ORCID Profile
0000-0002-5593-8851
Current Organisation
The University of Auckland
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Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9SM00932A
Abstract: Explaining antimicrobial battacin lipopeptides by investigating the solution structure – the propensity to aggregate may have a role in a declined antimicrobial activity.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0CC01618G
Abstract: An investigation using recombinant ribosomal proteins and synthetic peptide models was conducted to uncover the effect of the introduction of a negative charge at the C-terminal tail of ribosomal protein S15.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7CE00232G
Abstract: Synthetic antifreeze peptides based on the hyperactive antifreeze protein modify the shape of ice crystals and show enhanced antifreeze activity with the addition of a small molecule.
Publisher: Wiley
Date: 29-06-2021
Abstract: Hypoxia‐inducible factor prolyl hydroxylase domain 2 (PHD2) is an important oxygen sensor in animals. By using the CO‐releasing molecule‐2 (CORM‐2) as an in situ CO donor, we demonstrate that CO is an inhibitor of PHD2. This report provides further evidence about the emerging role of CO in oxygen sensing and homeostasis.
Publisher: American Chemical Society (ACS)
Date: 10-11-2017
DOI: 10.1021/ACS.BIOMAC.7B01245
Abstract: Six guanidine functionalized aliphatic biodegradable polycarbonates with varying molecular weights and charge densities were synthesized via postsynthesis modification of alkyne containing polycarbonates using Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. The concept of passive diluting group was to modify the cationic charge density of the polycarbonate without changing its hydrophilicity. Within the molecular weight range from 8000 to 30000 g mol
Publisher: American Chemical Society (ACS)
Date: 04-12-2020
DOI: 10.1021/ACS.JMEDCHEM.9B01694
Abstract: Cell-penetrating peptide conjugated peptide aldehydes
Publisher: Elsevier BV
Date: 11-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6OB02616H
Abstract: We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides.
Publisher: Informa UK Limited
Date: 11-2019
DOI: 10.1111/CXO.12899
Abstract: Povidone-iodine is used as a cost-effective broad-spectrum antiseptic in the prophylaxis and treatment of certain ocular infections. In this study, the stability, ophthalmic irritation potential and antibacterial efficacy of an extemporaneous povidone-iodine preparation was determined using established ex vivo and in vitro assays. Extemporaneous iodine was prepared by simple dilution in normal saline. Preparation stability was evaluated by monitoring concentration and pH. Ocular safety was determined using the bovine cornea opacity and permeability assay. Efficacy was assessed by determining the minimum inhibitory and minimum bactericidal concentration of the preparation on Staphylococcus aureus and Pseudomonas aeruginosa. Diluted povidone-iodine maintained its stability over the 28-day evaluation. The formulation caused mild ocular irritation at the lowest prepared concentration (0.5 per cent w/v), with irritation noticeably increased at higher concentrations. The preparation showed minimum bactericidal and inhibitory concentrations of 0.078 and 0.3 per cent w/v on S. aureus and P. aeruginosa, respectively. This study confirms the stability and broad-spectrum antibacterial efficacy of povidone-iodine, while addressing the ocular irritation potential of this chemical.
Publisher: Elsevier BV
Date: 03-2016
DOI: 10.1016/J.BMC.2016.01.047
Abstract: Seventy nine derivatives of thieno[2,3-b]quinolines, tetrahydrothieno[2,3-b]quinoline, dihydrocyclopenta[b]thieno[3,2-e]pyridine, cyclohepta[b]thieno[3,2-e]pyridine and hexahydrocycloocta[b]thieno[3,2-e]pyridine were either synthesized or obtained commercially and tested for their antiproliferative activity against HCT116, MDA-MB-468 and MDA-MB-231 human cancer cell lines. The most potent eight compounds were active against all cell lines with IC50 values in the 80-250nM range. In general hexahydrocycloocta[b]thieno[3,2-e]pyridines were most active with increasing activity observed as larger cycloalkyl rings were fused to the pyridine ring.
Publisher: Elsevier BV
Date: 2021
No related grants have been discovered for Viji Sarojini.