ORCID Profile
0000-0001-8423-0409
Current Organisations
University of Queensland
,
Chinese Academy of Medical Sciences
,
Garvan Institute of Medical Research
,
Peking Union Medical College
,
University of Michigan
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Publisher: American Chemical Society (ACS)
Date: 23-08-2018
Abstract: Induction of effective antigen-specific CD8
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9BM01183H
Abstract: Exogenous antigens processed in the cytosol and subsequently cross-presented on major histocompatibility complex class I (MHC-I) molecules activate cytotoxic CD8 + lymphocytes (CTL), which are crucial in cancer immunotherapy.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0BM00908C
Abstract: hSNPs elicit robust anti-tumor immune responses through targeted evading the immune suppressive function of Tregs and TIM3 + exhausted-like CD8 + T cells while promoting CD4 + T cells, especially ICOS + Th1-like CD4 + T cells, and CD8 + effector T cells in a nonredundant fashion.
Publisher: Elsevier BV
Date: 09-2017
Publisher: Elsevier BV
Date: 09-2016
Publisher: Springer Science and Business Media LLC
Date: 19-12-2005
DOI: 10.1007/S00406-005-0630-6
Abstract: It is known that in the pathogenesis of mental retardation (MR), both genetic and environmental factors (particularly iodine deficiency) appear to play a critical role. Transthyretin (TTR) transports between 20% and 30% of serum thyroxine in normal in iduals and it is the main T(4)-binding protein in CSF. Variability in the TTR gene may influence risk for iodine-deficiency-based MR. The SNPs we selected from dbSNP were detected and identified using ARMS-PCR and sequencing methods, and we identified five novel sequence variants. Singular-locus association analysis indicated no association between the TTR gene and MR. In haplotype analysis, however, we found a haplotype CGTG+ (rs723744/G+6649C/T+6690C/rs2276382/del9) showed a weak positive association with MR (chi(2) = 6.699, p = 0.035). Finally, we concluded that the weak positive result is more likely to be due to s ling error and the small size of this haplotype resulting from its relative low frequency. Our negative results provide no evidence that variants of TTR gene influence susceptibility to MR in the iodine-deficient areas of China and suggest that there may be a compensatory mechanism(s) in humans and mice, which work(s) to compensate the effect of mutation in the TTR gene on MR.
Location: China
No related grants have been discovered for Yanfeng Han.