ORCID Profile
0000-0003-4386-0740
Current Organisations
The Chinese University of Hong Kong, Shenzhen
,
University of Oxford
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Publisher: Wiley
Date: 17-02-2015
Publisher: American Chemical Society (ACS)
Date: 08-12-2016
Publisher: Wiley
Date: 04-05-2021
DOI: 10.1002/VIW.20210003
Abstract: Cytokines are signaling molecules between cells in immune system. Cytokine storm, due to the sudden acute increase in levels of pro‐inflammatory circulating cytokines, can result in disease severity and major‐organ damage. Thus, there is urgent need to develop rapid, sensitive, and specific methods for monitoring of cytokines in biology and medicine. Undoubtedly, point‐of‐care testing (POCT) will provide clinical significance in disease early diagnosis, management, and prevention. This review aims to summarize and discuss the latest technologies for detection of cytokines with a focus on POCT. The overview of diseases resulting from imbalanced cytokine levels, such as COVID‐19, sepsis and other cytokine release syndromes are presented. The clinical cut‐off levels of cytokine as biomarkers for different diseases are summarized. The challenges and perspectives on the development of cytokine POCT devices are also proposed and discussed. Cytokine POCT devices are expected to be the ongoing spotlight of disease management and prevention during COVID‐19 pandemic and also the post COVID‐19 pandemic era.
Publisher: Springer Science and Business Media LLC
Date: 24-07-2015
DOI: 10.1038/SREP12539
Abstract: Integrating loop-mediated isothermal lification (LAMP) with capacitively coupled contactless conductivity detection (C 4 D), we have developed an electrical sensor for the simultaneous lification and detection of specific sequence DNA. Using the O26- wzy gene as a model, the amount of initial target gene could be determined via the threshold time obtained by monitoring the progression of the LAMP reaction in real time. Using the optimal conditions, a detection limit of 12.5 copy/μL can be obtained within 30 min. Monitoring the LAMP reaction by C 4 D has not only all the advantages that existing electrochemical methods have, but also additional attractive features including being completely free of carryover contamination risk, high simplicity and extremely low cost. These benefits all arise from the fact that the electrodes are separated from the reaction solution, that is C 4 D is a contactless method. Hence in proof of principle, the new strategy promises a robust, simple, cost-effective and sensitive method for quantitative determination of a target gene, that is applicable either to specialized labs or at point-of-care.
Publisher: Wiley
Date: 29-01-2016
Abstract: An unclonable plasmonic anti-counterfeiting strategy is demonstrated, which involves the use of molecule-embedded metal@silica core-shell nanoparticles as information carriers. A shadow-mask-lithography-assisted self-assembly is developed for the fabrication of the plasmonic security labels. The produced security labels show multiple sets of coding information that are highly unique, technically unreplicable, and can be robustly decoded by portable microscopes within seconds.
Publisher: Elsevier BV
Date: 2017
Publisher: American Chemical Society (ACS)
Date: 06-02-2017
Abstract: Aryldiazonium salts as coupling agents for surface chemistry have evidenced their wide applications for the development of sensors. Combined with advances in nanomaterials, current trends in sensor science and a variety of particular advantages of aryldiazonium salt chemistry in sensing have driven the aryldiazonium salt-based sensing strategies to grow at an astonishing pace. This review focuses on the advances in the use of aryldiazonium salts for modifying interfaces in sensors and biosensors during the past decade. It will first summarize the current methods for modification of interfaces with aryldiazonium salts, and then discuss the sensing applications of aryldiazonium salts modified on different transducers (bulky solid electrodes, nanomaterials modified bulky solid electrodes, and nanoparticles). Finally, the challenges and perspectives that aryldiazonium salt chemistry is facing in sensing applications are critically discussed.
Publisher: Elsevier BV
Date: 10-2015
Publisher: American Chemical Society (ACS)
Date: 03-03-2016
DOI: 10.1021/ACS.LANGMUIR.5B04550
Abstract: Controlling the composition of an interface is very important in tuning the chemical and physical properties of a surface in many applications including biosensors, biomaterials, and chemical catalysis. Frequently, this requires one molecular component to a minor component in a mixed layer. Such subtle control of composition has been difficult to achieve using aryldiazonium salts. Herein, aryldiazonium salts of carboxyphenyl (CP) and phenylphosphorylcholine (PPC), generated in situ from their corresponding anilines, are electrografted to form molecular platform that are available for further functionalization. These two components are chosen because CP provides a convenient functionality for further coupling of biorecognition species while PPC offers resistance to nonspecific adsorption of proteins to the surface. Mixed layers of CP and PPC were prepared by grafting them either simultaneously or consecutively. The latter strategy allows an interface to be developed in a controlled way where one component is at levels of less than 1% of the total layer.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Cheng Jiang.