ORCID Profile
0000-0002-2733-8250
Current Organisation
University of the Sunshine Coast
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Oxford University Press (OUP)
Date: 13-03-2019
DOI: 10.1039/C8MT00370J
Abstract: Manganese is an essential metal that is required for a wide range of biological functions. Ferroportin (FPN), the only known cellular exporter of iron, has also been proposed to play a role in manganese export, but this relationship is incompletely understood. To investigate this in more detail in vivo, we examined the relative distributions of manganese and iron in TMPRSS6 deficient mice, which are characterized by constitutively high expression of the iron regulatory hormone hepcidin and, consequently, very low FPN levels in their tissues. Tmprss6−/− mice showed frank iron deficiency and reduced iron levels in most tissues, consistent with FPN playing an important role in the distribution of this metal, but manganese levels were largely unaffected. Associated studies using intestine-specific FPN knockout mice showed that loss of FPN significantly reduced the dietary absorption of iron, but had no effect on manganese intake. Taken together, our data suggest that FPN does not play a major role in Mn transport in vivo. They do not exclude a minor role for FPN in manganese homeostasis, nor the possibility that the transporter may be relevant at high Mn levels, but at physiological levels of this metal, other transport proteins appear to be more important.
Publisher: Informa UK Limited
Date: 20-02-2020
Publisher: Springer Science and Business Media LLC
Date: 23-02-2019
DOI: 10.1007/S10534-019-00181-9
Abstract: Inadequate iron levels during early life can have adverse consequences for the developing infant. Iron deficiency during this critical period of growth can affect brain development and cognitive function, problems that can be lifelong despite subsequent correction of the iron deficit. Therefore, it is critical that the suckling infant has sufficient iron for their developmental needs. Much of the iron used in the immediate post-natal period is stored iron that was acquired from the mother in the final trimester of pregnancy, however, despite having low iron levels, breast milk can also make a significant contribution to infant iron needs. This reflects the ability of the suckling infant to absorb dietary iron far more efficiently than is possible after weaning. The mechanisms underlying this enhanced iron absorption are poorly understood. The iron export protein ferroportin is essential for this process, as it is in adults, however, the role of other molecules normally involved in iron absorption following weaning is less clear. The composition and distribution of iron in breast milk may be important, as could the contribution of more distal parts of the gastrointestinal tract. This review discusses the potential role of each of the above components in intestinal iron absorption during suckling and highlights the need for further research into this important process.
Publisher: Informa UK Limited
Date: 06-07-2020
Publisher: Wiley
Date: 25-05-2018
Publisher: Wiley
Date: 13-01-2020
Publisher: University of Alicante
Date: 15-01-2023
Abstract: Internationally, there is an under-supply of intellectual capital to provide for STEM-related employment. One contributing factor is the low number of female students selecting STEM school subjects and careers. Despite the literature recommending students engage in STEM activities earlier, many initiatives are not implemented until high school. This paper reports on an Australian project named MindSET-do which provided students with early positive STEM experiences prior to high school to raise awareness of, interest in, and aspirations for STEM-related subjects and careers. The case study surveyed n = 107 Year 6 boys’ and girls’ interests, ability beliefs and expectations in STEM school subjects and careers. Students’ awareness and interest in STEM-related subjects and careers increased significantly following experiences with inquiry-based STEM activities, χ2(1, n = 107) = 4.57 to 63.67, p .05. Expectancy for success in mathematics was significantly higher for males than for females (U = 1125, p = .044, r = .2). Expectancy for success in science was slightly lower for the female group, but p .05. Logistic regression found females were 24 percent less likely to have a positive view of mathematics than males (p = .003). Gender differences in STEM ability versus ability beliefs and expectancies for success are discussed, with recommendations for earlier positive experiences with STEM tasks.
Publisher: Ferrata Storti Foundation (Haematologica)
Date: 14-06-2018
Location: Australia
No related grants have been discovered for Natalie McMaster.