foram utilizados o Mini-Exame do Estado Mental e o Teste de Desenvolvimento Motor Grosso – segunda edição, respectivamente. Análise de regressão linear simples foi realizada e o tamanho do efeito calculado. RESULTADOS: Quinze (60%) eram meninos, com idade média de 7,81 (± 1,90), sete com deficiência intelectual, oito com transtorno do espectro autista, cinco com transtorno do déficit de atenção e hiperatividade, dois com transtornos de comunicação e três com transtornos específicos de aprendizagem. A pontuação do Mini-Exame do Estado Mental foi significativamente associada e capaz de explicar a variabilidade das habilidades de locomoção (R2=0,25 p=0,006), das habilidades de controle de objetos (R2=0,29 p=0,003) e do quociente motor grosso (R2=0,40 p=0,0001). CONCLUSÃO: A função cognitiva está associada e pode explicar o desenvolvimento motor grosso de crianças com transtornos do neurodesenvolvimento entre 5 e 10 anos de idade. Esses resultados podem contribuir para um melhor entendimento da influência da função cognitiva no desenvolvimento das habilidades motoras grossas dessa população.
Publisher: Elsevier BV
Date: 10-2016
DOI: 10.1016/J.BBI.2016.05.005
Abstract: In addition to the well-known functions as a neurotransmitter, acetylcholine (ACh) can modulate of the immune system. Nonetheless, how endogenous ACh release inflammatory responses is still not clear. To address this question, we took advantage of an animal model with a decreased ACh release due a reduction (knockdown) in vesicular acetylcholine transporter (VAChT) expression (VAChT-KD(HOM)). These animals were challenged with lipopolysaccharide (LPS). Afterwards, we evaluated sickness behavior and quantified systemic and cerebral inflammation as well as neuronal activation in the dorsal vagal complex (DVC). VAChT-KD(HOM) mice that were injected with LPS (10mg/kg) showed increased mortality rate as compared to control mice. In line with this result, a low dose of LPS (0.1mg/kg) increased the levels of pro-inflammatory (TNF-α, IL-1β, and IL-6) and anti-inflammatory (IL-10) cytokines in the spleen and brain of VAChT-KD(HOM) mice in comparison with controls. Similarly, serum levels of TNF-α and IL-6 were increased in VAChT-KD(HOM) mice. This excessive cytokine production was completely prevented by administration of a nicotinic receptor agonist (0.4mg/kg) prior to the LPS injection. Three hours after the LPS injection, c-Fos expression increased in the DVC region of VAChT-KD(HOM) mice compared to controls. In addition, VAChT-KD(HOM) mice showed behavioral changes such as lowered locomotor and exploratory activity and reduced social interaction after the LPS challenge, when compared to control mice. Taken together, our results show that the decreased ability to release ACh exacerbates systemic and cerebral inflammation and promotes neural activation and behavioral changes induced by LPS. In conclusion, our findings support the notion that activity of cholinergic pathways, which can be modulated by VAChT expression, controls inflammatory and neural responses to LPS challenge.
Publisher: Elsevier BV
Date: 09-2023
Publisher: Wiley
Date: 26-03-2018
DOI: 10.1111/JPC.13903
Abstract: Penetrating head injuries (pHIs) are associated with high morbidity and mortality. Data on pHIs in children outside North America are limited. We describe the mechanism of injuries, neuroimaging findings, neurosurgery and mortality for pHIs in Australia and New Zealand. This was a planned secondary analysis of a prospective observational study of children 24 h, admission >2 days and abnormal computed tomography). Of 20 137 evaluable patients with a head injury, 21 (0.1%) were identified to have sustained a pHI. All injuries were of non-intentional nature, and there were no gunshot wounds. The mechanisms of injuries varied from falls, animal attack, motor vehicle crashes and impact with objects. Mean Glasgow Coma Scale on ED arrival was 10 10 (48%) had a history of loss of consciousness, and 7 (33%) children were intubated pre-hospital or in the ED. Fourteen (67%) children underwent neurosurgery, two (10%) craniofacial surgery, and five (24%) were treated conservatively four (19%) patients died. Paediatric pHIs are very rare in EDs in Australia and New Zealand but are associated with high morbidity and mortality. The absence of firearm-related injuries compared to North America is striking and may reflect Australian and New Zealand firearm regulations.
Publisher: BMJ
Date: 06-06-2020
DOI: 10.1136/BJSPORTS-2018-099747
Abstract: To determine the effectiveness of conservative treatment (CT) on pain and function in patients with patellar tendinopathy (PT) compared with minimal intervention (MI) or other invasive intervention, or in addition to decline eccentric squat. Searches were performed in MEDLINE, Embase, Cochrane, PEDro, SPORTDiscus, CINAHL and AMED databases. All randomised trials that evaluated CT (any intervention not involving invasive procedures or medication) in in iduals with PT were included. Two reviewers screened studies, extracted data and assessed risk of bias of all included studies. Where suitable, meta-analyses were conducted we assessed certainty of the evidence using GRADE methodology. When compared with MI, CT did not improve pain (weighted mean difference (WMD) −2.6, 95% CI −6.5 to 1.2) or function (WMD 1.8, 95% CI −2.4 to 6.1) in the short-term (up to 3 months) follow-up. When compared with invasive intervention, CT did not improve pain (WMD 0.7, 95% CI −0.1 to 1.4) or function (WMD −6.6, 95% CI −13.3 to 0.2) in the short-term follow-up. No overall effects were found for combined CT (when a conservative intervention was added to decline eccentric squat) on pain (WMD −0.5, 95% CI −1.4 to 0.4) or function (WMD −2.3, 95 % –9.1 to 4.6) at short-term follow-up. Single studies showed an effect on pain with iontophoresis at short-term follow-up (d = 2.42) or dry needling at medium/long-term follow-up (d = 1.17) and function with exercise intervention at medium/long-term follow-up (over 3 months) (d = 0.83). Our estimates of treatment effect have only low to very low certainty evidence to support them. This field of sports medicine/sports physiotherapy urgently needs larger, high-quality studies with pain and function among the potential primary outcomes.
Publisher: FapUNIFESP (SciELO)
Date: 2020
DOI: 10.1590/1984-0462/2020/38/2018165
Abstract: ABSTRACT Objective: To describe the prevalence of interactive media (tablets and smartphones) use by children aged two to four years old, as well as to characterize this use, and investigate habits, practices, parents’ participation and opinion about their child’s interactive media use. Methods: A cross-sectional study with 244 parents or legal guardians of children enrolled in daycare centers in a small Brazilian municipality was conducted. A questionnaire based on interactive media use and related habits were applied, and economic level was assessed. Children were ided into three different groups according to media use: Group 1 did not use (n=81) Group 2 uses up to 45 min/day (n=83) and Group 3 uses more than 45 min/day (n=80). Then, they were compared with regard to the sociodemographic variables and media use by the Chi-square test and Student’s t-test. Results: The prevalence of interactive media use was 67.2%, with a mean time of use of 69.2 minutes/day (confidence interval of 95% - 95%CI 57.1-81.2). The activities most performed were watching videos (55%), listening to music (33%) and playing games (28%). Most parents reported allowing media use in order to stimulate their child’s development (58.4%), accompanying them during use (75.2%), and limiting media time (86.4%). Conclusions: We observed high interactive media use prevalence. The predominant way of using these devices was marked by parent-child participation. Most parents reported believing in the benefits of interactive media. Passive activities were more frequent, with restricted time of use.
Publisher: Informa UK Limited
Date: 21-12-2020
DOI: 10.1080/00207454.2020.1860970
Abstract: Zika virus (ZIKV) infection during the pregnancy period is related to microcephaly and neurobehavioral disorders at birth, while prenatal exercise is supposed to provide neuroprotection in newborns pups. The aim of this study was to investigate the neurological consequences of exercise during prenatal ZIKV exposure to mice pups. Twelve weeks female mice were randomly assigned into three groups: Control group, intraperitoneally injected with saline (Control) untrained group, intraperitoneally injected with ZIKV (ZIKV) and trained group, intraperitoneally injected with ZIKV (ZIKV/swim). There was one familiarization week prior to the beginning of the swimming training. Dams swam for 60 min/session, 5 days/week, during 4 weeks. Mating occurred between the fifth and seventh day of the first week of the swimming training. ZIKV 10 Exercise during prenatal ZIKV exposure prevented brain atrophy, development of depression, anxiety, and disruption of social behavior. Exercise during prenatal ZIKV exposure inhibited the overexpression of microglia (IBA-1) and astrocytes (GFAP), with reduction of BDNF levels in the hippoc i of female and male mice pups. No significant changes were seen in syntaxin-1 levels. Our findings reveal beneficial effects of exercise during pregnancy exposure to ZIKV in mice pups.
Publisher: Public Library of Science (PLoS)
Date: 11-2018
Publisher: Elsevier BV
Date: 10-2021
DOI: 10.1016/J.JBMT.2021.08.002
Abstract: To investigate the cardiorespiratory responses to the 6-min pegboard and ring test (6PBRT) and to assess its reproducibility in healthy adolescents. It was a cross-sectional study with 52 healthy adolescents (11-18 years old of both genders). The 6PBRT was performed twice on two different days by the same examiner. Intra-rater reliability, percentage of the minimal difference chance (MDC%) and agreement of the number of moving rings were analyzed. Also, cardiopulmonary parameters were collected before and after tests. Intraclass correlation coefficient (ICC) for the number of rings moved was 0.87 (95%CI 0.69-0.93). The mean number of moved rings during the second test was higher. The MDC% with a 95 % confidence interval was greater than acceptable values. Bland-Altman analysis did not show agreement between measurements (bias = 30.1) with upper and lower limits of agreement of -67.8 to 127.9, respectively. There was a significant increase in dyspnea, fatigue and HR values at the end of the tests (p < 0.0001). In both tests, participants reached HR equivalent to 48 % of the maximum predicted. Together, the results suggest that the 6PBRT is not a reliable measure for a population of healthy adolescents, which indicates the necessity to perform more than one test. The 6PBRT is suggested to be a submaximal test for this population.
Publisher: Wiley
Date: 23-08-2012
DOI: 10.1111/J.1471-4159.2012.07898.X
Abstract: Although it is well known that regular exercise may promote neuroprotection, the mechanisms underlying this effect are still not fully understood. We investigated if swim training promotes neuroprotection by potentiating antioxidant pathways, thereby decreasing the effects of oxidative stress on glutamate and nitric oxide release. Male Wistar rats (n=36) were evenly randomized into a trained group (TRA) (5 days/week, 8 weeks, 30 min) and a sedentary group (SED). Forty-eight hours after the last session of exercise, animals were killed and brain was collected for in vitro ischemia. Cortical slices were ided into two groups: a group in which oxidative stress was induced by oxygen and glucose deprivation (OGD), and a group of non-deprived controls (nOGD). Interestingly, exercise by itself increased superoxide dismutase activity (nOGD, SED vs. TRA animals) with no effect on pro-oxidative markers. In fact, TRA-OGD slices showed lowered levels of lactate dehydrogenase when compared with SED-OGD controls, reinforcing the idea that exercise affords a neuroprotective effect. We also demonstrated that exercise decreased glutamate and nitrite release as well as lipid membrane damage in the OGD cortical slices. Our data suggest that under conditions of metabolic stress, swim training prevents oxidative damage caused by glutamate and nitric oxide release.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 12-08-2022
Publisher: Informa UK Limited
Date: 06-12-2020
Publisher: Informa UK Limited
Date: 07-08-2023
Publisher: Frontiers Media SA
Date: 18-09-2019
Publisher: Informa UK Limited
Date: 2018
Publisher: Elsevier BV
Date: 06-2021
Publisher: Informa UK Limited
Date: 17-04-2023
Publisher: Wiley
Date: 27-06-2014
DOI: 10.1111/JNC.12786
Abstract: The role of physical exercise as a neuroprotective agent against ischemic injury has been extensively discussed. Nevertheless, the mechanisms underlying the effects of physical exercise on cerebral ischemia remain poorly understood. Here, we investigate the hypothesis that physical exercise increases ischemic tolerance by decreasing the induction of cellular apoptosis and glutamate release. Rats (n = 50) were submitted to a swimming exercise protocol for 8 weeks. Hippoc al slices were then submitted to oxygen and glucose deprivation. Cellular viability, pro-apoptotic markers (Caspase 8, Caspase 9, Caspase 3, and apoptosis-inducing factor), and glutamate release were analyzed. The percentage of cell death, the amount of glutamate release, and the expression of the apoptotic markers were all decreased in the exercise group when compared to the sedentary group after oxygen and glucose deprivation. Our results suggest that physical exercise protects hippoc al slices from the effects of oxygen and glucose deprivation, probably by a mechanism involving both the decrease of glutamatergic excitotoxicity and apoptosis induction.
Publisher: Elsevier BV
Date: 05-2017
DOI: 10.1016/J.BBR.2017.02.030
Abstract: This study aimed to verify the association between obesity-related biomarkers and cognitive and motor development in infants between 6 and 24 months of age. A cross-sectional study was conducted with 50 infants and plasma levels of leptin, adiponectin, resistin, soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2), chemokines, brain-derived neurotrophic factor (BDNF), serum cortisol and redox status were measured. The Bayley-III test was utilized to evaluate cognitive and motor development, and multiple linear stepwise regression models were performed to verify the association between selected biomarkers and cognitive and motor development. A significant association was found among plasma leptin and sTNFR1 levels with cognitive composite scores, and these two independents variables together explained 37% of the variability of cognitive composite scores (p=0.001). Only plasma sTNFR1 levels were associated and explained 24% of the variability of motor composite scores (p=0.003). Plasma levels of sTNFR1 were associated with the increase in cognitive and motor development scores in infants between 6 and 24 months of age through a mechanism not directly related to excess body weight. Moreover, increase in plasma levels of leptin reduced the cognitive development in this age range.
Publisher: Informa UK Limited
Date: 07-04-2023
Publisher: FapUNIFESP (SciELO)
Date: 2016
Publisher: Elsevier BV
Date: 05-2021
Publisher: Informa UK Limited
Date: 22-04-2019
DOI: 10.1080/00222895.2019.1602505
Abstract: To evaluate whether frequent interactive tablet-use at preschool age is associated with improved fine motor skills and to describe tablet-use in young children. Cross-sectional study with 78 children, aged 24-42 months: group 1 with previous frequent tablet-use exposure (
Publisher: Elsevier BV
Date: 06-2018
Publisher: FapUNIFESP (SciELO)
Date: 2023
DOI: 10.1590/1809-2950/E22012423EN
Abstract: ABSTRACT Given the gap in the literature regarding the peak of oxygen consumption (VO2peak) for adolescents of both sexes, this study aimed to propose an equation to predict the VO2peak in healthy adolescents using the Modified Shuttle Test (MST). This is a cross-sectional study with 84 healthy adolescents between 12 and 18 years old, female and male. The MST is an external paced test, in which the speed increases at each minute. Two MST were performed with at least 30 minutes of rest between them. The test with the longest walked distance was considered for analysis. VO2 was directly monitored by an open circuit spirometry. Mean age was 14.67±1.82 and the walked distance was 864.86±263.48m. Variables included in the prediction equation were walked distance and sex, explaining the VO2peak variability of 53% during MST performance. The prediction equation for VO2peak with the MST was: predicted VO2peak=18.274+(0.18×Distance Walked, meters)+(7.733×Sex) R2=0.53 and p .0001 (sex: 0 for girls, 1 for boys). This MST equation, proposed to predict VO2peak in healthy adolescents of both sexes, can be used as a reference to assess exercise capacity in healthy adolescents and to investigate cardiopulmonary function in adolescents with reduced functional capacity.
Publisher: Mary Ann Liebert Inc
Date: 02-2022
Abstract: This study investigated the effect of s le storage duration on the quantification of oxidative stress markers in the gastrocnemius, heart, and brain of mice submitted to a maximum swimming exercise. Thiobarbituric acid reactive substances (TBARSs), protein carbonyl derivatives, total antioxidant capacity (TAC), and the activity of superoxide dismutase (SOD) and catalase (CAT) were quantified in fresh tissues and in s les stored at -80°C for 1, 3, or 6 months, from exercised (
Publisher: Wiley
Date: 08-08-2022
DOI: 10.1111/DMCN.15371
Abstract: Identificar os instrumentos de avaliação para pessoas com distrofia muscular e investigar a qualidade/nível de evidência de suas propriedades de medidas. Uma revisão sistemática de medidas de resultado relatadas pelos pacientes foi conduzida nas bases de dados MEDLINE, Embase, AMED, DiTA e PsycINFO em agosto de 2020. Foram incluídos estudos psicométricos que investigaram a validade, confiabilidade e responsividade de instrumentos de medida que avaliam atividade e participação para distrofia muscular de qualquer tipo (Duchenne, becker, cinturas, facioescapuloumeral, congênita e miotônica) e idade. Dois revisores independentes selecionaram os estudos, extraíram dados e avaliaram a qualidade e nível de evidência dos instrumentos de medida seguindo o checklist COnsensus‐based Standards for the Selection of health status Measurement INstruments (COSMIN). A busca identificou 6675 referências um total de 46 estudos com 28 instrumentos de medida de condição‐específica ou genéricos foram incluídos. As propriedades de medidas da maioria dos instrumentos tiveram resultados suficientes (68.8%) ou indeterminados (25.7%) de acordo com o COSMIN. A qualidade da evidência das propriedades de medidas foi moderada (23.8%) ou baixa (22.6%) de acordo com o Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Existem poucos instrumentos de medida de alta qualidade que tiveram suas propriedades adequadamente medidas. O instrumento com maior qualidade é o Muscular Dystrophy Functional Rating Scale. O Motor Function Measure (instrumento genérico), Duchenne Muscular Dystrophy Upper‐limb Patient‐reported Outcome Measure, North Star Ambulatory Assessment e Myotonic Dystrophy Type 1 Activity and Participation Scale for Clinical Use (específicos) também são recomendados.
Publisher: Frontiers Media SA
Date: 12-01-2021
DOI: 10.3389/FPHYS.2020.469499
Abstract: To compare the effect of Whole-Body Vibration Exercise (WBVE) applied in push-up modified and half-squat positions, on handgrip strength (HS) and on the electromyography registry (EMGrms) of the flexor digitorum superficialis muscle (FDSM) of the dominant hand. Nineteen healthy women (age 23.40 ± 4.03 years, bodyweight: 58.89 ± 9.87 kg), performed in a randomized order five different tests: (S1) Control (S2) Push-up modified (S3) Push-up placebo (S4) Half-squatting (S5) Half-squatting placebo. The HS and the EMGrms were assessed at baseline and immediately after the tests. ANOVA two-way design mixed test, with Tukey post hoc , was used to evaluate the HS, EMGrms and the ratio between EMGrms and HS, i.e., neural ratio (NR). Thus, the lower NR represents the greater neuromuscular modifications. The statistical significance level was set up at p & 0.05. WBVE on S2 increased HS compared to the stimulus applied to the S4 ( p = 0.0001). The increase in HS was associated with a reduction in the EMGrms of the FDSM ( p & 0.001) and a lower NR ( p & 0.0001), i.e., greater neuromuscular modifications, in the S2 compared to the S4 after the tests. The distance of the stimulus and the positioning on the vibratory platform influence the maximum muscular strength due to neuromuscular modifications of hands in healthy women.
Publisher: Wiley
Date: 24-10-2021
DOI: 10.1111/DMCN.15094
Abstract: Identificar e avaliar os estudos publicados sobre fisioterapia em crianças e adolescentes brasileiros com paralisia cerebral (PC), usando o modelo da Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF). Artigos em inglês e português publicados até outubro de 2020, sem restrição de data, foram pesquisados em diferentes bases bibliográficas. Foram extraídos dados sobre as características do estudo, métricas do periódico, características da amostra, domínios da CIF explorados a partir dos componentes e desfechos das intervenções. Para caracterizar as evidências, os estudos foram classificados de acordo com os níveis de evidência do Centro de Medicina Baseada em Evidência de Oxford. Noventa e quatro estudos foram incluídos. Crianças com PC espástica e com menores limitações nas habilidades motoras grossas foram as mais reportadas 67% dos estudos apresentaram baixos níveis de evidência e foram publicados em periódicos sem fator de impacto. As três intervenções mais frequentes foram o conceito neuroevolutivo Bobath/terapia do neurodesenvolvimento, a terapia com vestes e a estimulação transcraniana por corrente contínua. Os componentes das intervenções exploraram estruturas e funções do corpo (73,4%), atividade (59,6%) e ambiente (2,1%). Entretanto não exploraram a participação (0%). Os desfechos investigados abordaram atividade (79,8%), estruturas e funções do corpo (67,0%), participação (1%) e ambiente (0%). Os estudos de intervenções fisioterapêuticas para crianças e adolescentes brasileiros com PC, apresentam maior foco em minimizar deficiências em estruturas e funções do corpo e limitações de atividades. São necessários mais estudos, com melhor nível de evidência e foco liado para a participação e os fatores ambientais.
Publisher: Escola Bahiana de Medicina e Saude Publica
Date: 10-02-2021
DOI: 10.17267/2238-2704RPF.V11I1.3445
Abstract: BACKGROUND: Whole-body vibration (WBV) has been widely used as a therapeutic resource in pediatric rehabilitation. However, the cardiopulmonary responses are still unknown. OBJECTIVE: To investigate the intensity of dynamic squatting exercise with and without WBV in healthy adolescents in order to characterize cardiorespiratory responses. METHODS: This was a quasi-experimental study. Twenty-five adolescents (14.1 ± 1.7 years), 10 girls and 15 boys, underwent to oxygen consumption (VO2) and heart rate (HR) assessments during a protocol of squatting with and without vibration. Inclusion criteria were age between 12 and 18 years old of both sexes, have normal weight according to BMI. Exclusion criteria were to present chronic or acute, neurological, orthopedic, respiratory, cardiac and endocrine disease and no self-reported contraindication for WBV (i.e. deep vein thrombosis, metal implants, pacemaker, epilepsy, tumors, arterial aneurysm, or arrhythmia). RESULTS: WBV was able to significantly increase VO2, HR and perceived exertion during squatting exercise when compared to rest and squatting without-WBV. WBV associated with squatting reached 24.7% of the VO2max and 56% of the HRmax predicted for age. Subjects during WBV reported a perceived exertion score between somewhat hard and hard compared to between very light and light in the Without-WBV protocol. CONCLUSION: Squatting associated to WBV was considered a light intensity exercise that can be tolerated by healthy adolescents. This study provided valid results of this training modality and could be used as a tool to define the energy consumption spent in this training modality.
Publisher: Elsevier BV
Date: 08-2021
DOI: 10.1016/J.BBR.2021.113371
Abstract: Maternal high-fat diets (HFD) can generate inflammation in the offspring's amygdala, which can lead to anxiety-like behaviors. Conversely, lipopolysaccharide (LPS) tolerance can reduce neuroinflammation in the offspring caused by maternal high-fat diets. This study evaluated the combination of LPS tolerance and high-fat maternal diet on amygdala's inflammatory parameters and the anxiety-like behavior in adolescent offspring. Female pregnant Wistar rats received randomly a standard diet or a high-fat diet during gestation and lactation. On gestation days 8, 10, and 12, half of the females in each group were intraperitonially injected with LPS (0.1 mg.kg
Publisher: FapUNIFESP (SciELO)
Date: 2019
Publisher: Wiley
Date: 18-12-2022
DOI: 10.1111/DMCN.15487
Abstract: Identificar e fornecer uma visão geral descritiva dos estudos de desenvolvimento de crianças, adolescentes e jovens adultos com paralisia cerebral (PC) e mapear áreas de foco de acordo com os componentes da Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF) da OMS. Estudos longitudinais do desenvolvimento de crianças, adolescentes e/ou jovens adultos com PC foram incluídos nesta revisão de escopo. A busca por estudos elegíveis foi realizada nas bases de dados: MEDLINE, PubMed, LILACS, EMBASE, Cochrane, CINAHL, Scopus, e foi restrita aos anos de 2002–2022. Todas os desfechos dos estudos foram classificados em componentes da CIF. Nos 56 estudos incluídos, houve 19.438 participantes, envolvendo principalmente crianças, seguidas de adolescentes e, por último, jovens adultos. Todos os componentes da CIF foram investigados e muitos estudos relataram resultados em mais de um componente. O componente atividade foi o mais investigado (67,9% n = 38 estudos), seguida da estrutura e função corporal (42,9% n = 24 estudos). A participação (14,2% n = 8 estudos) e os fatores ambientais (3,6% n = 2 estudos) foram os menos estudados. Nenhum dos estudos investigou fatores pessoais como desfecho. Esta revisão de escopo fornece uma visão geral dos estudos sobre o desenvolvimento de crianças, adolescentes e jovens adultos com PC, usando a estrutura da CIF, identificando áreas atuais de foco e lacunas. Estudos futuros devem visar a participação, os fatores contextuais e a transição para a vida adulta. A CIF pode ser usada para mapear uma série de desfechos por meio de estudos de desenvolvimento. Os principais desfechos investigados em crianças com PC foram atividade e estrutura e função corporal. Pouco tem sido explorado os desfechos de participação e fatores contextuais ao longo do tempo. A principal classificação utilizada para estratificar os participantes foi o Sistema de Classificação da Função Motora Grossa. Estudos futuros devem liar seu foco para diferentes áreas da CIF, e na transição para a vida adulta.
Publisher: Elsevier BV
Date: 2022
DOI: 10.1016/J.PHYSBEH.2021.113628
Abstract: Lipopolysaccharide (LPS) tolerance can reduce the neuroinflammation caused by high fat maternal diets however, there are no reports that have evaluated the effects of prenatal LPS exposure on the memories of the offspring of high-fat diet fed dams. This study evaluated the effects of prenatal LPS exposure on the inflammatory parameters and redox status in the brain, as well as the object recognition memory of adolescent offspring of Wistar rat dams that were treated with a high-fat diet during gestation and lactation. Female pregnant Wistar rats randomly received a standard diet (17.5% fat) or a high-fat diet (45.0% fat) during gestation and lactation. On gestation days 8, 10, and 12, half of the females in each group were intraperitoneally treated with LPS (0.1 mg.kg
Publisher: Wiley
Date: 05-12-2022
DOI: 10.1111/DMCN.15484
Abstract: To identify and provide a descriptive overview of the development of children, adolescents, and young adults with cerebral palsy (CP) in longitudinal studies and map areas of focus according to the components of the World Health Organization's International Classification of Functioning, Disability, and Health (ICF). Longitudinal studies of the development of children, adolescents, and/or young adults with CP were included in this scoping review. A search for eligible studies was conducted in the databases MEDLINE, PubMed, LILACS, EMBASE, Cochrane, CINAHL, and Scopus, and was restricted to the years 2002 to 2022. All outcome measures of the studies were classified into ICF components. In the 56 studies included, there were 19 438 participants, involving mainly children, followed by adolescents, and lastly young adults. All components of the ICF were investigated and many studies reported outcomes in more than one component. Activity was the most investigated (67.9% n = 38 studies), followed by body functions and structures (42.9% n = 24 studies). Participation (14.2% n = 8 studies) and environmental factors (3.6% n = 2 studies) were the least studied. None of the studies investigated personal factors as an outcome. This scoping review provides an overview of studies on the development of children, adolescents, and young adults with CP, using the ICF framework, identifying current areas of focus and gaps in the research. Future studies should target participation, contextual factors, and the transition into adulthood. The International Classification of Functioning, Disability, and Health can be used to map a range of outcomes through developmental studies. The main outcomes investigated in children with cerebral palsy were activity, and body functions and structures. Little has been explored in participation and contextual factors outcomes over time. The main classification used to stratify the participants was the Gross Motor Function Classification System.
Publisher: American Physiological Society
Date: 08-2018
DOI: 10.1152/JAPPLPHYSIOL.01037.2017
Abstract: Whole body vibration training (WBVT) has been identified as an alternative intervention to improve exercise capacity and quality of life of patients with chronic obstructive pulmonary disease (COPD). However, the effect of WBVT on inflammatory-oxidative biomarkers remains unknown. The aim of this trial was to investigate the effects of WBVT on quality of life and physical and inflammatory-oxidative parameters in patients with COPD. Twenty patients were equally ided into 1) an intervention group (IG) that performed the WBVT, and 2) a control group (CG) that did not receive any intervention. Intervention consisted in performing static squatting on a vibrating platform, in six series of 30 s, 3 days/wk, for 12 wk. Patients were evaluated for plasma levels of IL-6, IL-8, IFN-γ, soluble receptors of TNF-α white cell count plasma levels of oxidant and antioxidant markers 6-min walking distance (6MWD) peak oxygen uptake (V̇o 2peak ) handgrip strength quality of life timed 5-chair sit-to-stand (5STS) and timed get-up and go test (TUG). After WBVT, patients from IG showed a significant increase in the 6MWD, V̇o 2peak , and handgrip strength ( P 0.05). Furthermore, patients from the IG reached minimal clinically important difference regarding quality of life. No significant differences were found in 5STS, TUG, inflammatory-oxidative biomarkers, and white cell count in the IG. The CG did not show significant improvement in all assessments ( P 0.05). Taken together, our results demonstrated that the WBVT induced clinically significant benefits regarding exercise capacity, muscle strength, and quality of life in patients with COPD that were not related to inflammatory-oxidative biomarker changes. NEW & NOTEWORTHY Whole body vibration training is a new option for nonpharmacological treatment of chronic obstructive pulmonary disease (COPD). This study showed the potential of this training to improve exercise capacity, quality of life, and muscle strength in patients with COPD. Furthermore, to our knowledge this was the first study showing that vibration exercise does not modify the plasma levels of inflammatory-oxidative biomarkers, suggesting that the beneficial effects on physical measures and quality of life are independent of changes in biomarkers.
Publisher: Wiley
Date: 06-08-2017
DOI: 10.1111/JPC.13644
Abstract: To examine Australian and New Zealand emergency department (ED) staff's training, knowledge and confidence regarding trauma-informed care for children after trauma, and barriers to implementation. ED staff's perspectives on trauma-informed care were assessed using a web-based self-report questionnaire. Participants included 468 ED staff (375 nursing and 111 medical staff) from hospitals in Australia and New Zealand. Data analyses included descriptive statistics, χ Over 90% of respondents had not received training in trauma-informed care and almost all respondents (94%) wanted training in this area. While knowledge was associated with a respondent's previous training and profession, confidence was associated with the respondent's previous training, experience level and workplace. Dominant barriers to the implementation of trauma-informed care were lack of time and lack of training. There is a need and desire for training and education of Australian and New Zealand ED staff in trauma-informed care. This study demonstrates that experience alone is not sufficient for the development of knowledge of paediatric traumatic stress reactions and trauma-informed care practices. Existing education materials could be adapted for use in the ED and to accommodate the training preferences of Australian and New Zealand ED staff.
Publisher: Elsevier BV
Date: 10-2018
DOI: 10.1016/J.JTHERBIO.2018.08.014
Abstract: There is evidence that central cholinergic stimulation increases heat dissipation in normotensive rats besides causing changes on the cardiovascular system via modulation of baroreceptors activity. However, the contribution of the central cholinergic system on thermoregulatory responses and its relationship with cardiovascular adjustments in spontaneously hypertensive rats (SHRs), an animal model of reduced baroreceptor sensitivity and thermoregulatory deficit, has not been completely clarified. Therefore, the aim of this study was to verify the involvement of the central cholinergic system in cardiovascular and thermoregulatory adjustments in SHRs. Male Wistar rats (n = 17) and SHRs (n = 17) were implanted with an intracerebroventricular cannula for injections of 2 µL of physostigmine (phy) or saline solution. Tail temperature (T
Publisher: Informa UK Limited
Date: 06-03-2022
Publisher: Universidade Federal de Sao Paulo
Date: 31-03-2001
DOI: 10.34024/RNC.2012.V20.8232
Abstract: Introdução. Estudos ressaltam que a música pode ocasionar diferentes respostas fisiológicas no organismo humano, como, por exemplo, alteração da pressão arterial, frequência cardíaca, respiratória, redução da ansiedade e limiar de dor, e melhora da qualidade de vida. Objetivo. O objetivo do presente trabalho foi realizar uma revisão de literatura a respeito da influência da música nos mecanismos fisiológicos no organismo humano, em especial, na variável pressão arterial, além de identificar os mecanismos neurais do processamento da música através dos artigos científicos encontrados na literatura vigente. Método. Foi realizada uma revisão da literatura, através da utilização das bases de dados Medline, Bireme, PEDro, Lilacs e Scielo. Resultados. Os resultados sugerem que a música interfere em alguns aspectos nas variáveis fisiológicas, influenciando no controle da pressão arterial, frequência cardíaca e respiratória. Acredita-se que esta redução seja devido a um balanço entre sistema nervoso autônomo simpático e parassimpático, em favor do parassimpático, através do possível envolvimento de áreas límbicas cerebrais que modulariam funções hipotálamo-hipofisárias. Conclusão. Conclui-se que a música pode ter um papel real na regulação de níveis pressóricos, da frequência cardíaca e respiratória, dentre outros benefícios tais como redução da ansiedade e dor.
Publisher: Elsevier BV
Date: 10-2012
DOI: 10.1016/J.NEUINT.2012.06.018
Abstract: Brain ischemic tolerance is a protective mechanism induced by a preconditioning stimulus, which prepare the tissue against harmful insults. Preconditioning with N-methyl-d-aspartate (NMDA) agonists induces brain tolerance and protects it against glutamate excitotoxicity. Recently, the glycine transporters type 1 (GlyT-1) have been shown to potentiate glutamate neurotransmission through NMDA receptors suggesting an alternative strategy to protect against glutamate excitotoxicity. Here, we evaluated the preconditioning effect of sarcosine pre-treatment, a GlyT-1 inhibitor, in rat hippoc al slices exposed to ischemic insult. Sarcosine (300 mg/kg per day, i.p.) was administered during seven consecutive days before induction of ischemia in hippoc us by oxygen/glucose deprivation (OGD). To access the damage caused by an ischemic insult, we evaluated cells viability, glutamate release, nitric oxide (NO) production, lactate dehydrogenase (LDH) levels, production of reactive oxygen species (ROS), and antioxidant enzymes as well as the impact of oxidative stress in the tissue. We observed that sarcosine reduced cell death in hippoc us submitted to OGD, which was confirmed by reduction on LDH levels in the supernatant. Cell death, glutamate release, LDH levels and NO production were reduced in sarcosine hippoc al slices submitted to OGD when compared to OGD controls (without sarcosine). ROS production was reduced in sarcosine hippoc al slices exposed to OGD, although no changes were found in antioxidant enzymes activities. This study demonstrates that preconditioning with sarcosine induces ischemic tolerance in rat hippoc al slices submitted to OGD.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 10-2014
Publisher: Public Library of Science (PLoS)
Date: 12-2016
Publisher: Elsevier BV
Date: 11-2019
DOI: 10.1016/J.PHYSBEH.2019.112675
Abstract: It is known that a single session of high-intensity interval exercise (HIIE) contributes to the increase of the reactive species of oxygen, accompanied by a greater antioxidant activity. However, it is poorly understood if a single session of HIIE has similar effects on the brain tissue. This study evaluated the effects of a single HIIE on the hippoc al redox status. Sixteen males Wistar rats were allocated into HIIE (n = 8) and control (n = 8) groups. Maximum oxygen consumption (VO
Publisher: Elsevier BV
Date: 11-2013
DOI: 10.1016/J.JNEUROIM.2013.08.014
Abstract: The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. In the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, and the clinical score was attenuated. Although, the cytokine levels were decreased in the brain and increased in the spinal cord, BDNF was elevated in both compartments with a tendency of lesser demyelization volume in the spinal cord of the exercised EAE group compared with the unexercised.
Publisher: American Academy of Pediatrics (AAP)
Date: 04-2018
Abstract: To determine the prevalence of traumatic brain injuries in children who vomit after head injury and identify variables from published clinical decision rules (CDRs) that predict increased risk. Secondary analysis of the Australasian Paediatric Head Injury Rule Study. Vomiting characteristics were assessed and correlated with CDR predictors and the presence of clinically important traumatic brain injury (ciTBI) or traumatic brain injury on computed tomography (TBI-CT). Isolated vomiting was defined as vomiting without other CDR predictors. Of the 19 920 children enrolled, 3389 (17.0%) had any vomiting, with 2446 (72.2%) & years of age. In 172 patients with ciTBI, 76 had vomiting (44.2% 95% confidence interval [CI] 36.9%–51.7%), and in 285 with TBI-CT, 123 had vomiting (43.2% 95% CI 37.5%–49.0%). With isolated vomiting, only 1 (0.3% 95% CI 0.0%–0.9%) had ciTBI and 2 (0.6% 95% CI 0.0%–1.4%) had TBI-CT. Predictors of increased risk of ciTBI with vomiting by using multivariate regression were as follows: signs of skull fracture (odds ratio [OR] 80.1 95% CI 43.4–148.0), altered mental status (OR 2.4 95% CI 1.0–5.5), headache (OR 2.3 95% CI 1.3–4.1), and acting abnormally (OR 1.86 95% CI 1.0–3.4). Additional features predicting TBI-CT were as follows: skull fracture (OR 112.96 95% CI 66.76–191.14), nonaccidental injury concern (OR 6.75 95% CI 1.54–29.69), headache (OR 2.55 95% CI 1.52–4.27), and acting abnormally (OR 1.83 95% CI 1.10–3.06). TBI-CT and ciTBI are uncommon in children presenting with head injury with isolated vomiting, and a management strategy of observation without immediate computed tomography appears appropriate.
Publisher: Informa UK Limited
Date: 25-08-2023
Publisher: Public Library of Science (PLoS)
Date: 12-12-2018
Publisher: Elsevier BV
Date: 12-2019
DOI: 10.1016/J.BBR.2019.112181
Abstract: High-intensity interval training (HIIT) is associated with better physical performance, but there is limited information about the effects of HIIT on redox state of cerebellar tissue, cerebral cortex, and cognition. The aim of this study was to evaluate the effects of HIIT on redox state parameters in cerebellar tissue, cerebral cortex, and cognitive function of Wistar rats. Forty-three young male Wistar rats were housed under controlled environmental conditions with food, and water ad libitum. Animals were assigned to HIIT or Non-trained groups. HIIT protocol was performed during six weeks. Speed was determined through the assesstment of the maximum oxygen consumption (VO
Publisher: Walter de Gruyter GmbH
Date: 14-01-2020
Abstract: The salivary circadian diurnal cortisol plays an important role in growth and development. Inappropriate levels may induce changes associated with an increased risk of obesity later in life. It is unknown if there are differences in cortisol secretion pattern between overweight/obese infants when compared with theirs peers in infancy. Thus, this study aimed to compare the salivary cortisol secretion pattern in overweight/obese and normal-weight infants. Thirty-three (overweight/obese = 17 and normal weight = 16) infants between 6 and 24 months of age had saliva s les collected upon awakening (T1), 30 min after waking (T2), at 12:00 am or before the baby’s meal (T3), and prior to bedtime (T4). Highly sensitive enzyme immunoassays were used for cortisol analyses. Salivary cortisol levels were similar between the groups: T1 (p = 0.22 95% confidence interval [CI]: −5.65, 1.37), T2 (p = 0.24 95% CI: −8.23, 2.17), T3 (p = 0.95 95% CI: −3.16, 2.96), and T4 (p = 0.81 95% CI: −1.39, 1.08) and no differences were observed between area under the curve (AUC) (p = 0.80 95% CI: −4.58–13.66). The cortisol level reduced in T4 (95% CI: 1.35–2.96) compared to T1 (95% CI: 5.15–8.49) and T2 in the overweight/obese group (p 0.001 95% CI: 6.02–11.04). In the normal-weight group, the cortisol reduced in T3 (95% CI: 2.86–8.18) compared to T1 (95% CI: 5.64–12.28) and decreased until T4 (p = 0.001 95% CI: 1.25–3.37). The overweight/obese infant group presented a different pattern of cortisol secretion, although cortisol levels did not differ between the control group.
Publisher: Wiley
Date: 26-11-2019
Publisher: Frontiers Media SA
Date: 25-06-2019
Publisher: Elsevier BV
Date: 02-2019
DOI: 10.1016/J.MSKSP.2018.10.001
Abstract: Musculoskeletal conditions are common health issues with great impact on in iduals. Although many factors have been associated with the development of musculoskeletal pain, such as perinatal factors, its aetiology is still poorly understood. To systematically investigate whether perinatal factors can increase the risk of having musculoskeletal pain across the lifespan. MEDLINE, CINAHL, Scopus, Web of Science and EMBASE databases were searched from their inception to December 2017. Descriptors used in our search strategy were related to "perinatal factors" and "musculoskeletal pain". There were no language, age, sex or date restrictions. Meta-analysis was used to pool the estimates of association between perinatal factors and musculoskeletal pain. Among the six articles included in this systematic review, three were extracted for the meta-analysis. The pooled of three and two studies showed no association between chronic musculoskeletal pain and low birth weight (OR 1.8, 95% CI 0.9-3.8, I In adults, our meta-analysis showed no association between birth weight or pre-term birth and musculoskeletal pain, and the quality of the evidence was very low. Thus, the very low quality of evidence and limited number of studies do not suggest a direct clear association. Further high-quality longitudinal studies accounting for more relevant confounders are needed to better understand the complex mechanism that may operate between perinatal factors and musculoskeletal pain.
Publisher: Informa UK Limited
Date: 18-03-2021
Publisher: FapUNIFESP (SciELO)
Date: 2018
Publisher: Universidade Federal de Sao Paulo
Date: 31-03-2001
DOI: 10.34024/RNC.2010.V18.8445
Abstract: Introdução. A doença de Charcot-Marie-Tooth é uma neuropatia periférica hereditária com atrofia muscular de predomínio distal nos membros inferiores associada a déficit de força muscular, hipoestesia e diminuição dos reflexos profundos. Objetivo. Investigar os efeitos da hidroterapia associada à cinesioterapia em um paciente com doença de Charcot-Marie-Tooth. Método. Foram realizadas duas avaliações entre março e junho de 2007, sendo realizados os testes Timed up and go, velocidade da marcha, subir e descer escadas, caminhada de 6 minutos, aplicação do questionário de qualidade de vida SF-36 e da escala de equilíbrio de Berg. O tratamento consistiu de duas consultas semanais de 1 hora, envolvendo atividades de circuito, transferência de ajoelhado para de pé, exercício de mini-agachamento no solo e exercícios aquáticos. Resultados. Observou-se uma melhora quantitativa da qualidade de vida, equilíbrio, tempo para subir e descer escadas, velocidade da marcha e distância percorrida no teste de caminhada de 6 minutos e uma melhora qualitativa do padrão de marcha, mudanças de postura e da queixa funcional da paciente. Conclusão. A associação da hidroterapia com cinesioterapia pode melhorar a funcionalidade e qualidade de vida de pacientes com doença de Charcot-Marie-Tooth.
Publisher: Elsevier BV
Date: 07-2019
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 24-04-2023
DOI: 10.1097/PEP.0000000000001019
Abstract: To describe the patterns, preferences, and predictors of participation in leisure activities of children and young people with physical disabilities from Brazil. This is a cross-sectional study that included 50 children/young people with physical disabilities from the southeast of Brazil. The children were assessed using the Children's Assessment of Participation and Enjoyment and Preferences for Activities. Children/young people participated in an average of 38% of the activities, with a greater number and frequency of informal, recreational, social, and self-improvement activities. The average frequency of participation in the activities was twice in the previous 4 months. The enjoyment in the participated activities was high. There was a greater preference for recreational, social, and physical activities. Age and functional classification were predictors of participation. This study of children with disabilities from the southeast of Brazil supports studies in other low- and middle-income countries, demonstrating low ersity and intensity of participation in leisure activities, but with high levels of enjoyment.
Publisher: Universidade Federal de Sao Paulo
Date: 05-02-2014
Publisher: Hindawi Limited
Date: 30-11-2021
DOI: 10.1155/2021/7593802
Abstract: This study aimed to investigate the efficacy of whole-body vibration training (WBVT) on blood brain-derived neurotrophic factor (BDNF) levels and determine the clinical and functional outcomes in patients with fibromyalgia syndrome (FMS). Thirty-two women with FMS were randomized into an intervention group (IG), receiving 6 weeks of WBVT, or a control group (CG) with no intervention. The outcomes at the baseline and follow-up in both groups included blood BDNF levels, sit-to-stand test (STS), 6-minute walk test (6MWT), Fibromyalgia Impact Questionnaire (FIQ), Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), and visual analogue scale (VAS). WBVT resulted in a group-by-time interaction effect. Thus, after the intervention time, the IG had increased blood BDNF levels ( p = 0.045 ), a higher number of repetitions on the STS test ( p = 0.011 ), and increased walking distance on the 6MWT ( p = 0.010 ), compared to CG. Moreover, there was a reduction in the scores of the FIQ ( p = 0.001 ), the PSQI ( p = 0.001 ), the BDI ( p = 0.017 ), and pain assessed using VAS ( p = 0.008 ) in IG. The results demonstrate that WBVT promotes an increase in blood BDNF levels, with concomitant improvement in lower limb muscle strength, aerobic capacity, clinical symptoms, and quality of life in women with FMS. This trial is registered with Brazilian Clinical Trials Registry (REBEC RBR-38nbbx) (ensaiosclinicos.gov.br/rg/RBR-38nbbx).
Publisher: Korean Society of Exercise Rehabilitation
Date: 27-06-2022
Abstract: Peripheral nerve injuries are cause of sensory disturbances and in functional abilities, and are associated personal and social costs. Strat-egies that maximize nerve regeneration and functional recovery are necessary, the exercise is an option. This study evaluated the effects of forced swimming exercise on neuromuscular histomorphometry and on functional recovery in a median nerve crush model. Sixteen Wistar rats underwent median nerve crush and were ided into control group (CG) and swimming group (SG). The forced swimming protocol started one week after the injury and was performed for 1 hr a day, 5 days per week, for 2 weeks. The rats swam with an overload of 5% and 10% of body weight in the first and second week, respectively. The functional recovery was assessed in three moments using the grasping test. On day 21, fragments of the median nerve and of the forearm flexors mus-cles were removed for histomorphometric analysis. The SG had func-tional recovery impaired ( i /i .001) and presented lower myelinated fi-bers number, fiber and axon minimal diameter, myelin thickness and g-ratio in the proximal e distal segments of the median nerve ( i /i .005) and area muscle fiber ( i /i .005) than CG. Also, the SG presented a number of capillaries in the proximal segments of the median nerve greater than CG ( i /i .005). The exercise protocol used in this study im-paired the regeneration of the median nerve and negatively influenced the functional recovery.
Publisher: Springer International Publishing
Date: 25-07-2019
Publisher: Informa UK Limited
Date: 19-07-2022
DOI: 10.1080/09638288.2022.2098394
Abstract: To analyze the effectiveness of sports-focused interventions on the participation of children and adolescents with cerebral palsy (CP). Study searches were conducted on EMBASE, PubMed, Scielo, PEDro, CINAHL, SPORTDiscuss in June 2022. We included randomized controlled trials that investigated the effectiveness of sports-focused interventions in children and adolescents with CP in comparison with control. Risk of bias was assessed with PEDro scale and evidence certainty with GRADE approach. Data were pooled in random-effects meta-analyses and results were presented as standardized mean differences. Ten RCTs were selected with different modalities, mostly for ambulant children and adolescents. Significant pooled effects on participation in leisure-time physical activity were seen only in group interventions (modified sports, gross motor training, and fitness training), in comparison with control [SMD(95% CI) = 0.32(0.01-0.73) Positive results on leisure-time participation were seen at short-term follow-up for group interventions. Sports-focused interventions did not improve participation in other life areas, reinforcing the importance of specificity when conducting participation interventions. Studies investigating sports-focused interventions including non-ambulatory in iduals are still necessary. IMPLICATIONS FOR REHABILITATIONSports-focused interventions target leisure-time physical activity participation.They present moderate evidence of their effectiveness to improve physical activity participation in in iduals with cerebral palsy.Group interventions are effective in improving leisure-time physical activity participation.Sports-focused interventions did not improve participation in other life areas.
Publisher: Informa UK Limited
Date: 17-07-2022
DOI: 10.1080/17518423.2022.2099995
Abstract: To systematically review the effectiveness of physical therapy interventions in infants, children and adolescents with brachial plexus birth injury (BPBI). Systematic review of randomized controlled trials including patients under 18 years old with BPBI was conducted on Medline, Cochrane, Embase, Amed and Pedro databases. Methodological quality was assessed by the PEDro score and quality of evidence by the GRADE system. The primary outcomes measured were range of motion, muscle strength and bone mineral density. Seven studies were included, two in infant and 5 in children, of 932 title and abstracts screened. The interventions, characteristics of the participants and outcomes were erse. The largest effect was found when other intervention was combined with conventional physical therapy in the primary outcomes, with low quality of evidence. Physical therapy interventions alone or in combination with other treatment modalities are effective in improving short-term disabilities in children with BPBI.
Publisher: Elsevier BV
Date: 07-2012
DOI: 10.1016/J.BRAINRESBULL.2012.04.005
Abstract: Physical activity has been proposed as a behavioral intervention that improves learning and memory nevertheless, the mechanisms underlying these health benefits are still not well understood. Neuronal Calcium Sensor-1 (NCS-1) is a member of a superfamily of proteins that respond to local Ca(2+) changes shown to have an important role in learning and memory. The aim of the present study was to investigate the effects of swimming training on NCS-1 levels in the rat brain after accessing cognitive performance. Wistar rats were randomly assigned to sedentary (SG) or exercised groups (EG). The EG was subject to forced swimming activity, 30 min/day, 5 days/week, during 8 weeks. Progressive load trials were performed in the first and last week in order to access the efficiency of the training. After the 8 week training protocol, memory performance was evaluated by the novel object preference and object location tasks. NCS-1 levels were measured in the cortex and hippoc us using immunoblotting. The EG performed statistically better for the spatial short-term memory (0.73 ± 0.01) when compared to the SG (0.63 ± 0.02 P 0.05). In addition, chronic exercise promoted a significant increase in hippoc al NCS-1 levels (1.8 ± 0.1) when compared to SG (1.17 ± 0.08 P 0.05). Results suggest that physical exercise would modulate the state of the neural network regarding its potential for plastic changes: physical exercise could be modulating NCS-1 in an activity dependent manner, for specific neural substrates, thus enhancing the cellular/neuronal capability for plastic changes in these areas which, in turn, would differentially effect ORM task performance for object recognition and displacement.
Publisher: BMJ
Date: 2023
DOI: 10.1136/BMJOPEN-2022-068486
Abstract: There is a need to investigate relevant, acceptable and feasible approaches that promote participation in leisure-time physical activity for children with cerebral palsy (CP). The aim of this study is to assess the feasibility of a randomised controlled trial comparing a peer-group intervention focused on improving physical literacy (Sports Stars) with the combination of Sports Stars and a context-focused intervention (Pathways and Resources for Engagement and Participation, PREP) for ambulant children with CP in Brazil. In this feasibility trial, 18 ambulant children (aged 6–12 years) with CP will be randomised into two groups (nine per group): (1) Sports Stars and (2) Sports Stars plus PREP. The Sports Stars group will receive 8 weekly group sessions, focusing on developing the physical, social, cognitive and psychological skills required to participate in popular Brazilian sports. The combined Sports Stars and PREP group will receive Sports Stars in addition to eight in idual PREP sessions focused on overcoming environmental barriers to participation. The primary outcome will include feasibility measures: willingness to participate in an RCT, eligibility and recruitment rates, maintenance of evaluator blinding, acceptability of screening procedures and random allocation, feasibility of evaluating outcomes, contamination between the groups, intervention adherence, treatment satisfaction, understanding of the intervention and implementation resources. Additional instruments will be applied to obtain data related to leisure-time physical activity participation goals, overall participation (home, school and community), physical literacy, level of physical activity and family empowerment. Outcomes will be assessed before, after and 12 weeks after intervention. This feasibility trial has been approved by ethical Federal University of Minas Gerais’ Ethics Review Committee (CAAE: 33238520.5.0000.5149). All potential subjects will provide written informed consent. The results of this study will be published in peer-reviewed journals and be presented at academic conferences. RBR-4m3b4b6, U1111-1256-4998.
Publisher: Elsevier BV
Date: 10-2020
Publisher: Springer Science and Business Media LLC
Date: 06-12-2019
DOI: 10.1007/S00586-018-5850-3
Abstract: To investigate associations between anthropometric measures (birthweight, weight gain and current BMI) and back pain and to determine whether these associations differ between those born with low or full birthweight. The cross-sectional associations between the lifetime prevalence of back pain and anthropometric measures (birthweight, weight gain and current BMI) among 2754 adult twins were investigated in three stages: total s le within-pair case-control for monozygotic and dizygotic twins together and within-pair case-control analysis separated by dizygotic and monozygotic. Results were expressed as odds ratios (OR) and 95% confidence intervals (CI). Birthweight was not associated with back pain (OR 0.99 95% CI 0.99-1.00), but a weak association was found between weight gain (OR 1.01 CI 1.00-1.01) or current BMI (OR 1.02 95% CI 1.00-1.05) and back pain in the total s le analysis. These associations did not remain significant after adjusting for genetics. The associations did not differ between those whose were born with low or full birthweight. Birthweight was not associated with prevalence of back pain in adulthood. Weight gain and current BMI were weakly associated with back pain prevalence in the total s le analysis but did not differ between those born with low or full birthweight. However, the small-magnitude association only just achieved significance and appeared to be confounded by genetics and the early shared environment. Our results suggest that a direct link between these predictors and back pain in adults is unlikely. These slides can be retrieved under Electronic Supplementary Material.
Publisher: Springer Science and Business Media LLC
Date: 08-2020
Publisher: Springer Science and Business Media LLC
Date: 12-10-2018
Publisher: American Academy of Pediatrics (AAP)
Date: 05-2018
Abstract: A 4-variable abusive head trauma (AHT) clinical prediction rule (CPR) for use in the PICU was derived and validated for children & years of age by the Pediatric Brain Injury Research Network (PediBIRN). We aimed to externally validate PediBIRN as designed (PICU only) as well as using broader inclusion criteria (admitted children with head injuries). This was a secondary analysis of a prospective multicenter study of pediatric head injuries at 5 Australian and New Zealand tertiary pediatric centers. Possible AHT was identified by clinician suspicion, epidemiology codes, or a high-risk group (& years of age, admitted, abnormal neuroimaging results). At 1 center, we additionally reviewed head injuries in the forensic database. We designated patients as positive for AHT, negative for AHT, or having indeterminate outcome after multidisciplinary review and applied the PediBIRN CPR, blinded to outcome, to PICU admissions only, and any head injury admissions. CPR accuracy was calculated by using 95% confidence intervals. One hundred and forty-one patients were admitted with abnormal neuroimaging results. Twenty-eight (20%) were positive for AHT, 94 (67%) were negative for AHT, and 19 (13%) had indeterminate outcome. Excluding indeterminate cases, in the PICU (n = 28), the CPR was 100% (75%–100%) sensitive and 11% (0%–48%) specific in all admitted patients (n = 141), sensitivity was 96% (82%–100%) and specificity of 43% (32%–53%). This validation revealed high sensitivity and low specificity for PICU patients. Specificity was improved but moderate in a broader group of admitted head injury patients.
Publisher: Public Library of Science (PLoS)
Date: 07-02-2019
Publisher: Hindawi Limited
Date: 02-12-2021
DOI: 10.1155/2021/9774980
Abstract: Objective. Rheumatoid arthritis (RA) causes progressive changes in the musculoskeletal system compromising neuromuscular control especially in the hands. Whole-body vibration (WBV) could be an alternative for the rehabilitation in this population. This study investigated the immediate effect of WBV while in the modified push-up position on neural ratio (NR) in a single session during handgrip strength (HS) in women with stable RA. Methods. Twenty-one women with RA (diagnosis of disease: ±8 years, erythrocyte sedimentation rate: ±24.8, age: 54± 11 years, BMI: 28 ± 4 kg ·m-2) received three experimental interventions for five minutes in a randomized and balanced cross-over order: (1) control—seated with hands at rest, (2) sham—push-up position with hands on the vibration platform that remained disconnected, and (3) vibration—push-up position with hands on the vibration platform turned on (45 Hz, 2 mm, 159.73 m·s-2). At the baseline and immediately after the three experimental interventions, the HS, the electromyographic records (EMGrms), and range of motion (ROM) of the dominant hand were measured. The NR, i.e., the ratio between EMGrms of the flexor digitorum superficialis (FDS) muscle and HS, was also determined. The lower NR represented the greater neuromuscular efficiency (NE). Results. The NR was similar at baseline in the three experimental interventions. Despite the nonsignificance of within-interventions ( p = 0.0611 ) and interaction effect ( p = 0.1907 ), WBV exercise reduced the NR compared with the sham and control ( p = 0.0003 , F = 8.86 , η 2 = 0.85 , power = 1.00 ). Conclusion. Acute WBV exercise under the hands promotes neuromuscular modifications during the handgrip of women with stable RA. Thus, acute WBV exercise may be used as a preparatory exercise for the rehabilitation of the hands in this population. This trial is registered with trial registration 2.544.850 (ReBEC-RBR-2n932c).
Publisher: Springer International Publishing
Date: 25-07-2019
Publisher: Elsevier BV
Date: 05-2019
Publisher: Elsevier BV
Date: 02-2018
DOI: 10.1016/J.PHYSBEH.2017.10.027
Abstract: Although High Intensity Interval Training (HIIT) are being associated to increase cardiovascular and metabolic adaptation, there is controversy and limited information about the effects of HIIT on hippoc al oxidative stress, pro- and anti-inflammatory cytokines balance and neurotrophic status. Thus, this study evaluated the effects of six weeks of HIIT on hippoc al redox state (oxidative damage and enzymatic and non-enzymatic antioxidant defenses), neuroimmune mediators (TNFα, IL-6, IL-1β and IL-10) and brain-derived neurotrophic (BDNF) levels. After six weeks of HIIT young adults male Wistar rats presented reduced oxidative damage and increased enzymatic (superoxide dismutase) and non-enzymatic activity in hippoc us. Moreover HIIT induced a decrease in cytokine content (TNFα, IL-6, IL-1β and IL-10) and enhanced hippoc al BDNF levels. In conclusion, the present study showed for the first time a positive effect of six weeks of HIIT on reducing hippoc al oxidative stress by decreasing lipoperoxidation and inflammatory markers, as well enhancing antioxidant defenses and BDNF content.
Publisher: University of Toronto Press Inc. (UTPress)
Date: 02-2023
Abstract: Purpose: To describe the initial steps in the development of a family-completed, modified version of the Gross Motor Function Measure (GMFM-88) to report gross motor function of young people with cerebral palsy in their natural environments. Methods: Development of the Gross Motor Function – Family Report (GMF-FR) was based on expert opinion involving 13 experienced clinicians and researchers, in four steps: (1) item identification to target items that reflect functional gross motor performance (2) item selection (3) critical analysis of the items and (4) item and scoring modification. Results: Several modifications to existing items and scoring were made, including wording changes to optimize ease of families’ understanding, the addition of photographs to illustrate all items, changes to the items to enable use of furniture instead of specialized equipment, and modifications to scoring criteria to ensure a focus on functional motor skills. Ultimately, 30 items were selected, and specific testing/scoring instructions were created for each item. Conclusions: GMF-FR is a new family-report tool, based on the GMFM-88. When validated, it can be used as a telehealth outcome measure to capture family-reported functional motor skill performance in home and community environments.
Publisher: BMJ
Date: 20-08-2018
DOI: 10.1136/EMERMED-2017-207435
Abstract: The National Emergency X-Radiography Utilisation Study II (NEXUS II) clinical decision rule (CDR) can be used to optimise the use of CT in children with head trauma. We set out to externally validate this CDR in a large cohort. We performed a prospective observational study of patients aged <18 years presenting with head trauma of any severity to 10 Australian/New Zealand EDs. In a planned secondary analysis, we assessed the accuracy of the NEXUS II CDR (with 95% CI) to detect clinically important intracranial injury (ICI). We also assessed clinician accuracy without the rule. Of 20 137 total patients, we excluded 28 with suspected penetrating injury. Median age was 4.2 years. CTs were obtained in ED for 1962 (9.8%), of whom 377 (19.2%) had ICI as defined by NEXUS II. 74 (19.6% of ICI) patients underwent neurosurgery.Sensitivity for ICI based on the NEXUS II CDR was 379/383 (99.0 (95% CI 97.3% to 99.7%)) and specificity was 9320/19 726 (47.2% (95% CI 46.5% to 47.9%)) for the total cohort. Sensitivity in the CT-only cohort was similar. Of the 18 022 children without CT in ED, 49.4% had at least one NEXUS II risk criterion. Sensitivity for ICI by the clinicians without the rule was 377/377 (100.0% (95% CI 99.0% to 100.0%)) and specificity was 18 147/19 732 (92.0% (95% CI 91.6% to 92.3%)). NEXUS II had high sensitivity, similar to the derivation study. However, approximately half of unimaged patients were positive for NEXUS II risk criteria this may result in an increased CT rate in a setting with high clinician accuracy.
Publisher: Research, Society and Development
Date: 18-09-2022
DOI: 10.33448/RSD-V11I12.34356
Abstract: Aim: To translate, cross-cultural adapt and investigate the measurement properties of the 25-point Friendship Scale to Brazilian-Portuguese. Methods: Translation and adaptation of the 25-point Friendship Scale to Brazilian-Portuguese was conducted at first. Then, the new version was administered to 160 Brazilians to investigate test-retest reliability, internal consistency, standard error of the measurement (SEM), minimal detectable change (MDC), ceiling and floor effects, and concurrent validity. To investigate concurrent validity, the Brazilian–Portuguese version of the 0-100 EuroQol Visual Analog Scale (EQ VAS) was used to assess people’s self-reported health status. Results: The Brazilian-Portuguese version has good to excellent reliability (ICC of 0.76, 95% CI 0.61 – 0.85) and had moderate internal consistency (Cronbach’s alpha value of 0.78, 95% CI: 0.73 – 0.83). To avoid measurement error and to exceed variability, scores need to be greater than 1.33 (SEM) and 3.69 (MDC) on the 25-point scale, respectively. There was no ceiling and floor effects. For concurrent validity, there was a small positive correlation between the Friendship Scale and the EQ VAS (Spearman rs = 0.24 p .01). Conclusions: The new Brazilian–Portuguese version of the Friendship Scale has acceptable measurement properties to assess people over 18 years old’s perception of social isolation.
Publisher: FapUNIFESP (SciELO)
Date: 2017
Location: Brazil
No related grants have been discovered for Hercules Leite.