ORCID Profile
0000-0002-9666-149X
Current Organisation
The University of Manitoba
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Publisher: MDPI AG
Date: 19-10-2023
Publisher: Frontiers Media SA
Date: 30-05-2023
DOI: 10.3389/FPED.2023.1180392
Abstract: Cytomegalovirus (CMV) is a ubiquitous virus which causes a mild illness in healthy in iduals. In immunocompromised in iduals, such as children receiving haematopoietic stem cell transplantation, CMV can reactivate, causing serious disease and increasing the risk of death. CMV can be effectively treated with antiviral drugs, but antiviral resistance is an increasingly common complication. Available therapies are associated with adverse effects such as bone marrow suppression and renal impairment, making the choice of appropriate treatment challenging. New agents are emerging and require evaluation in children to establish their role. This review will discuss established and emerging diagnostic tools and treatment options for CMV, including antiviral resistant CMV, in children undergoing haematopoietic stem cell transplant.
Publisher: MDPI AG
Date: 24-08-2022
DOI: 10.3390/DIAGNOSTICS12092056
Abstract: The continuous transmission and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has required that diagnostic capabilities be constantly monitored and updated as new variants emerge and prior variants disappear. Although whole genome sequencing provides full characterisation of SARS-CoV-2 directly from patient s les, this has limited throughput and requires sufficient resources. To enhance screening for circulating variants, we designed a rapid in-house RT-PCR assay to target a spike mutation (D950N) in Delta variants, which is not detected in the remaining variants of concern (VOCs). Assay sensitivity for detecting Delta variants was 93% and specificity was 100% using a sequenced s le bank of several lineages. As the D950N mutation is prevalent in % of the global Delta variant sequences deposited in GISAID, this assay has the potential to provide rapid results to determine if the s les are presumptively Delta variants and can support clinicians in timely clinical decision-making for effective treatments and surveillance.
Publisher: Frontiers Media SA
Date: 24-08-2021
Publisher: Universidad Ricardo Palma
Date: 08-2023
Abstract: In this paper, we are focusing on the conceptions of femininity, female bodies, and beauty in sport that women high-level karate fighters and their coaches developed in order to perform in a traditionally male-oriented sport. With so much higher public profile for women in sports (e.g., soccer, rugby, cricket, traditionally male sports), has anything changed in the traditional order of the male preserve? Thus, our aim here is to reflect on the set of shown conceptions and assumptions in order to add to the produced literature on women's sports studies and hopefully contribute to sought advancements, claiming change. We interviewed the 14 women athletes and their four men coaches composing the women's Spanish Olympic karate squad in preparation for the 2020 (2021) Tokyo Olympic Games. Two open-ended semi-structured interviews were carried out with each of the participants. We conclude that the sportive-martial environment is still strongly male-oriented, even though female participation has been increasing nevertheless, girls and women still face several challenges to achieve belonging. They enter the environment and reach the status of black belts, or elite athletes. Notwithstanding, we argue that the amount of power they truly exercise is limited and submitted to the male hierarchy.
Publisher: Elsevier BV
Date: 12-2023
Publisher: MDPI AG
Date: 25-09-2023
Publisher: Universidad de Alicante
Date: 2020
Publisher: Oxford University Press (OUP)
Date: 06-10-2020
DOI: 10.1093/JAC/DKAA402
Publisher: Universidad Nacional de La Plata
Date: 04-04-2022
Abstract: Con esta investigación hemos tratado de verificar procesos subjetivos de negociación del lugar de las mujeres en el kárate, entendido como masculino, y elevado a deporte olímpico. Para tanto, realizamos un estudio cualitativo de carácter interpretativo, valiéndonos de las técnicas de recogida de informaciones observación sistematizada no-participante y análisis documental, contrastando los materiales provenientes del c o con la literatura. Nuestra base teórica ha estado apoyada en trabajos etnográficos y antropológicos que tienen en común, también con nosotros, algún grado de inspiración en la teoría crítica del deporte. La observación se ha centrado en el 24th Karate World Ch ionships Madrid 2018. Con los resultados y discusión percibimos preliminarmente, pues se trata del inicio de una investigación mayor, algunos elementos para la reflexión, por ejemplo: sobre la mujer karateca recae una gran exigencia de eficiencia técnica se espera que ella presente capacidad de enseñar la feminidad hegemónica de forma objetiva, algunas veces incluso atestando orientación heterosexual se valora en el medio que la mujer corresponda a unos estándares de belleza estipulados por la industria de consumo, incluyendo estereotipos relacionados a la sensualidad. En conclusión, el espacio designado a la mujer en este ambiente masculino parece requerir negociaciones para su aceptación y pertenencia.
Publisher: Universidade Federal do Rio Grande do Sul
Date: 23-05-2012
Abstract: Investigamos o atletismo, o caratê e o balé, interessando-nos pelos dispositivos de subjetivação que se instituem por meio de técnicas, rotinas, rituais, representações e discursos que os sujeitos elaboram, atualizam, repetem, reconstituem, tomando como núcleo as relações com o corpo mediadas pelo treinamento. Para tal, realizamos incursões etnográficas em uma academia de dança, uma equipe de atletismo e um dojo de caratê. A análise do material empírico permite dizer que é a trama entre técnica, dor, sofrimento e projeto, um eixo central na conformação subjetiva de atletas, lutadores e bailarinas.
Publisher: MDPI AG
Date: 29-11-2021
DOI: 10.3390/V13122390
Abstract: Positive-strand RNA virus evolution is partly attributed to the process of recombination. Although common between closely genetically related viruses, such as within species of the Enterovirus genus of the Picornaviridae family, inter-species recombination is rarely observed in nature. Recent studies have shown recombination is a ubiquitous process, resulting in a wide range of recombinant genomes and progeny viruses. While not all recombinant genomes yield infectious progeny virus, their existence and continued evolution during replication have critical implications for the evolution of the virus population. In this study, we utilised an in vitro recombination assay to demonstrate inter-species recombination events between viruses from four enterovirus species, A-D. We show that inter-species recombinant genomes are generated in vitro with polymerase template-switching events occurring within the virus polyprotein coding region. However, these genomes did not yield infectious progeny virus. Analysis and attempted recovery of a constructed recombinant cDNA revealed a restriction in positive-strand but not negative-strand RNA synthesis, indicating a significant block in replication. This study demonstrates the propensity for inter-species recombination at the genome level but suggests that significant sequence plasticity would be required in order to overcome blocks in the virus life cycle and allow for the production of infectious viruses.
Publisher: American Society for Microbiology
Date: 31-05-2023
DOI: 10.1128/JVI.00451-23
Publisher: Australian Government Department of Health
Date: 19-05-2022
Abstract: An ongoing outbreak of syphilis in Australia, first reported in the state of Queensland in 2011, has led to increasing cases of congenital syphilis, including several deaths. Here, we applied multi-locus sequence typing (MLST) on available Treponema pallidum PCR-positive s les from the state of Queensland from the beginning of the outbreak to July 2020. In total, 393 s les from 337 males and 56 females were genotyped. Of 36 different Treponema pallidum sequence types (ST) observed, the two most common STs, ST 1 (also reported to be a dominant strain in various other countries) and ST 100 (the latter differing from ST 1 by only one single nucleotide polymorphism (SNP) based on the MLST scheme), together comprised 69% (271/393) of all s les, including the majority of s les in females (79% 44/56). ST 1 was prevalent throughout the entire study period. Both strains remained the most common STs during the year 2020 where social distancing and other measures were implemented due to the COVID-19 pandemic. Both STs had high male-to-female ratios and included male rectal infections, therefore suggestive of occurrence primarily among men-who-have-sex-with-men (MSM). Hence, bridging from MSM to heterosexual networks may potentially contribute to infections among females, but further studies are needed to confirm this. Overall, there was considerable ersity of Treponema pallidum genotypes observed throughout the study period, but the fact that two key strains accounted for the majority of infections, including among females, stresses the need for further investigations into the transmission of these strains, and potentially a need for targeted public health interventions to better control the spread of syphilis in Queensland.
Publisher: American Society for Microbiology
Date: 27-06-2023
Publisher: Springer Science and Business Media LLC
Date: 04-05-2018
DOI: 10.1007/S10753-018-0797-4
Abstract: Shedding of the endothelial glycocalyx precedes leukocyte activation and adherence in acute inflammation. Rapid administration of crystalloid or colloid fluids for treating hemorrhagic shock may cause endothelial glycocalyx shedding, thereby increasing inflammation. This study aimed to compare the effect of different fluid treatments in a canine shock model on glycocalyx biomarker, hyaluronan, and inflammatory biomarkers. Greyhound dogs under general anesthesia subject to hemorrhage for 60 min were given 20 mL kg
Publisher: Informa UK Limited
Date: 20-09-2022
Publisher: American Society for Microbiology
Date: 22-09-2020
DOI: 10.1128/JCM.01432-20
Publisher: Springer Science and Business Media LLC
Date: 08-06-2023
Publisher: S. Karger AG
Date: 06-09-2018
DOI: 10.1159/000492301
Abstract: b i Background: /i /b We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of “hub genes” and upstream regulators during anaphylaxis. b i Methods: /i /b S les were collected from patients with anaphylaxis on their arrival at the emergency department, and after 1 and 3 h. mRNA levels of 11 genes ( i interleukin-6 [IL-6], IL-10, oncostatin M [OSM], S100A8, S100A9, matrix metalloproteinase 9 [MMP9], FASL, toll-like receptor 4 [TLR4], MYD88, triggering receptor expressed on myeloid cells 1 [TREM1] /i , and i cluster of differentiation 64 [CD64] /i ) were measured in peripheral blood leucocytes using qPCR. Serum protein concentrations were measured by ELISA or cytometric bead array for 6 of these candidates. b i Results: /i /b Of 69 anaphylaxis patients enrolled, 36 (52%) had severe reactions, and 38 (55%) were female. Increases in both mRNA and protein of IL-10, S100A9, MMP9, and TREM1 were observed. i OSM /i , i S100A8 /i , i TLR4 /i , and i CD64 /i were upregulated and IL-6 protein concentrations were increased during anaphylaxis. Both i FASL /i and soluble Fas ligand decreased during anaphylaxis. b i Conclusion: /i /b These results provide evidence for the involvement of innate immune pathways and myeloid cells during human anaphylaxis, validating previous microarray findings. Elevated i S100A8 /i , i S100A9 /i , i TLR4 /i , and i TREM1 /i expression, and increased S100A9 and soluble TREM1 protein concentrations strongly suggest that neutrophils are activated during acute anaphylaxis.
Publisher: Elsevier BV
Date: 10-2023
Publisher: American Society for Microbiology
Date: 22-06-2023
Publisher: Frontiers Media SA
Date: 13-11-2020
Abstract: Health problems in society are numerous, not least stress and stress-related illness. Physical activities, including martial arts, are increasingly viewed as a means of managing such risks to health. While there are forms of karate that have a philosophical and meditative character that is related to spiritual wellness, karate as a competitive sport is less likely to be thought of in this light. The purpose of this paper is to present through a participant observation study the representations that karateka of the dojo , make of sportive karate as a resource to achieve wellness. Drawing on an eight months' immersion in the dojo , we identify five themes that express these karateka 's views of sport karate and wellness, the importance of fitness, beauty in punches and kicks, how to embrace fear, the aggressive attitude as a posture in life, and the superiority given by control. The findings lead us to reflect on the need for further research to see if they are repeated in other martial arts, and if many more groups find wellness as a primary motivation for their participation.
Publisher: American Chemical Society (ACS)
Date: 07-04-2023
Publisher: FapUNIFESP (SciELO)
Date: 12-2011
DOI: 10.1590/S0104-026X2011000300013
Abstract: O presente trabalho relata aspectos de uma etnografia realizada em um dojo de caratê, cujo objetivo foi pesquisar a produção e as relações com dor e sofrimento corporal aliadas a afirmações de masculinidade. Não tratamos aqui dos resultados da pesquisa, mas do percurso, das questões que deram forma a ela, considerando uma especificidade: a responsável pelo trabalho de c o é carateca desse dojo e seu movimento de respeitada faixa preta para pesquisadora produziu novas formas de desafio naquele espaço. Problematizamos essa questão tentando demonstrar as dificuldades desse embate que combina um conflito de gênero com a conciliação possível da condição do/a pesquisador/a em relação ao c o do qual faz parte e no qual, inevitavelmente, se conflagra.
Publisher: MDPI AG
Date: 18-08-2020
Abstract: Dengue virus (DENV) is the most important mosquito-borne viral pathogen of humans, comprising four serotypes (DENV-1 to -4) with a myriad of genotypes and strains. The kinetics of DENV replication within the mosquito following ingestion of a blood meal influence the pathogen’s ability to reach the salivary glands and thus the transmission potential. The influence of DENV serotype and strain ersity on virus kinetics in the two main vector species, Aedes aegypti and Ae. albopictus, has been poorly characterized. We tested whether DENV replication kinetics vary systematically among serotypes and strains, using Australian strains of the two vectors. Mosquitoes were blood fed with two strains per serotype, and s led at 3, 6, 10 and 14-days post-exposure. Virus infection in mosquito bodies, and dissemination of virus to legs and wings, was detected using qRT-PCR. For both vectors, we found significant differences among serotypes in proportions of mosquitoes infected, with higher numbers for DENV-1 and -2 versus other serotypes. Consistent with this, we observed that DENV-1 and -2 generally replicated to higher RNA levels than other serotypes, particularly at earlier time points. There were no significant differences in either speed of infection or dissemination between the mosquito species. Our results suggest that DENV ersity may have important epidemiological consequences by influencing virus kinetics in mosquito vectors.
Location: United Kingdom of Great Britain and Northern Ireland
Location: Australia
No related grants have been discovered for Kym Lowry.