ORCID Profile
0000-0002-0044-8257
Current Organisations
Tokyo University of Science
,
University of Aberdeen
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Publisher: Elsevier BV
Date: 02-2023
Publisher: Research Square Platform LLC
Date: 09-06-2023
DOI: 10.21203/RS.3.RS-2996566/V1
Abstract: Breast cancer prognosis and management for both men and women are reliant upon estrogen receptor alpha (ERα) and progesterone receptor (PR) expression to inform therapy. Previous studies have shown that there are sex-specific binding characteristics of ERα and PR in breast cancer and, counterintuitively, ERα expression is more common in male than female breast cancer. We hypothesized that these differences could have morphological manifestations that are undetectable to human observers but could be elucidated computationally. To investigate this, we trained attention-based multiple instance learning prediction models for ERα and PR using H& E-stained images of female breast cancer from the Cancer Genome Atlas (TCGA) (n = 1085), and deployed them on external female (n = 192) and male breast cancer images (n = 245). Both targets were predicted in the internal (AUROC for ERα prediction: 0.86 ± 0.02, p 0.001 AUROC for PR prediction = 0.76 ± 0.03, p 0.001) and external female cohorts (AUROC for ERα prediction: 0.78 ± 0.03, p 0.001 AUROC for PR prediction = 0.80 ± 0.04, p 0.001) but not the male cohort (AUROC for ERα prediction: 0.66 ± 0.14, p = 0.43 AUROC for PR prediction = 0.63 ± 0.04, p = 0.05). This suggests that subtle morphological differences invisible upon visual inspection may exist between the sexes, supporting previous immunohistochemical, genomic, and transcriptomic analyses.
Publisher: Elsevier BV
Date: 03-1983
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4TA05307A
Abstract: A simple, versatile, high-throughput nanofabrication method based on electrostatic self-assembly is developed for the large-scale generation of well-defined asymmetric plasmonic dimers, enabling the study of interparticle plasmon coupling and the "hot-spot" phenomenon in SERS.
Location: United States of America
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United States of America
No related grants have been discovered for Hiroyuki Ohshima.