ORCID Profile
0000-0003-4952-7009
Current Organisation
Université Paris Descartes
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Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 16-02-2021
DOI: 10.1212/WNL.0000000000011413
Abstract: Identifying a structural brain lesion on MRI has important implications in epilepsy and is the most important factor that correlates with seizure freedom after surgery in patients with drug-resistant focal onset epilepsy. However, at conventional magnetic field strengths (1.5 and 3T), only approximately 60%–85% of MRI examinations reveal such lesions. Over the last decade, studies have demonstrated the added value of 7T MRI in patients with and without known epileptogenic lesions from 1.5 and/or 3T. However, translation of 7T MRI to clinical practice is still challenging, particularly in centers new to 7T, and there is a need for practical recommendations on targeted use of 7T MRI in the clinical management of patients with epilepsy. The 7T Epilepsy Task Force—an international group representing 21 7T MRI centers with experience from scanning over 2,000 patients with epilepsy—would hereby like to share its experience with the neurology community regarding the appropriate clinical indications, patient selection and preparation, acquisition protocols and setup, technical challenges, and radiologic guidelines for 7T MRI in patients with epilepsy. This article mainly addresses structural imaging in addition, it presents multiple nonstructural MRI techniques that benefit from 7T and hold promise as future directions in epilepsy. Answering to the increased availability of 7T MRI as an approved tool for diagnostic purposes, this article aims to provide guidance on clinical 7T MRI epilepsy management by giving recommendations on referral, suitable 7T MRI protocols, and image interpretation.
Publisher: Wiley
Date: 30-03-2021
DOI: 10.1002/ACN3.51292
Publisher: Cold Spring Harbor Laboratory
Date: 25-08-2020
DOI: 10.1101/2020.08.24.265173
Abstract: studies of motor outcome after Neonatal Arterial Ischemic Stroke (NAIS) often rely on lesion mapping using MRI. However, clinical measurements indicate that motor deficit can be different than what would solely be anticipated by the lesion extent and location. Because this may be explained by the cortical disconnections between motor areas due to necrosis following the stroke, the investigation of the motor network can help in the understanding of visual inspection and outcome discrepancy. In this study, we propose to examine the structural connectivity between motor areas in NAIS patients compared to healthy controls in order to define the cortical and subcortical connections that can reflect the motor outcome 30 healthy controls and 32 NAIS patients with and without Cerebral Palsy (CP) underwent MRI acquisition and manual assessment. The connectome of all participants was obtained from T1-weighted and diffusion-weighted imaging. significant disconnections in the lesioned and contra-lesioned hemispheres of patients were found. Furthermore, significant correlations were detected between the structural connectivity metric of specific motor areas and manuality assessed by the Box and Block Test (BBT) scores in patients. using the connectivity measures of these links the BBT score can be estimated using a multiple linear regression model. In addition, the presence or not of CP can also be predicted using the KNN classification algorithm. According to our results, the structural connectome can be an asset in the estimation of gross manual dexterity and can help uncover structural changes between brain regions related to NAIS.
Publisher: Elsevier BV
Date: 07-2022
DOI: 10.1016/J.MRI.2022.04.002
Abstract: The use of dielectric pads to redistribute the radiofrequency fields is currently a popular solution for 7 T MRI practical applications, especially in brain imaging. In this work, we tackle several downsides of the previous generation of dielectric pads. This new silicon carbide recipe makes them MR invisible and greatly extends the performance lifespan. We produce a set of two 10x10x1cm SiC pads are compared to state-of-the-art perovskite based dielectric pads with similar dielectric properties (barium titanate). Numerical simulations confirm that head and local SAR are similar. MRI measurements confirm that the pads do not induce susceptibility artefacts and improve B We demonstrate the long-term performance and invisibility of these new pads in order to increase the contrast in the brain temporal lobes in a commercial 7 T MRI head coil.
Location: France
No related grants have been discovered for Lucie Hertz-Pannier.