ORCID Profile
0000-0003-2921-8348
Current Organisation
University of Alabama at Birmingham
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Publisher: Wiley
Date: 09-2017
DOI: 10.1002/MDS.27115
Publisher: Wiley
Date: 11-06-2015
DOI: 10.1002/MDS.26248
Publisher: Elsevier BV
Date: 05-2019
Publisher: The American Association of Immunologists
Date: 07-2019
Abstract: Tau protein is found to be aggregated and hyperphosphorylated (p-tau) in many neurologic disorders, including Parkinson disease (PD) and related parkinsonisms, Alzheimer disease, traumatic brain injury, and even in normal aging. Although not known to produce autoimmune responses, we hypothesized that the appearance of aggregated tau and p-tau with disease could activate the immune system. We thus compared T cell responses to tau and p-tau–derived peptides between PD patients, age-matched healthy controls, and young healthy controls (& y old who are less likely to have high levels of tau aggregates). All groups exhibited CD4+ T cell responses to tau-derived peptides, which were associated with secretion of IFN-γ, IL-5, and/or IL-4. The PD and control participants exhibited a similar magnitude and breadth of responses. Some tau-derived epitopes, consisting of both unmodified and p-tau residues, were more highly represented in PD participants. These results were verified in an independent set of PD and control donors (either age-matched or young controls). Thus, T cells recognizing tau epitopes escape central and peripheral tolerance in relatively high numbers, and the magnitude and nature of these responses are not modulated by age or PD disease.
Publisher: Wiley
Date: 04-03-2015
DOI: 10.1002/MDS.26170
Publisher: Springer Science and Business Media LLC
Date: 19-06-2011
DOI: 10.1038/NG.859
Location: United States of America
No related grants have been discovered for David Standaert.