ORCID Profile
0000-0003-2349-1888
Current Organisation
University of California, San Diego
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Publisher: Springer Science and Business Media LLC
Date: 08-2016
DOI: 10.1038/NBT.3597
Publisher: American Chemical Society (ACS)
Date: 26-04-2021
Publisher: Elsevier BV
Date: 11-2011
Publisher: Proceedings of the National Academy of Sciences
Date: 10-03-2014
Abstract: Microbial natural products are a major source of new drug leads, yet discovery efforts are constrained by the lack of information describing the ersity and distributions of the associated biosynthetic pathways among bacteria. Using the marine actinomycete genus Salinispora as a model, we analyzed genome sequence data from 75 closely related strains. The results provide evidence for high levels of pathway ersity, with most being acquired relatively recently in the evolution of the genus. The distributions and evolutionary histories of these pathways provide insight into the mechanisms that generate new chemical ersity and the strategies used by bacteria to maximize their population-level capacity to produce erse secondary metabolites.
Publisher: American Chemical Society (ACS)
Date: 13-07-2011
DOI: 10.1021/NP200323E
Publisher: Springer Science and Business Media LLC
Date: 2014
Publisher: Springer Science and Business Media LLC
Date: 07-2013
DOI: 10.1007/S10886-013-0316-X
Abstract: Marine bacteria are known to produce a wide variety of structurally erse and biologically active secondary metabolites. Considerably less is known about the ecological functions of these compounds, in part due to methodological challenges associated with this field of research. Here, we review the antagonistic activities mediated by marine bacteria with a focus on activities linked to structurally defined secondary metabolites. Bacterial antagonism has been documented against other marine bacteria as well as eukaryotes, and includes antibiosis, the inhibition of quorum sensing, larval settlement deterrence, and defense against predation. These compounds likely play important ecological roles that ultimately affect ecosystem structure and function, however, much remains to be learned before these roles can be fully appreciated. Recent technological advances coupled with a better understanding of the erse processes mediated by secondary metabolites provide new opportunities to expand our understanding of the chemical ecology of bacterial antagonism in the marine environment.
Location: United States of America
No related grants have been discovered for paul jensen.