ORCID Profile
0000-0002-3325-0263
Current Organisations
Universitaire Ziekenhuis Gasthuisberg
,
University of Leeds
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Publisher: Oxford University Press (OUP)
Date: 08-2020
DOI: 10.1530/EJE-20-0401
Abstract: The COVID-19 pandemic has required rapid transformation and adaptation of healthcare services. Women with gestational diabetes mellitus (GDM) are one of the largest high-risk groups accessing antenatal care. In reformulating the care offered to those with GDM, there is a need to balance the sometimes competing requirement of lowering the risk of direct viral transmission against the potential adverse impact of service changes. We suggest pragmatic options for screening of GDM in a pandemic setting based on blood tests, and risk calculators applied to underlying risk factors. Alternative models for antenatal care provision for women with GDM, including targeting high-risk groups, early lifestyle interventions and remote monitoring are provided. Testing options and their timing for postpartum screening in women who had GDM are also considered. Our suggestions are only applicable in a pandemic scenario, and usual guidelines and care pathways should be re-implemented as soon as possible and appropriate.
Publisher: American Physical Society (APS)
Date: 06-12-2011
Publisher: Springer Science and Business Media LLC
Date: 17-12-2006
DOI: 10.1038/NMAT1809
Abstract: Exchange bias is commonly manifested as the hysteresis-loop shift observed when a ferromagnet is in contact with an antiferromagnet. Here, we report observations of exchange bias with unusual features of a ferromagnet in contact with a spin glass, demonstrating that this is a phenomenon of greater generality. The easily measured properties of the ferromagnet allow access to the internal magnetic degrees of freedom of the glass to which they are coupled. Our results show that a Co/CuMn bilayer system exhibits all the rich phenomena of coercivity enhancement, bias-field shifts and training effects associated with a conventional ferromagnet/antiferromagnet system. Nevertheless, striking differences arise, such as an orientation reversal of the bias field in a small temperature range just below the blocking temperature. We argue that all features can be understood within the context of a random-field model for long-ranged oscillatory Ruderman-Kittel-Kasuya-Yosida (RKKY) coupled spins.
Publisher: American Physical Society (APS)
Date: 16-03-2017
Publisher: IOP Publishing
Date: 23-11-2016
Publisher: The Endocrine Society
Date: 30-10-2021
Abstract: Early diagnosis and treatment of gestational diabetes (GDM) may reduce adverse obstetric and neonatal outcomes, especially in high-risk women. However, there is a lack of data for other outcomes. We compared cardiometabolic and mental health outcomes in women with early (eGDM) and classical (cGDM) GDM. This prospective cohort included 1185 All women with cGDM and 76 women with eGDM. The eGDM group had GDM risk factors (BMI & kg/m2, family history of diabetes, history of GDM, ethnicity), were tested at & weeks gestational age, and diagnosed using American Diabetes Association prediabetes criteria. All women underwent lifestyle adaptations. Obstetric, neonatal, mental, and cardiometabolic outcomes were assessed during pregnancy and postpartum. The eGDM group had lower gestational weight gain than cGDM (10.7 ± 6.2 vs 12.6 ± 6.4 P = 0.03) but needed more medical treatment (66% vs 42% P & 0.001). They had similar rates of adverse maternal and neonatal outcomes, except for increased large-for-gestational-age infants (25% vs 15% P = 0.02). Mental health during pregnancy and postpartum did not differ between groups. eGDM had more atherogenic postpartum lipid profile than cGDM (P ≤ 0.001). In eGDM, the postpartum prevalence of the metabolic syndrome (MetS) was 1.8-fold, prediabetes was 3.1-fold, and diabetes was 7.4-fold higher than cGDM (waist circumference-based MetS: 62% vs 34%/BMI-based MetS: 46% vs 24% prediabetes: 47.5% vs 15.3% diabetes: 11.9% vs 1.6%, all P & 0.001). These differences remained unchanged after adjusting for GDM risk factors. Compared with cGDM, eGDM was not associated with differences in mental health, but with increased adverse cardiometabolic outcomes, independent of GDM risk factors and gestational weight gain. This hints to a preexisting risk profile in eGDM.
Publisher: American Physical Society (APS)
Date: 19-02-2013
Publisher: Frontiers Media SA
Date: 22-07-2022
DOI: 10.3389/FENDO.2022.948716
Abstract: The COVID-19 pandemic has been associated with worsened metabolic and mental health in the general and perinatal population. The postpartum is a critical moment regarding these outcomes particularly in women with gestational diabetes mellitus (GDM). We investigated the cardio-metabolic and mental health outcomes before and during the pandemic in this population. This cohort study included 418 women with GDM, recruited during two distinct periods. This included 180 women exposed to the pandemic (E+) and recruited between May 2020-April 2021 and 238 women who were not exposed to the pandemic during their postpartum period (attended a year before=non-exposed (E-)) and recruited between January-December 2019. Among the E+, a nested-subcohort of 120 women were exposed both during pregnancy and postpartum. During the pandemic, we adopted a hybrid follow-up of women that consisted of in-person consultations, regular contact via phone calls (35%), sent recorded exercise guide to patients to follow at home and linked to our website. We specifically focused on maintaining motivation and keeping a strong focus on healthy lifestyle behaviors. Obstetric, neonatal, cardio-metabolic and mental health outcomes were assessed during pregnancy and postpartum. The pandemic was not associated with worsened weight, weight retention, glucose tolerance, metabolic syndrome, well-being or depression in the postpartum with the exception of a minimally increased HbA1c, diastolic blood pressure and lower emotional eating scores in E+ women (all p ≤ 0.046). In the nested subcohort, E+ women had a slightly increased HbA1c at the first GDM visit and a higher need for glucose-lowering medication (both p ≤ 0.014), but HbA1c at the end of pregnancy and other cardio-metabolic, mental health, obstetric and neonatal outcomes during pregnancy were similar. The pandemic was not associated with any clinically relevant worsening of cardio-metabolic, mental health, obstetrical and neonatal outcomes in our GDM cohort. This was possibly due to a continued hybrid follow-up, and the partial lockdown in Switzerland.
Publisher: Springer Science and Business Media LLC
Date: 08-11-2019
Publisher: IOP Publishing
Date: 30-03-2010
Publisher: IOP Publishing
Date: 21-10-2009
DOI: 10.1088/0957-4484/20/46/465302
Abstract: Making use of focused Ga-ion beam (FIB) fabrication technology, the evolution with device dimension of the low-temperature electrical properties of Nb nanowires has been examined in a regime where crossover from Josephson-like to insulating behaviour is evident. Resistance-temperature data for devices with a physical width of order 100 nm demonstrate suppression of superconductivity, leading to dissipative behaviour that is shown to be consistent with the activation of phase-slip below T(c). This study suggests that by exploiting the Ga-impurity poisoning introduced by the FIB into the periphery of the nanowire, a central superconducting phase-slip nanowire with sub-10 nm dimensions may be engineered within the core of the nanowire.
Publisher: IOP Publishing
Date: 20-03-2012
Publisher: American Physical Society (APS)
Date: 17-07-2012
Publisher: Springer Science and Business Media LLC
Date: 20-01-2020
Publisher: AIP Publishing
Date: 10-03-2017
DOI: 10.1063/1.4978315
Abstract: We present a comparative study of the spin wave properties in two magnetic films patterned into an artificial square spin ice-like geometry. The array elements are rectangular islands with the same lateral dimensions but with different thicknesses: 10 nm and 30 nm. Using Brillouin light scattering, the frequencies of spin wave excitations were measured as a function of the magnetic field going from positive to negative saturation. We find substantial changes with thickness to spin wave mode frequencies and the number of detected modes. Frequencies of spin waves localized at element edges are observed to evolve non-monotonically with magnetic fields and soften at critical fields. These critical fields enable us to extract information of the magnetization reversal of in idual islands within the array. Finally, we discuss the effects of separation between islands and examine the possibilities for dynamic coupling through the overlap of collective edge modes.
Publisher: American Physical Society (APS)
Date: 08-02-2011
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Katrien Benhalima.