ORCID Profile
0000-0002-4373-3293
Current Organisations
University of California Davis
,
University of Electronic Science and Technology of China
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Publisher: Wiley
Date: 16-10-2020
DOI: 10.1002/HBM.25227
Publisher: SAGE Publications
Date: 31-10-2018
Abstract: To derive new criteria sets for defining manic and hypomanic episodes (and thus for defining the bipolar I and II disorders), an international Task Force was assembled and termed AREDOC reflecting its role of Assessment, Revision and Evaluation of DSM and other Operational Criteria. This paper reports on the first phase of its deliberations and interim criteria recommendations. The first stage of the process consisted of reviewing Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and recent International Classification of Diseases criteria, identifying their limitations and generating modified criteria sets for further in-depth consideration. Task Force members responded to recommendations for modifying criteria and from these the most problematic issues were identified. Principal issues focussed on by Task Force members were how best to differentiate mania and hypomania, how to judge ‘impairment’ (both in and of itself and allowing that functioning may sometimes improve during hypomanic episodes) and concern that rejecting some criteria (e.g. an imposed duration period) might risk false-positive diagnoses of the bipolar disorders. This first-stage report summarises the clinical opinions of international experts in the diagnosis and management of the bipolar disorders, allowing readers to contemplate diagnostic parameters that may influence their clinical decisions. The findings meaningfully inform subsequent Task Force stages (involving a further commentary stage followed by an empirical study) that are expected to generate improved symptom criteria for diagnosing the bipolar I and II disorders with greater precision and to clarify whether they differ dimensionally or categorically.
Publisher: Oxford University Press (OUP)
Date: 28-04-2017
Publisher: BMJ
Date: 03-11-2017
Abstract: Clinical brain MRI is normal in the majority of patients with anti- N -methyl-D-aspartate receptor (NMDAR) encephalitis. However, extensive deep white matter damage wasrecently identifiedin these patients using diffusion weighted imaging. Here, our aim was to study a particularly vulnerable brain compartment, the late myelinating superficial white matter. Forty-six patients with anti-NMDAR encephalitis were included. Ten out of these were considered neurologically recovered (modified Rankin scale of zero), while 36 patients were non-recovered. In addition, 30 healthy controls were studied. MRI data were collected from all subjects and superficial white matter mean diffusivity derived from diffusion tensor imaging was compared between groups in whole brain, lobar and vertex-based analyses. Patients underwent comprehensive cognitive testing, and correlation analyses were performed between cognitive performance and superficial white matter integrity. Non-recovered patients showed widespread superficial white matter damage in comparison to recovered patients and healthy controls. Vertex-based analyses revealed that damage predominated in frontal and temporal lobes. In contrast, the superficial white matter was intact in recovered patients. Importantly, persistent cognitive impairments in working memory, verbal memory, visuospatial memory and attention significantly correlated with damage of the superficial white matter in patients. Anti-NMDAR encephalitis is associated with extensive superficial white matter damage in patients with incomplete recovery. The strong association with impairment in several cognitive domains highlights the clinical relevance of white matter damage in this disorder and warrants investigations of the underlying pathophysiological mechanisms.
Publisher: Wiley
Date: 17-11-2021
DOI: 10.1002/INF2.12263
Abstract: The intrinsic phase instability of CsPbI 2 Br perovskite hinders its development and application in solar cells. Herein, we adopt 1‐butyl‐3‐methylimidazolium hexafluorophosphate (BMIMPF 6 ), a hydrophobic ionic liquid (IL), to improve the phase stability of CsPbI 2 Br. Density functional theory calculation reveals that the formation energy of CsPbI 2 Br with BMIMPF 6 is reduced, thereby restraining the [PbX 6 ] 4− octahedral tilting. The reduced structural distortion and relaxed lattice strain result in improved phase stability of CsPbI 2 Br. In addition, the interfacial dipole moment increases after introducing BMIMPF 6 , which facilitates the charge transfer. Consequently, the CsPbI 2 Br solar cells with BMIMPF 6 deliver a power conversion efficiency (PCE) of 16.2% along with excellent stability. The unencapsulated devices with BMIMPF 6 maintain 98.9%, 88.6%, and 99.5% of the initial PCEs after 1200 h storage in N 2 , 1000 h storage in air (30% relative humidity), and 200 thermal cycles (25–100°C), respectively. image
Location: China
Location: United States of America
Location: United States of America
Location: United States of America
No related grants have been discovered for Manpreet Singh.