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ORCID Profile
Orcid icon. 0000-0003-1585-2161

Current Organisations
Leibniz Institute for Neurobiology , Technical University of Munich , Guangxi University , Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences

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Publications

Publication

Astrocytes exhibit diverse Ca2+ changes at subcellular domains during brain aging

Publisher: Frontiers Media SA

Date: 28-10-2022

DOI: 10.3389/FNAGI.2022.1029533

Abstract: Astrocytic Ca 2+ transients are essential for astrocyte integration into neural circuits. These Ca 2+ transients are primarily sequestered in subcellular domains, including primary branches, branchlets and leaflets, and endfeet. In previous studies, it suggests that aging causes functional defects in astrocytes. Until now, it was unclear whether and how aging affects astrocytic Ca 2+ transients at subcellular domains. In this study, we combined a genetically encoded Ca 2+ sensor (GCaMP6f) and in vivo two-photon Ca 2+ imaging to determine changes in Ca 2+ transients within astrocytic subcellular domains during brain aging. We showed that aging increased Ca 2+ transients in astrocytic primary branches, higher-order branchlets, and terminal leaflets. However, Ca 2+ transients decreased within astrocytic endfeet during brain aging, which could be caused by the decreased expressions of Aquaporin-4 (AQP4). In addition, aging-induced changes of Ca 2+ transient types were heterogeneous within astrocytic subcellular domains. These results demonstrate that the astrocytic Ca 2+ transients within subcellular domains are affected by aging differently. This finding contributes to a better understanding of the physiological role of astrocytes in aging-induced neural circuit degeneration.

Publication

REM sleep-active hypothalamic neurons may contribute to hippocampal social-memory consolidation

Publisher: Elsevier BV

Date: 12-2022

DOI: 10.1016/J.NEURON.2022.09.004

Abstract: The hippoc al CA2 region plays a key role in social memory. The encoding of such memory involves afferent activity from the hypothalamic supramammillary nucleus (SuM) to CA2. However, the neuronal circuits required for consolidation of freshly encoded social memory remain unknown. Here, we used circuit-specific optical and single-cell electrophysiological recordings in mice to explore the role of sleep in social memory consolidation and its underlying circuit mechanism. We found that SuM neurons projecting to CA2 were highly active during rapid-eye-movement (REM) sleep but not during non-REM sleep or quiet wakefulness. REM-sleep-selective optogenetic silencing of these neurons impaired social memory. By contrast, the silencing of another group of REM sleep-active SuM neurons that projects to the dentate gyrus had no effect on social memory. Therefore, we provide causal evidence that the REM sleep-active hypothalamic neurons that project to CA2 are specifically required for the consolidation of social memory.

Publication

A Visual-Cue-Dependent Memory Circuit for Place Navigation

Publisher: Elsevier BV

Date: 07-2018

Location: France

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Related Funding Activities

No related grants have been discovered for Hongbo Jia.

Hongbo Jia

Researcher

Related Links

Publications

Astrocytes exhibit diverse Ca2+ changes at subcellular domains during brain aging

REM sleep-active hypothalamic neurons may contribute to hippocampal social-memory consolidation

A Visual-Cue-Dependent Memory Circuit for Place Navigation

Related Organisations

Leibniz Institute For Neurobiology

Technical University Of Munich

Guangxi University

Suzhou Institute Of Biomedical Engineering And Technology, Chinese Academy Of Sciences

Peking University

Technische Universität München

Ecole Normale Supérieure Département De Physique

Ecole Normale Supérieure Département De Biologie

Related Funding Activities

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