ORCID Profile
0000-0001-8750-3062
Current Organisations
Stony Brook University
,
Deakin University - Melbourne Burwood Campus
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Publisher: Emerald
Date: 22-02-2011
DOI: 10.1108/13673271111108666
Abstract: This paper seeks to scope the nature and form of practices, understandings and institutional arrangements that might contribute to the successful “design” and continuity of Communities of Practice (CoP) in a state government department in Australia. The study aims to provide research evidence to support the design and establishment of a CoP based on systems thinking within this department. A total of 13 semi‐structured interviews were undertaken involving 14 informants. The interviewer also attended one CoP meeting. An emergent approach to research design was adopted with data analysis guided by previous studies on CoPs. The research revealed the existence of six CoPs that were purposefully created internally by the department. Six “design” and practice considerations were suggested for practitioners aiming to create and sustain successful CoPs. Interview material was the only source of primary data and it was gathered from one organisation only – a state government department in Australia. Findings indicate that the role of the CoP coordinator is still not fully understood. The results from this study can be used in re‐designing a systems thinking CoP to support systems thinking within the department. The study also revealed that purposefully designing CoPs is possible and useful for practitioners aiming to collaborate and share expertise across disciplinary and isional boundaries. This study provides some guidance for the purposeful design of CoPs, which has been under‐examined in the literature.
Publisher: Inderscience Publishers
Date: 2019
Publisher: MDPI AG
Date: 20-11-2020
DOI: 10.3390/SU12229683
Abstract: Urban green infrastructure (UGI) has the potential to address a wide range of challenges associated with rapidly growing cities in a changing climate, while also providing multiple environmental, economic and social benefits. However, the location of projects is often determined according to a single potential benefit rather than a set of benefits. Furthermore, while UGI is recognized as a successful strategy to support resilience in many cities around the world, it has not been implemented in Uruguay. This study develops a model to identify priority areas in need of green infrastructure in Montevideo, Uruguay. The GIS-based model, termed the “Green Infrastructure Suitability Model” (GISM) is based on a multi-criteria decision analysis approach and is similar in structure to land suitability analysis. The model considers a range of socioeconomic, biophysical and environmental factors to prioritize the need for UGI across the case-study region. Resulting suitability maps identify areas for multifunctional UGI localization in places where benefits can be maximized. The GISM has potential as a tool to support future planning for multifunctional UGI.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0EW00830C
Abstract: Cyanobacterial bloom changes in spatial scale and variability can be partially addressed using UAVs, achieving efficient and accurate risk assessments.
Publisher: IWA Publishing
Date: 08-12-2019
DOI: 10.2166/WPT.2018.118
Abstract: Precise information on the extent of inundated land is required for flood monitoring, relief, and protective measures. In this paper, two spectral indices, Normalized Difference Water Index (NDWI) and Modified Normalized Difference Water Index (MNDWI), were used to identify inundated areas during heavy rainfall events in the Tarwin catchment, Victoria, Australia, using Landsat-8 OLI imagery. By integrating the assessed condition of levees, this research also explains the inefficiency of the flood control measures of this region of Australia. NDWI and MNDWI indices performed well, but water features were enhanced better in the NDWI-derived image, with an accuracy of 96.04% and Kappa coefficient of 0.83.
Publisher: Elsevier BV
Date: 05-2021
Publisher: American Association for Cancer Research (AACR)
Date: 08-2016
DOI: 10.1158/1541-7786.MCR-16-0090
Abstract: The Cancer Target Discovery and Development (CTD2) Network was established to accelerate the transformation of “Big Data” into novel pharmacologic targets, lead compounds, and biomarkers for rapid translation into improved patient outcomes. It rapidly became clear in this collaborative network that a key central issue was to define what constitutes sufficient computational or experimental evidence to support a biologically or clinically relevant finding. This article represents a first attempt to delineate the challenges of supporting and confirming discoveries arising from the systematic analysis of large-scale data resources in a collaborative work environment and to provide a framework that would begin a community discussion to resolve these challenges. The Network implemented a multi-tier framework designed to substantiate the biological and biomedical relevance as well as the reproducibility of data and insights resulting from its collaborative activities. The same approach can be used by the broad scientific community to drive development of novel therapeutic and biomarker strategies for cancer. Mol Cancer Res 14(8) 675–82. ©2016 AACR.
Publisher: CSIRO Publishing
Date: 2021
DOI: 10.1071/MF19266
Abstract: Mitigating the expansion of harmful cyanobacterial blooms in Uruguayan catchments is a major challenge facing researchers and decision makers. To make matters worse, these events are expected to occur more often as the climate changes. Taking Australia’s experience as an ex le, minimising the effect of algal blooms involves a range of catchment land use policy and regulatory measures that are underpinned by comprehensive monitoring systems, hydrological modelling platforms and land suitability analysis considering the effects of climate change. The lack of these technological tools means that policies and regulations cannot be implemented effectively. In this paper, we analyse the effects of climate change on Laguna Del Sauce Catchment (Uruguay) and discuss the effects of a possible new land use configuration defined using approaches typically used in Australia. We identify that the likely future of the catchment, according to biophysical modelling, is in conflict with its likely future as defined by its existing land use trajectory and associated agricultural policy. Our analysis provides new insights into the possible effects of climate change on Laguna Del Sauce, and thus fills an important knowledge gap to inform and amend the current policies and institutional frameworks.
Publisher: Springer Science and Business Media LLC
Date: 07-04-2015
Publisher: IWA Publishing
Date: 09-03-2010
DOI: 10.2166/WH.2010.102
Abstract: The purpose of this study was to investigate the occurrence of antibiotic resistance genes (ARGs) in water used for irrigation in the Werribee River Basin, Australia, including river water and reclaimed effluent water (reclaimed water). S les of reclaimed water, collected over a one-year period, were screened for the occurrence of ARGs using PCR detection assays. The presence of ARGs in the reclaimed water s les were contrasted with that of water s les taken from the Werribee River Basin, collected over the same time period, from five points selected for varying levels of urban and agricultural impact. Of the 54 river water s les collected, 2 (4%), 2 (4%), 0 and 0 were positive for methicillin, sulfonamide, gentamicin and vancomycin-resistant genes, respectively, while 6 of 11 reclaimed water s les were positive for methicillin (9%) and sulfonamide (45%). The presence/absence of ARGs did not appear to correlate with other measured water quality parameters. The low detection of ARGs in river water indicates that, regardless of its poor quality, the river has not yet been severely contaminated with ARGs. The greater prevalence of ARGs in reclaimed water indicates that this important agricultural water source will need to be monitored into the future.
Publisher: MDPI AG
Date: 20-06-2016
DOI: 10.3390/IJGI5060099
Publisher: CSIRO Publishing
Date: 2011
DOI: 10.1071/FP11026
Abstract: Microarray analysis was used to investigate changes in host gene expression during the primary stages of the interaction between the susceptible plant Arabidopsis thaliana (L.) Heynh ecotype Col-0 and the biotrophic pathogen Plasmodiophora brassicae Woronin. Analyses were conducted at 4, 7 and 10 days after inoculation (DAI) and revealed significant induction or suppression of a relatively low number of genes in a range of functional categories. At 4 DAI, there was induced expression of several genes known to be critical for pathogen recognition and signal transduction in other resistant host–pathogen interactions. As the pathogen further colonised root tissue and progressed through the primary plasmodium stage to production of zoosporangia at 7 and 10 DAI, respectively, fewer genes showed changes in expression. The microarray results were validated by examining a subset of induced genes at 4 DAI by quantitative real-time reverse transcriptase PCR (RT-qPCR) analysis all of which correlated positively with the microarray data. The two A. thaliana mutants jar1 and coiI tested were found to be susceptible to P. brassicae. The involvement of defence-related hormones in the interaction was further investigated and the findings indicate that addition of salicylic acid can suppress clubroot disease in A. thaliana plants.
Publisher: Wiley
Date: 11-2017
DOI: 10.1002/FES3.122
Publisher: Elsevier BV
Date: 06-2022
Publisher: Research, Society and Development
Date: 20-03-2020
Abstract: Condições climáticas afetam a produtividade e a viabilidade econômica da agricultura que é desafiada pelas constantes variações de temperatura e precipitação ao longo do tempo. O objetivo deste trabalho foi estimar alterações climáticas na microrregião de Guarapuava no estado do Paraná, analisando os impactos sobre a cultura do milho, utilizando modelagem para cenários futuros e comparando com um cenário base do passado. Foram ajustados modelos de adequação matemática utilizando Análise de Múltiplos Critérios (MCA) e Processo de Hierarquia Analítica (AHP), utilizando os cenários climáticos RCP4.5 e RCP8.5 (IPCC) para o cálculo do índice de aptidão agrícola da cultura considerando as variáveis solo, topografia e clima. Concluiu-se que a projeção de aumento da temperatura média durante o ciclo de cultivo é o fator ambiental de maior impacto para a redução do índice de aptidão agrícola para o milho na microrregião de Guarapuava no ano de 2050.
Publisher: IWA Publishing
Date: 27-02-2013
DOI: 10.2166/WRD.2013.019
Abstract: In 2008, vegetable growers observed stunted lettuce plants showing signs of chlorosis and wilting. It was suspected that monochloramine in the recycled water used for irrigation, in combination with extreme environmental conditions (high irrigation water salinity and extreme heat), was responsible for these crop failures. A series of glasshouse studies was conducted to evaluate the impact of monochloramine concentration alone on iceberg lettuce seedlings, as well as in combination with high salinity and hot ambient temperatures. Monochloramine concentrations up to 9 and 15 mg L−1 Cl2 for continuous and initial irrigation only, respectively, did not affect the weight of iceberg lettuce heads (p & 0.05), while the combination of monochloramine (4–5 mg L−1 Cl2) and salinity (3,500 μS cm−1) did not significantly affect harvest measurements (p & 0.05). We therefore conclude that it is unlikely that monochloramine was responsible for the observed crop failures.
Publisher: Elsevier BV
Date: 02-2020
Publisher: Springer Science and Business Media LLC
Date: 10-11-2011
Publisher: Elsevier BV
Date: 06-2006
Publisher: American Association for Cancer Research (AACR)
Date: 09-2012
DOI: 10.1158/2159-8290.CD-12-0116
Abstract: Understanding factors required for DNA replication will enrich our knowledge of this important process and potentially identify vulnerabilities that can be exploited in cancer therapy. We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. We identify an important role for DDX5 in G1–S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. We find that the DDX5 locus is frequently lified in breast cancer and that breast cancer–derived cells with lification of DDX5 are much more sensitive to its depletion than breast cancer cells and a breast epithelial cell line that lacks DDX5 lification. Our results show a novel role for DDX5 in cancer cell proliferation and suggest DDX5 as a therapeutic target in breast cancer treatment. Significance: DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is lified, and this has uncovered a dependence on DDX5 for cell proliferation. Given the high frequency of DDX5 lification in breast cancer, our results highlight DDX5 as a promising candidate for targeted therapy of breast tumors with DDX5 lification, and indeed we show that DDX5 inhibition sensitizes a subset of breast cancer cells to trastuzumab. Cancer Discov 2(9) 812–25. ©2012 AACR. This article is highlighted in the In This Issue feature, p. 753.
Publisher: Walter de Gruyter GmbH
Date: 09-2019
Abstract: Storm-water management is a common concern in rural catchments where development-related growth causes increases of storm-water flows. Greater magnitude and frequency of storm-water create greater challenges for mitigating storm-water damage and improving water quality. The concept of Blue-Green Infrastructure (BGI) as a solution incorporates a wide range of applicable components with the aim of minimizing the effect of catchment development on flow regimes without changing the watershed morphology. BGI components manage storm-water by decreasing impermeable cover and expanding natural and semi-natural systems to store water or recharge and filter storm-water into the ground. In this paper, guidelines for designing a pond as a component of BGI are provided and, configuration and size of the pond are determined. Moreover, the impacts of the designed pond on storm-water peak flow and quality are assessed for the Tarwin catchment, State of Victoria, Australia. The results indicate that the introduction of the pond would have reduced outfall inflow by 94 % and would have achieved the reduction of 88.3, 75.5 and 50.7 % for total suspended solids, total phosphorus, and total nitrogen respectively, during the extreme weather event in June 2012.
Publisher: Elsevier BV
Date: 08-2020
Publisher: Springer Science and Business Media LLC
Date: 20-12-2019
Publisher: GN1 Genesis Network
Date: 2018
Publisher: FapUNIFESP (SciELO)
Date: 03-2021
Abstract: Resumo As evidências de que ocorrerão mudanças climáticas globais em função do aumento da concentração de gases de efeito estufa têm se apresentado cada vez mais consistentemente e aceitas pela comunidade científica internacional. O objetivo deste trabalho foi avaliar estimativas de alterações climáticas na microrregião de Guarapuava no estado do Paraná, analisando os impactos sobre a cultura do trigo, utilizando modelagem para cenários futuros e comparando com um cenário base do passado. Foram ajustados modelos de adequação matemática utilizando Análise de Múltiplos Critérios (MCA) e Processo de Hierarquia Analítica (AHP), com a finalidade de avaliar os possíveis impactos das mudanças climáticas na cultura de trigo, utilizando os cenários climáticos RCP4.5 e RCP8.5 (IPCC) para o cálculo do índice de aptidão agrícola da cultura na microrregião de Guarapuava-PR. Os resultados indicam que o fator de maior impacto para a redução do índice de aptidão agrícola do trigo nos próximos 30 anos, é a projeção de aumento da temperatura média mensal em aproximadamente 1,5 a 2 °C durante o ciclo de desenvolvimento da cultura no c o.
Publisher: CSIRO Publishing
Date: 26-08-2021
DOI: 10.1071/MF21081
Abstract: Cyanobacterial harmful algal blooms (CyanoHABs) are increasingly being reported worldwide owing to several reasons, including widespread eutrophication and enhanced scientific monitoring. Catchment and water management, organisations, industry, farmers and local governments are all confronting the effects of climate change, which stimulate the growth of cyanobacteria and affect the efficacy of adaptation measures in water systems. To tackle climate change and CyanoHABs growth, actors at different levels require both ‘top-down’ and ‘bottom-up’ assessments to help them in formulating and implementing adaptation measures. Potential solutions must also be assessed locally to limit associated adverse effects, in particular, negative effects on water quality. Thus, having a better understanding of the synergies, conflicts and trade-offs between adaptation practices and climate-change effects on CyanoHABs makes a valuable contribution to a more integrated climate policy and the effective climate-proofing of our water bodies. This article examines adaptation practices focused on tackling CyanoHABs occurrence in a changing climate. It fills an important gap between a major environmental problem and potential solutions. The practices and measures advanced as a result of the analysis can be used by persons with different expertise and skill levels for improving the relevant institutional frameworks and policies to protect their local water bodies.
Publisher: SDEWES Centre
Date: 03-2020
Publisher: Springer Science and Business Media LLC
Date: 05-2009
Publisher: Springer Science and Business Media LLC
Date: 22-02-2009
DOI: 10.1038/NBT.1526
Publisher: International Journal on Food System Dynamics
Date: 2019
Publisher: Springer Science and Business Media LLC
Date: 07-12-2013
Publisher: Springer Science and Business Media LLC
Date: 2009
DOI: 10.1071/AP08093
Publisher: Springer International Publishing
Date: 2018
No related grants have been discovered for Robert Faggian.