ORCID Profile
0000-0003-0852-5533
Current Organisations
University of Queensland
,
Baker IDI Heart and Diabetes Institute
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Publisher: Wiley
Date: 20-09-2015
DOI: 10.1002/BIO.3028
Abstract: To date, several fluorescent probes modified by a single targeting agent have been explored. However, studies on the preparation of dual-function quantum dot (QD) fluorescent probes with dual-targeting action and a therapeutic effect are rare. Here, a dual-targeting CdTe/CdS QD fluorescent probe with a bovine serum albumin-glycyrrhetinic acid conjugate and arginine-glycine-aspartic acid was successfully prepared that could induce the apoptosis of liver cancer cells and showed enhanced targeting in in vitro cell imaging. Therefore, the as-prepared fluorescent probe in this work is an efficient diagnostic tool for the simultaneous detection of liver cancer and breast cancer cells.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5RA14156G
Abstract: Doxorubicin (Dox) and Taxol can be covalently bonded to the same peptide segment via proper structural modification.
Publisher: American Chemical Society (ACS)
Date: 06-02-2020
Publisher: University of Queensland Library
Date: 2022
DOI: 10.14264/B67489A
Publisher: American Chemical Society (ACS)
Date: 11-03-2020
Publisher: Elsevier BV
Date: 2019
Publisher: Elsevier BV
Date: 11-2020
Publisher: Elsevier BV
Date: 12-2019
DOI: 10.1016/J.PHARMTHERA.2019.107404
Abstract: Lysophosphatidic acid (LPA) is a collective name for a set of bioactive lipid species. Via six widely distributed G protein-coupled receptors (GPCRs), LPA elicits a plethora of biological responses, contributing to inflammation, thrombosis and atherosclerosis. There have recently been considerable advances in GPCR signaling especially recognition of the extended role for GPCR transactivation of tyrosine and serine/threonine kinase growth factor receptors. This review covers LPA signaling pathways in the light of new information. The use of transgenic and gene knockout animals, gene manipulated cells, pharmacological LPA receptor agonists and antagonists have provided many insights into the biological significance of LPA and in idual LPA receptors in the progression of atherosclerosis and vascular diseases. This review provides a comprehensive presentation of LPA with the highlight of the distinct role of its receptors in cell and animal models that relate to atherosclerosis and vascular diseases, and therefore provides new opportunities to reduce the burden of cardiovascular diseases. The recent drug development strategies that target LPA signaling pathways are also included in this review.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5CC05503B
Abstract: In this communication we report the first supramolecular hydrogel based on an antiepileptic drug carbamazepine (CBZ). CBZ plays a dual role of a drug molecule and an aromatic capping group in this self-delivery system.
Publisher: Bioscientifica
Date: 14-08-2019
DOI: 10.1530/VB-18-0004
Abstract: The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm. GPCRs can transactivate protein tyrosine kinase receptors (PTKRs) and serine/threonine kinase receptors (S/TKRs), notably the epidermal growth factor receptor (EGFR) and transforming growth factor-β type 1 receptor (TGFBR1), respectively. Initial comprehensive mechanistic studies suggest that these two transactivation pathways are distinct. Currently, there is a focus on GPCR inhibitors as drug targets, and they have proven to be efficacious in vascular diseases. With the broadening of GPCR transactivation signalling, it is therefore important from a therapeutic perspective to find a common transactivation pathway of EGFR and TGFBR1 that can be targeted to inhibit complex pathologies activated by the combined action of these receptors. Reactive oxygen species (ROS) are highly reactive molecules and they act as second messengers, thus modulating cellular signal transduction pathways. ROS are involved in different mechanisms of GPCR transactivation of EGFR. However, the role of ROS in GPCR transactivation of TGFBR1 has not yet been studied. In this review, we will discuss the involvement of ROS in GPCR transactivation-dependent signalling.
Publisher: Elsevier BV
Date: 12-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6RA06667D
Abstract: The present research reports a smart multifunctional oxidized single-wall carbon nanohorns (oxSWNHs) drug delivery system (DDS) which could enhance the anti-tumor effect of methotrexate (MTX).
No related grants have been discovered for Ying Zhou.