ORCID Profile
0000-0002-2798-3794
Current Organisations
Institute of Chemistry Chinese Academy of Sciences
,
Royal Society of Chemistry
,
The Chinese University of Hong Kong, Shenzhen
,
Hong Kong University of Science and Technology
,
Tongji University
,
the Hong Kong Materials Research Society
,
the Hong Kong Institute of Science
,
Wiley-VCH
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World Scientific Publishing
,
Wiley VCH Verlag GmbH und Co KG
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Versita
,
Taylor & Francis Group
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the Asian and Oceania Photochemistry Association
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the Hong Kong Chemical Society
,
the Hong Kong Chapter of the American Chemical Society
,
Optoelectronics Science & Technology Frontiers Series, Science Press
,
Nature Publishing Group
,
Old City Publishing
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Northeast Normal University
,
Journal of Molecular Engineering & Systems Biology, Herbert Publications Limited
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MD Publications Pvt Ltd
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Materials Research Society
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Materials Chemistry Frontiers, Royal Society of Chemistry
,
South China University of Technology
,
Springer
,
Qingdao Normal University
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Progress in Chemistry, Chinese Academy of Sciences
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Science China: Chemistry, Science China Press
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Royal Society of Chemistry Cambridge
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RSC Polymer Chemistry Series, Royal Society of Chemistry
,
American Scientific Publishers Inc
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AIMS Press
,
Aggregation-induced Emission: Phenomena, Materials and Application Wiley
,
American Chemical Society
,
American Biographical Institute
,
Chinese Chemical Society and Elsivier
,
Chinese Chemical Society
,
Chinese Materials Research Society
,
Chinese Chemical Society and Wiley
,
Bentham Open
,
Chinese Academy of Sciences
,
, Special Issue on Functional Polymers for Optoelectronic Applications in Polymer Bulletin
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Advances in Polymer Science, Springer
,
Innovation China
,
International Society for Optical Engineering
,
Elsevier BV
,
Elsevier
,
Executive Committee of the Hong Kong Chapter of the Society of Plastics Engineers
,
Dove Medical Press
,
HKUST Shenzhen Research Institute
,
Hong Kong Institution of Science
,
Hong Kong Branch of National Engineering Research Center for Tissue Restoration & Reconstruction, Hong Kong, China
,
Hangzhou Normal University
,
Gordon Research Conferences
,
Higher Education Press and Springer-Verlag GmbH
,
Herbert Publications Ltd.
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Publisher: American Chemical Society (ACS)
Date: 18-08-2021
Publisher: Springer Science and Business Media LLC
Date: 05-02-2020
DOI: 10.1038/S41588-019-0562-0
Abstract: About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 38 histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We identified 19,166 somatically acquired retrotransposition events, which affected 35% of s les and spanned a range of event types. Long interspersed nuclear element (LINE-1 L1 hereafter) insertions emerged as the first most frequent type of somatic structural variation in esophageal adenocarcinoma, and the second most frequent in head-and-neck and colorectal cancers. Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes leads to the removal of tumor-suppressor genes, and can induce complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage–fusion–bridge cycles, leading to high-level lification of oncogenes. These observations illuminate a relevant role of 22 L1 retrotransposition in remodeling the cancer genome, with potential implications for the development of human tumors.
Publisher: Springer Science and Business Media LLC
Date: 31-10-2012
DOI: 10.1038/NATURE11632
Publisher: Springer Science and Business Media LLC
Date: 08-12-2014
DOI: 10.1038/NG.3165
Abstract: Prostate cancer is driven by a combination of genetic and/or epigenetic alterations. Epigenetic alterations are frequently observed in all human cancers, yet how aberrant epigenetic signatures are established is poorly understood. Here we show that the gene encoding BAZ2A (TIP5), a factor previously implicated in epigenetic rRNA gene silencing, is overexpressed in prostate cancer and is paradoxically involved in maintaining prostate cancer cell growth, a feature specific to cancer cells. BAZ2A regulates numerous protein-coding genes and directly interacts with EZH2 to maintain epigenetic silencing at genes repressed in metastasis. BAZ2A overexpression is tightly associated with a molecular subtype displaying a CpG island methylator phenotype (CIMP). Finally, high BAZ2A levels serve as an independent predictor of biochemical recurrence in a cohort of 7,682 in iduals with prostate cancer. This work identifies a new aberrant role for the epigenetic regulator BAZ2A, which can also serve as a useful marker for metastatic potential in prostate cancer.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1TC03022A
Abstract: A series of pyrene-based AIEgens have been employed in the preparation of fluorescent inks with less colour migration for anti-counterfeiting applications over the ultra-low to high concentration range and avoids the ACQ effect.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0MA00409J
Abstract: Aggregation-induced emission (AIE)-based fluorescent nanofibers (FNFs) and thin-coating films (FTFs) are employed as visual fluorescent sensors, and their performance dynamics is compared.
Publisher: Springer Science and Business Media LLC
Date: 04-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00342H
Abstract: Preparation and study of the rapid formation of electrospun fluorescent thermosetting fibers via chemical knitting of a thermosetting polymer with AIEgens and their possible applications as fluorescent probes.
Publisher: American Chemical Society (ACS)
Date: 24-07-2023
Publisher: Wiley
Date: 08-2021
DOI: 10.1002/EXP.20210002
Abstract: Biological applications of nanomaterials as delivery carriers have been embedded in traditional biomedical research for decades. Despite lagging behind, recent significant breakthroughs in the use of nanocarriers as tools for plant biotechnology have created great interest. In this Perspective, we review the outstanding recent works in nanocarrier‐mediated plant transformation and its agricultural applications. We analyze the chemical and physical properties of nanocarriers determining their uptake efficiency and transport throughout the plant body.
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No related grants have been discovered for Jan Korbel.