ORCID Profile
0000-0002-5485-9406
Current Organisation
University of Melbourne
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Quantum Physics not elsewhere classified | Medical biotechnology diagnostics (incl. biosensors) | Analytical Chemistry not elsewhere classified | Quantum technologies | Quantum Physics | Optical Physics | Medical Devices | Condensed Matter Physics | Biocatalysis and enzyme technology | Surfaces and Structural Properties of Condensed Matter | Quantum Information, Computation and Communication | Photonics, Optoelectronics and Optical Communications | Quantum physics | Biological physics |
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Physical Sciences | Expanding Knowledge in Technology | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Medical and Health Sciences |
Related Links
Publications
Magnetic spin imaging under ambient conditions with sub-cellular resolution
Publisher: Springer Science and Business Media LLC
Date: 19-03-2013
DOI: 10.1038/NCOMMS2588
Abstract: The detection of small numbers of magnetic spins is a significant challenge in the life, physical and chemical sciences, especially when room temperature operation is required. Here we show that a proximal nitrogen-vacancy spin ensemble serves as a high precision sensing and imaging array. Monitoring its longitudinal relaxation enables sensing of freely diffusing, unperturbed magnetic ions and molecules in a microfluidic device without applying external magnetic fields. Multiplexed charge-coupled device acquisition and an optimized detection scheme permits direct spin noise imaging of magnetically labelled cellular structures under ambient conditions. Within 20 s we achieve spatial resolutions below 500 nm and experimental sensitivities down to 1,000 statistically polarized spins, of which only 32 ions contribute to a net magnetization. The results mark a major step towards versatile sub-cellular magnetic imaging and real-time spin sensing under physiological conditions providing a minimally invasive tool to monitor ion channels or haemoglobin trafficking inside live cells.
Magneto-optical imaging of thin magnetic films using spins in diamond
Publisher: Springer Science and Business Media LLC
Date: 14-03-2016
DOI: 10.1038/SREP22797
Abstract: Imaging the fields of magnetic materials provides crucial insight into the physical and chemical processes surrounding magnetism and has been a key ingredient in the spectacular development of magnetic data storage. Existing approaches using the magneto-optic Kerr effect, x-ray and electron microscopy have limitations that constrain further development and there is increasing demand for imaging and characterisation of magnetic phenomena in real time with high spatial resolution. Here we show how the magneto-optical response of an array of negatively-charged nitrogen-vacancy spins in diamond can be used to image and map the sub-micron stray magnetic field patterns from thin ferromagnetic films. Using optically detected magnetic resonance, we demonstrate wide-field magnetic imaging over 100 × 100 μm 2 with sub-micron spatial resolution at video frame rates, under ambient conditions. We demonstrate an all-optical spin relaxation contrast imaging approach which can image magnetic structures in the absence of an applied microwave field. Straightforward extensions promise imaging with sub-μT sensitivity and sub-optical spatial and millisecond temporal resolution. This work establishes practical diamond-based wide-field microscopy for rapid high-sensitivity characterisation and imaging of magnetic s les, with the capability for investigating magnetic phenomena such as domain wall and skyrmion dynamics and the spin Hall effect in metals.
Analytic solutions to the central-spin problem for nitrogen-vacancy centers in diamond
Publisher: American Physical Society (APS)
Date: 18-08-2014
Quantum measurement and orientation tracking of fluorescent nanodiamonds inside living cells
Publisher: Springer Science and Business Media LLC
Date: 08-05-2011
Abstract: Fluorescent particles are routinely used to probe biological processes. The quantum properties of single spins within fluorescent particles have been explored in the field of nanoscale magnetometry, but not yet in biological environments. Here, we demonstrate optically detected magnetic resonance of in idual fluorescent nanodiamond nitrogen-vacancy centres inside living human HeLa cells, and measure their location, orientation, spin levels and spin coherence times with nanoscale precision. Quantum coherence was measured through Rabi and spin-echo sequences over long (>10 h) periods, and orientation was tracked with effective 1° angular precision over acquisition times of 89 ms. The quantum spin levels served as fingerprints, allowing in idual centres with identical fluorescence to be identified and tracked simultaneously. Furthermore, monitoring decoherence rates in response to changes in the local environment may provide new information about intracellular processes. The experiments reported here demonstrate the viability of controlled single spin probes for nanomagnetometry in biological systems, opening up a host of new possibilities for quantum-based imaging in the life sciences.
Wide-band nanoscale magnetic resonance spectroscopy using quantum relaxation of a single spin in diamond
Publisher: American Physical Society (APS)
Date: 05-10-2016
Quantum measurement in living cells: Fluorescent diamond nanocrystals for biology
Publisher: IEEE
Date: 08-2011
Proximity-Induced Artefacts in Magnetic Imaging with Nitrogen-Vacancy Ensembles in Diamond
Publisher: MDPI AG
Date: 23-04-2018
DOI: 10.3390/S18041290
Polarization Transfer to External Nuclear Spins Using Ensembles of Nitrogen-Vacancy Centers
Publisher: American Physical Society (APS)
Date: 24-05-2021
Quantum Magnetic Imaging of Iron Biomineralization in Teeth of the Chiton Acanthopleura hirtosa
Publisher: Wiley
Date: 19-01-2020
Anticrossing Spin Dynamics of Diamond Nitrogen-Vacancy Centers and All-Optical Low-Frequency Magnetometry
Publisher: American Physical Society (APS)
Date: 02-12-2016
Microwave-free nuclear magnetic resonance at molecular scales
Publisher: Springer Science and Business Media LLC
Date: 03-07-2017
DOI: 10.1038/NCOMMS15950
Abstract: The implementation of nuclear magnetic resonance (NMR) at the nanoscale is a major challenge, as the resolution of conventional methods is limited to mesoscopic scales. Approaches based on quantum spin probes, such as the nitrogen-vacancy (NV) centre in diamond, have achieved nano-NMR under ambient conditions. However, the measurement protocols require application of complex microwave pulse sequences of high precision and relatively high power, placing limitations on the design and scalability of these techniques. Here we demonstrate NMR on a nanoscale organic environment of proton spins using the NV centre while eliminating the need for microwave manipulation of either the NV or the environmental spin states. We also show that the sensitivity of our significantly simplified approach matches that of existing techniques using the NV centre. Removing the requirement for coherent manipulation while maintaining measurement sensitivity represents a significant step towards the development of robust, non-invasive nanoscale NMR probes.
Towards single-molecule NMR detection and spectroscopy using single spins in diamond
Publisher: American Physical Society (APS)
Date: 27-02-2014
In vivo imaging and tracking of individual nanodiamonds in drosophila melanogaster embryos
Publisher: The Optical Society
Date: 20-03-2014
DOI: 10.1364/BOE.5.001250
Prospects for nuclear spin hyperpolarization of molecular samples using nitrogen-vacancy centers in diamond
Publisher: American Physical Society (APS)
Date: 21-01-2021
High spatial and temporal resolution wide-field imaging of neuron activity using quantum NV-diamond
Publisher: Springer Science and Business Media LLC
Date: 09-05-2012
DOI: 10.1038/SREP00401
Re-examining ferritin-bound iron: current and developing clinical tools
Publisher: Walter de Gruyter GmbH
Date: 22-10-2020
Abstract: Iron is a highly important metal ion cofactor within the human body, necessary for haemoglobin synthesis, and required by a wide range of enzymes for essential metabolic processes. Iron deficiency and overload both pose significant health concerns and are relatively common world-wide health hazards. Effective measurement of total iron stores is a primary tool for both identifying abnormal iron levels and tracking changes in clinical settings. Population based data is also essential for tracking nutritional trends. This review article provides an overview of the strengths and limitations associated with current techniques for diagnosing iron status, which sets a basis to discuss the potential of a new serum marker – ferritin-bound iron – and the improvement it could offer to iron assessment.
Method for In-Solution, High-Throughput T 1
Publisher: American Physical Society (APS)
Date: 11-09-2023
Nonvanishing effect of detuning errors in dynamical-decoupling-based quantum sensing experiments
Publisher: American Physical Society (APS)
Date: 09-01-2019
Electron paramagnetic resonance microscopy using spins in diamond under ambient conditions
Publisher: Springer Science and Business Media LLC
Date: 06-09-2017
Tuning a Spin Bath through the Quantum-Classical Transition
Publisher: American Physical Society (APS)
Date: 15-05-2012
Nanoscale magnetometry through quantum control of nitrogen–vacancy centres in rotationally diffusing nanodiamonds
Publisher: IOP Publishing
Date: 17-01-2013
Ultrasensitive diamond magnetometry using optimal dynamic decoupling
Publisher: American Physical Society (APS)
Date: 29-07-2010
Quantum Bath Control with Nuclear Spin State Selectivity via Pulse-Adjusted Dynamical Decoupling
Publisher: American Physical Society (APS)
Date: 22-11-2019
A diamond voltage imaging microscope
Publisher: Springer Science and Business Media LLC
Date: 08-09-2022
Detection of atomic spin labels in a lipid bilayer using a single-spin nanodiamond probe
Publisher: Proceedings of the National Academy of Sciences
Date: 17-06-2013
Abstract: Magnetic field fluctuations arising from fundamental spins are ubiquitous in nanoscale biology, and are a rich source of information about the processes that generate them. However, the ability to detect the few spins involved without averaging over large ensembles has remained elusive. Here, we demonstrate the detection of gadolinium spin labels in an artificial cell membrane under ambient conditions using a single-spin nanodiamond sensor. Changes in the spin relaxation time of the sensor located in the lipid bilayer were optically detected and found to be sensitive to near-in idual (4 ± 2) proximal gadolinium atomic labels. The detection of such small numbers of spins in a model biological setting, with projected detection times of 1 s [corresponding to a sensitivity of ∼5 Gd spins per Hz 1/2 ], opens a pathway for in situ nanoscale detection of dynamical processes in biology.
A quantum spin-probe molecular microscope
Publisher: Springer Science and Business Media LLC
Date: 11-10-2016
DOI: 10.1038/NCOMMS12667
Abstract: Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule using a quantum spin probe acting simultaneously as the magnetic resonance sensor and source of magnetic field gradient. Signals corresponding to specific regions of the molecule’s nuclear spin density are encoded on the quantum state of the probe, which is used to produce a 3D image of the molecular structure. Quantum simulations of the protocol applied to the rapamycin molecule (C 51 H 79 NO 13 ) show that the hydrogen and carbon substructure can be imaged at the angstrom level using current spin-probe technology. With prospects for scaling to large molecules and/or fast dynamic conformation mapping using spin labels, this method provides a realistic pathway for single-molecule microscopy.
Temperature and angle dependent magnetic imaging of biological iron nanoparticles using quantum diamond microscopy
Publisher: AIP Publishing
Date: 16-01-2023
DOI: 10.1063/5.0114998
Abstract: Quantum diamond microscopy is an emerging versatile technique for studying the magnetic properties of materials. It has been applied extensively in condensed matter physics and materials science and has blossomed into a unique platform for the magnetic study of biological systems. To date, biological demonstrations of quantum diamond microscopy have been performed under ambient conditions. Here, we extend this magnetic microscopy platform to cryogenic temperatures to study magnetic anisotropy and the blocking temperature from an in idual iron organelle found within the inner ear of pigeons. Our work confirms that the interface between thin histological tissue sections and diamond can be maintained under cryogenic temperatures. Our magnetic images provide evidence of magnetic anisotropy from a single iron organelle with sub-cellular resolution using this correlative optical imaging method. This approach may be extended to a broad range of systems where magnetic materials play structural and functional roles in biological systems.
Sensing of Fluctuating Nanoscale Magnetic Fields Using Nitrogen-Vacancy Centers in Diamond
Publisher: American Physical Society (APS)
Date: 25-11-2009
Nanoscale sensing and imaging in biology using the nitrogen-vacancy center in diamond
Publisher: Springer Science and Business Media LLC
Date: 02-2013
DOI: 10.1557/MRS.2013.24
Detection of nanoscale electron spin resonance spectra demonstrated using nitrogen-vacancy centre probes in diamond
Publisher: Springer Science and Business Media LLC
Date: 05-01-2016
DOI: 10.1038/NCOMMS10211
Abstract: Electron spin resonance (ESR) describes a suite of techniques for characterizing electronic systems with applications in physics, chemistry, and biology. However, the requirement for large electron spin ensembles in conventional ESR techniques limits their spatial resolution. Here we present a method for measuring ESR spectra of nanoscale electronic environments by measuring the longitudinal relaxation time of a single-spin probe as it is systematically tuned into resonance with the target electronic system. As a proof of concept, we extracted the spectral distribution for the P1 electronic spin bath in diamond by using an ensemble of nitrogen-vacancy centres, and demonstrated excellent agreement with theoretical expectations. As the response of each nitrogen-vacancy spin in this experiment is dominated by a single P1 spin at a mean distance of 2.7 nm, the application of this technique to the single nitrogen-vacancy case will enable nanoscale ESR spectroscopy of atomic and molecular spin systems.
Dynamical decoupling of a single-electron spin at room temperature
Publisher: American Physical Society (APS)
Date: 02-02-2011
Ambient nanoscale sensing with single spins using quantum decoherence
Publisher: IOP Publishing
Date: 23-07-2013
Rapid, High‐Resolution Magnetic Microscopy of Single Magnetic Microbeads
Publisher: Wiley
Date: 26-03-2019
Abstract: Magnetic microparticles or "beads" are used in a variety of research applications from cell sorting through to optical force traction microscopy. The magnetic properties of such particles can be tailored for specific applications with the uniformity of in idual beads critical to their function. However, the majority of magnetic characterization techniques quantify the magnetic properties from large bead ensembles. Developing new magnetic imaging techniques to evaluate and visualize the magnetic fields from single beads will allow detailed insight into the magnetic uniformity, anisotropy, and alignment of magnetic domains. Here, diamond-based magnetic microscopy is applied to image and characterize in idual magnetic beads with varying magnetic and structural properties: ferromagnetic and superparamagnetic aramagnetic, shell (coated with magnetic material), and solid (magnetic material dispersed in matrix). The single-bead magnetic images identify irregularities in the magnetic profiles from in idual bead populations. Magnetic simulations account for the varying magnetic profiles and allow to infer the magnetization of in idual beads. Additionally, this work shows that the imaging technique can be adapted to achieve illumination-free tracking of magnetic beads, opening the possibility of tracking cell movements and mechanics in photosensitive contexts.
Monitoring ion-channel function in real time through quantum decoherence
Publisher: Proceedings of the National Academy of Sciences
Date: 11-10-2010
Abstract: In drug discovery, there is a clear and urgent need for detection of cell-membrane ion-channel operation with wide-field capability. Existing techniques are generally invasive or require specialized nanostructures. We show that quantum nanotechnology could provide a solution. The nitrogen-vacancy (NV) center in nanodiamond is of great interest as a single-atom quantum probe for nanoscale processes. However, until now nothing was known about the quantum behavior of a NV probe in a complex biological environment. We explore the quantum dynamics of a NV probe in proximity to the ion channel, lipid bilayer, and surrounding aqueous environment. Our theoretical results indicate that real-time detection of ion-channel operation at millisecond resolution is possible by directly monitoring the quantum decoherence of the NV probe. With the potential to scan and scale up to an array-based system, this conclusion may have wide-ranging implications for nanoscale biology and drug discovery.
Related Organisations
Related Funding Activities
Linkage Projects - Grant ID: LP190100528
Start Date: 11-2020
End Date: 11-2023
Amount: $368,617.00
Funder: Australian Research Council
View Funded ActivityDiscovery Early Career Researcher Award - Grant ID: DE200101785
Start Date: 05-2021
End Date: 05-2023
Amount: $424,978.00
Funder: Australian Research Council
View Funded ActivityDiscovery Projects - Grant ID: DP200103712
Start Date: 2020
End Date: 12-2022
Amount: $441,000.00
Funder: Australian Research Council
View Funded ActivityARC Centres Of Excellence - Grant ID: CE230100021
Start Date: 12-2023
End Date: 12-2030
Amount: $35,000,000.00
Funder: Australian Research Council
View Funded Activity