ORCID Profile
0000-0003-3166-5980
Current Organisations
Nursing Faculty at Rio de Janeiro State University
,
University of Illinois Chicago College of Pharmacy
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Publications
Studying Mass Balance and the Stability of (Z)-Ligustilide from Angelica sinensis Helps to Bridge a Botanical Instability–Bioactivity Chasm
Publisher: American Chemical Society (ACS)
Date: 03-09-2019
Residual Complexity Does Impact Organic Chemistry and Drug Discovery: The Case of Rufomyazine and Rufomycin
Publisher: American Chemical Society (ACS)
Date: 24-05-2018
Quality Control of Therapeutic Peptides by 1H NMR HiFSA Sequencing
Publisher: American Chemical Society (ACS)
Date: 22-02-2019
Unprecedented Benzoquinone Motifs Reveal Post-Oligomerizational Modification of Proanthocyanidins
Publisher: American Chemical Society (ACS)
Date: 25-09-2023
Structural Sequencing of Oligopeptides Aided by
Publisher: American Chemical Society (ACS)
Date: 16-10-2017
DOI: 10.1021/ACS.JNATPROD.7B00207
Abstract: This report describes an approach using
New Rufomycins from Streptomyces atratus MJM3502 Expand Anti-Mycobacterium tuberculosis Structure–Activity Relationships
Publisher: American Chemical Society (ACS)
Date: 04-10-2022
Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives
Publisher: American Chemical Society (ACS)
Date: 07-03-2018
Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8NP90041H
Abstract: Correction for ‘The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research’ by James B. McAlpine et al. , Nat. Prod. Rep. , 2018, DOI: 10.1039/c7np00064b.
Targeting Trimeric and Tetrameric Proanthocyanidins of Cinnamomum verum Bark as Bioactives for Dental Therapies
Publisher: American Chemical Society (ACS)
Date: 05-11-2020
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C7NP00064B
Abstract: With contributions from the global natural product (NP) research community, and continuing the Raw Data Initiative, this review collects a comprehensive demonstration of the immense scientific value of disseminating raw nuclear magnetic resonance (NMR) data, independently of, and in parallel with, classical publishing outlets.
Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus
Publisher: Springer Science and Business Media LLC
Date: 08-03-2017
DOI: 10.1038/NATURE21674
Abstract: Recent genomic data have revealed multiple interactions between Neanderthals and modern humans, but there is currently little genetic evidence regarding Neanderthal behaviour, diet, or disease. Here we describe the shotgun-sequencing of ancient DNA from five specimens of Neanderthal calcified dental plaque (calculus) and the characterization of regional differences in Neanderthal ecology. At Spy cave, Belgium, Neanderthal diet was heavily meat based and included woolly rhinoceros and wild sheep (mouflon), characteristic of a steppe environment. In contrast, no meat was detected in the diet of Neanderthals from El Sidrón cave, Spain, and dietary components of mushrooms, pine nuts, and moss reflected forest gathering. Differences in diet were also linked to an overall shift in the oral bacterial community (microbiota) and suggested that meat consumption contributed to substantial variation within Neanderthal microbiota. Evidence for self-medication was detected in an El Sidrón Neanderthal with a dental abscess and a chronic gastrointestinal pathogen (Enterocytozoon bieneusi). Metagenomic data from this in idual also contained a nearly complete genome of the archaeal commensal Methanobrevibacter oralis (10.2× depth of coverage)-the oldest draft microbial genome generated to date, at around 48,000 years old. DNA preserved within dental calculus represents a notable source of information about the behaviour and health of ancient hominin specimens, as well as a unique system that is useful for the study of long-term microbial evolution.
The Untargeted Capability of NMR Helps Recognizing Nefarious Adulteration in Natural Products
Publisher: American Chemical Society (ACS)
Date: 12-03-2021
Food Allergy Readiness and Anaphylaxis Management in Early Childhood Education and Care in Western Australia
Publisher: SAGE Publications
Date: 12-2018
Abstract: WITH THE INCREASE IN prevalence of food allergy (FA) in young children, early childhood education and care (ECEC) providers are likely to have more enrolments of children who are at risk of anaphylaxis. This study examines the status of FA management in ECEC, and assesses the services’ current readiness to prevent and manage FA. A cross-sectional study comprising an online survey with multiple-choice and open-ended questions was conducted with 53 long day care services in Western Australia. Among the respondents, 83 per cent of services had at least one child enrolled with FA, 96 per cent had an FA policy, and 91 per cent required staff to undertake anaphylaxis training. A high level of self-reported confidence and skills were demonstrated however, gaps were identified in risk-minimisation knowledge, use of adrenaline (epinephrine) autoinjectors and available resources. Extensive promotion of available resources will help improve compliance with anaphylaxis guidelines.
Classification of Flavonoid Metabolomes via Data Mining and Quantification of Hydroxyl NMR Signals
Publisher: American Chemical Society (ACS)
Date: 28-02-2020
Silica Gel-mediated Oxidation of Prenyl Motifs Generates Natural Product-Like Artifacts
Publisher: Georg Thieme Verlag KG
Date: 11-05-2021
DOI: 10.1055/A-1472-6164
Abstract: Prenyl moieties are commonly encountered in the natural products of terpenoid and mixed biosynthetic origin. The reactivity of unsaturated prenyl motifs is less recognized and shown here to affect the acyclic Rhodiola rosea monoterpene glycoside, kenposide A (8), which oxidizes readily on silica gel when exposed to air. The major degradation product mediated under these conditions was a new aldehyde, 9. Exhibiting a shortened carbon skeleton formed through the breakdown of the terminal isopropenyl group, 9 is prone to acetalization in protic solvents. Further investigation of minor degradation products of both 8 and 8-prenylapigenin (8-PA, 12), a flavonoid with an ortho-prenyl substituent, revealed that the aldehyde formation was likely realized through epoxidation and subsequent cleavage at the prenyl olefinic bond. Employment of 1H NMR full spin analysis (HiFSA) achieved the assignment of all chemical shifts and coupling constants of the investigated terpenoids and facilitated the structural validation of the degradation product, 9. This study indicates that prenylated compounds are generally susceptible to oxidative degradation, particularly in the presence of catalytic mediators, but also under physiological conditions. Such oxidative artifact/metabolite formation leads to a series of compounds with prenyl-derived (cyclic) partial structures that are analogous to species formed during Phase I metabolism in vivo. Phytochemical and pharmacological studies should take precautions or at least consider the impact of (unavoidable) exposure of prenyl-containing compounds to catalytic and/or oxidative conditions.
Tandem of Countercurrent Separation and qHNMR Enables Gravimetric Analyses: Absolute Quantitation of the Rhodiola rosea Metabolome
Publisher: American Chemical Society (ACS)
Date: 16-08-2021
Fathers’ Experiences of Caring for a Child with a Chronic Illness: A Systematic Review
Publisher: MDPI AG
Date: 20-01-2023
Abstract: The prevalence of children living with chronic health conditions is increasing worldwide and can disrupt family roles, relationships, function, and parental involvement in family caregiving. The purpose of this systematic review was to explore fathers’ experiences and involvement in caring for a child with a chronic condition. Systematic searches using seven databases were conducted. Study criteria included (1) peer-reviewed original research in English, Spanish, French, or Portuguese, (2) children less than 19 years of age with a chronic condition, (3) fathers (biological or guardian) as direct informants, and (4) outcomes addressing fathers’ experience, perceptions, and/or involvement in the child’s care. Data were synthesized from ten articles reflecting eight separate studies that utilized quantitative designs. Three areas of focus were identified: Family Functioning, Father’s Psychological Health, and Need for Support. Data suggested increased involvement from the father in caring for their child with a chronic condition was associated with improved family functioning, increased anxiety and distress, decreased self-esteem, and increased need for support. This review revealed a paucity of data regarding fathers’ experiences and involvement when caring for a child with a chronic condition, with that available primarily from developed countries. Rigorous empirical studies are needed to deepen understanding of how fathers are involved in the care of their child with a chronic condition.
Geraniol-Derived Monoterpenoid Glucosides from Rhodiola rosea: Resolving Structures by QM-HifSA Methodology
Publisher: American Chemical Society (ACS)
Date: 06-02-2023
Related Organisations
Universidade Federal De São Carlos - Campus Sorocaba
Location: Brazil
Universidade Federal De São Carlos Departamento De Medicina
Location: Brazil
Universidade De São Paulo Faculdade De Medicina De Ribeirão Preto
Location: Brazil
University Of Illinois Chicago College Of Pharmacy
Location: United States of America
G.D. Searle Pharmaceutical Company
Location: United States of America
Related Funding Activities
No related grants have been discovered for David Lankin.