ORCID Profile
0000-0002-8224-1005
Current Organisation
University of California, Irvine
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Publisher: Public Library of Science (PLoS)
Date: 13-08-2015
Publisher: Springer Science and Business Media LLC
Date: 13-08-2015
Publisher: Royal College of Psychiatrists
Date: 02-2016
DOI: 10.1192/BJP.BP.114.156976
Abstract: Bipolar disorder is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for bipolar disorder in the expression quantitative trait loci (eQTL) in the brain. We sought to assess the impact of eQTL variants on bipolar disorder risk by combining data from both bipolar disorder genome-wide association studies (GWAS) and brain eQTL. To detect single nucleotide polymorphisms (SNPs) that influence expression levels of genes associated with bipolar disorder, we jointly analysed data from a bipolar disorder GWAS (7481 cases and 9250 controls) and a genome-wide brain (cortical) eQTL (193 healthy controls) using a Bayesian statistical method, with independent follow-up replications. The identified risk SNP was then further tested for association with hippoc al volume ( n = 5775) and cognitive performance ( n = 342) among healthy in iduals. Integrative analysis revealed a significant association between a brain eQTL rs6088662 on chromosome 20q11.22 and bipolar disorder (log Bayes factor = 5.48 bipolar disorder P = 5.85×10 –5 ). Follow-up studies across multiple independent s les confirmed the association of the risk SNP (rs6088662) with gene expression and bipolar disorder susceptibility ( P = 3.54×10 –8 ). Further exploratory analysis revealed that rs6088662 is also associated with hippoc al volume and cognitive performance in healthy in iduals. Our findings suggest that 20q11.22 is likely a risk region for bipolar disorder they also highlight the informative value of integrating functional annotation of genetic variants for gene expression in advancing our understanding of the biological basis underlying complex disorders, such as bipolar disorder.
Publisher: Elsevier BV
Date: 2010
DOI: 10.1016/J.NEUROPSYCHOLOGIA.2009.09.005
Abstract: This study investigated the influence of the symbol type and numerical distance of numbers on the litudes and peak latencies of event-related potentials (ERPs). Our aim was to (1) determine the point in time of magnitude information access in visual number processing and (2) identify at what stage the advantage of Arabic digits over Chinese verbal numbers occur. ERPs were recorded from 64 scalp sites while subjects (n=26) performed a classification task. Results showed that larger ERP litudes were elicited by numbers with distance-close condition in comparison to distance-far condition in the VPP component over centro-frontal sites. Furthermore, the VPP latency varied as a function of the symbol type, but the N170 did not. Such results demonstrate that magnitude information access takes place as early as 150 ms after onset of visual number stimuli and the advantage of Arabic digits over verbal numbers should be localized to the VPP component. We establish the VPP component as a critical ERP component to report in studies of numerical cognition and our results call into question the N170/VPP association hypothesis and the serial-stage model of visual number comparison processing.
Publisher: Springer Science and Business Media LLC
Date: 10-2020
Abstract: Figure 5b of the paper [1] contained a misinterpretation in the comparison between the reported new ATLAS measurement of the process pp → Xp and previously published CMS data [2]. The ATLAS measurement corresponds to cases where either proton dissociates.
No related grants have been discovered for Chuansheng Chen.