ORCID Profile
0000-0003-4725-5409
Current Organisation
University of Hyderabad
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Publisher: Elsevier BV
Date: 06-2021
Publisher: MDPI AG
Date: 20-11-2022
DOI: 10.3390/PATHOGENS11111387
Abstract: Background: To examine the relationship between single-nucleotide polymorphisms (SNPs) in interleukin (IL) genes and keratitis and its clinical manifestations. Methods: SNPs in IL1B, IL6, CXCL8, IL10, and IL12B were analysed. Differences in frequencies of alleles, genotypes and haplotypes between cases and controls as well as associations between SNPs and clinical variables were calculated by χ2 tests with odds ratios. Results: The minor homologous genotype in IL1B rs16944 (p = 0.036 odds ratio (OR) = 2.063, 95% confidence interval (CI): 1.048–4.061) and CXCL8 rs4073 (p = 0.041 OR = 0.463, 95% CI: 0.224–0.956) and the heterologous genotypes in IL6 rs1800795 (p = 0.046 OR = 0.563, 95% CI: 0.326–0.972) and IL12B rs2569254 (p = 0.0446 OR = 0.557, 95% CI: 0.314–0.989) or rs730691 (p = 0.0051 OR = 0.451, 95% CI: 0.260–0.784) were associated with keratitis. The minor genotype of rs16944 was associated with severe infection (p = 0.046). The heterologous genotype in rs2569254 was associated with hospital admission, photophobia, and mode of contact lens wear (p ≤ 0.041). The heterologous genotype in rs730691 was associated with blurred vision, discharge, anterior chamber reaction, and mode of wear (p ≤ 0.047). Conclusions: This study demonstrates that SNPs in IL1B and CXCL8 are associated with risk of developing keratitis. The study also found relationships between SNPs and clinical measures of keratitis. The potential for ethnic differences in frequency of SNPs and their association with keratitis should be followed up using different populations.
Publisher: Elsevier BV
Date: 1999
DOI: 10.1016/S1367-0484(99)80011-3
Abstract: To increase our knowledge of factors leading to Acanthamoeba keratitis in contact lens wearers, we determined the ability of this organism to adhere to corneal epithelial cells (EC) recovered from non-lens wearers (NL) and from subjects using hydrogel contact lenses on a daily (DW) and extended wear (EW) schedule. ECs were incubated with trophozoites of Acanthamoeba and, after 3 h, the median per cent of cells exhibiting adherence was 24, 23 and 23 for NL, DW and EW groups respectively (P=0.552, Kruskal-Wallis Test). There were no differences between the groups for the number of adherent amoebae and a significant majority had only one adherent trophozoite per EC. No difference in adherence was seen with increasing exposure time. Factors other than amoebic adherence to superficial corneal EC are responsible for the increased incidence of Acanthamoeba keratitis in lens wearers.
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Date: 30-06-2021
DOI: 10.1167/TVST.10.7.32
Publisher: MDPI AG
Date: 03-01-2022
DOI: 10.3390/ANTIBIOTICS11010058
Abstract: (1) Purpose: This study aimed to investigate the effects of Mel4 antimicrobial contact lenses (MACL) on the ocular surface and comfort during extended wear. (2) Methods: A prospective, randomised, double-masked, contralateral clinical trial was conducted with 176 subjects to evaluate the biocompatibility of contralateral wear of MACL. The wearing modality was 14-day extended lens wear for three months. The participants were assessed at lens dispensing, after one night, two weeks, one month and three months of extended wear and one month after study completion. (3) Results: There were no significant differences (p 0.05) in ocular redness or palpebral roughness between Mel4 and control eyes at any of the study visits. There was no significant difference (p 0.05) in corneal staining between Mel4 and control eyes. There were no significant differences in front surface wettability or deposits or back surface debris (p 0.05). No statistically significant differences (p 0.05) were found in comfort, dryness, CLDEQ-8 scores lens or edge awareness. There was no evidence for delayed reactions on the ocular surface after cessation of lens wear. (4) Conclusion: The novel MACLs showed similar comfort to control lenses and were biocompatible during extended wear. Thus, these lenses were compatible with the ocular surface.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 2014
Publisher: Informa UK Limited
Date: 31-01-2022
DOI: 10.1080/09286586.2022.2032202
Abstract: To determine the prevalence of refractive error (RE) and associated risk factors for myopic refractive errors in children and young adults from the urban region of Hyderabad, South India. Four thousand sixty-five (4,065) participants aged 6-22 years were enrolled and examined in this cross-sectional study conducted from October 2013 to January 2015. Participants were enrolled from a random s le of schools and universities in regions representative of urban Hyderabad. RE was determined using cycloplegic autorefraction. The association of demographic factors such as age, gender, and socio-economic category (SEC) (low/mid/high) with myopia was explored with logistic regression with robust standard error. Of the total participants, 2,259 were children aged 6-15 years and 1,806 were adolescents and young adults aged 16-22 years. Overall prevalence of myopia, high myopia (≤ -5.00D and ≤ -6.00 D), hyperopia, emmetropia, and astigmatism was 29.8% (95% CI: 26.0% to 33.6%, n = 1,216), 2.9% (95% CI: 1.9% to 3.9%, n = 120), 1.1% (95%CI: 0.7% to 1.5%, n = 46), 14.7% (95% CI: 12.4% to 17.0%, n = 599), 46.9% (95% CI: 43.7% to 50.1%, n = 1913) and 8.6% (95% CI: 7.4% to 9.9%, n = 352) respectively. A strong correlation existed between age and prevalence of myopia (R Myopia was the most prevalent refractive error and increased with age in this urban population. More myopia was observed in schools of low SEC.
Publisher: Wiley
Date: 30-11-2022
DOI: 10.1111/OPO.12923
Abstract: To evaluate the visual photosensitivity threshold and objective photosensitivity luminance in healthy eyes, thereby providing a normative dataset that will lead to a better understanding of diseases causing photophobia. This was a prospective cross‐sectional study. Emmetropes whose visual acuity was better than 0.18 logMAR (6/9) with no other ocular abnormality were included. Headache Impact Test‐6 and visual light sensitivity questionnaires were administered. Visual photosensitivity threshold was measured subjectively using the ocular photosensitivity analyser. Objective photosensitivity luminance was assessed manually by evaluating videos recorded using an infrared camera and noting the intensity of light at the first squeezing reflex. Seventy five normal subjects (age range, 7–71 years) were included. Median age was 32.7 years (inter‐quartile range, 20.3–47.9 years). Forty (53.3%) were males. Median Headache Impact Test score was 38 (inter‐quartile range, 36–42) and visual light sensitivity questionnaire score was 11 (inter‐quartile range, 8–15). Mean (standard deviation) right eye, left eye and binocular visual photosensitivity threshold was 3.34 (0.78), 3.33 (0.81) and 3.37 (0.78) loglux, respectively. There was a significant negative correlation of visual light sensitivity questionnaire scores with right eye, left eye and binocular visual photosensitivity thresholds, and positive correlation of age with binocular visual photosensitivity thresholds. Mean (standard deviation) right eye, left eye and binocular objective photosensitivity luminance was 3.25 (0.55), 3.35 (0.47) and 3.15 (0.52) loglux, respectively. Age was only positively correlated with binocular objective photosensitivity luminance, and there was no correlation between age and right eye or left eye objective photosensitivity luminance. The study characterised, for the first time, objective photosensitivity luminance and established normative data for both visual photosensitivity threshold and objective photosensitivity luminance. The data will help in understanding the pathophysiology of diseases causing photophobia, monitoring the disease progression and evaluating treatment modalities.
Publisher: Elsevier BV
Date: 02-2022
DOI: 10.1016/J.CLAE.2021.02.017
Abstract: The purpose of this study was to investigate the effect of Mel4 antimicrobial peptide-coated contact lenses (MACL) on the microbiota of the conjunctiva and lenses during three months of extended wear. One hundred and seventy-six participants were recruited into a randomised, contralateral, double masked, biweekly extended wear MACL and uncoated control lens trial. At the one month and 3-month visit, the conjunctival microbiota was s led using sterile cotton swabs and contact lenses were collected aseptically. Standard microbiological procedures were employed for culture of the swabs and contact lenses and identification of the isolated microorganisms. Gram-positive bacteria (predominantly coagulase-negative staphylococci) were the most frequently isolated microbes from both contact lenses and conjunctiva. There was no difference in the frequency of isolation of most bacteria or fungi from the conjunctival swabs of eyes wearing either MACL or control lenses. The only exception was a higher frequency of eyes harbouring Staphylococcus arlettae when wearing control lenses (5%) versus MACL ( 1 microbial type per s ling occasion for either conjunctiva swabs or contact lenses. MACL wear did not change the conjunctival microbiota during extended wear, and the types of microbes isolated from MACL were similar to those isolated from control lenses.
No related grants have been discovered for Nagaraju Konda.