ORCID Profile
0000-0001-6485-6965
Current Organisation
Bond University
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Publisher: Public Library of Science (PLoS)
Date: 04-10-2019
Publisher: SAGE Publications
Date: 02-02-2021
Abstract: This article analyses how the financial literacy of elderly people affects their decisions on the adoption of various financial strategies. Multiple mediator models with bootstrap techniques are used to identify the mediating mechanisms of financial concerns that transmit the effects of financial literacy onto specific financial strategies. We find (1) financial concerns mediate the majority of financial literacy-strategy nexuses specifically, financially illiterate people are more likely to have financial concerns and are more likely to cut back on spending, seek job opportunities, increase debts and downsize or sell their residence as a result (2) financially literate people are more likely to seek professional financial advice, purchase a life annuity, contribute more to superannuation and invest more conservatively, regardless of their concerns. Our findings suggest professional advisors and robo-advisor developers take into account financial concerns when recommending advice. JEL Classification: D14, J14, J26, I31, G11
Publisher: Informa UK Limited
Date: 06-2012
Publisher: Inderscience Publishers
Date: 2006
Publisher: Springer Science and Business Media LLC
Date: 05-1983
DOI: 10.1007/BF00952964
Abstract: To assess the validity of an exposure score obtained from the Xm Using data from in iduals with chronic pain, e The s le of 149 in iduals used a mean of 12.6 (SD = 4.6) strategies to manage pain and had a mean Xm Xm
Publisher: CRC Press
Date: 26-06-2009
Publisher: Mary Ann Liebert Inc
Date: 10-2008
Abstract: Spleen stromal cells are critical determinants of dendritic cell (DC) development in spleen. The spleen stromal line, namely STX3, supports DC differentiation in vitro from overlaid bone marrow cells while the lymph node stromal line, namely 2RL22, does not. Here we have characterised the hematopoietic support capacity of each stroma, and analysed lineage origin of the stromal cell lines by gene profiling using microarrays. Stromal co-culture experiments were performed using bone marrow cells as a source of hematopoietic progenitors. A characteristic immature myeloid-like CD11c(+)CD11b(+)CD86(+)MHC-II(/lo)B220()CD8alpha() DC is produced after 14 days in STX3 cocultures, while 2RL22 cocultures produce only monocyte/macrophage-like cells. No other hematopoietic cell type is produced. The STX3 and 2RL22 stroma were compared by transcriptome analysis utilising Affymetrix Murine U74Av2 genechips to identify gene expression related to differential hematopoietic support function. Data mining was used to determine cell surface marker expression reflecting endothelial cells and fibroblasts, as well as adhesion molecules contributing to the microenvironment. STX3 shows gene expression reflective of early endothelial cells, while 2RL22 expresses markers specific to fibroblasts. The expression of genes like Flt1, CD34, Mcam, and Eng distinguishes STX3 as an early immature endothelial cell lacking markers of angioblasts or hemangioblasts like Tal1/SCL, Tie1, Tie2, Kdr or Prom1/AC133. The absence of expression of genes like Vwf and Cd31 distinguishes STX3 from fully differentiated vascular endothelial cells. In contrast, the 2RL22 lymph node stroma specifically expresses genes related to fibroblastic-like cells like osteoblasts with expression of Vdr (Vitamin D receptor), and epithelial cells with expression of Krt13 (keratins). Gene expression data identifies STX3 as splenic endothelial cells, independently able to support the outgrowth of immature, myeloid DC-like cells from progenitors present in bone marrow, while 2RL22 lymph node fibroblastic cells provide support for development of monocytes/macrophages.
Publisher: Inderscience Publishers
Date: 2007
Publisher: SAGE Publications
Date: 08-2010
Abstract: We compare the performance of in idual and two-person teams in an electronic share-trading task. Trader profits are negatively related to the amount of trader market activity and positively related to trader confidence. While we find no evidence of a difference in trading profit between in idual and team traders, profit volatility is more sensitive to trading activity for teams. Team trading profit is positively related to attitude and negatively related to perceptions of the difficulty of the task, with overall team trading activity negatively related to views of team members’ abilities. JEL Code: D44, G14
Publisher: Informa UK Limited
Date: 06-2006
Publisher: Wiley
Date: 14-04-2019
DOI: 10.1111/ACFI.12362
Publisher: Informa UK Limited
Date: 03-2005
Publisher: Wiley
Date: 06-2006
Publisher: Elsevier
Date: 2007
Publisher: Wiley
Date: 03-2009
DOI: 10.1111/J.1445-5994.2008.01886.X
Abstract: In 1989 BreastScreen SA started screening for breast cancer in South Australia. The programme concentrated on women between the ages of 50 and 69, using a 24-month screening interval and a joint method of mammography, clinical examination and self-detection. This paper is a summary of our efforts to provide an assessment of the impact of the screening programme in terms of additional survival time past the age of first detection of the disease. The concept of benchmarks is introduced, and the survival advantages for screened women is measured from these benchmarks. The women in the BreastScreen SA service, who had primary breast tumours, had an estimated additional survival advantage of 2.6 years. Some statistical modelling allowed us to extrapolate to other screening designs.
Publisher: Informa UK Limited
Date: 27-08-2008
Publisher: Wiley
Date: 18-06-2019
DOI: 10.1111/JCMM.14382
Abstract: A novel myeloid antigen presenting cell can be generated through in vitro haematopoiesis in long‐term splenic stromal cocultures. The in vivo equivalent subset was recently identified as phenotypically and functionally distinct from the spleen subsets of macrophages, conventional (c) dendritic cells (DC), resident monocytes, inflammatory monocytes and eosinophils. This novel subset which is myeloid on the basis of cell surface phenotype, but dendritic‐like on the basis of cell surface marker expression and antigen presenting function, has been tentatively labelled “L‐DC.” Transcriptome analysis has now been employed to determine the lineage relationship of this cell type with known splenic cDC and monocyte subsets. Principal components analysis showed separation of “L‐DC” and monocytes from cDC subsets in the second principal component. Hierarchical clustering then indicated a close lineage relationship between this novel subset, resident monocytes and inflammatory monocytes. Resident monocytes were the most closely aligned, with no genes specifically expressed by the novel subset. This subset, however, showed upregulation of genes reflecting both dendritic and myeloid lineages, with strong upregulation of several genes, particularly CD300e. While resident monocytes were found to be dependent on Toll‐like receptor signalling for development and were reduced in number in Myd88 ‐/‐ and Trif ‐/‐ mutant mice, both the novel subset and inflammatory monocytes were unaffected. Here, we describe a novel myeloid cell type closely aligned with resident monocytes in terms of lineage but distinct in terms of development and functional capacity.
Publisher: Informa UK Limited
Date: 04-2006
Publisher: Elsevier BV
Date: 02-2018
Publisher: Wiley
Date: 30-09-2020
DOI: 10.1111/ACFI.12545
Publisher: Elsevier BV
Date: 02-1995
DOI: 10.1016/0145-2126(94)00120-Y
Abstract: Leukemogenesis induced by slowly transforming retroviruses is a multistep process which is difficult to dissect because of its long latency and the problem of distinguishing oncogenic from differentiative events. A method for leukemia induction in mice has been developed using a cell line isolated following in vitro infection with the slowly transforming murine radiation leukemia virus (RadLV). The CI-V13D cell line represents a lymphoid precursor cell type at an early stage in cell transformation and can develop subcutaneous tumors in irradiated syngeneic hosts but not in allogeneic mice even after sublethal irradiation. Selective growth in allogeneic (CBA/H) mouse thymus has been demonstrated, but this requires preirradiation of the recipient. Upon reisolation from CBA/H thymus, C1-V13D progeny clones displayed increased tumorigenic potential in comparison to the 'parental' CI-V13D cell line. Tumorigenicity was shown to increase with serial passage through thymus and electron micrographs of clones also revealed increased production of C-type retroviruses. This new model for oncogenic progression should be more amenable to analysis of early genetic changes occurring during replication of leukemia in the thymus.
Publisher: Wiley
Date: 08-2016
Publisher: JSTOR
Date: 03-1993
DOI: 10.2307/2532618
Publisher: Inderscience Publishers
Date: 2008
Publisher: World Scientific Pub Co Pte Lt
Date: 12-2004
DOI: 10.1142/S0219024904002803
Abstract: In this paper we propose a forward time update algorithm to recursively estimate subset vector autoregressive models (including an intercept term) with a forgetting factor, using the exact window case. The proposed recursions cover, for the first time, subset vector autoregressive models (VAR) with a forgetting factor and an intercept variable. We then present two applications. In the first application we apply the proposed estimation algorithm to the quarterly aluminium prices on the London Metal Exchange. The findings show that the proposed algorithm can improve the forecasting performance. In the second application a bivariate system investigates the relationship between the Australian's All Ordinaries Share Price Index (SPI) futures and BHP share price (BHP). The proposed algorithm also introduces the Monte Carlo Integration approach into the proposed algorithm to generate error bands for the impulse responses. These results confirm that the SPI Granger causes BHP, but not vice versa.
Publisher: Wiley
Date: 29-05-2007
Abstract: Gene profiling provides a multitude of data on in idual gene expression. The view is expressed here that unreplicated data can be used in a descriptive way to compare cell populations in terms of their lineage characteristics and function. In these studies, the aim is to provide a snapshot of gene expression or its absence as a reflection of cell lineage or type, rather than gain a reliable expression measure for all genes expressed. The data set used in this analysis represents gene expression in the splenic stroma STX3 supportive of dendritic cell hematopoiesis and the lymph node stroma 2RL22, which is non-supportive. These were obtained by hybridization of Affymetrix U74Av2 genechips. The use of P-value selection to identify genes with a high probability of differential expression has been used effectively to detect differentially expressed genes. Genes that relate to a niche environment for hematopoiesis have been selected for further study to make predictions about the cell types of supportive stroma.
Publisher: Inderscience Publishers
Date: 2007
Publisher: Informa UK Limited
Date: 07-2006
Publisher: Emerald Group Publishing Limited
Date: 2009
Publisher: Oxford University Press (OUP)
Date: 1992
Abstract: Several murine lymphoid cell lines have been tested for specific capacity to localize in thymus. These are all continuous, cloned Radiation leukemia virus-induced cell lines which have a common phenotype resembling lymphoid stem cells or immature T cells. Since each of these cell lines has a cloning efficiency approaching 100%, the number of cells which enters thymus during a 3 h homing assay has been estimated by limit dilution cloning analysis taking into account extra-binomial variation caused by in idual mice. Only two out of seven of these cell lines have been found to have this specific property. These two cell lines, 16C1 and 5C2B, have been characterized as immature lymphoid cells, bearing no rearrangement at the TCR gamma and beta loci, and having the phenotype of CD3+CD4-CD8-, immature T cells. A maximum number of 2000 16C1 cells and 2500 5C2B cells can enter thymus during a 3 h homing assay, suggesting a limited number of sites in thymus to which these cells can bind. The capacity of 16C1 to enter thymus in low frequency has been found to be a stable property and was not increased by repetitive passage through mouse thymus. Using this assay, we have also been able to confirm that entry of 16C1 cells into thymus can be inhibited by antibody specific for the Ly24 (Pgp-1) molecule.
Publisher: Elsevier BV
Date: 11-2014
Publisher: Springer Science and Business Media LLC
Date: 22-10-2006
DOI: 10.1245/S10434-006-9203-9
Abstract: The focus of this study was the relative survival rates of breast cancer patients whose treatment was breast-conserving surgery compared with that of mastectomy, adjusting for tumor size and nodal status because these factors may be intrinsically associated with mastectomy being the treatment of choice. Patient age was also accounted for in the model. By adjusting for these factors, we mitigate them as confounders of treatment choice in assessing effects on survival rates. Data were sourced from linked administrative data from the Western Australian Department of Health Record Linkage Unit. The data consisted of linked records containing the diagnosis, subsequent hospital admission, and death records of about 3000 women diagnosed with cancer in Western Australia between 1 January 1995 and 31 December 1999. Cox proportional hazards regression was used to investigate survival outcomes of breast-conserving surgery compared with that of mastectomy, adjusting for tumor size, nodal status, and subject age. The hazard of death is reduced by a factor of about one half for subjects whose treatment was breast-conserving surgery over treatment by mastectomy. Furthermore, the hazard of death increases substantially for subjects with nodal involvement over subjects for whom there has been no identified spread to regional lymph nodes. Hazard of death increases as both age and tumor size increase. Western Australian breast cancer patients treated with breast-conserving surgery have improved survival outcomes over those treated with mastectomy, after allowing for tumor size, patient age, and lymph node involvement.
Publisher: Springer Science and Business Media LLC
Date: 05-2022
DOI: 10.1007/S11626-022-00693-8
Abstract: Murine spleen has been shown to harbour stromal cells that support hematopoiesis with production of myeloid antigen–presenting cells. Similar stromal lines have now been isolated from long-term cultures (LTC) of human spleen. When human progenitor populations from spleen, bone marrow and cord blood were employed as a source of progenitors for co-culture above splenic stromal lines, myelopoiesis was supported. Human splenocytes gave production of predominantly myeloid dendritic-like cells, with minor subsets resembling conventional dendritic cells (cDC) cells, and myeloid or monocyte-derived DC. Human bone marrow progenitors gave rise to myelopoiesis from hematopoietic progenitors, while human cord blood supported limited myelopoiesis from existing myeloid precursors. Transcriptome analysis compared two stromal lines differing in myelopoietic support capacity. Gene profiling revealed both stromal lines to reflect perivascular reticular cells with osteogenic characteristics. However, the 5C6 stroma which failed to support hematopoiesis uniquely expressed several inhibitors of the WNT pathway. Combined data now show that splenic stroma of both human and murine origin provides a mesenchymal stromal cell microenvironment which is WNT pathway–dependent, and which supports in vitro myelopoiesis with production of specific subsets of myeloid and dendritic-like cells.
Publisher: Springer Science and Business Media LLC
Date: 20-04-2006
Publisher: Elsevier BV
Date: 09-2015
Publisher: Elsevier BV
Date: 12-2004
DOI: 10.1016/J.EXPHEM.2004.08.013
Abstract: Although dendritic cell (DC) precursors have been isolated from many lymphoid sites, the regulation and location of early DC development is still poorly understood. Here we describe a splenic microenvironment that supports DC hematopoiesis in vitro and identify gene expression specific for that niche. The DC supportive function of the STX3 splenic stroma and the lymph node-derived 2RL22 stroma for overlaid bone marrow cells was assessed by coculture over 2 weeks. The DC supportive function of SXT3 was identified in terms of specific gene expression in STX3 and not 2RL22 using Affymetrix microchips. STX3 supports DC differentiation from overlaid bone marrow precursors while 2RL22 does not. A dataset of 154 genes specifically expressed in STX3 and not 2RL22 was retrieved from Affymetrix results. Functional annotation has led to selection of 26 genes as candidate regulators of the microenvironment supporting DC hematopoiesis. Specific expression of 14 of these genes in STX3 and not 2RL22 was confirmed by reverse transcription-polymerase chain reaction. Some genes specifically expressed in STX3 have been previously associated with hematopoietic stem cell niches. A high proportion of genes encode growth factors distinct from those commonly used for in vitro development of DC from precursors. Potential regulators of a DC microenvironment include genes involved in angiogenesis, hematopoiesis, and development, not previously linked to DC hematopoiesis.
Publisher: Emerald (MCB UP )
Date: 2008
Publisher: Emerald
Date: 02-2018
DOI: 10.1016/J.ACCLIT.2017.05.003
Abstract: This paper analyses the use of big data techniques in auditing, and finds that the practice is not as widespread as it is in other related fields. We first introduce contemporary big data techniques to promote understanding of their potential application. Next, we review existing research on big data in accounting and finance. In addition to auditing, our analysis shows that existing research extends across three other genealogies: financial distress modelling, financial fraud modelling, and stock market prediction and quantitative modelling. Auditing is lagging behind the other research streams in the use of valuable big data techniques. A possible explanation is that auditors are reluctant to use techniques that are far ahead of those adopted by their clients, but we refute this argument. We call for more research and a greater alignment to practice. We also outline future opportunities for auditing in the context of real-time information and in collaborative platforms and peer-to-peer marketplaces.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 02-2007
DOI: 10.1016/J.JAMCOLLSURG.2006.11.004
Abstract: Unplanned hospital readmissions after surgical treatment for breast cancer are an indicator of morbidity. We explore the relationship between the rate of unplanned hospital readmissions within 42 days of initial treatment and various factors, including tumor size and histology, lymph node involvement, type of surgical treatment, mastectomy, or breast-conserving surgery, and patient demographics. Linked Western Australian cancer mortality and hospital morbidity data were used in the assessment of readmissions within a period of 42 days after initial surgical treatment for breast cancer. Planned admissions for adjuvant treatment such as chemotherapy or radiotherapy were deleted. Survival models for multiple events per subject were applied to analyze the data. The analysis reveals that patients more likely to experience lower recurrence of short-term unplanned hospital readmissions include those with smaller tumors, private insurance, and who reside in metropolitan areas. The model also includes important two-way interaction terms involving tumor histology, area of residence, and surgical treatment, and between lymph node involvement and patient age. This study suggests that the choice of breast-conserving surgery as a treatment for breast cancer does not invariably result in better postoperative morbidity, but rather, that other factors, including tumor size and patient demographics, play a critical role in the short term. These results differ from a previous study of longterm hospital readmissions-country of birth and method of payment were found to be associated with short-term hospital admission but not with longterm readmissions.
No related grants have been discovered for Terence O'Neill.