ARDC Research Link Australia

ORCID Profile
Orcid icon. 0000-0001-7243-0817

Current Organisations
The University of Edinburgh , Royal Edinburgh Hospital , University of Glasgow , Leverndale Hospital , Gogarburn Hospital , Royal Alexandra Hospital , NHS Greater Glasgow and Clyde , CRC Scotland & London , Gartnavel Royal Hospital , Dykebar Hospital

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.

Publications

Publication

Oxidative & nitrosative stress in depression: Why so much stress?

Publisher: Elsevier BV

Date: 09-2014

DOI: 10.1016/J.NEUBIOREV.2014.05.007

Abstract: Many studies support a crucial role for oxidative & nitrosative stress (O&NS) in the pathophysiology of unipolar and bipolar depression. These disorders are characterized inter alia by lowered antioxidant defenses, including: lower levels of zinc, coenzyme Q10, vitamin E and glutathione increased lipid peroxidation damage to proteins, DNA and mitochondria secondary autoimmune responses directed against redox modified nitrosylated proteins and oxidative specific epitopes. This review examines and details a model through which a complex series of environmental factors and biological pathways contribute to increased redox signaling and consequently increased O&NS in mood disorders. This multi-step process highlights the potential for future interventions that encompass a erse range of environmental and molecular targets in the treatment of depression.