ORCID Profile
0000-0003-2181-0718
Current Organisations
Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences
,
The University of Edinburgh
,
University of Warwick
,
University of Cambridge
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Publisher: American Chemical Society (ACS)
Date: 17-03-2022
Publisher: American Chemical Society (ACS)
Date: 06-01-2022
Abstract: Extracellular matrix (ECM) of the tumor microenvironment (TME), including topography and biological molecules, is crucial in cancer cell attachment, growth, and even the sensitivity to the chemo and cell drugs treatment. This study hypothesizes that mimic ECM structures can alter the attachment and drug sensitivity of cancer cells. A family of artificial ECM called colloidal self-assembled patterns (cSAPs) was fabricated to mimic tumor ECM structures. Cell adhesion, proliferation, and drug sensitivity of the A549 non-small cell lung cancer (NSCLC) cells were studied on 24 cSAPs, named cSAP#1-cSAP#24, where surface topography and wettability were distinct. The results showed that cell adhesion and cell spreading were generally reduced on cSAPs compared to the flat controls. In addition, the synergistic effect of cSAPs and several chemo drugs on cell survival was investigated. Interestingly, A549 cells were more sensitive to the combination of doxorubicin and cSAP#4. Under this condition, the focal adhesion kinase (FAK) signaling was downregulated while p53 signaling was upregulated, confirmed by real-time PCR and western blot analysis. It indicates that the specific surface structure could induce higher drug sensitivity and in vitro anoikis of A549 cells. A serum alternative, human platelet lysate (hPL), and different cSAPs were examined to verify our hypothesis. The result further confirmed that cell adhesion strongly affected the drug sensitivity of A549 cells. This study demonstrates that the tumor ECM is vital in cancer cell activity and drug sensitivity therefore, it should be considered in drug discovery and therapeutic regimens.
Publisher: American Chemical Society (ACS)
Date: 23-02-2022
Publisher: Wiley
Date: 12-2007
Abstract: Glycopolymers have been synthesised by post‐functionalisation of well‐defined alkyne‐functional polymers with sugar azides to yield N ‐glycosyl 1,2,3‐triazole functional polymers. The Cu(I)‐catalysed Huisgen cycloaddition was used to attach α‐mannoside, β‐galactoside and β‐lactoside derivatives via an azide functionality bound directly to the sugar anomeric carbon. Three different catalytic systems were investigated for the click reactions [(PPh 3 ) 3 Cu(I)Br], TBTA/Cu(I)Br and bathophenanthrolinedisulphonic acid disodium salt/Cu(I)Br. The latter of these was found to be the most efficient for the attachment of the larger/more sterically hindered disaccharide lactose moiety. The interaction of the lactose‐ and galactose‐bearing glycopolymers with Ricinus Communis Agglutinin (RCA I) lectin was investigated by affinity HPLC analysis. The rate of the interaction between mannose polymer and concanavalin A (Con A) lectin was assessed by turbidimetry. The results from the lectin conjugation studies indicate that the glycopolymers prepared in this work are able to function as multivalent ligands, further suggesting that the attachment of the triazole directly to the sugar anomeric carbon has no significant effect on the interaction of these glycopolymers with Con A and RCA I.
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B709080C
Abstract: The biotin-terminated PAMAM dendron has been synthesized and the asymmetric dendron used to modify the protein avidin via non-covalent bioconjugation.
Publisher: American Chemical Society (ACS)
Date: 17-11-2007
DOI: 10.1021/JA072999X
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0CC06313D
Abstract: Real-time live cell imaging and quantification of biothiol dynamics are important for understanding pathophysiological processes.
Publisher: Royal Society of Chemistry (RSC)
Date: 2008
DOI: 10.1039/B718112D
Abstract: Polymers containing poly(ethylene glycol) methacrylate and 2-(2-methoxyethoxy)ethyl methacrylate have been synthesized by Cu(0)-mediated radical polymerisation for use as thermoresponsive water-dispersants for carbon nanotubes.
Publisher: American Chemical Society (ACS)
Date: 15-09-2007
DOI: 10.1021/MA071362V
Location: China
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Jin Geng.