ORCID Profile
0000-0002-5507-9399
Current Organisations
Universitätsklinikum Hamburg-Eppendorf
,
Imam Mohammad Ibn Saud Islamic University
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Publisher: SPIE
Date: 11-07-2016
DOI: 10.1117/12.2242708
Publisher: MDPI AG
Date: 07-05-2021
DOI: 10.3390/PATHOGENS10050565
Abstract: The pathogenesis of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still not fully unraveled. Though preventive vaccines and treatment methods are out on the market, a specific cure for the disease has not been discovered. Recent investigations and research studies primarily focus on the immunopathology of the disease. A healthy immune system responds immediately after viral entry, causing immediate viral annihilation and recovery. However, an impaired immune system causes extensive systemic damage due to an unregulated immune response characterized by the hypersecretion of chemokines and cytokines. The elevated levels of cytokine or hypercytokinemia leads to acute respiratory distress syndrome (ARDS) along with multiple organ damage. Moreover, the immune response against SARS-CoV-2 has been linked with race, gender, and age hence, this viral infection’s outcome differs among the patients. Many therapeutic strategies focusing on immunomodulation have been tested out to assuage the cytokine storm in patients with severe COVID-19. A thorough understanding of the erse signaling pathways triggered by the SARS-CoV-2 virus is essential before contemplating relief measures. This present review explains the interrelationships of hyperinflammatory response or cytokine storm with organ damage and the disease severity. Furthermore, we have thrown light on the erse mechanisms and risk factors that influence pathogenesis and the molecular pathways that lead to severe SARS-CoV-2 infection and multiple organ damage. Recognition of altered pathways of a dysregulated immune system can be a loophole to identify potential target markers. Identifying biomarkers in the dysregulated pathway can aid in better clinical management for patients with severe COVID-19 disease. A special focus has also been given to potent inhibitors of proinflammatory cytokines, immunomodulatory and immunotherapeutic options to ameliorate cytokine storm and inflammatory responses in patients affected with COVID-19.
Publisher: Springer Science and Business Media LLC
Date: 05-04-2020
DOI: 10.1186/S13148-020-00840-6
Abstract: Many CpGs become hyper or hypo-methylated with age. Multiple methods have been developed by Horvath et al. to estimate DNA methylation (DNAm) age including Pan-tissue, Skin & Blood, PhenoAge, and GrimAge. Pan-tissue and Skin & Blood try to estimate chronological age in the normal population whereas PhenoAge and GrimAge use surrogate markers associated with mortality to estimate biological age and its departure from chronological age. Here, we applied Horvath’s four methods to calculate and compare DNAm age in 499 subjects with type 1 diabetes (T1D) from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study using DNAm data measured by Illumina EPIC array in the whole blood. Association of the four DNAm ages with development of diabetic complications including cardiovascular diseases (CVD), nephropathy, retinopathy, and neuropathy, and their risk factors were investigated. Pan-tissue and GrimAge were higher whereas Skin & Blood and PhenoAge were lower than chronological age ( p 0.0001). DNAm age was not associated with the risk of CVD or retinopathy over 18–20 years after DNAm measurement. However, higher PhenoAge ( β = 0.023, p = 0.007) and GrimAge ( β = 0.029, p = 0.002) were associated with higher albumin excretion rate (AER), an indicator of diabetic renal disease, measured over time. GrimAge was also associated with development of both diabetic peripheral neuropathy (OR = 1.07, p = 9.24E−3) and cardiovascular autonomic neuropathy (OR = 1.06, p = 0.011). Both HbA1c ( β = 0.38, p = 0.026) and T1D duration ( β = 0.01, p = 0.043) were associated with higher PhenoAge. Employment ( β = − 1.99, p = 0.045) and leisure time ( β = − 0.81, p = 0.022) physical activity were associated with lower Pan-tissue and Skin & Blood, respectively. BMI ( β = 0.09, p = 0.048) and current smoking ( β = 7.13, p = 9.03E−50) were positively associated with Skin & Blood and GrimAge, respectively. Blood pressure, lipid levels, pulse rate, and alcohol consumption were not associated with DNAm age regardless of the method used. Various methods of measuring DNAm age are sub-optimal in detecting people at higher risk of developing diabetic complications although some work better than the others.
Publisher: Hindawi Limited
Date: 19-02-2021
DOI: 10.1155/2021/6684918
Abstract: A new lifetime distribution, called exponential doubly Poisson distribution, is proposed with decreasing, increasing, and upside-down bathtub-shaped hazard rates. One of the reasons for introducing the new distribution is that it can describe the failure time of a system connected in the form of a parallel-series structure. Some properties of the proposed distribution are addressed. Four methods of estimation for the involved parameters are considered based on progressively type II censored data. These methods are maximum likelihood, moments, least squares, and weighted least squares estimations. Through an extensive numerical simulation, the performance of the estimation methods is compared based on the average of mean squared errors and the average of absolute relative biases of the estimates. Two real datasets are used to compare the proposed distribution with some other well-known distributions. The comparison indicates that the proposed distribution is better than the other distributions to match the data provided.
Publisher: MDPI AG
Date: 27-08-2023
DOI: 10.3390/S23177452
Abstract: Electroencephalography (EEG) is a non-invasive method employed to discern human behaviors by monitoring the neurological responses during cognitive and motor tasks. Machine learning (ML) represents a promising tool for the recognition of human activities (HAR), and eXplainable artificial intelligence (XAI) can elucidate the role of EEG features in ML-based HAR models. The primary objective of this investigation is to investigate the feasibility of an EEG-based ML model for categorizing everyday activities, such as resting, motor, and cognitive tasks, and interpreting models clinically through XAI techniques to explicate the EEG features that contribute the most to different HAR states. The study involved an examination of 75 healthy in iduals with no prior diagnosis of neurological disorders. EEG recordings were obtained during the resting state, as well as two motor control states (walking and working tasks), and a cognition state (reading task). Electrodes were placed in specific regions of the brain, including the frontal, central, temporal, and occipital lobes (Fz, C1, C2, T7, T8, Oz). Several ML models were trained using EEG data for activity recognition and LIME (Local Interpretable Model-Agnostic Explanations) was employed for interpreting clinically the most influential EEG spectral features in HAR models. The classification results of the HAR models, particularly the Random Forest and Gradient Boosting models, demonstrated outstanding performances in distinguishing the analyzed human activities. The ML models exhibited alignment with EEG spectral bands in the recognition of human activity, a finding supported by the XAI explanations. To sum up, incorporating eXplainable Artificial Intelligence (XAI) into Human Activity Recognition (HAR) studies may improve activity monitoring for patient recovery, motor imagery, the healthcare metaverse, and clinical virtual reality settings.
Publisher: MDPI AG
Date: 22-12-2022
DOI: 10.3390/HEALTHCARE11010031
Abstract: Good vaccine safety and reliability are essential for successfully countering infectious disease spread. A small but significant number of adverse reactions to COVID-19 vaccines have been reported. Here, we aim to identify possible common factors in such adverse reactions to enable strategies that reduce the incidence of such reactions by using patient data to classify and characterise those at risk. We examined patient medical histories and data documenting postvaccination effects and outcomes. The data analyses were conducted using a range of statistical approaches followed by a series of machine learning classification algorithms. In most cases, a group of similar features was significantly associated with poor patient reactions. These included patient prior illnesses, admission to hospitals and SARS-CoV-2 reinfection. The analyses indicated that patient age, gender, taking other medications, type-2 diabetes, hypertension, allergic history and heart disease are the most significant pre-existing factors associated with the risk of poor outcome. In addition, long duration of hospital treatments, dyspnoea, various kinds of pain, headache, cough, asthenia, and physical disability were the most significant clinical predictors. The machine learning classifiers that are trained with medical history were also able to predict patients with complication-free vaccination and have an accuracy score above 90%. Our study identifies profiles of in iduals that may need extra monitoring and care (e.g., vaccination at a location with access to comprehensive clinical support) to reduce negative outcomes through classification approaches.
Publisher: Oxford University Press (OUP)
Date: 08-2023
DOI: 10.1093/PNASNEXUS/PGAD247
Abstract: Placental abnormalities cause impaired fetal growth and poor pregnancy outcome (e.g. preecl sia [PE]) with long-lasting consequences for the mother and offspring. The molecular dialogue between the maternal niche and the developing placenta is critical for the function of this organ. Galectin-1 (gal-1), a highly expressed glycan-binding protein at the maternal–fetal interface, orchestrates the maternal adaptation to pregnancy and placenta development. Down-regulation or deficiency of gal-1 during pregnancy is associated with the development of PE however, the maternal- and placental-derived gal-1 contributions to the disease onset are largely unknown. We demonstrate that lack of gal-1 imposes a risk for PE development in a niche-specific manner, and this is accompanied by a placental dysfunction highly influenced by the absence of maternal-derived gal-1. Notably, differential placental glycosylation through the Sda-capped N-glycans dominates the invasive trophoblast capacity triggered by maternal-derived gal-1. Our findings show that gal-1 derived from the maternal niche is essential for healthy placenta development and indicate that impairment of the gal-1 signaling pathway within the maternal niche could be a molecular cause for maternal cardiovascular maladaptation during pregnancy.
Publisher: Hindawi Limited
Date: 07-2021
DOI: 10.1155/2021/9050026
Abstract: Chloroflexus aurantiacus is a thermophilic bacterium that produces a multitude of proteins within its genome. Bioinformatics strategies can facilitate comprehending this organism through functional and structural interpretation assessments. This study is aimed at allocating the structure and function through an in silico approach required for bacterial protein biosynthesis. This in silico viewpoint provides copious properties, including the physicochemical properties, subcellular location, three-dimensional structure, protein-protein interactions, and functional elucidation of the protein (WP_012256288.1). The STRING program is utilized for the explication of protein-protein interactions. The in silico investigation documented the protein’s hydrophilic nature with predominantly alpha (α) helices in its secondary structure. The tertiary-structure model of the protein has been shown to exhibit reasonably high consistency based on various quality assessment methods. The functional interpretation suggested that the protein can act as a translation initiation factor, a protein required for translation and protein biosynthesis. Protein-protein interactions also demonstrated high credence that the protein interconnected with 30S ribosomal subunit involved in protein synthesis. This study bioinformatically examined that the protein (WP_012256288.1) is affiliated in protein biosynthesis as a translation initiation factor IF-3 of C. aurantiacus.
Publisher: MDPI AG
Date: 22-08-2023
DOI: 10.3390/ELECTRONICS12173541
Abstract: The Internet of Medical Things (IoMT) has become an attractive playground to cybercriminals because of its market worth and rapid growth. These devices have limited computational capabilities, which ensure minimum power absorption. Moreover, the manufacturers use simplified architecture to offer a competitive price in the market. As a result, IoMTs cannot employ advanced security algorithms to defend against cyber-attacks. IoMT has become easy prey for cybercriminals due to its access to valuable data and the rapidly expanding market, as well as being comparatively easier to exploit.As a result, the intrusion rate in IoMT is experiencing a surge. This paper proposes a novel Intrusion Detection System (IDS), namely SafetyMed, combining Convolutional Neural Networks (CNN) and Long Short-Term Memory (LSTM) networks to defend against intrusion from sequential and grid data. SafetyMed is the first IDS that protects IoMT devices from malicious image data and sequential network traffic. This innovative IDS ensures an optimized detection rate by trade-off between False Positive Rate (FPR) and Detection Rate (DR). It detects intrusions with an average accuracy of 97.63% with average precision and recall, and has an F1-score of 98.47%, 97%, and 97.73%, respectively. In summary, SafetyMed has the potential to revolutionize many vulnerable sectors (e.g., medical) by ensuring maximum protection against IoMT intrusion.
Publisher: MDPI AG
Date: 12-03-2021
DOI: 10.3390/E23030335
Abstract: In this paper, we study the concomitants of dual generalized order statistics (and consequently generalized order statistics) when the parameters γ1,…,γn are assumed to be pairwise different from Huang–Kotz Farlie–Gumble–Morgenstern bivariate distribution. Some useful recurrence relations between single and product moments of concomitants are obtained. Moreover, Shannon’s entropy and the Fisher information number measures are derived. Finally, these measures are extensively studied for some well-known distributions such as exponential, Pareto and power distributions. The main motivation of the study of the concomitants of generalized order statistics (as an important practical kind to order the bivariate data) under this general framework is to enable researchers in different fields of statistics to use some of the important models contained in these generalized order statistics only under this general framework. These extended models are frequently used in the reliability theory, such as the progressive type-II censored order statistics.
Publisher: Public Library of Science (PLoS)
Date: 06-05-2021
DOI: 10.1371/JOURNAL.PONE.0250660
Abstract: Alzheimer’s disease (AD) is the commonest progressive neurodegenerative condition in humans, and is currently incurable. A wide spectrum of comorbidities, including other neurodegenerative diseases, are frequently associated with AD. How AD interacts with those comorbidities can be examined by analysing gene expression patterns in affected tissues using bioinformatics tools. We surveyed public data repositories for available gene expression data on tissue from AD subjects and from people affected by neurodegenerative diseases that are often found as comorbidities with AD. We then utilized large set of gene expression data, cell-related data and other public resources through an analytical process to identify functional disease links. This process incorporated gene set enrichment analysis and utilized semantic similarity to give proximity measures. We identified genes with abnormal expressions that were common to AD and its comorbidities, as well as shared gene ontology terms and molecular pathways. Our methodological pipeline was implemented in the R platform as an open-source package and available at the following link: nchowdhury/AD_comorbidity . The pipeline was thus able to identify factors and pathways that may constitute functional links between AD and these common comorbidities by which they affect each others development and progression. This pipeline can also be useful to identify key pathological factors and therapeutic targets for other diseases and disease interactions.
Publisher: MDPI AG
Date: 06-05-2022
DOI: 10.3390/MATH10091565
Abstract: The Truncated Cauchy Power Weibull-G class is presented as a new family of distributions. Unique models for this family are presented in this paper. The statistical aspects of the family are explored, including the expansion of the density function, moments, incomplete moments (IMOs), residual life and reversed residual life functions, and entropy. The maximum likelihood (ML) and Bayesian estimations are developed based on the Type-II censored s le. The properties of Bayes estimators of the parameters are studied under different loss functions (squared error loss function and LINEX loss function). To create Markov-chain Monte Carlo s les from the posterior density, the Metropolis–Hasting technique was used with posterior density. Using non-informative and informative priors, a full simulation technique was carried out. The maximum likelihood estimator was compared to the Bayesian estimators using Monte Carlo simulation. To compare the performances of the suggested estimators, a simulation study was carried out. Real-world data sets, such as strength measured in GPA for single carbon fibers and impregnated 1000-carbon fiber tows, maximum stress per cycle at 31,000 psi, and COVID-19 data were used to demonstrate the relevance and flexibility of the suggested method. The suggested models are then compared to comparable models such as the Marshall–Olkin alpha power exponential, the extended odd Weibull exponential, the Weibull–Rayleigh, the Weibull–Lomax, and the exponential Lomax distributions.
Publisher: Cold Spring Harbor Laboratory
Date: 08-06-2020
DOI: 10.1101/2020.06.07.20124594
Abstract: This study aims to propose a deep learning model to detect COVID-19 positive cases more precisely utilizing chest X-ray images. We have collected and merged all the publicly available chest X-ray datasets of COVID-19 infected patients from Kaggle and Github, and pre-processed it using random s ling approach. Then, we proposed and applied an enhanced convolutional neural network (CNN) model to this dataset and obtained a 94.03% accuracy, 95.52% AUC and 94.03% f-measure for detecting COVID-19 positive patients. We have also performed a comparative performance between our proposed CNN model with several state-of-the-art machine learning classifiers including support vector machine, random forest, k-nearest neighbor, logistic regression, gaussian naïve bayes, bernoulli naïve bayes, decision tree, Xgboost, multilayer perceptron, nearest centroid and perceptron as well as deep learning and pre-trained models such as deep neural network, residual neural network, visual geometry group network 16, and inception network V3 were employed, where our model yielded outperforming results compared to all other models. While evaluating the performance of our models, we have emphasized on specificity along with accuracy to identify non-COVID-19 in iduals more accurately, which may potentially facilitate the early detection of COVID-19 patients for their preliminary screening, especially in under-resourced health infrastructure with insufficient PCR testing systems and testing facilities. Moreover, this model could also be applicable to the cases of other lung infections.
Publisher: MDPI AG
Date: 25-07-2022
DOI: 10.3390/JPM12081211
Abstract: One of the common types of cancer for women is ovarian cancer. Still, at present, there are no drug therapies that can properly cure this deadly disease. However, early-stage detection could boost the life expectancy of the patients. The main aim of this work is to apply machine learning models along with statistical methods to the clinical data obtained from 349 patient in iduals to conduct predictive analytics for early diagnosis. In statistical analysis, Student’s t-test as well as log fold changes of two groups are used to find the significant blood biomarkers. Furthermore, a set of machine learning models including Random Forest (RF), Support Vector Machine (SVM), Decision Tree (DT), Extreme Gradient Boosting Machine (XGBoost), Logistic Regression (LR), Gradient Boosting Machine (GBM) and Light Gradient Boosting Machine (LGBM) are used to build classification models to stratify benign-vs.-malignant ovarian cancer patients. Both of the analysis techniques recognized that the serums les carbohydrate antigen 125, carbohydrate antigen 19-9, carcinoembryonic antigen and human epididymis protein 4 are the top-most significant biomarkers as well as neutrophil ratio, thrombocytocrit, hematocrit blood s les, alanine aminotransferase, calcium, indirect bilirubin, uric acid, natriumas as general chemistry tests. Moreover, the results from predictive analysis suggest that the machine learning models can classify malignant patients from benign patients with accuracy as good as 91%. Since generally, early-stage detection is not available, machine learning detection could play a significant role in cancer diagnosis.
Publisher: MDPI AG
Date: 30-04-2023
DOI: 10.3390/COMPUTERS12050092
Abstract: Autism Spectrum Disorder (ASD) is a neurological impairment condition that severely impairs cognitive, linguistic, object recognition, interpersonal, and communication skills. Its main cause is genetic, and early treatment and identification can reduce the patient’s expensive medical costs and lengthy examinations. We developed a machine learning (ML) architecture that is capable of effectively analysing autistic children’s datasets and accurately classifying and identifying ASD traits. We considered the ASD screening dataset of toddlers in this study. We utilised the SMOTE method to balance the dataset, followed by feature transformation and selection methods. Then, we utilised several classification techniques in conjunction with a hyperparameter optimisation approach. The AdaBoost method yielded the best results among the classifiers. We employed ML and statistical approaches to identify the most crucial characteristics for the rapid recognition of ASD patients. We believe our proposed framework could be useful for early diagnosis and helpful for clinicians.
Publisher: MDPI AG
Date: 28-02-2022
DOI: 10.3390/MATH10050771
Abstract: The Tsallis entropy is an extension of the Shannon entropy and is used extensively in physics. The cumulative residual Tsallis entropy, which is a generalization of the Tsallis entropy, plays an important role in the measurement uncertainty of random variables and has simple relationships with other important information and reliability measures. In this paper, some novel properties of the cumulative residual Tsallis entropy are disclosed. Moreover, this entropy measure is applied to testing the uniformity, where the limit distribution and an approximation of the distribution of the test statistic are derived. In addition, the property of stability is discussed. Furthermore, the percentage points and power against seven alternative distributions of this test statistic are presented. Finally, to compare the power of the suggested test with that of other tests of uniformity, a simulation study is conducted.
Publisher: Hindawi Limited
Date: 12-04-2021
DOI: 10.1155/2021/5567970
Abstract: This paper discusses the study of optical solitons that are modeled by Riesz fractional Chen-Lee-Liu model, one of the versions of the famous nonlinear Schrödinger equation. This model is solved by the assistance of consecutive spectral collocation technique with two independent approaches. The first is the approach of the spatial variable, while the other is the approach of the temporal variable. It is concluded that the method of the current paper is far more efficient and credible for the proposed problem. Numerical results illustrate the performance efficiency of the algorithm. The results also point out that the scheme can lead to spectral accuracy of the studied model.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2021
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2021
Publisher: JMIR Publications Inc.
Date: 13-04-2021
DOI: 10.2196/25884
Abstract: Accurate prediction of the disease severity of patients with COVID-19 would greatly improve care delivery and resource allocation and thereby reduce mortality risks, especially in less developed countries. Many patient-related factors, such as pre-existing comorbidities, affect disease severity and can be used to aid this prediction. Because rapid automated profiling of peripheral blood s les is widely available, we aimed to investigate how data from the peripheral blood of patients with COVID-19 can be used to predict clinical outcomes. We investigated clinical data sets of patients with COVID-19 with known outcomes by combining statistical comparison and correlation methods with machine learning algorithms the latter included decision tree, random forest, variants of gradient boosting machine, support vector machine, k-nearest neighbor, and deep learning methods. Our work revealed that several clinical parameters that are measurable in blood s les are factors that can discriminate between healthy people and COVID-19–positive patients, and we showed the value of these parameters in predicting later severity of COVID-19 symptoms. We developed a number of analytical methods that showed accuracy and precision scores % for disease severity prediction. We developed methodologies to analyze routine patient clinical data that enable more accurate prediction of COVID-19 patient outcomes. With this approach, data from standard hospital laboratory analyses of patient blood could be used to identify patients with COVID-19 who are at high risk of mortality, thus enabling optimization of hospital facilities for COVID-19 treatment.
Publisher: MDPI AG
Date: 27-07-2022
DOI: 10.3390/E24081033
Abstract: In this article, a new one parameter survival model is proposed using the Kavya–Manoharan (KM) transformation family and the inverse length biased exponential (ILBE) distribution. Statistical properties are obtained: quantiles, moments, incomplete moments and moment generating function. Different types of entropies such as Rényi entropy, Tsallis entropy, Havrda and Charvat entropy and Arimoto entropy are computed. Different measures of extropy such as extropy, cumulative residual extropy and the negative cumulative residual extropy are computed. When the lifetime of the item under use is assumed to follow the Kavya–Manoharan inverse length biased exponential (KMILBE) distribution, the progressive-stress accelerated life tests are considered. Some estimating approaches, such as the maximum likelihood, maximum product of spacing, least squares, and weighted least square estimations, are taken into account while using progressive type-II censoring. Furthermore, interval estimation is accomplished by determining the parameters’ approximate confidence intervals. The performance of the estimation approaches is investigated using Monte Carlo simulation. The relevance and flexibility of the model are demonstrated using two real datasets. The distribution is very flexible, and it outperforms many known distributions such as the inverse length biased, the inverse Lindley model, the Lindley, the inverse exponential, the sine inverse exponential and the sine inverse Rayleigh model.
Publisher: MDPI AG
Date: 09-11-2020
DOI: 10.3390/MATH8111997
Abstract: In this paper, we obtained several recurrence relations for the single and product moments under progressively Type-II right censored order statistics and then use these results to compute the means and variances of two parameter reduced Kies distribution. Besides, these moments are then utilized to derived best linear unbiased estimators of the scale and location parameters of two parameter reduced Kies distribution. The parameters of the two parameter reduced Kies distribution are estimated under progressive type-II censoring scheme. The model parameters are estimated using the maximum likelihood estimation method. Further, we explore the asymptotic confidence intervals for the model parameters. Monte Carlo simulations are performed to compare between the proposed estimation methods under progressive type-II censoring scheme. Based on our study, we can conclude that maximum likelihood estimators is decreasing with respect to an increase of the schemes and comparing the three censoring schemes, it is clear that the mean sum of squares, confidence interval lengths are smaller for scheme 1 than schemes 2 and 3.
Publisher: MDPI AG
Date: 21-07-2022
DOI: 10.3390/SU14148942
Abstract: This article proposes a new lifetime-generated family of distributions called the sine-exponentiated Weibull-H (SEW-H) family, which is derived from two well-established families of distributions of entirely different nature: the sine-G (S-G) and the exponentiated Weibull-H (EW-H) families. Three new special models of this family include the sine-exponentiated Weibull exponential (SEWEx), the sine-exponentiated Weibull Rayleigh (SEWR) and sine-exponentiated Weibull Burr X (SEWBX) distributions. The useful expansions of the probability density function (pdf) and cumulative distribution function (cdf) are derived. Statistical properties are obtained, including quantiles (QU), moments (MO), incomplete MO (IMO), and order statistics (OS) are computed. Six numerous methods of estimation are produced to estimate the parameters: maximum likelihood (ML), least-square (LS), a maximum product of spacing (MPRSP), weighted LS (WLS), Cramér–von Mises (CRVM), and Anderson–Darling (AD). The performance of the estimation approaches is investigated using Monte Carlo simulations. The total factor productivity (TFP) of the United Kingdom food chain is an indication of the efficiency and competitiveness of the food sector in the United Kingdom. TFP growth suggests that the industry is becoming more efficient. If TFP of the food chain in the United Kingdom grows more rapidly than in other nations, it suggests that the sector is becoming more competitive. TFP, also known as multi-factor productivity in economic theory, estimates the fraction of output that cannot be explained by traditionally measured inputs of labor and capital employed in production. In this paper, we use five real datasets to show the relevance and flexibility of the suggested family. The first dataset represents the United Kingdom food chain from 2000 to 2019, whereas the second dataset represents the food and drink wholesaling in the United Kingdom from 2000 to 2019 as one factor of FTP the third dataset contains the tensile strength of single carbon fibers (in GPa) the fourth dataset is often called the breaking stress of carbon fiber dataset the fifth dataset represents the TFP growth of agricultural production for thirty-seven African countries from 2001–2010. The new suggested distribution is very flexible and it outperforms many known distributions.
Publisher: Elsevier BV
Date: 04-2023
Publisher: PeerJ
Date: 29-09-2021
DOI: 10.7717/PEERJ-CS.638
Abstract: Hearing deficiency is the world’s most common sensation of impairment and impedes human communication and learning. Early and precise hearing diagnosis using electroencephalogram (EEG) is referred to as the optimum strategy to deal with this issue. Among a wide range of EEG control signals, the most relevant modality for hearing loss diagnosis is auditory evoked potential (AEP) which is produced in the brain’s cortex area through an auditory stimulus. This study aims to develop a robust intelligent auditory sensation system utilizing a pre-train deep learning framework by analyzing and evaluating the functional reliability of the hearing based on the AEP response. First, the raw AEP data is transformed into time-frequency images through the wavelet transformation. Then, lower-level functionality is eliminated using a pre-trained network. Here, an improved-VGG16 architecture has been designed based on removing some convolutional layers and adding new layers in the fully connected block. Subsequently, the higher levels of the neural network architecture are fine-tuned using the labelled time-frequency images. Finally, the proposed method’s performance has been validated by a reputed publicly available AEP dataset, recorded from sixteen subjects when they have heard specific auditory stimuli in the left or right ear. The proposed method outperforms the state-of-art studies by improving the classification accuracy to 96.87% (from 57.375%), which indicates that the proposed improved-VGG16 architecture can significantly deal with AEP response in early hearing loss diagnosis.
Publisher: MDPI AG
Date: 19-05-2021
DOI: 10.20944/PREPRINTS202105.0429.V1
Abstract: Although automated Acute Lymphoblastic Leukemia (ALL) detection is essential, it is challenging due to the morphological correlation between malignant and normal cells. The traditional ALL classification strategy is arduous, time-consuming, often suffers inter-observer variations, and necessitates experienced pathologists. This article has automated the ALL detection task, employing deep Convolutional Neural Networks (CNNs). We explore the weighted ensemble of deep CNNs to recommend a better ALL cell classifier. The weights are estimated from ensemble candidates' corresponding metrics, such as accuracy, F1-score, AUC, and kappa values. Various data augmentations and pre-processing are incorporated for achieving a better generalization of the network. We train and evaluate the proposed model utilizing the publicly available C-NMC-2019 ALL dataset. Our proposed weighted ensemble model has outputted a weighted F1-score of 88.6%, a balanced accuracy of 86.2%, and an AUC of 0.941 in the preliminary test set. The qualitative results displaying the gradient class activation maps confirm that the introduced model has a concentrated learned region. In contrast, the ensemble candidate models, such as Xception, VGG-16, DenseNet-121, MobileNet, and InceptionResNet-V2, separately produce coarse and scatter learned areas for most ex le cases. Since the proposed ensemble yields a better result for the aimed task, it can experiment in other domains of medical diagnostic applications.
Publisher: JMIR Publications Inc.
Date: 20-11-2020
Abstract: ccurate prediction of the disease severity of patients with COVID-19 would greatly improve care delivery and resource allocation and thereby reduce mortality risks, especially in less developed countries. Many patient-related factors, such as pre-existing comorbidities, affect disease severity and can be used to aid this prediction. ecause rapid automated profiling of peripheral blood s les is widely available, we aimed to investigate how data from the peripheral blood of patients with COVID-19 can be used to predict clinical outcomes. e investigated clinical data sets of patients with COVID-19 with known outcomes by combining statistical comparison and correlation methods with machine learning algorithms the latter included decision tree, random forest, variants of gradient boosting machine, support vector machine, k-nearest neighbor, and deep learning methods. ur work revealed that several clinical parameters that are measurable in blood s les are factors that can discriminate between healthy people and COVID-19–positive patients, and we showed the value of these parameters in predicting later severity of COVID-19 symptoms. We developed a number of analytical methods that showed accuracy and precision scores & % for disease severity prediction. e developed methodologies to analyze routine patient clinical data that enable more accurate prediction of COVID-19 patient outcomes. With this approach, data from standard hospital laboratory analyses of patient blood could be used to identify patients with COVID-19 who are at high risk of mortality, thus enabling optimization of hospital facilities for COVID-19 treatment.
Publisher: MDPI AG
Date: 23-05-2022
DOI: 10.3390/APP12105275
Abstract: We consider non-Newtonian boundary-layer fluid flow, governed by a power-law Ostwald-de Waele rheology. Boundary-layer flows of non-Newtonian fluids have far-reaching applications, and are very frequently encountered in physical, as well as, engineering and industrial processes. A similarity transformation results in a BVP consisting of an ODE and some boundary conditions. Our aim is to derive highly accurate analytical relationships between the physical and mathematical parameters associated with the BVP and boundary-layer flow problem. Mathematical analyses are employed, where the results are verified at the numerical computational level, illustrating the accuracy of the derived relations. A set of “Crocco variables” is used to transform the problem, and, where appropriate, techniques are used to deal with the resulting singularities in order to establish an efficient computational setting. The resulting computational setting provides an alternative, which is different from those previously used in the literature. We employ it to carry out our numerical computations.
Publisher: MDPI AG
Date: 08-05-2021
DOI: 10.3390/APP11094266
Abstract: The first case in Bangladesh of the novel coronavirus disease (COVID-19) was reported on 8 March 2020, with the number of confirmed cases rapidly rising to over 175,000 by July 2020. In the absence of effective treatment, an essential tool of health policy is the modeling and forecasting of the progress of the pandemic. We, therefore, developed a cloud-based machine learning short-term forecasting model for Bangladesh, in which several regression-based machine learning models were applied to infected case data to estimate the number of COVID-19-infected people over the following seven days. This approach can accurately forecast the number of infected cases daily by training the prior 25 days s le data recorded on our web application. The outcomes of these efforts could aid the development and assessment of prevention strategies and identify factors that most affect the spread of COVID-19 infection in Bangladesh.
Publisher: MDPI AG
Date: 04-08-2022
DOI: 10.3390/MATH10152771
Abstract: The progressive-stress accelerated life test is discussed under the ordered ranked set s ling procedure. It is assumed that the lifetime of an item under use stress is exponentially distributed and the law of inverse power is considered as the relationship between the scale parameter and the applied stress. The involved parameters are estimated using the Bayesian technique, under symmetric and asymmetric loss functions, based on ordered ranked set s les and simple random s les subject to type-II censoring. Real and simulated data sets are used to illustrate the theoretical results presented in this paper. Finally, a simulation study followed by numerical calculations is performed to evaluate the Bayesian estimation performance based on the two s ling types.
Publisher: MDPI AG
Date: 02-07-2023
DOI: 10.3390/INFO14070376
Abstract: Diabetes is a chronic disease caused by a persistently high blood sugar level, causing other chronic diseases, including cardiovascular, kidney, eye, and nerve damage. Prompt detection plays a vital role in reducing the risk and severity associated with diabetes, and identifying key risk factors can help in iduals become more mindful of their lifestyles. In this study, we conducted a questionnaire-based survey utilizing standard diabetes risk variables to examine the prevalence of diabetes in Bangladesh. To enable prompt detection of diabetes, we compared different machine learning techniques and proposed an ensemble-based machine learning framework that incorporated algorithms such as decision tree, random forest, and extreme gradient boost algorithms. In order to address class imbalance within the dataset, we initially applied the synthetic minority overs ling technique (SMOTE) and random overs ling (ROS) techniques. We evaluated the performance of various classifiers, including decision tree (DT), logistic regression (LR), support vector machine (SVM), gradient boost (GB), extreme gradient boost (XGBoost), random forest (RF), and ensemble technique (ET), on our diabetes datasets. Our experimental results showed that the ET outperformed other classifiers to further enhance its effectiveness, we fine-tuned and evaluated the hyperparameters of the ET. Using statistical and machine learning techniques, we also ranked features and identified that age, extreme thirst, and diabetes in the family are significant features that prove instrumental in the detection of diabetes patients. This method has great potential for clinicians to effectively identify in iduals at risk of diabetes, facilitating timely intervention and care.
Publisher: MDPI AG
Date: 26-04-2022
DOI: 10.3390/SYM14050883
Abstract: In this paper, we present a new univariate flexible generator of distributions, namely, the odd Perks-G class. Some special models in this class are introduced. The quantile function (QFUN), ordinary and incomplete moments (MOMs), generating function (GFUN), moments of residual and reversed residual lifetimes (RLT), and four different types of entropy are all structural aspects of the proposed family that hold for any baseline model. Maximum likelihood (ML) and maximum product spacing (MPS) estimates of the model parameters are given. Bayesian estimates of the model parameters are obtained. We also present a novel log-location-scale regression model based on the odd Perks–Weibull distribution. Due to the significance of the odd Perks-G family and the survival discretization method, both are used to introduce the discrete odd Perks-G family, a novel discrete distribution class. Real-world data sets are used to emphasize the importance and applicability of the proposed models.
Publisher: MDPI AG
Date: 16-10-2022
DOI: 10.3390/APP122010431
Abstract: In this article, a four parameter lifetime model called the Topp–Leone modified Weibull distribution is proposed. The suggested distribution can be considered as an alternative to Kumaraswamy Weibull, generalized modified Weibull, extend odd Weibull Lomax, Weibull-Lomax, Marshall-Olkin alpha power extended Weibull and exponentiated generalized alpha power exponential distributions, etc. The suggested model includes the Topp-Leone Weibull, Topp-Leone Linear failure rate, Topp-Leone exponential and Topp-Leone Rayleigh distributions as a special case. Several characteristics of the new suggested model including quantile function, moments, moment generating function, central moments, mean, variance, coefficient of skewness, coefficient of kurtosis, incomplete moments, the mean residual life and the mean inactive time are derived. The probability density function of the Topp–Leone modified Weibull distribution can be right skewed and uni-modal shaped but, the hazard rate function may be decreasing, increasing, J-shaped, U-shaped and bathtub on its parameters. Three different methods of estimation as maximum likelihood, maximum product spacing and Bayesian methods are used to estimate the model parameters. For illustrative reasons, applications of the Topp–Leone modified Weibull model to four real data sets related to medical and engineering sciences are provided and contrasted with the fit reached by several other well-known distributions.
Publisher: Elsevier BV
Date: 10-2023
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2022
Publisher: MDPI AG
Date: 31-05-2021
Abstract: Autism spectrum disorder (ASD) is a complex neuro-developmental disorder that affects social skills, language, speech and communication. Early detection of ASD in iduals, especially children, could help to devise and strategize right therapeutic plan at right time. Human faces encode important markers that can be used to identify ASD by analyzing facial features, eye contact, and so on. In this work, an improved transfer-learning-based autism face recognition framework is proposed to identify kids with ASD in the early stages more precisely. Therefore, we have collected face images of children with ASD from the Kaggle data repository, and various machine learning and deep learning classifiers and other transfer-learning-based pre-trained models were applied. We observed that our improved MobileNet-V1 model demonstrates the best accuracy of 90.67% and the lowest 9.33% value of both fall-out and miss rate compared to the other classifiers and pre-trained models. Furthermore, this classifier is used to identify different ASD groups investigating only autism image data using k-means clustering technique. Thus, the improved MobileNet-V1 model showed the highest accuracy (92.10%) for k = 2 autism sub-types. We hope this model will be useful for physicians to detect autistic children more explicitly at the early stage.
Publisher: MDPI AG
Date: 12-03-2023
DOI: 10.3390/MATH11061377
Abstract: In this work, we reveal some distributional characteristics of concomitants of generalized order statistics (GOS) with parameters that are pairwise different, arising from iterated Farlie–Gumbel–Morgenstern (IFGM) family of bivariate distributions. Additionally, the joint distribution and product moments of concomitants of GOS for this family are discussed. Moreover, some well-known information measures, i.e., extropy, cumulative residual extropy (CRJ), and negative cumulative extropy (NCJ), are derived. Applications of these results are given for order statistics, record values, and progressive type-II censored order statistics with uniform marginals distributions. Additionally, the issue of estimating the CRJ and NCJ is looked into, utilizing the empirical technique and the concomitant of GOS. Finally, bivariate real-world data sets have been analyzed for illustrative purposes, and the performance of the proposed method is quite satisfactory.
Publisher: MDPI AG
Date: 29-08-2022
DOI: 10.3390/SYM14091791
Abstract: A new three-parameter survival model is proposed using the Kavya–Manoharan (KM) transformation family and the exponentiated Weibull (EW) distribution. The shapes of the pdf for the new model can be asymmetric and symmetric shapes, such as unimodal, decreasing, right-skewed and symmetric. In addition, the shapes of the hrf for the suggested model can be increasing, decreasing, constant and J-shaped. Statistical properties are obtained: quantile function, mode, moments, incomplete moments, residual life time, reversed residual life time, probability weighted moments, order statistics and entropy. We discuss the maximum likelihood estimation for the model. The relevance and flexibility of the model are demonstrated using two real datasets. The distribution is very flexible, and it outperforms many known distributions, such as the three-parameter exponentiated Weibull, the modified Weibull model, the Kavya–Manoharan Weibull, the extended Weibull, the odd Weibull inverse Topp–Leone and the extended odd Weibull inverse Nadarajah–Haghigh model. A bivariate step-stress accelerated life test based on progressive type-I censoring (PTIC) using the model is presented. This pattern is noticed when a particular number of lifetime test units are routinely eliminated from the test at the conclusion of each post-test period of time. Minimizing the asymptotic variance of the MLE of the log of the scale parameter at design stress under PTIC yields an expression for the ideal test plan under PTIC.
Publisher: MDPI AG
Date: 30-04-2021
DOI: 10.3390/JPM11050363
Abstract: Nowadays, cervical cancer (CC) is treated as the leading cancer among women throughout the world. Despite effective vaccination and improved surgery and treatment, CC retains its fatality rate of about half of the infected population globally. The major screening biomarkers and therapeutic target identification have now become a global concern. In the present study, we have employed systems biology approaches to retrieve the potential biomarkers and pathways from transcriptomic profiling. Initially, we have identified 76 of each up-regulated and down-regulated gene from a total of 4643 differentially expressed genes. The up-regulatory genes mainly concentrate on immune-inflammatory responses, and the down-regulatory genes are on receptor binding and gamma-glutamyltransferase. The involved pathways associated with these genes were also assessed through pathway enrichment, and we mainly focused on different cancer pathways, immunoresponse, and cell cycle pathways. After the subsequent enrichment of these genes, we have identified 12 hub genes, which play a crucial role in CC and are verified by expression profile analysis. From our study, we have found that genes LILRB2 and CYBB play crucial roles in CC, as reported here for the first time. Furthermore, the survivability of the hub genes was also assessed, and among them, finally, CXCR4 has been identified as one of the most potential differentially expressed genes that might play a vital role in the survival of CC patients. Thus, CXCR4 could be used as a prognostic and/or diagnostic biomarker and a drug target for CC.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2023
Publisher: MDPI AG
Date: 08-08-2022
Abstract: A new class of distribution called the Fréchet binomial (FB) distribution is proposed. The new suggested model is very flexible because its probability density function can be unimodal, decreasing and skewed to the right. Furthermore, the hazard rate function can be increasing, decreasing, up-side-down and reversed-J form. Important mixture representations of the probability density function (pdf) and cumulative distribution function (cdf) are computed. Numerous sub-models of the FB distribution are explored. Numerous statistical and mathematical features of the FB distribution such as the quantile function (QUNF) moments (MO) incomplete MO (IMO) conditional MO (CMO) MO generating function (MOGF) probability weighted MO (PWMO) order statistics and entropy are computed. When the life test is shortened at a certain time, acceptance s ling (ACS) plans for the new proposed distribution, FB distribution, are produced. The truncation time is supposed to be the median lifetime of the FB distribution multiplied by a set of parameters. The smallest s le size required ensures that the specified life test is obtained at a particular consumer’s risk. The numerical results for a particular consumer’s risk, FB distribution parameters and truncation time are generated. We discuss the method of maximum likelihood to estimate the model parameters. A simulation study was performed to assess the behavior of the estimates. Three real datasets are used to illustrate the importance and flexibility of the proposed model.
Publisher: MDPI AG
Date: 07-05-2021
DOI: 10.3390/APP11094233
Abstract: The COVID-19 pandemic requires the rapid isolation of infected patients. Thus, high-sensitivity radiology images could be a key technique to diagnose patients besides the polymerase chain reaction approach. Deep learning algorithms are proposed in several studies to detect COVID-19 symptoms due to the success in chest radiography image classification, cost efficiency, lack of expert radiologists, and the need for faster processing in the pandemic area. Most of the promising algorithms proposed in different studies are based on pre-trained deep learning models. Such open-source models and lack of variation in the radiology image-capturing environment make the diagnosis system vulnerable to adversarial attacks such as fast gradient sign method (FGSM) attack. This study therefore explored the potential vulnerability of pre-trained convolutional neural network algorithms to the FGSM attack in terms of two frequently used models, VGG16 and Inception-v3. Firstly, we developed two transfer learning models for X-ray and CT image-based COVID-19 classification and analyzed the performance extensively in terms of accuracy, precision, recall, and AUC. Secondly, our study illustrates that misclassification can occur with a very minor perturbation magnitude, such as 0.009 and 0.003 for the FGSM attack in these models for X-ray and CT images, respectively, without any effect on the visual perceptibility of the perturbation. In addition, we demonstrated that successful FGSM attack can decrease the classification performance to 16.67% and 55.56% for X-ray images, as well as 36% and 40% in the case of CT images for VGG16 and Inception-v3, respectively, without any human-recognizable perturbation effects in the adversarial images. Finally, we analyzed that correct class probability of any test image which is supposed to be 1, can drop for both considered models and with increased perturbation it can drop to 0.24 and 0.17 for the VGG16 model in cases of X-ray and CT images, respectively. Thus, despite the need for data sharing and automated diagnosis, practical deployment of such program requires more robustness.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2023
Publisher: Elsevier BV
Date: 09-2023
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2021
Publisher: MDPI AG
Date: 13-06-2022
DOI: 10.3390/SYM14061222
Abstract: A new class of statistical distributions called the Type II half-Logistic odd Fréchet-G class is proposed. The new class is a continuation of the unusual Fréchet class. This class is analytically feasible and could be used to evaluate real-world data effectively. The new suggested class of distributions has many new symmetrical and asymmetrical sub-models. We propose new four sub-models from the new class of distributions which are called Type II half-Logistic odd Fréchet exponential distribution, Type II half-Logistic odd Fréchet Rayleigh distribution, Type II half-Logistic odd Fréchet Weibull distribution, and Type II half-Logistic odd Fréchet Lindley distribution. Some statistical features of Type II half-Logistic odd Fréchet-G class such as ordinary moments (ORMs), incomplete moments (INMs), moment generating function (MGEF), residual life (REL), and reversed residual life (RREL) functions, and Rényi entropy (RéE) are derived. Six methods of estimation such as maximum likelihood, least-square, a maximum product of spacing, weighted least square, Cramér-von Mises, and Anderson–Darling are produced to estimate the parameters. To test the six estimation methods’ performance, a simulation study is conducted. Four real-world data sets are utilized to highlight the importance and applicability of the proposed method.
Publisher: Elsevier BV
Date: 09-2016
Publisher: MDPI AG
Date: 05-03-2021
DOI: 10.20944/PREPRINTS202103.0197.V1
Abstract: Nowadays, cervical cancer (CC) is treated as the leading cancer among women throughout the world. Despite effective vaccination and improved surgery and treatment, CC remains its fatality rate about half of the infected populations globally. The major screening biomarkers and therapeutic target identification have now become a global concern. The present study, we have employed systems biology approaches to retrieve the potential biomarkers and pathways from the transcriptomic profiling. Initially, we have identified 76 of each up-regulated and down-regulated gene from a total of 4,643 differentially expressed genes. The up-regulatory genes are mainly concentrating on immune-inflammatory response and the down-regulatory genes are on receptor binding and gamma-glutamyltransferase. The involved pathways associated with these genes were also assessed through pathway enrichment and they were mainly focused on different cancer pathways, immunoresponse, and cell cycle pathways. After the subsequent enrichment of these genes, we have identified 12 hub genes, which play a crucial role in CC. Furthermore, the survival of the hub genes was also assessed, and among them, finally, CXCR4 has identified as one of the most potential differentially expressed gene that might play a vital role to the survival of CC patients. Thus CXCR4 could be used as a prognostic biomarker and development of a drug target for CC.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2021
Publisher: Elsevier BV
Date: 10-2021
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2021
Publisher: MDPI AG
Date: 11-09-2023
Publisher: MDPI AG
Date: 27-02-2022
DOI: 10.3390/MATH10050760
Abstract: This work will address the problem of estimating the parameters for the Nadaraj ah–Haghighi (NH) distribution using progressive Type-1 censoring (PT1C) utilizing Bayesian and non-Bayesian approaches. To apply PT1C, censoring times for each stage of censoring needed to be known before the experiment started. To solve this issue of censoring time selection, qauntiles from the NH lifetime distribution will be used as PT1C censoring time points. Maximum likelihood (ML) estimators (MLEs) and asymptotic confidence intervals (ACoIs) are produced with a focus on the censoring technique. Bayes estimates (BEs) and accompanying maximum posterior density (PD) credible interval estimations are also created via the squared error (SEr) loss function. The BEs are evaluated using the Markov Chain Monte Carlo (MCMC) technique and the Metropolis–Hasting (MH) algorithm. An analysis of an actual data set demonstrates the theoretical implications of MLEs and BEs for defined schemes of PT1C s les. Finally, simulation results will be used to compare the performance of the various recommended estimators.
Publisher: Elsevier BV
Date: 10-2023
Publisher: MDPI AG
Date: 31-08-2023
DOI: 10.3390/MATH11173747
Abstract: The Molodtsov-initiated soft set theory plays an important role as a powerful mathematical tool for handling uncertainty. As an extension of the soft set, the fuzzy soft set can be seen to be more generic and flexible than utilizing the soft set only that fails to represent problem parameters fuzziness. Through this progress, the fuzzy soft set theory cannot deal with decision-making problems involving multi-attribute sets, bipolarity, or some effective considered parameters. Therefore, the goal of this article is to adapt effectiveness and bipolarity concepts with the multi-fuzzy soft set of order n. One can see that this approach generates a novel, extended, effective decision-making environment that is more applicable than any previously introduced one. In addition, types, concepts, and operations of effective bipolar-valued multi-fuzzy soft sets of dimension n are provided, each with an ex le. Furthermore, properties like absorption, associative, distributive, commutative, and De Morgan’s laws of those new sets are investigated. Moreover, a decision-making methodology under effective bipolar-valued multi-fuzzy soft settings is established. This technique facilitates reaching the final decision that this student is qualified to take a certain education level, or this patient is suffering from a certain disease, etc. In addition, a case study represented in a medical diagnosis ex le is discussed in detail to make the proposed algorithm clearer. Applying matrix techniques in this ex le as well as using MATLAB®, not only makes it easier and faster in doing calculations, but also gives more accurate, optimal, and effective decisions. Finally, the sensitivity analysis, as well as a comparison with the existing methods, are conducted in detail and are summarized in a chart to show the difference between them and the current one.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2022
Location: No location found
No related grants have been discovered for Dr. Salem A. Alyami.