ORCID Profile
0000-0003-3505-5522
Current Organisations
University of Southampton
,
Jeonbuk National University
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Publisher: Elsevier BV
Date: 2017
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TA01184B
Abstract: A hierarchical 3D Zn–Ni–P nanosheet arrays based all-solid-state ASC exhibits an excellent energy density of ∼90.12 W h kg −1 at 0.61 kW kg −1 , power density of ∼8.77 kW kg −1 at 65.83 W h kg −1 , and extraordinary cycling stability of ∼93.05% capacitance retention after 20 000 cycles.
Publisher: Elsevier BV
Date: 11-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0TA12414A
Abstract: A novel cobalt-doped molybdenum oxynitride quantum dot@N-doped carbon nanosheets with abundant oxygen vacancies have been established. The optimal V O -CMON@NCN air-cathode achieved tremendous peak power density and ultralong cycle life for 500 h.
Publisher: Wiley
Date: 12-09-2018
Publisher: Elsevier BV
Date: 06-2020
Publisher: American Chemical Society (ACS)
Date: 23-05-2019
Publisher: The American Association of Immunologists
Date: 15-07-2022
Abstract: NK cells are promising cellular therapeutics against hematological and solid malignancies. Immunogenetic studies have identified that various activating killer cell Ig-like receptors (KIRs) are associated with cancer outcomes. Specifically, KIR2DS2 has been associated with reduced incidence of relapse following transplant in hematological malignancies and improved outcomes in solid tumors, but the mechanism remains obscure. Therefore, we investigated how KIR2DS2 expression impacts NK cell function. Using a novel flow cytometry panel, we show that human NK cells with high KIR2DS2 expression have enhanced spontaneous activation against malignant B cell lines, liver cancer cell lines, and primary chronic lymphocytic leukemia cells. Surface expression of CD16 was increased on KIR2DS2high NK cells, and, accordingly, KIR2DS2high NK cells had increased activation against lymphoma cells coated with the clinically relevant anti-CD20 Abs rituximab and obinutuzumab. Bulk RNA sequencing revealed that KIR2DS2high NK cells have upregulation of NK-mediated cytotoxicity, translation, and FCGR gene pathways. We developed a novel single-cell RNA-sequencing technique to identify KIR2DS2+ NK cells, and this confirmed that KIR2DS2 is associated with enhanced NK cell–mediated cytotoxicity. This study provides evidence that KIR2DS2 marks a population of NK cells primed for anticancer activity and indicates that KIR2DS2 is an attractive target for NK-based therapeutic strategies.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7TA04807F
Abstract: A novel hybrid of 2D Ni–Mo–S nanosheet integrated nitrogen doped graphene (NG) is successfully developed via a simple, scalable, and cost-effective hydrothermal process, and its application towards energy conversion devices is explored.
Publisher: Elsevier BV
Date: 03-2020
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Balamurugan Jayaraman.