ORCID Profile
0000-0003-0416-2165
Current Organisation
University of California, San Diego
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Publisher: Elsevier BV
Date: 06-2009
Publisher: IEEE
Date: 02-2011
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-2005
DOI: 10.1109/TUFFC.2005.1509792
Abstract: A 1.8 cc silent bidirectional traveling-wave, self-moving linear microactuator is shown to be capable of generating a sliding velocity of 0.22 m/s and sliding force of 1.1 N. Through the use of computational analysis in the actuator's design, the vibration characteristics were improved in order to obtain a better actuator. The generation of a radial traveling wave about the circumference of the actuator, akin to a ring, is shown to exist despite the unusual shape, and the presence of traveling wave motion along the output face also is shown to exist. By using short-time sinusoidal signals, slider displacements as small as 82 nm were obtained from the actuator, and by using direct current (DC) input, displacements of up to +/-107 nm were obtained, suggesting a way to obtain subnanometer positioning accuracy over arbitrary sliding distances. By reversing the phase between the paired driving signals, the direction of motion was reversed at up to 300 Hz the slider displacement and velocity was found to be inversely proportional to the phase-reversal rate, and the slider's peak velocity and maximum thrust force were directly proportional to the phase between the driving signals. The output force and velocity of the actuator was fairly insensitive to the input frequency, giving measurable motion between 132.5 and 141.5 kHz, but was sensitive to the input voltage, requiring at least 38 V input for operation, and was approximately quadratically dependent on the applied preload centered about 2.25 N.
Publisher: SPIE
Date: 21-12-2011
DOI: 10.1117/12.903172
Publisher: Springer Science and Business Media LLC
Date: 26-05-2010
Publisher: AIP Publishing
Date: 15-03-2010
DOI: 10.1063/1.3259624
Abstract: Polydimethylsiloxane (PDMS) is nearly ubiquitous in microfluidic devices, being easy to work with, economical, and transparent. A detailed protocol is provided here for using PDMS in the fabrication of microfluidic devices to aid those interested in using the material in their work, with information on the many potential ways the material may be used for novel devices.
Publisher: IEEE
Date: 05-2009
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/C001501F
Abstract: A new method for in-gel s le processing and tryptic digestion of proteins is described. S le preparation, rehydration, in situ digestion and peptide extraction from gel slices are dramatically accelerated by treating the gel slice with surface acoustic waves (SAWs). Only 30 minutes total workflow time is required for this new method to produce base peak chromatograms (BPCs) of similar coverage and intensity to those observed for traditional processing and overnight digestion. Simple set up, good reproducibility, excellent peptide recoveries, rapid turnover of s les and high confidence protein identifications put this technology at the fore-front of the next generation of proteomics s le processing tools.
Publisher: American Chemical Society (ACS)
Date: 17-09-2008
DOI: 10.1021/LA802255B
Abstract: We demonstrate the possibility of producing regular, long-range, spatially ordered polymer patterns without requiring the use of physical or chemical templating through the interfacial destabilization of a thin polymer film driven by surface acoustic waves (SAWs). The periodicity and spot size of the pattern are observed to be dependent on a single parameter, that is, the SAW frequency (or wavelength), therefore offering a rapid, simple, yet novel method for self-organized regular spatial polymer pattern formation that is far more tunable than conventional polymer patterning procedures.
Publisher: Wiley
Date: 15-12-2015
Publisher: IEEE
Date: 07-2013
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2001
DOI: 10.1109/58.935722
Abstract: This paper presents a new mechanism for traveling wave excitation of the flexural vibration in a ring. A torsional-flexural composite transducer was used to excite two degenerate flexural vibration modes spatially and temporally orthogonal to each other in the ring. The proto-type, composed of a 32-mm diameter composite transducer attached along the outer edge of an 180-mm diameter aluminum annular ring, was designed, constructed, and tested. The ring was designed via finite element analysis to operate using a (0.8) transverse flexural traveling wave, and the motion was confirmed experimentally.
Publisher: Wiley
Date: 12-03-2015
Publisher: AIP Publishing
Date: 07-2008
DOI: 10.1063/1.2951467
Abstract: We report the use of focused surface acoustic waves (SAWs) generated on 128° rotated Y-cut X-propagating lithium niobate (LiNbO3) for enhancing the actuation of fluids and the manipulation of particle suspensions at microscale dimensions. In particular, we demonstrate increased efficiency and speed in carrying out particle concentration/separation and in generating intense micromixing in microliter drops within which acoustic streaming is induced due to the focused SAW beneath the drop. Concentric circular and elliptical single-phase unidirectional transducers (SPUDTs) were used to focus the SAW. We benchmark our results against a straight SPUDT which does not cause focusing of the SAW. Due to the increased wave intensity and asymmetry of the wave, we found both circular and elliptical SPUDTs concentrate particles in under 1 s, which is one order of magnitude faster than the straight SPUDT and several orders of magnitude faster than conventional microscale devices. The concentric circular SPUDT was found to be most effective at a given input power since it generated the largest azimuthal velocity gradient within the fluid to drive particle shear migration. On the other hand, the concentric elliptical SPUDT generated the highest micromixing intensity due to the more narrowly focused SAW radiation that substantially enhances acoustic streaming in the fluid.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6LC01310D
Abstract: Cell agglomeration is essential both to the success of drug testing and to the development of tissue engineering. Here, a MHz-order acoustic wave is used to generate acoustic streaming in the wells of a 24-well plate to drive particle and cell agglomeration. Acoustic streaming is known to manipulate particles in microfluidic devices, and even provide concentration in sessile droplets, but concentration of particles or cells in in idual wells has never been shown, principally due to the drag present along the periphery of the fluid in such a well. The agglomeration time for a range of particle sizes suggests that shear-induced migration plays an important role in the agglomeration process. Particles with a diameter of 45 μm agglomerated into a suspended pellet under exposure to 2.134 MHz acoustic waves at 1.5 W in 30 s. Additionally, BT-474 cells also agglomerated as adherent masses at the center bottom of the wells of tissue-culture treated 24-well plates. By switching to low cell binding 24-well plates, the BT-474 cells formed suspended agglomerations that appeared to be spheroids, fully fifteen times larger than any cell agglomerates without the acoustic streaming. In either case, the viability and proliferation of the cells were maintained despite acoustic irradiation and streaming. Intermittent excitation was effective in avoiding temperature excursions, consuming only 75 mW per well on average, presenting a convenient means to form fully three-dimensional cellular masses potentially useful for tissue, cancer, and drug research.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2016
Publisher: IOP Publishing
Date: 08-10-2008
DOI: 10.1088/0957-4484/19/45/455103
Abstract: We describe the fabrication of a surface acoustic wave (SAW) atomizer and show its ability to generate monodisperse aerosols and particles for drug delivery applications. In particular, we demonstrate the generation of insulin liquid aerosols for pulmonary delivery and solid protein nanoparticles for transdermal and gastrointestinal delivery routes using 20 MHz SAW devices. Insulin droplets around 3 µm were obtained, matching the optimum range for maximizing absorption in the alveolar region. A new approach is provided to explain these atomized droplet diameters by returning to fundamental physical analysis and considering viscous-capillary and inertial-capillary force balance rather than employing modifications to the Kelvin equation under the assumption of parametric forcing that has been extended to these frequencies in past investigations. In addition, we consider possible mechanisms by which the droplet ejections take place with the aid of high-speed flow visualization. Finally, we show that nanoscale protein particles (50-100 nm in diameter) were obtained through an evaporative process of the initial aerosol, the final size of which could be controlled merely by modifying the initial protein concentration. These results illustrate the feasibility of using SAW as a novel method for rapidly producing particles and droplets with a controlled and narrow size distribution.
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/C004822D
Abstract: Ultrafast particle and cell concentration is essential to the success of subsequent analytical procedures and the development of miniaturized biological and chemical sensors. Here, surface acoustic wave (SAW) devices were used to excite a MHz-order acoustic wave that propagates into a microlitre droplet to drive spatial concentration and separation of two different sized suspended microparticles. The rapid concentration process, occurring within just three seconds to facilitate spatial partitioning between the two particle species, exploited two acoustic phenomena acting on the suspended particles: the drag force arising from acoustic streaming and the acoustic radiation force, both driving particles in different directions. This study elucidates the very intricate and interesting interplay of physics between fluid drag and acoustic forcing on the particles within a droplet, and, for the first time, demonstrates the existence of a frequency-dependent crossover particle size that can be used to effect species partitioning: depending on the operating frequency of the SAW device and the particle size, it is possible to cause one phenomenon to dominate over the other. A theoretical analysis revealed the extent to which each force would affect the particle trajectory (particle size range: 2-31 μm), subsequently verified through experimentation. Based on these findings, 6 and 31 μm polystyrene particles were successfully partitioned in a water droplet using a 20 MHz SAW device. This study reveals the suitability of using acoustic actuation methods for the useful partitioning of particle species within a discrete fluid volume.
Publisher: AIP Publishing
Date: 2016
DOI: 10.1063/1.4939757
Abstract: We investigate the enhancement of heat transfer in the nucleate boiling regime by inducing high frequency acoustic waves (f ∼ 106 Hz) on the heated surface. In the experiments, liquid droplets (deionized water) are dispensed directly onto a heated, vibrating substrate. At lower vibration litudes (ξs ∼ 10−9 m), the improved heat transfer is mainly due to the detachment of vapor bubbles from the heated surface and the induced thermal mixing. Upon increasing the vibration litude (ξs ∼ 10−8 m), the heat transfer becomes more substantial due to the rapid bursting of vapor bubbles happening at the liquid-air interface as a consequence of capillary waves travelling in the thin liquid film between the vapor bubble and the air. Further increases then lead to rapid atomization that continues to enhance the heat transfer. An acoustic wave displacement litude on the order of 10−8 m with 106 Hz order frequencies is observed to produce an improvement of up to 50% reduction in the surface temperature over the case without acoustic excitation.
Publisher: Wiley
Date: 18-02-2020
Publisher: AIP Publishing
Date: 02-01-2023
DOI: 10.1063/5.0131467
Abstract: Over the years, a erse range of physical and chemical phenomena have been explored and applied to devise reliable, small thrusters for stationkeeping and orientation of spacecraft. Commercial space flight is accelerating this need. Here, we consider acoustically driven melting of a frozen working fluid in the nozzle of an acoustic device, followed by acoustofluidic atomization from the nozzle to produce thrust. Fifty-five MHz acoustic waves generated by piezoelectric transducers couple into liquid and transfer energy in the form of both acoustic radiation and streaming, producing a directed atomized spray. A challenge in this system, as with most liquid-thrust systems, is the risk of phase change due to the extreme thermal environment in space, particularly in the freezing of the working fluid. Though acoustic energy is known to produce rapid and controllable heating, it so far has not been used to produce phase changes. The atomization produces capillary pressure sufficient to draw in fluid from a reservoir, though we do use a simple pressure-driven pump to support greater atomization rates. We provide a simple energy conservation model to explain the acoustothermal interaction and validate this with experiments. The specific impulse and thrust of this type of thruster are quite modest at 0.1–0.4 s and 12.3 μN, respectively, but the thruster component is small, light, and is without moving parts, a fascinating potential alternative to current technologies.
Publisher: Wiley
Date: 07-11-2021
Abstract: Ultrasound has been used to manipulate cells in both humans and animal models. While intramembrane cavitation and lipid clustering have been suggested as likely mechanisms, they lack experimental evidence. Here, high‐speed digital holographic microscopy (kiloHertz order) is used to visualize the cellular membrane dynamics. It is shown that neuronal and fibroblast membranes deflect about 150 nm upon ultrasound stimulation. Next, a biomechanical model that predicts changes in membrane voltage after ultrasound exposure is developed. Finally, the model predictions are validated using whole‐cell patch cl electrophysiology on primary neurons. Collectively, it is shown that ultrasound stimulation directly defects the neuronal membrane leading to a change in membrane voltage and subsequent depolarization. The model is consistent with existing data and provides a mechanism for both ultrasound‐evoked neurostimulation and sonogenetic control.
Publisher: American Chemical Society (ACS)
Date: 11-09-2014
DOI: 10.1021/LA502301F
Abstract: Poloidal flow is curiously formed in a microliter sessile water drop over 157-225 MHz because of acoustic streaming from three-dimensional standing Lamb waves in a lithium niobate substrate. The flow possesses radial symmetry with downwelling at the center and upwelling around the periphery of the drop. Outside this frequency range, the attenuation occurs over a length scale incompatible with the drop size and the poloidal flow vanishes. Remarkably, shear-induced migration was found to drive toroidal particle ring formation with diameters inversely proportional to the frequency of the acoustic irradiation.
Publisher: IOP Publishing
Date: 02-2011
Publisher: Elsevier BV
Date: 03-2009
Publisher: IEEE
Date: 02-2009
Publisher: AIP Publishing
Date: 21-11-2011
DOI: 10.1063/1.3662931
Abstract: A surface acoustic wave (SAW) actuated rotary motor is reported here, consisting of a millimeter-sized spherical metal rotor placed on the surface of a lead zirconate titanate piezoelectric substrate upon which the SAW is made to propagate. At the design frequency of 3.2 MHz and with a fixed preload of 41.1 μN, the maximum rotational speed and torque achieved were approximately 1900 rpm and 5.37 μN-mm, respectively, producing a maximum output power of 1.19 μW. The surface vibrations were visualized using laser Doppler vibrometry and indicate that the rotational motion arises due to retrograde elliptical motions of the piezoelectric surface elements. Rotation about orthogonal axes in the plane of the substrate has been obtained by using orthogonally placed interdigital electrodes on the substrate to generate SAW impinging on the rotor, offering a means to generate rotation about an arbitrary axis in the plane of the substrate.
Publisher: IOP Publishing
Date: 06-2005
DOI: 10.1143/JJAP.44.4666
Abstract: An noncontact ultrasonic motor, which is composed of two metal disks for a low-profile configuration and 30 mm in diameter, is proposed. To enhance rotation characteristics, the resonant mode of the air gap between the stator and rotor is chosen to coincide with the resonance of stator vibration both in frequency and mode shape. The motor rotated at 1,260 rpm with the (1,1) flexural vibration mode of the disk stator, driven at about 25 kHz.
Publisher: Wiley
Date: 14-02-2020
Publisher: American Association for the Advancement of Science (AAAS)
Date: 11-08-2021
DOI: 10.1126/SCIROBOTICS.ABF0601
Abstract: Catheters used for endovascular navigation in interventional procedures lack dexterity at the distal tip. Neurointerventionists, in particular, encounter challenges in up to 25% of aneurysm cases largely due to the inability to steer and navigate the tip of the microcatheters through tortuous vasculature to access aneurysms. We overcome this problem with submillimeter diameter, hydraulically actuated hyperelastic polymer devices at the distal tip of microcatheters to enable active steerability. Controlled by hand, the devices offer complete 3D orientation of the tip. Using saline as a working fluid, we demonstrate guidewire-free navigation, access, and coil deployment in vivo, offering safety, ease of use, and design flexibility absent in other approaches to endovascular intervention. We demonstrate the ability of our device to navigate through vessels and to deliver embolization coils to the cerebral vessels in a live porcine model. This indicates the potential for microhydraulic soft robotics to solve difficult access and treatment problems in endovascular intervention.
Publisher: IOP Publishing
Date: 04-03-2008
DOI: 10.1088/0957-4484/19/14/145301
Abstract: We demonstrate a straightforward and rapid atomization process driven by surface acoustic waves that is capable of continuously producing spherical monodispersed submicron poly-ε-caprolactone particle aggregates between 150 and 200 nm, each of which are composed of nanoparticles of 5-10 nm in diameter. The size and morphologies of these particle assemblies were determined using dynamic light scattering, atomic force microscopy and transmission electron microscopy. Through scaling theory, we show that the larger particle aggregates are formed due to capillary instabilities lified by the acoustic forcing whereas the smaller particulates that form the aggregates arise due to a nucleate templating process as a result of rapid spatially inhomogeneous solvent evaporation. Minimization of the free energy associated with the evaporative process yields a critical cluster size for a single nucleus in the order of 10 nm, which roughly corresponds with the dimensions of the sub-50 nm particulates.
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2LC40085E
Abstract: Surface acoustic waves (SAWs) are appealing as a means to manipulate fluids within lab-on-a-chip systems. However, current acoustofluidic devices almost universally rely on elastomeric materials, especially PDMS, that are inherently ill-suited for conveyance of elastic energy due to their strong attenuation properties. Here, we explore the use of a low-viscosity UV epoxy resin for room temperature bonding of lithium niobate (LiNbO(3)), the most widely used anisotropic piezoelectric substrate used in the generation of SAWs, to standard micromachined superstrates such as Pyrex® and silicon. The bonding methodology is straightforward and allows for reliable production of sub-micron bonds that are capable of enduring the high surface strains and accelerations needed for conveyance of SAWs. Devices prepared with this approach display as much as two orders of magnitude, or 20 dB, improvement in SAW transmission compared to those fabricated using the standard PDMS elastomer. This enhancement enables a broad range of applications in acoustofluidics that are consistent with the low power requirements of portable battery-driven circuits and the development of genuinely portable lab-on-a-chip devices. The method is exemplified in the fabrication of a closed-loop bidirectional SAW pumping concept with applications in micro-scale flow control, and represents the first demonstration of closed channel SAW pumping in a bonded glass/LiNbO(3) device.
Publisher: Wiley
Date: 11-11-2010
Abstract: Harnessing the ability to precisely and reproducibly actuate fluids and manipulate bioparticles such as DNA, cells, and molecules at the microscale, microfluidics is a powerful tool that is currently revolutionizing chemical and biological analysis by replicating laboratory bench-top technology on a miniature chip-scale device, thus allowing assays to be carried out at a fraction of the time and cost while affording portability and field-use capability. Emerging from a decade of research and development in microfluidic technology are a wide range of promising laboratory and consumer biotechnological applications from microscale genetic and proteomic analysis kits, cell culture and manipulation platforms, biosensors, and pathogen detection systems to point-of-care diagnostic devices, high-throughput combinatorial drug screening platforms, schemes for targeted drug delivery and advanced therapeutics, and novel biomaterials synthesis for tissue engineering. The developments associated with these technological advances along with their respective applications to date are reviewed from a broad perspective and possible future directions that could arise from the current state of the art are discussed.
Publisher: ASMEDC
Date: 2008
Abstract: There has been some amount of confusion over the origin of electrohydrodynamic phenomena responsible for the actuation of dielectric fluids in the presence of an electric field. Previous studies have accounted for the possibility of conduction pumping, ion drag pumping and induction pumping as driving mechanisms but have ignored the possibility of Maxwell (electric) pressure driven flow. Until recently, this mechanism has been poorly understood and as a result has often been overlooked. This paper demonstrates how a Maxwell pressure gradient can induce flow in dielectric liquids in the presence of a non-uniform field. We derive, from first principles using lubrication theory, an expression for the flow velocity which exhibits a quadratic dependence on the applied voltage and also proportionality to the ratio of the permittivity and viscosity. The theoretical predictions are supported by experimental results. Although we have examined the phenomenon for a particular class of dielectric liquids, it is believed that this mechanism could well be responsible for the actuation of other low conductivity dielectric fluids previously attributed to conduction or ion drag pumping. In any case, we discuss ways to identify the dominant mechanism by comparing the salient features for a given type of flow.
Publisher: Elsevier BV
Date: 10-2010
Publisher: Elsevier BV
Date: 06-2002
DOI: 10.1016/S0041-624X(02)00260-3
Abstract: In this paper, a hybrid transducer ultrasonic motor is numerically analyzed by using two equivalent electrical circuit models. A transmission-line model for the torsional vibration in the stator, which can model any torsional vibration mode and their combinations, was introduced and compared with a lumped-element model, which modeled the fundamental torsional resonance mode in the stator. The calculation result by using the transmission-line model demonstrated that the second harmonic torsional vibration increased either with the static spring force by which the rotor was pressed to the stator or with the load torque placed on the rotor. The difference in the calculated motor performance between the two models appeared when the second harmonic torsional vibration became large at a sufficient static spring force.
Publisher: IOP Publishing
Date: 15-10-2010
Publisher: IEEE
Date: 2007
DOI: 10.1109/FBIT.2007.22
Publisher: IEEE
Date: 2004
Publisher: AIP Publishing
Date: 12-01-2009
DOI: 10.1063/1.3049128
Abstract: In this study, surface acoustic radiation is refracted from lithium niobate through a fluid coupling into a thin glass plate. We demonstrate and explain its propagation as an asymmetric Lamb wave along the glass plate with sufficient power to transport fluid droplets across the glass surface at 8 mm/s. Such technology enables the use of standard processing techniques to fabricate an inexpensive and disposable microfluidics device together with the power transmission capabilities of surface acoustic wave devices with an easily renewable coupling.
Publisher: AIP Publishing
Date: 22-10-2001
DOI: 10.1063/1.1412595
Abstract: A method for measuring the spatial variation of the macroscopic poling state of a piezoelectric material using an ultrasonic transducer is described. The relatively simple method clearly indicates the distribution of poling within the material, demonstrated by the testing of a collection of partially poled lead zirconate titanate s les.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3LC50933H
Abstract: We have designed and characterized a surface acoustic wave (SAW) fluid actuation platform that significantly improves the transmission of sound energy from the SAW device into the fluid in order to obtain enhanced performance. This is in distinct contrast to previous SAW microfluidic devices where the SAW substrate is simply interfaced with a microchannel without due consideration given to the direction in which the sound energy is transmitted into the fluid, thus resulting in considerable reflective and dissipative losses due to reflection and absorption at the channel walls. For the first time, we therefore demonstrate the ability for continuous fluid transfer between independent reservoirs driven by the SAW in a miniature device and report the associated pressure-flow rate relationship, in which a maximum flow rate of 100 μl min(-1) and pressure of 15 Pa were obtained. The pumping efficiency is observed to increase with input power and, at peak performance, offers an order-of-magnitude improvement over that of existing SAW micropumps that have been reported to date.
Publisher: Elsevier BV
Date: 2015
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2008
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2LC21065G
Abstract: Paper-based microfluidics has recently received considerable interest due to their ease and low cost, making them extremely attractive as point-of-care diagnostic devices. The incorporation of basic fluid actuation and manipulation schemes on paper substrates, however, afford the possibility to extend the functionality of this simple technology to a much wider range of typical lab-on-a-chip operations, given its considerable advantages in terms of cost, size and integrability over conventional microfluidic substrates. We present a convective actuation mechanism in a simple paper-based microfluidic device using surface acoustic waves to drive mixing. Employing a Y-channel structure patterned onto paper, the mixing induced by the 30 MHz acoustic waves is shown to be consistent and rapid, overcoming several limitations associated with its capillary-driven passive mixing counterpart wherein irreproducibilities and nonuniformities are often encountered in the mixing along the channel--capillary-driven passive mixing offers only poor control, is strongly dependent on the paper's texture and fibre alignment, and permits backflow, all due to the scale of the fibres being significant in comparison to the length scales of the features in a microfluidic system. Using a novel hue-based colourimetric technique, the mixing speed and efficiency is compared between the two methods, and used to assess the effects of changing the input power, channel tortuousity and fibre/flow alignment for the acoustically-driven mixing. The hue-based technique offers several advantages over grayscale pixel intensity analysis techniques in facilitating quantification without limitations on the colour contrast of the s les, and can be used, for ex le, for quantification in on-chip immunochromatographic assays.
Publisher: American Chemical Society (ACS)
Date: 07-04-2011
DOI: 10.1021/AC200380Q
Abstract: A surface acoustic wave-based s le delivery and ionization method that requires minimal to no s le pretreatment and that can operate under ambient conditions is described. This miniaturized technology enables real-time, rapid, and high-throughput analysis of trace compounds in complex mixtures, especially high ionic strength and viscous s les that can be challenging for conventional ionization techniques such as electrospray ionization. This technique takes advantage of high order surface acoustic wave (SAW) vibrations that both manipulate small volumes of liquid mixtures containing trace analyte compounds and seamlessly transfers analytes from the liquid s le into gas phase ions for mass spectrometry (MS) analysis. Drugs in human whole blood and plasma and heavy metals in tap water have been successfully detected at nanomolar concentrations by coupling a SAW atomization and ionization device with an inexpensive, paper-based s le delivery system and mass spectrometer. The miniaturized SAW ionization unit requires only a modest operating power of 3 to 4 W and, therefore, provides a viable and efficient ionization platform for the real-time analysis of a wide range of compounds.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2005
DOI: 10.1109/TUFFC.2005.1561627
Abstract: A new type of ultrasonic linear motor is presented using traveling waves excited along a ridge atop a substrate. The ridge cross section was designed to permit only the fundamental mode to be excited during operation of the motor, with a Langevin transducer used as the source of vibration in this study. The ridge waveguide was first made of lossy media to avoid reflecting vibration energy back toward the vibration source, forming a traveling wave. A 5-mm-wide, 15-mm-tall rectangular acrylic ridge was used to move a slider placed upon it toward the vibration source, in opposition to the direction of the traveling wave transmitted along the waveguide ridge. Using a low-loss 3 x 6-mm aluminum rectangular ridge combined with a d er cl ed onto the far end of the waveguide, similar results were obtained. To obtain bidirectional operation, the d er was replaced with a second Langevin transducer, giving a pair of transducers located perpendicularly to the ends of the ridge and driven with an appropriate phase difference. The moving direction of the slider was reversed by shifting this phase difference by about 180 degrees. With this simple configuration, it may soon be possible to fabricate a linear micromotor system on a silicon substrate or other semiconductor wafer adjacent to other electronic and optoelectronic devices.
Publisher: IOP Publishing
Date: 06-2005
DOI: 10.1143/JJAP.44.4662
Abstract: In this paper, we propose a new low-profile design for a linear bearing based on Near-Field Acoustic Levitation (NFAL). Two flat beams at a 45° angle are used as a guide rail, and a slider is levitated by ultrasonic bending vibrations excited along the beams. The beams are excited by a pair of Langevin transducers with “+”-shaped vibration direction converters (L-L converters) to install the transducers in the same plane of the beam and to lower the total height of the setup. First, the design of the vibration converter is described. Then, a two-phase driving system to excite a traveling wave is investigated theoretically and experimentally. The levitation characteristics and the sliding performance of the prototype stage are measured and discussed.
Publisher: AIP Publishing
Date: 06-2010
DOI: 10.1063/1.3430537
Abstract: Making use of mechanical resonance has many benefits for the design of microscale devices. A key to successfully incorporating this phenomenon in the design of a device is to understand how the resonant frequencies of interest are affected by changes to the geometric parameters of the design. For simple geometric shapes, this is quite easy, but for complex nonlinear designs, it becomes significantly more complex. In this paper, two novel modeling techniques are demonstrated to extract the axial and torsional resonant frequencies of a complex nonlinear geometry. The first decomposes the complex geometry into easy to model components, while the second uses scaling techniques combined with the finite element method. Both models overcome problems associated with using current analytical methods as design tools, and enable a full investigation of how changes in the geometric parameters affect the resonant frequencies of interest. The benefit of such models is then demonstrated through their use in the design of a prototype piezoelectric ultrasonic resonant micromotor which has improved performance characteristics over previous prototypes.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 09-2004
Publisher: American Physical Society (APS)
Date: 04-10-2022
Publisher: IOP Publishing
Date: 06-2005
DOI: 10.1143/JJAP.44.4658
Abstract: If an ultrasonically vibrating pipe is dipped into a liquid, the liquid is pumped up inside the pipe. We found in a previous study that the maximum pressure was improved from 1 kPa to 7.2 kPa if the end of the pipe was installed on a plate with a small gap. In this study, the configuration is modified for a practical design in which a still pipe is located at a right angle to a piston-vibrated surface. We investigate the difference in the pump characteristics between the former and new configurations. Our experiments show that a maximum pressure of 20.6 kPa is obtained by optimizing the inner and outer diameters of the pipe as well as the gap between the pipe end and the vibrator.
Publisher: AIP Publishing
Date: 10-2012
DOI: 10.1063/1.4759493
Abstract: A polydimethylsiloxane microfluidic device composed of a single microchannel with a thin flexible layer present over a short length along one side of the channel was fabricated and modelled in order to investigate the complex fluid-structure interaction that arises between a flowing fluid and a deformable wall. Experimental measurements of thin layer deformation and pressure drop are compared with predictions of two- and three-dimensional computational models that numerically solve the coupled set of equations governing both the elasticity of the thin layer and the fluid. It is shown that the two-dimensional model, which assumes the flexible thin layer comprises an infinitely wide elastic beam of finite thickness, reasonably approximates a three-dimensional model, and is in excellent agreement with experimental observations of the thin layer profile when the width of the thin layer is beyond a critical value, roughly twice the length of the thin layer.
Publisher: American Chemical Society (ACS)
Date: 03-2023
Publisher: American Chemical Society (ACS)
Date: 24-10-2013
DOI: 10.1021/NN4041987
Abstract: Two-dimensional (2D) transition metal dichalcogenide semiconductors offer unique electronic and optical properties, which are significantly different from their bulk counterparts. It is known that the electronic structure of 2D MoS2, which is the most popular member of the family, depends on the number of layers. Its electronic structure alters dramatically at near atomically thin morphologies, producing strong photoluminescence (PL). Developing processes for controlling the 2D MoS2 PL is essential to efficiently harness many of its optical capabilities. So far, it has been shown that this PL can be electrically or mechanically gated. Here, we introduce an electrochemical approach to actively control the PL of liquid-phase-exfoliated 2D MoS2 nanoflakes by manipulating the amount of intercalated ions including Li(+), Na(+), and K(+) into and out of the 2D crystal structure. These ions are selected as they are crucial components in many bioprocesses. We show that this controlled intercalation allows for large PL modulations. The introduced electrochemically controlled PL will find significant applications in future chemical and bio-optical sensors as well as optical modulators/switches.
Publisher: ASMEDC
Date: 2010
DOI: 10.1115/FEDSM-ICNMM2010-30181
Abstract: Though uncommon in most microfluidic systems due to the dominance of viscous and capillary stresses, it is possible to drive microscale fluid flows with considerable inertia using surface acoustic waves (SAWs), which are nanometer order litude electro-elastic waves that can be generated on a piezoelectric substrate. Due to the confinement of the acoustic energy to a thin localized region along the substrate surface and its subsequent leakage into the body of liquid with which the substrate comes into contact, SAWs are an extremely efficient mechanism for driving fast microfluidics. We demonstrate that it is possible to generate a variety of efficient microfluidic flows using the SAW. For ex le, the SAWs can be exploited to pump liquids in microchannels or to translate free droplets typically one or two orders of magnitude faster than conventional electroosmotic or electrowetting technology. In addition, it is possible to drive strong microcentrifugation for micromixing and bioparticle concentration or separation. In the latter, rich and complex colloidal pattern formation dynamics have also been observed. At large input powers, the SAW is a powerful means for the generation of jets and atomized aerosol droplets through rapid destabilization of the parent drop interface. In the former, slender liquid jets that persist up to centimeters in length can be generated without requiring nozzles or orifices. In the latter, a monodispersed distribution of 1–10 micron diameter aerosol droplets is obtained, which can be exploited for drug delivery and encapsulation, nanoparticle synthesis, and template-free polymer array patterning.
Publisher: AIP Publishing
Date: 11-2010
DOI: 10.1063/1.3505044
Abstract: This paper presents a numerical and experimental study of capillary wave motion excited by high frequency surface acoustic waves (SAWs). The objective of this study is to provide insight into the dynamic behavior of the fluid free surface and its dependence on the excitation litude. A two-dimensional numerical model that couples the motion of the piezoelectric substrate to a thin liquid layer atop the substrate is constructed. A perturbation method, in the limit of small- litude acoustic waves, is used to decompose the equations governing fluid motion to resolve the widely differing time scales associated with the high frequency excitation. While this model focuses on the free surface dynamics in the low- litude flow regime, the experimental study focuses on the high- litude flow regime. Transformation of time series data from both experiments and simulations into the frequency domain reveals that, in the low- litude regime, a fundamental resonant frequency and a superharmonic frequency are found in the frequency spectra. The former is found to be identical to that of the applied SAW, and the free surface displacement magnitude is comparable to that of the substrate displacement. Our numerical results also confirm previous speculation that the separation distance between two displacement antinodal points on the free surface is δSt≈λSAW/2 for a film and δSt≈λf/2 for a drop, where λSAW and λf denote the SAW wavelength and the acoustic wavelength in the fluid, respectively. Finally, in the high- litude regime, strong nonlinearities shift the acoustic energy to a lower frequency than that of the SAW this low-frequency broadband response, quite contrary to the subharmonic half-frequency capillary wave excitation predicted by the classical linear or weakly nonlinear Faraday theories, is supported by a scaling analysis of the momentum equations.
Publisher: ASMEDC
Date: 2010
Abstract: Surface acoustic waves (SAWs), which are 10 MHz order surface waves roughly 10 nm in litude propagating on the surface of a piezoelectric substrate, can offer a powerful method for driving fast microfluidic actuation and microparticle or biomolecule manipulation. We demonstrate that sessile drops can be linearly translated on planar substrates or fluid can be pumped through microchannels at typically one to two orders of magnitude faster than that achievable through current microfluidic technologies. Micromixing can be induced in the same microchannel in which fluid is pumped using the SAW simply by changing the SAW frequency to superimpose a chaotic oscillatory flow onto the uniform through flow. Strong inertial microcentrifugation for micromixing and particle concentration or separation can also be induced via symmetry-breaking. At low SAW litudes below that at which flow commences, the transverse standing wave that arises across the microchannel afford particle aggregation and hence sorting on nodal lines. Other microfluidic manipulations are also possible with the SAW. For ex le, capillary waves excited on a sessile drop by the SAW can be exploited for microparticle or nanoparticle collection and sorting. At higher litudes, the large substrate accelerations drives rapid destabilization of the drop interface giving rise to inertial liquid jets or atomization to produce 1–10 μm monodispersed aerosol droplets. These have significant implications for microfluidic chip mass spectrometry interfacing or pulmonary drug delivery. The atomization also provides a convenient means for the synthesis of 150–200 nm polymer or protein particles or to encapsulate proteins, peptides and other therapeutic molecules within biodegradable polymeric shells for controlled release drug delivery. The atomization of thin films containing polymer solutions, in addition, gives produces a unique regular, long-range spatial polymer spot patterning effect whose size and spacing are dependent on the SAW frequency, thus offering a simple and powerful method for surface patterning without requiring physical or chemical templating.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-2010
Publisher: IOP Publishing
Date: 05-2004
DOI: 10.1143/JJAP.43.3040
Abstract: Using a 3×4×5 mm torsional microtransducer attached to a 30-cm long, 0.3-mm diameter flexible stainless steel wire, torsional vibration and coupled torsional-flexural vibration is transmitted to a remotely-placed rotor. The torsional microtransducer uses flat, thickness-poled lead zirconate titanate (PZT) elements attached to the surface of a square-sided prism with a tapered horn and tip the elements twist the structure and generate torsional vibration lified by the horn and tip at 150–260 kHz. Swaged to the wire–the `acoustic waveguide'–torsional vibration is transmitted into the wire, and flexural vibration is developed in the wire due to strong torsional-flexural coupling, demonstrated by measurement of the vibration velocity. Standing wave vibration was generated (standing wave ratio, SWR≈7.5) in the waveguide with nothing on the waveguide tip, but upon using a rotor, traveling wave vibration transmitted energy to the rotor (SWR≈4), which acted essentially as a loss by placing a d ing material on the tip instead of a rotor, very similar traveling wave motion was obtained (SWR≈1.5). The few torsional resonances of the transducer were found to be greatly increased in number by the waveguide, and rotors, with a contact radius of 300 µm, were found to rotate for most of these resonances in either direction at up to 11,500 rpm and 3.5 µN-m.
Publisher: SPIE
Date: 07-12-2013
DOI: 10.1117/12.2034050
Publisher: The Royal Society
Date: 08-09-2014
Abstract: Arising from an interplay between capillary, acoustic and intermolecular forces, surface acoustic waves (SAWs) are observed to drive a unique and curious double flow reversal in the spreading of thin films. With a thickness at or less than the submicrometre viscous penetration depth, the film is seen to advance along the SAW propagation direction, and self-similarly over time t 1/4 in the inertial limit. At intermediate film thicknesses, beyond one-fourth the sound wavelength λ ℓ in the liquid, the spreading direction reverses, and the film propagates against the direction of the SAW propagation. The film reverses yet again, once its depth is further increased beyond one SAW wavelength. An unstable thickness region, between λ ℓ /8 and λ ℓ /4, exists from which regions of the film either rapidly grow in thickness to exceed λ ℓ /4 and move against the SAW propagation, consistent with the intermediate thickness films, whereas other regions decrease in thickness below λ ℓ /8 to conserve mass and move along the SAW propagation direction, consistent with the thin submicrometre films.
Publisher: IEEE
Date: 09-2009
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5SM01940K
Abstract: Novel microfluidic experiments enabled the measurement of extensional viscosities of copper nanowire suspensions and their complex buffer, whose characterisation is essential for the development of advanced inkjet applications.
Publisher: American Physical Society (APS)
Date: 19-05-2015
Publisher: IEEE
Date: 09-2009
Publisher: IEEE
Date: 2003
Publisher: AIP Publishing
Date: 07-01-2008
DOI: 10.1063/1.2814044
Abstract: A bidirectional linear microactuator with a stator less than 400μm3, fulfilling Feynman’s original criteria for a motor less than 1∕64th of an inch on a side [R. Feynman, Engineering and Science Magazine (Caltech) 4, 23 (1960)], is shown to generate forces over 30mN in either direction at speeds of up to 40mm∕s using a large 28g polished alumina slider. Using the thickness mode of a stepped piezoelectric block in conjunction with a pair of fundamental flexural modes of a pair of slanted beams—each slightly differs in configuration—gives the ability to generate silent bidirectional motion at an excitation frequency of about 1.7MHz. In addition to offering forces at least one order of magnitude larger than those of the other methods, the system also serves as a platform for studying nonlinear frictional phenomena on the nanoscale and its manipulation through acoustic irradiation of the contact interface for propulsion.
Publisher: American Physical Society (APS)
Date: 22-08-2008
Publisher: IEEE
Date: 2004
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4LC01453G
Abstract: Open droplet microfluidic platforms offer attractive alternatives to closed microchannel devices, including lower fabrication cost and complexity, significantly smaller s le and reagent volumes, reduced surface contact and adsorption, as well as drop scalability, reconfigurability, and in idual addressability.
Publisher: American Chemical Society (ACS)
Date: 15-11-2011
DOI: 10.1021/NN202833N
Abstract: The encapsulation of therapeutic molecules within multiple layers of biocompatible and biodegradable polymeric excipients allows exquisite design of their release profile, to the extent the drug can be selectively delivered to a specific target location in vivo. Here, we develop a novel technique for the assembly of multilayer polyelectrolyte nanocarriers based on surface acoustic wave atomization as a rapid and efficient alternative to conventional layer-by-layer assembly, which requires the use of a sacrificial colloidal template over which consecutive polyelectrolyte layers are deposited. Polymer nanocarriers are synthesized by atomizing a polymer solution and suspending them within a complementary polymer solution of opposite charge subsequent to their solidification in-flight as the solvent evaporates reatomizing this suspension produces nanocarriers with a layer of the second polymer deposited over the initial polymer core. Successive atomization-suspension layering steps can then be repeated to produce as many additional layers as desired. Specifically, we synthesize nanocarriers comprising two and three, and up to eight, alternating layers of chitosan (or polyethyleneimine) and carboxymethyl cellulose within which plasmid DNA is encapsulated and show in vitro DNA release profiles over several days. Evidence that the plasmid's viability is preserved and hence the potential of the technique for gene delivery is illustrated through efficient in vitro transfection of the encapsulated plasmid in human mesenchymal progenitor and COS-7 cells.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-2009
Publisher: AIP Publishing
Date: 04-09-2006
DOI: 10.1063/1.2345590
Abstract: In a similar fashion to Einstein’s tea leaf paradox, the rotational liquid flow induced by ionic wind above a liquid surface can trap suspended microparticles by a helical motion, spinning them down towards a bottom stagnation point. The motion is similar to Batchelor [Q. J. Mech. Appl. Math. 4, 29 (1951)] flows occurring between stationary and rotating disks and arises due to a combination of the primary azimuthal and secondary bulk meridional recirculation that produces a centrifugal and enhanced inward radial force near the chamber bottom. The technology is thus useful for microfluidic particle trapping/concentration the authors demonstrate its potential for rapid erythrocyte/blood plasma separation for miniaturized medical diagnostic kits.
Publisher: IOP Publishing
Date: 27-08-2021
Publisher: IEEE
Date: 02-2011
Publisher: SPIE
Date: 21-12-2011
DOI: 10.1117/12.904870
Publisher: American Chemical Society (ACS)
Date: 11-09-2014
DOI: 10.1021/JP5070006
Publisher: IOP Publishing
Date: 30-05-2003
DOI: 10.1143/JJAP.42.3000
Publisher: American Physical Society (APS)
Date: 20-11-2012
Publisher: Elsevier BV
Date: 07-2023
Publisher: American Chemical Society (ACS)
Date: 03-10-2016
Publisher: American Physical Society (APS)
Date: 10-2009
Publisher: AIP Publishing
Date: 08-04-2015
DOI: 10.1063/1.4917181
Abstract: Nebulizers have considerable advantages over conventional inhalers for pulmonary drug administration, particularly because they do not require coordinated breath actuation to generate and deliver the aerosols. Nevertheless, besides being less amenable to miniaturization and hence portability, some nebulizers are prone to denature macromolecular drugs due to the large forces generated during aerosolization. Here, we demonstrate a novel portable acoustomicrofluidic device capable of nebulizing epidermal growth factor receptor (EGFR) monoclonal antibodies into a fine aerosol mist with a mass median aerodynamic diameter of approximately 1.1 μm, optimal for deep lung deposition via inhalation. The nebulized monoclonal antibodies were tested for their stability, immunoactivity, and pharmacological properties, which confirmed that nebulization did not cause significant degradation of the antibody. In particular, flow cytometry demonstrated that the antigen binding capability of the antibody is retained and able to reduce phosphorylation in cells overexpressing the EGFR, indicating that the aerosols generated by the device were loaded with stable and active monoclonal antibodies. The delivery of antibodies via inhalation, particularly for the treatment of lung cancer, is thus expected to enhance the efficacy of this protein therapeutic by increasing the local concentration where they are needed.
Publisher: IEEE
Date: 07-2013
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2001
DOI: 10.1109/58.971713
Abstract: In this paper, operation of a symmetric hybrid transducer ultrasonic motor with output produced by two rotors connected together via a driveshaft is numerically analyzed and compared with the traditional asymmetric hybrid transducer motor design that produces its output from only one rotor. A one-dimensional finite element model for torsional vibration in the stator and a Coulomb friction model for rotor/stator contact associated with the longitudinal vibration of the motor are introduced. The calculation results demonstrate that the symmetric design is capable of performance comparable with the traditional asymmetric design when an optimum static spring force in the rotor/stator contact interface is applied during operation.
Publisher: American Institute of Aeronautics and Astronautics
Date: 15-04-1996
DOI: 10.2514/6.1996-1452
Publisher: IEEE
Date: 09-2009
Publisher: American Physical Society (APS)
Date: 21-01-2014
Publisher: Wiley
Date: 16-02-2022
Abstract: Ultrasound neuromodulation has rapidly developed over the past decade, a consequence of the discovery of strain‐sensitive structures in the membrane and organelles of cells extending into the brain, heart, and other organs. A key limitation to its use in the brain is the formation of standing waves within the skull. In standing acoustic waves, the maximum ultrasound intensity spatially varies from near zero to double the mean in one‐half of a wavelength, and has led to localized tissue damage and disruption of normal brain function while attempting to evoke a broader response. This phenomenon also produces a large spatial variation in the actual ultrasound exposure in tissue, leading to heterogeneous results. One approach to overcome this limitation is presented here: transducer‐mounted diffusers that result in spatiotemporally incoherent ultrasound. It is shown through experiment and analysis that adding a diffuser to the transducer leads to a twofold increase in ultrasound responsiveness of transient receptor potential ankyrin 1 (TRPA1)‐transfected human embryonic kidney cells. Furthermore, it is shown that the diffuser produces a uniform spatial distribution of pressure within the rodent skull. The approach offers uniform ultrasound delivery into irregular cavities for sonogenetics.
Publisher: AIP Publishing
Date: 07-2008
DOI: 10.1063/1.2953537
Abstract: Surface acoustic wave atomization is a rapid means for generating micron and submicron aerosol droplets. Little, however, is understood about the mechanisms by which these droplets form due to the complex hydrodynamic processes that occur across widely varying length and time scales. Through experiments, scaling theory, and simple numerical modeling, we elucidate the interfacial destabilization mechanisms that lead to droplet formation. Using a millimeter-order fluid drop exposed to surface acoustic waves as it sits atop a single-crystal lithium niobate piezoelectric substrate, large aerosol droplets on the length scale of the parent drop dimension are ejected through a whipping and pinch-off phenomenon, which occurs at the asymmetrically formed crest of the drop due to leakage of acoustic radiation at the Rayleigh angle. Smaller micron order droplets, on the other hand, are formed due to the axisymmetric breakup of cylindrical liquid jets that are ejected as a consequence of interfacial destabilization. The 10μm droplet dimension correlates with the jet radius and the instability wavelength, both determined from a simple scaling argument involving a viscous-capillary dominant force balance. The results are further supported by numerical solution of the evolution equation governing the interfacial profile of a sessile drop along which an acoustic pressure wave is imposed. Viscous and capillary forces dominate in the bulk of the parent drop, but inertia is dominant in the ejected jets and within a thin boundary layer adjacent to the substrate where surface and interfacial accelerations are large. With the specific exception of parent drops that spread into thin films with thicknesses on the order of the boundary layer dimension prior to atomization, the free surface of the drop is always observed to vibrate at the capillary-viscous resonance frequency—even if the exciting frequency of the surface acoustic wave is several orders of magnitude larger—contrary to common assumptions used in deriving subharmonic models resulting in a Mathieu equation for the capillary wave motion, which has commonly led to erroneous predictions of the droplet size.
Publisher: American Physical Society (APS)
Date: 21-11-2014
Publisher: Elsevier BV
Date: 10-2007
DOI: 10.1016/J.BIOMATERIALS.2007.06.005
Abstract: Surface acoustic waves (SAW) have been employed to drive a particle suspension into a porous scaffold as a means for cell seeding. Straight, simple interdigital electrode structures were fabricated on lithium niobate to permit the generation of Rayleigh SAW radiation. Fluorescent microscopy was used to investigate the seeding process the SAW-driven seeding process occurred in approximately 10s, much quicker than if the scaffold were to be seeded by gravity-driven diffusional processes alone (>30min). Analysis of high-speed micrographic images demonstrated that the SAW method could also drive particles deeper into the scaffold, thereby significantly improving the uniformity of the particle distribution. The proposed SAW technique therefore offers a promising technology to dramatically improve the speed and uniformity of cell seeding in scaffolds, which might contribute to rapid and uniform tissue regeneration.
Publisher: ASMEDC
Date: 2010
Abstract: Atomization has been widely applied in pulmonary drug delivery as a promising technology to transport drug formulations directly to the respiratory tract in the form of inhaled particles or droplets. Because of the targeted treatment, the drug can be delivered directly to the site of inflammation, thus the need for systemic exposure and the possibility of side effects are both reduced. Therefore pulmonary drug delivery has significant advantages over other methods in the treatment of respiratory diseases such as asthma. The most common atomization methods employed in pulmonary drug delivery are jet atomization and ultrasonic atomization. However, the difficulty is in producing monodispersed particles/droplets in a size range of 1–5 micron meter in diameter, necessary for deposition in the targeted lung area or lower respiratory airways, within a controllable fashion. In this paper, we demonstrate surface acoustic wave (SAW) atomization as an efficient technique to generate monodispersed aerosol to produce the required size distribution. The SAW atomizer is made of a 127.86 Y-X rotated single-crystal lithium niobate piezoelectric substrate, which is patterned with chromium-aluminum interdigital transducer (IDT) electrodes via UV lithography. When an alternating electric field is applied onto lithium niobate substrate through the IDT, a SAW, propagating across substrate surface with ten nanometer order litudes, is generated. When the SAW meets the liquid which is placed upon substrate, the acoustic energy carried by the wave induces atomization of the working fluid, which contains salbutamol as a model drug. In order to measure the size distribution of the atomized droplets, two methods are used. One is the laser diffraction based Spraytec technique and the other is an in-vitro lung modelthe one stage glass twin impinger. The former revealed that the mean diameter of the aerosol atomized was around 3 um which were confirmed by the lung model that demonstrated that nearly 80% of atomized drug aerosol was deposited in the simulated lung area. Moreover, the SAW atomizer only requires 1–3 W driving power, suggesting that it can be miniaturized for portable consumer use.
Publisher: AIP Publishing
Date: 07-08-2006
DOI: 10.1063/1.2221914
Abstract: Simple and reliable formation of biodegradable nanoparticles formed from poly-ε-caprolactone was achieved using 1.645MHz piston atomization of a source fluid of 0.5% w/v of the polymer dissolved in acetone the particles were allowed to descend under gravity in air 8cm into a 1mM solution of sodium dodecyl sulfate. After centrifugation to remove surface agglomerations, a symmetric monodisperse distribution of particles ϕ 186nm (SD=5.7, n=6) was obtained with a yield of 65.2%.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 04-2008
Publisher: Springer Science and Business Media LLC
Date: 21-05-2022
DOI: 10.1007/S10544-022-00617-Z
Abstract: Three-dimensional cell agglomerates are broadly useful in tissue engineering and drug testing. We report a well-free method to form large (1.4-mm) multicellular clusters using 100-MHz surface acoustic waves (SAW) without direct contact with the media or cells. A fluid couplant is used to transform the SAW into acoustic streaming in the cell-laden media held in a petri dish. The couplant transmits longitudinal sound waves, forming a Lamb wave in the petri dish that, in turn, produces longitudinal sound in the media. Due to recirculation, human embryonic kidney (HEK293) cells in the dish are carried to the center of the coupling location, forming a cluster in less than 10 min. A few minutes later, these clusters may then be translated and merged to form large agglomerations, and even repeatedly folded to produce a roughly spherical shape of over 1.4 mm in diameter for incubation—without damaging the existing intercellular bonds. Calcium ion signaling through these clusters and confocal images of multiprotein junctional complexes suggest a continuous tissue construct: intercellular communication. They may be formed at will, and the method is feasibly useful for formation of numerous agglomerates in a single petri dish.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4LC00704B
Abstract: A versatile, low-power traveling wave SAW microfluidic sorting device using a Schröder diffuser, adopted from its typical use in concert halls to the microscale.
Publisher: IEEE
Date: 11-2008
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4SM02742F
Abstract: Cell suspensions are model systems for studying properties of living materials. A comparison of theory against microfluidic experiments confirms that particle motility causes extensional viscosity to decrease in “pushers” and increase in “pushers”.
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1SM06054F
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 02-2003
DOI: 10.1109/TUFFC.2003.1182121
Abstract: This paper describes the design of a piezoelectric tuning-fork, dual-mode motor. The motor uses a single multilayer piezoelectric element in combination with tuning fork and shearing motion to form an actuator using a single drive signal. Finite-element analysis was used in the design of the motor, and the process is described along with the selection of the device's materials and its performance. Swaging was used to mount the multilayer piezoelectric element within the stator. Prototypes of the 25-mm long bidirectional actuator achieved a maximum linear no-load speed of 16.5 cm/s, a maximum linear force of 1.86 N, and maximum efficiency of 18.9%.
Publisher: American Physical Society (APS)
Date: 30-10-2020
Publisher: AIP Publishing
Date: 05-2015
DOI: 10.1063/1.4921192
Abstract: Overall precision of the simplified calibration method in J. E. Sader et al., Rev. Sci. Instrum. 83, 103705 (2012), Sec. III D, is dominated by the spring constant of the reference cantilever. The question arises: How does one take measurements from multiple reference cantilevers, and combine these results, to improve uncertainty of the reference cantilever’s spring constant and hence the overall precision of the method? This question is addressed in this note. Its answer enables manufacturers to specify of a single set of data for the spring constant, resonant frequency, and quality factor, from measurements on multiple reference cantilevers. With this data set, users can trivially calibrate cantilevers of the same type.
Publisher: Routledge
Date: 13-09-2016
Publisher: Elsevier BV
Date: 04-2007
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4LC00232F
Abstract: A practical, commercially viable microfluidic device relies upon the miniaturization and integration of all its components—including pumps, circuitry, and power supply—onto a chip-based platform.
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3SM00016H
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0LC01293A
Abstract: After exposing a plated C2C12 cells culture to PBS, ultrasound from the SAW device transmitted into the cell culture via a coupling water droplet. We can remove cells from an area 6 × 10 −3 mm 2 , equivalent to about 12 cells.
Publisher: AIP Publishing
Date: 11-2014
DOI: 10.1063/1.4901227
Abstract: A simplified method for calibrating atomic force microscope cantilevers was recently proposed by Sader et al. [Rev. Sci. Instrum. 83, 103705 (2012) Sec. III D] that relies solely on the resonant frequency and quality factor of the cantilever in fluid (typically air). This method eliminates the need to measure the hydrodynamic function of the cantilever, which can be time consuming given the wide range of cantilevers now available. Using laser Doppler vibrometry, we rigorously assess the accuracy of this method for a series of commercially available cantilevers and explore its performance under non-ideal conditions. This shows that the simplified method is highly accurate and can be easily implemented to perform fast, robust, and non-invasive spring constant calibration.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2020
Publisher: Springer Science and Business Media LLC
Date: 26-05-2007
DOI: 10.1007/S10544-007-9058-2
Abstract: A rapid particle concentration method in a sessile droplet has been developed using asymmetric surface acoustic wave (SAW) propagation on a substrate upon which the droplet is placed. Due to the asymmetry in the SAW propagation, azimuthal bulk liquid recirculation (acoustic streaming) is generated. Once the local particle concentration is sufficiently high within a particular streamline of the acoustic streaming convective flow, shear-induced migration gives rise to an inward radial force that concentrates the particles at the centre of the droplet. In this paper, a SAW device consists of a 0.75-mm thick, 127.68 degrees Y-X-axis-rotated cut, X-propagating LiNbO3 for a substrate and an interdigital transducer electrode (IDT) with 25 straight finger pairs in a simple repeating pattern, 12 mm aperture, and a wavelength of lambda=440 microm was patterned on the substrate. The IDT was then driven with a sinusoidal signal at the resonance frequency f0 of 8.611 MHz. To investigate the effect of particle type and size on the concentration process, three types of particles were used in this study, including fluorescent particles (1 microm), polystyrene microspheres (3, 6, 20, 45 microm), and living yeast cells (10-20 microm). Different RF powers were applied ranging from 120 to 510 mW. The concentration processes occurs within 2 to 20 s, depending on the particle size, type and input radio frequency (RF) power, much faster than currently available particle concentration mechanisms due to the large convective velocities achieved using the SAW device. Moreover, this concentration method is efficient, concentrating the particles into an aggregate one-tenth the size of the original droplet. Most importantly, bioparticles can also be concentrated by this method we have verified that yeast cells are not lysed by the SAW radiation during concentration. By using the rapid concentration process described in this work, the breadth of applications and measurement sensitivity of SAW biosensor systems should be greatly enhanced.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8LC00112J
Abstract: Acoustic actuation of fluids at small scales may finally enable a comprehensive lab-on-a-chip revolution in microfluidics, overcoming long-standing difficulties in fluid and particle manipulation on-chip.
Publisher: Wiley
Date: 29-08-2013
Abstract: In addition to the choice of appropriate material properties of the tissue construct to be used, such as its biocompatibility, biodegradability, cytocompatibility, and mechanical rigidity, the ability to incorporate microarchitectural patterns in the construct to mimic that found in the cellular microenvironment is an important consideration in tissue engineering and regenerative medicine. Both these issues are addressed by demonstrating a method for preparing biodegradable and photo-patternable constructs, where modified cellulose is cross-linked to form an insoluble structure in an aqueous environment. Specifically, hydroxypropyl cellulose (HPC) is rendered photocrosslinkable by grafting with methylacrylic anhydride, whose linkages also render the cross-linked construct hydrolytically degradable. The HPC is then cross-linked via a photolithography-based fabrication process. The feasibility of functionalizing these HPC structures with biochemical cues is verified post-fabrication, and shown to facilitate the adhesion of mesenchymal progenitor cells. The HPC constructs are shown to be biocompatible and hydrolytically degradable, thus enabling cell proliferation and cell migration, and therefore constituting an ideal candidate for long-term cell culture and implantable tissue scaffold applications. In addition, the potential of the HPC structure is demonstrated as an alternative substrate to paper microfluidic diagnostic devices for protein and cell assays.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0LC01012J
Abstract: Acoustically centrifuge and extract cells from blood s les using 152- Y -rotated lithium niobate and spiral electrodes with an extraction syringe.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2006
DOI: 10.1109/TUFFC.2006.1642514
Abstract: A new linear microactuator, using bulk PZT and electro-discharge-machined components, generates a sliding velocity and force of 100 mm/s and 12 mN, respectively, in either direction, and a peak velocity and force of 212 mm/s and 44 mN, respectively. Using a simple combination of two slightly different beams placed in contact with a slider, and vibrated at two different resonance frequencies, 508 and 522 kHz, by a specially designed, axially vibrating piezoelectric element, bidirectional linear motion was obtained. By simply reducing the length of the applied signal, the sliding distance was reduced to 90 nm +/- 2 nm, which could be improved with a variety of control methods. The design offers not only silent operation, slider cl ing upon removal of power, and all of the other advantages of piezoelectric actuators, but also the potential to be further reduced in size to sub-mm3 for microrobotics and other applications.
Publisher: AIP Publishing
Date: 03-2009
DOI: 10.1063/1.3055282
Publisher: Elsevier BV
Date: 06-2009
Publisher: American Physical Society (APS)
Date: 19-04-2021
Publisher: Wiley
Date: 20-09-2016
Publisher: Cambridge University Press (CUP)
Date: 20-07-2012
DOI: 10.1017/JFM.2012.293
Abstract: The classical Schlichting boundary layer theory is extended to account for the excitation of generalized surface waves in the frequency and velocity litude range commonly used in microfluidic applications, including Rayleigh and Sezawa surface waves and Lamb, flexural and surface-skimming bulk waves. These waves possess longitudinal and transverse displacements of similar magnitude along the boundary, often spatiotemporally out of phase, giving rise to a periodic flow shown to consist of a superposition of classical Schlichting streaming and uniaxial flow that have no net influence on the flow over a long period of time. Correcting the velocity field for weak but significant inertial effects results in a non-vanishing steady component, a drift flow, itself sensitive to both the litude and phase (prograde or retrograde) of the surface acoustic wave propagating along the boundary. We validate the proposed theory with experimental observations of colloidal pattern assembly in microchannels filled with dilute particle suspensions to show the complexity of the boundary layer, and suggest an asymptotic slip boundary condition for bulk flow in microfluidic applications that are actuated by surface waves.
Publisher: AIP Publishing
Date: 16-04-2012
DOI: 10.1063/1.3702579
Abstract: A 240-μm diameter ultrasonic micromotor is presented as a potential solution for an especially difficult task in minimally invasive neurosurgery, navigating a guidewire to an injury in the neurovasculature as the first step of surgery. The peak no-load angular velocity and maximum torque were 600 rad/s and 1.6 nN-m, respectively, and we obtained rotation about all three axes. By using a burst drive scheme, open-loop position and speed control were achieved. The construction method and control scheme proposed in this study remove most of the current limitations in minimally invasive, catheter-based actuation, enabling minimally invasive vascular surgery concepts to be pursued for a broad variety of applications.
Publisher: IEEE
Date: 08-2007
Publisher: Acoustical Society of Japan
Date: 2010
DOI: 10.1250/AST.31.115
Publisher: The Optical Society
Date: 08-01-2014
DOI: 10.1364/OME.4.000241
Publisher: AIP Publishing
Date: 28-09-2009
DOI: 10.1063/1.3238313
Abstract: We present a method for controlling the motion of microparticles suspended in an aqueous solution, which fills in a microchannel fabricated into a piezoelectric substrate, using propagating surface acoustic waves. The cross-sectional shape of this microchannel is trapezoidal, preventing the formation of acoustic standing waves across the channel width and therefore allowing the steering of microparticles. The induced acoustic streaming transports these particles to eliminate the use of external pumps for fluid actuation.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 09-2014
Publisher: Springer Science and Business Media LLC
Date: 21-04-2022
Publisher: AIP Publishing
Date: 02-2014
DOI: 10.1063/1.4864086
Abstract: Thermal noise spectra of nanomechanical resonators are used widely to characterize their physical properties. These spectra typically exhibit a Lorentzian response, with additional white noise due to extraneous processes. Least-squares fits of these measurements enable extraction of key parameters of the resonator, including its resonant frequency, quality factor, and stiffness. Here, we present general formulas for the uncertainties in these fit parameters due to s ling noise inherent in all thermal noise spectra. Good agreement with Monte Carlo simulation of synthetic data and measurements of an Atomic Force Microscope (AFM) cantilever is demonstrated. These formulas enable robust interpretation of thermal noise spectra measurements commonly performed in the AFM and adaptive control of fitting procedures with specified tolerances.
Publisher: AIP Publishing
Date: 20-06-2011
DOI: 10.1063/1.3600775
Abstract: We report on the design of a surface acoustic wave (SAW) driven fluid-coupled micromotor which runs at high rotational velocities. A pair of opposing SAWs generated on a lithium niobate substrate are each obliquely passed into either side of a fluid drop to drive rotation of the fluid, and the thin circular disk set on the drop. Using water for the drop, a 5 mm diameter disk was driven with rotation speeds and start-up torques up to 2250 rpm and 60 nN m, respectively. Most importantly for lab-on-a-chip applications, radial accelerations of 172 m/s2 was obtained, presenting possibilities for microcentrifugation, flow sequencing, assays, and cell culturing in truly microscale lab-on-a-chip devices.
Publisher: Wiley
Date: 06-2009
DOI: 10.1002/BIT.22243
Abstract: Flow visualization using fluorescent microparticles and cell viability investigations are carried out to examine the mechanisms by which cells are seeded into scaffolds driven by surface acoustic waves. The former consists of observing both the external flow prior to the entry of the suspension into the scaffold and the internal flow within the scaffold pores. The latter involves micro-CT (computed tomography) scans of the particle distributions within the seeded scaffolds and visual and quantitative methods to examine the morphology and proliferation ability of the irradiated cells. The results of these investigations elucidate the mechanisms by which particles are seeded, and hence provide valuable information that form the basis for optimizing this recently discovered method for rapid, efficient, and uniform scaffold cell seeding. Yeast cells are observed to maintain their size and morphology as well as their proliferation ability over 14 days after they are irradiated. The mammalian primary osteoblast cells tested also show little difference in their viability when exposed to the surface acoustic wave irradiation compared to a control set. Together, these provide initial feasibility results that demonstrate the surface acoustic wave technology as a viable seeding method without risk of denaturing the cells.
Publisher: Elsevier BV
Date: 12-2011
Publisher: AIP Publishing
Date: 26-11-2007
DOI: 10.1063/1.2814054
Abstract: Smoke particles (SPs) are used to directly visualize surface acoustic waves (SAWs) propagating on a 128°-rotated Y-cut X-propagating lithium niobate (LiNbO3) substrate. By electrically exciting a SAW device in a compartment filled with SP, the SP were found to collect along the regions where the SAW propagates on the substrate. The results of the experiments show that SPs are deposited adjacent to regions of large vibration litude and form a clear pattern corresponding to the surface wave profile on the substrate. Through an analysis of the SAW-induced acoustic streaming in the air adjacent to the substrate and the surface acceleration measured with a laser Doppler vibrometer, we postulate that the large transverse surface accelerations due to the SAW ejects SP from the surface and carries them aloft to relatively quiescent regions nearby via acoustic streaming. Offering finer detail than fine powders common in Chladni figures [E. Chladni, Entdeckungen über die Theorie des Klanges (Weidmanns, Erben und Reich, Leipzig, Germany, 1787)] the approach is an inexpensive and a quick counterpart to laser interferometric techniques, presenting a means to explore the controversial phenomena of particle agglomeration on surfaces.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0LC01008A
Abstract: Practical acoustofluidics for lab-on-a-chip applications is now enabled by battery-powered handheld circuits.
Publisher: American Physical Society (APS)
Date: 07-07-2009
Publisher: SPIE
Date: 07-12-2013
DOI: 10.1117/12.2033743
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2004
DOI: 10.1109/TUFFC.2004.1320747
Abstract: A torsional microtransducer for high-power applications was developed using standard bulk lead zirconium titantate (PZT) placed upon a small rectangular prism made from phosphor bronze, with a tapered conical end serving as a horn and a machined interior to improve the actuator's response. Torsion was obtained from a prototype at the design frequency of 192 kHz as well as over a wide range of frequencies from 136 kHz to 1.02 MHz. Torsional vibration velocities of 335 mm/s at 192 kHz were measured at 27.3 V(RMS) on the 1.5-mm diameter output tip, amounting to 25,600 degree/s vibration velocity along the outer circumference of the tip. At 1.02 MHz, a torsional vibration velocity of 1750 mm/s (134,000 degree/s) at 17.8 V(RMS) was obtained through use of the thickness mode of the PZT elements. Using the design described in this study, high-power torsional transducers with diameters of 5 mm and below are now possible.
Publisher: Elsevier BV
Date: 2004
Publisher: AIP Publishing
Date: 06-12-2010
DOI: 10.1063/1.3524511
Abstract: We present an experimental approach for controlled switching between uniform flow for pumping and vortical flow for mixing in a microchannel fabricated onto a piezoelectric substrate. For particle laden fluids, this arrangement permits a choice between transport and alignment of microparticles. Using surface acoustic waves with litudes beyond 1 nm, the transition from uniform to mixing flows occurs when the acoustic wavelength in the fluid is reduced to a dimension smaller than the channel width, i.e., λf≥Wch for uniform flow and λf& Wch for mixing flow. On the other hand, using relatively weak surface acoustic waves with litudes below 1 nm, particles in an initially homogeneous suspension agglomerate into equally spaced lines with a separation of λf/2. Switching the transducer between its fundamental resonant frequency f0 and its first harmonic frequency f1+∼2f0 causes a switch between uniform and mixing flow, while switching between large and small litude excitation allows one to choose whether to collect the particles in the flow along nodal lines parallel to the channel. These results are uniquely achieved without requiring the microfabrication of complex microchannel architectures and control schemes the switching is simply achieved by adjusting two parameters: the acoustic excitation frequency and litude.
Publisher: American Chemical Society (ACS)
Date: 08-01-2015
DOI: 10.1021/NL503563G
Abstract: The exhibition of plasmon resonances in two-dimensional (2D) semiconductor compounds is desirable for many applications. Here, by electrochemically intercalating lithium into 2D molybdenum disulfide (MoS2) nanoflakes, plasmon resonances in the visible and near UV wavelength ranges are achieved. These plasmon resonances are controlled by the high doping level of the nanoflakes after the intercalation, producing two distinct resonance peak areas based on the crystal arrangements. The system is also benchmarked for biosensing using bovine serum albumin. This work provides a foundation for developing future 2D MoS2 based biological and optical units.
Publisher: IOP Publishing
Date: 03-2009
Publisher: AIP Publishing
Date: 03-2009
DOI: 10.1063/1.3056040
Publisher: Annual Reviews
Date: 03-01-2014
DOI: 10.1146/ANNUREV-FLUID-010313-141418
Abstract: Fluid manipulations at the microscale and beyond are powerfully enabled through the use of 10–1,000-MHz acoustic waves. A superior alternative in many cases to other microfluidic actuation techniques, such high-frequency acoustics is almost universally produced by surface acoustic wave devices that employ electromechanical transduction in wafer-scale or thin-film piezoelectric media to generate the kinetic energy needed to transport and manipulate fluids placed in adjacent microfluidic structures. These waves are responsible for a erse range of complex fluid transport phenomena—from interfacial fluid vibration and drop and confined fluid transport to jetting and atomization—underlying a flourishing research literature spanning fundamental fluid physics to chip-scale engineering applications. We highlight some of this literature to provide the reader with a historical basis, routes for more detailed study, and an impression of the field's future directions.
Publisher: Wiley
Date: 07-04-2014
Abstract: Compared with preformed anisotropic matrices, an anisotropic matrix that allows users to alter its properties and structure in situ after synthesis offers the important advantage of being able to mimic dynamic in vivo microenvironments, such as in tissues undergoing morphogenesis or in wounds undergoing tissue repair. In this study, porous gradients are generated in situ in a hydrogel comprising enzymatically crosslinked gelatin hydroxyphenylpropionic acid (GTN-HPA) conjugate and carboxylmethyl cellulose tyramine (CMC-TYR) conjugate. The GTN-HPA component acts as the backbone of the hydrogel, while CMC-TYR acts as a biocompatible sacrificial polymer. The hydrogel is then used to immobilize HT1080 human fibrosarcoma cells in a microfluidic chamber. After diffusion of a biocompatible cellulase enzyme through the hydrogel in a spatially controlled manner, selective digestion of the CMC component of the hydrogel by the cellulase gives rise to a porosity gradient in situ instead of requiring its formation during hydrogel synthesis as with other methods. The influence of this in situ tunable porosity gradient on the chemotactic response of cancer cells is subsequently studied both in the absence and presence of chemoattractant. This platform illustrates the potential of hydrogel-based microfluidics to mimic the 3D in vivo microenvironment for tissue engineering and diagnostic applications.
Publisher: AIP Publishing
Date: 03-2007
DOI: 10.1063/1.2409629
Publisher: Royal Society of Chemistry (RSC)
Date: 2009
DOI: 10.1039/B819217K
Abstract: A new modality for chemical synthesis on a drop scale which employs a piezoelectric chip as the reactor and surface acoustic waves (SAWs) as the source of energy (and consequent heating) is described.
Publisher: Royal Society of Chemistry (RSC)
Date: 2007
DOI: 10.1039/B618044B
Abstract: The ability to detect microbes, pollens and other microparticles is a critically important ability given the increasing risk of bioterrorism and emergence of antibiotic-resistant bacteria. The efficient collection of microparticles via a liquid water droplet moved by a surface acoustic wave (SAW) device is demonstrated in this study. A fluidic track patterned on the SAW device directs the water droplet's motion, and fluid streaming induced inside the droplet as it moves along is a key advantage over other particle collection approaches, because it enhances microparticle collection and concentration. Test particles consisted of 2, 10, 12 and 45 microm diameter monodisperse polystyrene and melamine microparticles pollen from the Populus deltoides, Kochia scoparia, Secale cerale, and Broussonetia papyrifera (Paper Mulberry) species and Escherichia coli bacteria. The collection efficiency for the synthetic particles ranged from 16 to 55%, depending on the particle size and surface tension of the collection fluid. The method was more effective in collecting pollen and the bacteria with an efficiency of 45-68% and 61.0-69.8%, respectively. Pollen collection was strongly influenced by its diameter, size, and surface geometry in a manner contrary to initial expectations. Reasons for the consistent yet unexpected collection results include leaky SAW pressure boundary segregation and shear-induced concentration of larger particles, and the subtle effects of wetting interactions. These results demonstrate a new method for collecting microparticles requiring only about one second per run, and illustrate the inadequacy of using synthetic microparticles as a substitute for their biological counterparts in experiments studying particle collection and behavior.
Publisher: IEEE
Date: 02-2011
Publisher: AIP Publishing
Date: 03-2012
DOI: 10.1063/1.3673260
Abstract: We present experimental and simulation results for focused ion beam (FIB) milling of microchannels in lithium niobate in this paper. We investigate two different cuts of lithium niobate, Y- and Z-cuts, and observe that the experimental material removal rate in the FIB for both Y-cut and Z-cut s les was 0.3 μm3/nC, roughly two times greater than the material removal rate previously reported in the literature but in good agreement with the value we obtain from stopping and range of ions in matter (SRIM) simulations. Further, we investigate the FIB milling rate and resultant cross-sectional profile of microchannels at various ion beam currents and find that the milling rate decreases as a function of ion dose and correspondingly, the cross-sectional profiles change from rectangular to V-shaped. This indicates that material redeposition plays an important role at high ion dose or equivalently, high aspect ratio. We find that the experimental material removal rate decreases as a function of aspect ratio of the milled structures, in good agreement with our simulation results at low aspect ratio and in good agreement with the material removal rates previously reported in the literature at high aspect ratios. Our results show that it is indeed easier than previously assumed to fabricate nanochannels with low aspect ratio directly on lithium niobate using the FIB milling technique.
Publisher: AIP Publishing
Date: 10-2012
DOI: 10.1063/1.4757398
Abstract: The spring constant of an atomic force microscope cantilever is often needed for quantitative measurements. The calibration method of Sader et al. [Rev. Sci. Instrum. 70, 3967 (1999)]10.1063/1.1150021 for a rectangular cantilever requires measurement of the resonant frequency and quality factor in fluid (typically air), and knowledge of its plan view dimensions. This intrinsically uses the hydrodynamic function for a cantilever of rectangular plan view geometry. Here, we present hydrodynamic functions for a series of irregular and non-rectangular atomic force microscope cantilevers that are commonly used in practice. Cantilever geometries of arrow shape, small aspect ratio rectangular, quasi-rectangular, irregular rectangular, non-ideal trapezoidal cross sections, and V-shape are all studied. This enables the spring constants of all these cantilevers to be accurately and routinely determined through measurement of their resonant frequency and quality factor in fluid (such as air). An approximate formulation of the hydrodynamic function for microcantilevers of arbitrary geometry is also proposed. Implementation of the method and its performance in the presence of uncertainties and non-idealities is discussed, together with conversion factors for the static and dynamic spring constants of these cantilevers. These results are expected to be of particular value to the design and application of micro- and nanomechanical systems in general.
Publisher: SPIE
Date: 21-12-2011
DOI: 10.1117/12.903238
Publisher: AIP Publishing
Date: 09-2009
DOI: 10.1063/1.3194282
Publisher: Wiley
Date: 16-05-2021
Abstract: Controllable manipulation and effective mixing of fluids and colloids at the nanoscale is made exceptionally difficult by the dominance of surface and viscous forces. The use of megahertz (MHz)‐order vibration has dramatically expanded in microfluidics, enabling fluid manipulation, atomization, and microscale particle and cell separation. Even more powerful results are found at the nanoscale, with the key discovery of new regimes of acoustic wave interaction with 200 fL droplets of deionized water. It is shown that 40 MHz‐order surface acoustic waves can manipulate such droplets within fully transparent, high‐aspect ratio, 100 nm tall, 20–130 micron wide, 5‐mm long nanoslit channels. By forming traps as locally widened regions along such a channel, in idual fluid droplets may be propelled from one trap to the next, split between them, mixed, and merged. A simple theory is provided to describe the mechanisms of droplet transport and splitting.
Publisher: Springer Science and Business Media LLC
Date: 06-11-2012
DOI: 10.1038/NCOMMS2168
Abstract: Acoustic-fluid interactions not only has had a long history but has recently experienced renewed scrutiny because of their vast potential for microscale fluid and particle manipulation. Here we unravel a fascinating and anomalous ensemble of dynamic 'acoustowetting' phenomena in which a thin film drawn from a sessile drop first spreads in opposition to the acoustic wave propagation direction. The advancing film front then exhibits fingering instabilities akin to classical viscous fingering, but arising through a different and novel mechanism: transverse Fresnel diffraction of the underlying acoustic wave. Peculiar 'soliton-like' wave pulses are observed to grow above these fingers, which, on reaching a critical size, translate away along the wave propagation direction. By elucidating the complex hydrodynamics underpinning the spreading, and associated flow reversal and instability phenomena, we offer insight into the possibility of acoustically controlling fast and uniform film spreading, constituting a flexible and powerful alternative for microfluidic transport.
Publisher: American Chemical Society (ACS)
Date: 21-02-2013
DOI: 10.1021/AC3019125
Abstract: A desire for higher speed and performance in molecular profiling analysis at a reduced cost is driving a trend in miniaturization and simplification of procedures. Here we report the use of a surface acoustic wave (SAW) atomizer for fast s le handling in matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) peptide and protein profiling of Islets of Langerhans, for future type 2 diabetes (T2D) studies. Here the SAW atomizer was used for ultrasound (acoustic) extraction of insulin and other peptide hormones released from freshly prepared islets, stimulated directly on a membrane. A high energy propagating SAW atomizes the membrane-bound liquid into approximately 2 μm diameter droplets, rich in cell-released molecules. Besides acting as a s le carrier, the membrane provides a purification step by entrapping cell clusters and other impurities within its fibers. A new SAW-based s le-matrix deposition method for MALDI MS was developed and characterized by a strong insulin signal, and a limit of detection (LOD) lower than 100 amol was achieved. Our results support previous work reporting the SAW atomizer as a fast and inexpensive tool for ultrasound, membrane-based s le extraction. When interfaced with MALDI MS, the SAW atomizer constitutes a valuable tool for rapid cell studies. Other biomedical applications of SAW-MALDI MS are currently being developed, aiming at fast profiling of biofluids. The membrane s ling is a simplistic and noninvasive collection method of limited volume biofluids such as the gingival fluid and the tearfilm.
Publisher: AIP Publishing
Date: 06-2010
DOI: 10.1063/1.3435331
Publisher: IEEE
Date: 09-2009
Publisher: Wiley
Date: 10-04-2012
Abstract: A miniaturized centrifugal microfluidic platform for lab-on-a-chip applications is presented. Unlike its macroscopic Lab-on-a-CD counterpart, the miniature Lab-on-a-Disc (miniLOAD) device does not require moving parts to drive rotation of the disc, is inexpensive, disposable, and significantly smaller, comprising a 10-mm-diameter SU-8 disc fabricated through two-step photolithography. The disc is driven to rotate using surface acoustic wave irradiation incident upon a fluid coupling layer from a pair of offset, opposing single-phase unidirectional transducers patterned on a lithium niobate substrate. The irradiation causes azimuthally oriented acoustic streaming with sufficient intensity to rotate the disc at several thousand revolutions per minute. In this first proof-of-concept, the capability of the miniLOAD platform to drive capillary-based valving and mixing in microfluidic structures on a disc similar to much larger Lab-on-a-CD devices is shown. In addition, the ability to concentrate aqueous particle suspensions at radial positions in a channel in the disc dependent on the particles' size is demonstrated. To the best of our knowledge, the miniLOAD concept is the first centrifugal microfluidic platform small enough to be self-contained in a handheld device.
Publisher: Wiley
Date: 10-10-2022
Abstract: Stimuli‐responsive hydrogels with programmable shapes produced by defined patterns of particles are of great interest for the fabrication of small‐scale soft actuators and robots. Patterning the particles in the hydrogels during fabrication generally requires external magnetic or electric fields, thus limiting the material choice for the particles. Acoustically driven particle manipulation, however, solely depends on the acoustic impedance difference between the particles and the surrounding fluid, making it a more versatile method to spatially control particles. Here, an approach is reported by combining direct acoustic force to align photothermal particles and photolithography to spatially immobilize these alignments within a temperature‐responsive poly(N‐isopropylacrylamide) hydrogel to trigger shape deformation under temperature change and light exposure. The spatial distribution of particles can be tuned by the power and frequency of the acoustic waves. Specifically, changing the spacing between the particle patterns and position alters the bending curvature and direction of this composite hydrogel sheet, respectively. Moreover, the orientation (i.e., relative angle) of the particle alignments with respect to the long axis of laser‐cut hydrogel strips governs the bending behaviors and the subsequent shape deformation by external stimuli. This acousto‐photolithography provides a means of spatiotemporal programming of the internal heterogeneity of composite polymeric systems.
Publisher: SPIE
Date: 26-12-2009
DOI: 10.1117/12.813983
Publisher: Elsevier BV
Date: 03-2021
Publisher: Informa UK Limited
Date: 06-2006
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3TA14587E
Abstract: We report the morphogenesis and self-assembly of bismutite nanocrystals with fully tunable morphologies from square plates, octagonal sheets, and round disks into three-dimensional hierarchical nanostructures.
Publisher: Royal Society of Chemistry (RSC)
Date: 16-09-2014
DOI: 10.1039/C4TA04020A
Publisher: Elsevier BV
Date: 07-2014
DOI: 10.1016/J.ULTSONCH.2014.02.020
Abstract: In this paper we demonstrate the use of an energy-efficient surface acoustic wave (SAW) device for driving closed-vessel SAW-assisted (CVSAW), ligand-free Suzuki couplings in aqueous media. The reactions were carried out on a mmolar scale with low to ultra-low catalyst loadings. The reactions were driven by heating resulting from the penetration of acoustic energy derived from RF Raleigh waves generated by a piezoelectric chip via a renewable fluid coupling layer. The yields were uniformly high and the reactions could be executed without added ligand and in water. In terms of energy density this new technology was determined to be roughly as efficient as microwaves and superior to ultrasound.
Publisher: Springer Science and Business Media LLC
Date: 05-05-2010
Publisher: Elsevier BV
Date: 07-2014
Publisher: IOP Publishing
Date: 20-01-2009
Publisher: American Chemical Society (ACS)
Date: 07-03-2013
DOI: 10.1021/LA304608A
Abstract: Low frequency (O(10 Hz-10 kHz)) vibration excitation of capillary waves has been extensively studied for nearly two centuries. Such waves appear at the excitation frequency or at rational multiples of the excitation frequency through nonlinear coupling as a result of the finite displacement of the wave, most often at one-half the excitation frequency in so-called Faraday waves and twice this frequency in superharmonic waves. Less understood, however, are the dynamics of capillary waves driven by high-frequency vibration (>O(100 kHz)) and small interface length scales, an arrangement ideal for a broad variety of applications, from nebulizers for pulmonary drug delivery to complex nanoparticle synthesis. In the few studies conducted to date, a marked departure from the predictions of classical Faraday wave theory has been shown, with the appearance of broadband capillary wave generation from 100 Hz to the excitation frequency and beyond, without a clear explanation. We show that weak wave turbulence is the dominant mechanism in the behavior of the system, as evident from wave height frequency spectra that closely follow the Rayleigh-Jeans spectral response η ≈ ω(-17/12) as a consequence of a period-halving, weakly turbulent cascade that appears within a 1 mm water drop whether driven by thickness-mode or surface acoustic Rayleigh wave excitation. However, such a cascade is one-way, from low to high frequencies. The mechanism of exciting the cascade with high-frequency acoustic waves is an acoustic streaming-driven turbulent jet in the fluid bulk, driving the fundamental capillary wave resonance through the well-known coupling between bulk flow and surface waves. Unlike capillary waves, turbulent acoustic streaming can exhibit subharmonic cascades from high to low frequencies here it appears from the excitation frequency all the way to the fundamental modes of the capillary wave at some four orders of magnitude in frequency less than the excitation frequency, enabling the capillary weakly turbulent wave cascade to form from the fundamental capillary wave upward.
Publisher: American Physical Society (APS)
Date: 20-06-2011
Publisher: SPIE
Date: 21-12-2011
DOI: 10.1117/12.903220
Publisher: AIP Publishing
Date: 05-08-2013
DOI: 10.1063/1.4817271
Abstract: We report the presence of surface acoustic wave (SAW) band gap on acoustic superlattice (ASL) in a single-crystal lithium niobate structure. The band gap behavior is determined by calculating the SAW band structure and also by simulating the transmission of an acoustic wave through a finite length section of ASL using finite element analysis. The calculated band gap appears at a frequency twice the value expected from purely acoustic Bragg scattering. We have identified the band gap as originating from a polariton-based mechanism due to the coupling between the electromagnetic wave and the surface vibrations. We have examined the influence of the band gap on SAW generation with the ASL and have shown that the calculated frequency resonance of the SAW lies in the vicinity of the upper stop-band edges. This results in the localization of the SAW in the ASL. Experimental confirmation is achieved through direct measurement of the SAW displacement by laser vibrometry on an actual ASL SAW transducer. The localization of generated SAW to the ASL transducer is observed confirming the prediction of the existence of a band gap.
Publisher: Wiley
Date: 15-04-2014
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4SM02397H
Abstract: The dissolution dynamics of microscopic oil droplets (less than 1 μm in height, i.e. nanodroplets) on a hydrophobilized silicon surface in water was experimentally studied. The lateral diameter was monitored using confocal microscopy, whereas the contact angle was measured by (disruptive) droplet polymerisation of the droplet. In general, we observed the droplets to dissolve in a mixed mode, i.e., neither in the constant contact angle mode nor in the constant contact radius mode. This means that both the lateral diameter and the contact angle of the nanodroplets decrease during the dissolution process. On average, the dissolution rate is faster for droplets with larger initial size. Droplets with the same initial size can, however, possess different dissolution rates. We ascribe the non-universal dissolution rates to chemical and geometric surface heterogeneities (that lead to contact line pinning) and cooperative effects from the mass exchange among neighbouring droplets.
Publisher: AIP Publishing
Date: 16-08-2011
DOI: 10.1063/1.3625605
Abstract: Treatment of surfaces to change the interaction of fluids with them is a critical step in constructing useful microfluidics devices, especially those used in biological applications. Silanization, the generic term applied to the formation of organosilane monolayers on substrates, is both widely reported in the literature and troublesome in actual application for the uninitiated. These monolayers can be subsequently modified to produce a surface of a specific functionality. Here various organosilane deposition protocols and some application notes are provided as a basis for the novice reader to construct their own silanization procedures, and as a practical resource to a broader range of techniques even for the experienced user.
Publisher: AIP Publishing
Date: 16-01-2012
DOI: 10.1063/1.3676660
Abstract: Surface acoustic waves (SAWs) are used to drive a 1 mm diameter rotor at speeds exceeding 9000 rpm and torque of nearly 5 nNm. Unlike recent high-speed SAW rotary motors, however, the present design does not require a fluid coupling layer but interestingly exploits adhesive stiction as an internal preload, a force usually undesirable at these scales with additional preloads, smaller rotors can be propelled to 15 000 rpm. This solid-state motor has no moving parts except for the rotor and is sufficiently simple to allow integration into miniaturized drive systems for potential use in microfluidic diagnostics, optical switching and microrobotics.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4LC00182F
Abstract: We replicated a wide range of chip-scale acoustofluidics merely with aluminium foil as electrodes on piezoelectric substrates for microfabrication-free low-cost operation.
Publisher: Elsevier BV
Date: 06-2010
Publisher: AIP Publishing
Date: 15-03-2010
DOI: 10.1063/1.3353329
Abstract: Capillary wave phenomena are challenging to study, especially for microfluidics where the wavelengths are short, the frequencies are high, and the frequency distribution is rarely confined to a narrow range, let alone a single frequency. Those that have been studying Faraday capillary waves generated by vertical oscillation have chosen to work at larger scales and at low frequencies as a solution to this problem, trading simplicity in measurement for issues with gravity, boundary conditions, and the fidelity of the subharmonic capillary wave motion. Laser Doppler vibrometry using a Mach–Zehnder interferometer is an attractive alternative: The interface’s motion can be characterized at frequencies up to 40 MHz and displacements of as little as a few tens of picometers.
Publisher: IOP Publishing
Date: 08-2009
Publisher: Wiley
Date: 08-05-2015
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2007
Abstract: This paper presents a noncontact sliding table design and measurements of its performance via ultrasonic levitation. A slider placed atop two vibrating guide rails is levitated by an acoustic radiation force emitted from the rails. A flexural traveling wave propagating along the guide rails allows noncontact transportation of the slider. Permitting a transport mechanism that reduces abrasion and dust generation with an inexpensive and simple structure. The profile of the sliding table was designed using the finite-element analysis (FEA) for high levitation and transportation efficiency. The prototype sliding table was made of alumina ceramic (Al2O3) to increase machining accuracy and rigidity using a structure composed of a pair of guide rails with a triangular cross section and piezoelectric transducers. Two types of transducers were used: bolt-cl ed Langevin transducers and bimorph transducers. A 40-mm long slider was designed to fit atop the two rail guides. Flexural standing waves and torsional standing waves were observed along the guide rails at resonance, and the levitation of the slider was obtained using the flexural mode even while the levitation distance was less than 10 microm. The levitation distance of the slider was measured while increasing the slider's weight. The levitation pressure, rigidity, and vertical displacement litude of the levitating slider thus were measured to be 6.7 kN/m2, 3.0 kN/microm/m2, and less than 1 microm, respectively. Noncontact transport of the slider was achieved using phased drive of the two transducers at either end of the vibrating guide rail. By controlling the phase difference, the slider transportation direction could be switched, and a maximum thrust of 13 mN was obtained.
Publisher: Cold Spring Harbor Laboratory
Date: 22-08-2021
DOI: 10.1101/2021.08.21.457135
Abstract: The field of ultrasound neuromodulation has rapidly developed over the past decade, a consequence of the discovery of strain-sensitive structures in the membrane and organelles of cells extending into the brain, heart, and other organs. Notably, clinical trials are underway for treating epilepsy using focused ultrasound to elicit an organized local electrical response. A key limitation to this approach is the formation of standing waves within the skull. In standing acoustic waves, the maximum ultrasound intensity spatially varies from near zero to double the mean in one half a wavelength, and can lead to localized tissue damage and disruption of normal brain function while attempting to evoke a broader response. This phenomenon also produces a large spatial variation in the actual ultrasound exposure in tissue, leading to heterogeneous results and challenges with interpreting these effects. One approach to overcome this limitation is presented herein: transducer-mounted diffusers that result in spatiotemporally incoherent ultrasound. The signal is numerically and experimentally quantified in an enclosed domain with and without the diffuser. Specifically, we show that adding the diffuser leads to a two-fold increase in ultrasound responsiveness of hsTRPA1 transfected HEK cells. Furthermore, we demonstrate the diffuser allow us to produce an uniform spatial distribution of pressure in the rodent skull. Collectively, we propose that our approach leads to a means to deliver uniform ultrasound into irregular cavities for sonogenetics.
Publisher: AIP Publishing
Date: 21-11-2011
DOI: 10.1063/1.3662032
Abstract: A spin current generated from a surface acoustic wave (SAW) was observed in an Y3Fe5O12 (YIG)/Pt hybrid structure. At the YIG/Pt interface, a SAW generated in the YIG layer was found to pump a spin current into the Pt layer, which was detected through the inverse spin-Hall effect in the Pt. The YIG/Pt lateral structure combined with a piezoelectric wedge transducer enables the systematic investigation of the spin-voltage distribution due to the SAW in the YIG. Since the observed phenomenon has high affinity with SAW-based electronics, it will pave the way for constructing spintronic SAW devices.
Publisher: Elsevier
Date: 2013
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/B915833B
Abstract: Paper has been proposed as an inexpensive and versatile carrier for microfluidics devices with abilities well beyond simple capillary action for pregnancy tests and the like. Unlike standard microfluidics devices, extracting a fluid from the paper is a challenge and a drawback to its broader use. Here, we extract fluid from narrow paper strips using surface acoustic wave (SAW) irradiation that subsequently atomizes the extracted fluid into a monodisperse aerosol for use in mass spectroscopy, medical diagnostics, and drug delivery applications. Two protein molecules, ovalbumin and bovine serum albumin (BSA), have been preserved in paper and then extracted using atomized mist through SAW excitation protein electrophoresis shows there is less than 1% degradation of either protein molecule in this process. Finally, a solution of live yeast cells was infused into paper, which was subsequently dried for preservation then remoistened to extract the cells via SAW atomization, yielding live cells at the completion of the process. The successful preservation and extraction of fluids, proteins and yeast cells significantly expands the usefulness of paper in microfluidics.
Publisher: IEEE
Date: 2005
Publisher: IEEE
Date: 11-2008
Location: United States of America
Location: United States of America
No related grants have been discovered for James Friend.