ORCID Profile
0000-0001-5249-6536
Current Organisations
University of North Carolina at Chapel Hill
,
Shanghai Jiaotong University
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Publisher: IEEE
Date: 05-2015
Publisher: Springer Science and Business Media LLC
Date: 12-2005
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 04-2019
Publisher: IEEE Comput. Soc
Date: 2004
Publisher: Springer Science and Business Media LLC
Date: 14-04-2009
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2016
Publisher: IEEE
Date: 06-2013
Publisher: IEEE
Date: 11-2015
DOI: 10.1109/CCBD.2015.33
Publisher: ACM
Date: 04-07-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-2015
Publisher: IEEE
Date: 2005
Publisher: IEEE
Date: 2008
Publisher: IEEE
Date: 09-2015
DOI: 10.1109/EDCC.2015.15
Publisher: Springer International Publishing
Date: 2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5TA00737B
Abstract: ZnFe 2 O 4 /ZnO nanoheterostructures are synthesized by a facile template method. The hydrogen generation rate of ZnFe 2 O 4 /ZnO nanoheterostructures without co-catalysts is up to 2.15 mmol h −1 g −1 under visible light irradiation ( λ 420 nm), which is 45 times higher than the best yields ever reported for ZnFe 2 O 4 -based photocatalysts.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 2020
DOI: 10.1097/PCC.0000000000002159
Abstract: To determine the feasibility of a personalized music intervention with mechanically ventilated patients in the PICU. Pilot study with a quasi-experimental design. Tertiary children’s hospital in China with a 40-bed PICU. Children, 1 month to 7 years, with mechanical ventilation were recruited and assigned to music group ( n = 25) and control group ( n = 25). Children in the music group received their own favorite music and listened for 60 minutes three times a day. The control group receive routine care without music. Primary outcome measure was comfort measured with the COMFORT Behavior scale 5 minutes before and after the music. Secondary outcome measures were physiologic variables heart rate, respiration, blood pressure, oxygen saturation. Mechanical ventilation time, length of stay, and sedation medication were also collected. Qualitative analysis revealed that nurses had a positive attitude in delivering the interventions and identified improvements for the main trial. Children in the music group had lower COMFORT Behavior scores (15.7 vs 17.6 p = 0.011). Children in the music group had better physiologic outcomes heart rate (140 vs 144 p = 0.039), respiration rate (40 vs 43 p = 0.036), systolic blood pressure (93 vs 95 mm Hg p = 0.031), oxygen saturation (96% vs 95% p 0.001), diastolic blood pressure was not significantly (52 vs 53 mm Hg p = 0.11). Children in the music group had a shorter ventilation time (148.7 vs 187.6 p = 0.044) and a shorter length of stay, but not significant (11.2 vs 13.8 p = 0.071). Children in the control group had higher total amount of on-demand midazolam (29 vs 33 mg p = 0.040). Our pilot study indicates that personalized music intervention is feasible and might improve the comfort of children with mechanical ventilation. Further studies are needed to provide conclusive evidence in confirming the effectiveness of music interventions comforting critically ill children in PICUs.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2020
Publisher: IEEE
Date: 10-2017
DOI: 10.1109/LCN.2017.75
Publisher: Spandidos Publications
Date: 18-07-2013
DOI: 10.3892/OR.2013.2624
Abstract: Paclitaxel, one of the broadest-spectrum anticancer agents, is currently being used in the treatment of patients with solid tumors. In the present study, we compared the effect of paclitaxel on two types of leukemia cells. Our results showed that paclitaxel could inhibit the proliferation of MEL and K562 cells in a dose- and time-dependent manner. The mechanism of proliferative inhibition in K562 cells treated by paclitaxel was related to the cell cycle arrest in the G2/M phase, as well as the induction of apoptosis. By contrast, MEL cells treated by paclitaxel showed significant characteristics of necrosis, which indicated that the mode of cell death induced by paclitaxel in these two types of leukemia cells differed. Advances in research of the cell cycle, apoptosis and necrosis will extend our understanding of the mechanisms of paclitaxel-induced cell death, particularly in leukemia cells. Further elucidation of the mechanisms of necrosis in MEL cells may expedite the development of improved paclitaxel-based regimens for cancer therapy.
Publisher: Elsevier BV
Date: 05-2015
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2017
Publisher: Springer International Publishing
Date: 2018
Publisher: Fuji Technology Press Ltd.
Date: 20-01-2019
DOI: 10.20965/JACIII.2019.P0146
Abstract: Although the present attendance management system, adopted by universities, determines students’ physical presence. It does not determine whether they perform physical activities. It is important to monitor students’ extracurricular physical exercise scientifically and effectively to solve the actual effect of extracurricular physical exercise attendance and exercise. Calorie management is one solution to this problem. Additionally, an extracurricular physical exercise monitoring and management system is developed to record the energy consumption of students during their physical activities. To realize the demand for the management of calories and the monitoring and analysis of the energy consumption of students through the two development of the energy consumption instrument. This plan has certain significance for solving the actual effect of extracurricular physical training.
Publisher: Springer Berlin Heidelberg
Date: 2007
Publisher: IEEE
Date: 09-2015
DOI: 10.1109/EDCC.2015.12
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 08-2018
DOI: 10.1097/PCC.0000000000001586
Abstract: To evaluate the effectiveness and safety of a family-centered care intervention in a Chinese neonatal ICU. Pilot study using a randomized controlled trial design to inform a main randomized controlled trial study. Stand-alone tertiary children’s hospital in China with a 60-bed neonatal ICU serving as a regional neonatal ICU center. Premature infants ( n = 61) and their parents ( n = 110). Parent education program followed by parents’ participation in care as primary caregiver until discharge for a minimum of 4 hours per day. Primary outcomes were infants’ weight gain at discharge, length of stay, and readmission. Parental outcomes were stress, anxiety, satisfaction, and clinical knowledge. Infants in family-centered care group ( n = 31) had higher weight gain (886 g vs 542 g p = 0.013), less neonatal ICU length of stay in days (43 vs 46 p = 0.937), and decreased readmission rate at 1 week (41.9 vs 70.0 p = 0.045) and at 1 month (6.5% vs 50% p 0.001) compared with the control group ( n = 30). Total Mean Parental Stress and Anxiety scores were lower in the family-centered care group (42 vs 59 p ≤ 0.007), mean satisfaction rates in family-centered care group were higher compared with control group (96 vs 90 p 0.001), and parents in the family-centered care group had better educational outcomes related to neonatal specialized care skills ( p 0.05). Involving parents in the care of their infant improved clinical outcomes of infants. Family-centered care also contributed to a better understanding of parent’s clinical education, decrease stress levels, and increased parental satisfaction. Our study suggests that involving parents in the daily care of their infants is feasible and should be promoted by neonatal ICU clinicians.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2019
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2018
Publisher: IEEE
Date: 2004
Publisher: IEEE
Date: 07-2007
Publisher: Springer International Publishing
Date: 2017
Publisher: IEEE
Date: 10-05-2021
Publisher: Informa UK Limited
Date: 13-03-2013
Publisher: Springer Science and Business Media LLC
Date: 25-05-2021
DOI: 10.1038/S41467-021-23236-3
Abstract: Arbuscular mycorrhizal (AM) and ectomycorrhizal (EcM) associations are critical for host-tree performance. However, how mycorrhizal associations correlate with the latitudinal tree beta- ersity remains untested. Using a global dataset of 45 forest plots representing 2,804,270 trees across 3840 species, we test how AM and EcM trees contribute to total beta- ersity and its components (turnover and nestedness) of all trees. We find AM rather than EcM trees predominantly contribute to decreasing total beta- ersity and turnover and increasing nestedness with increasing latitude, probably because wide distributions of EcM trees do not generate strong compositional differences among localities. Environmental variables, especially temperature and precipitation, are strongly correlated with beta- ersity patterns for both AM trees and all trees rather than EcM trees. Results support our hypotheses that latitudinal beta- ersity patterns and environmental effects on these patterns are highly dependent on mycorrhizal types. Our findings highlight the importance of AM-dominated forests for conserving global forest bio ersity.
Publisher: Elsevier
Date: 2020
DOI: 10.1016/BS.MIE.2019.09.005
Abstract: The high-sensitive and rapid detection of critical biomarkers, e.g., disease-related nucleic acids and proteins, is always desired. Compared with the routine homogenous detection strategies, the on-bead flow cytometry (FCM)-based assays have drawn a lot of interests owing to their unique advantages. On one hand, microbeads (MBs) are employed for the enrichment of fluorescent signals, allowing the size encoding for multiplexed detection of biomarkers. On the other hand, FCM enables the fast read-out of the total fluorescent signals enriched on the MBs and the decoding of MBs' size information. For an improved sensitivity and versatile application scenarios, the signal lification on MBs is required. However, the enzyme-catalyzed on-bead reactions remain challenging owing to the critical reaction conditions on the MBs/solution interface. Toward the high-sensitive detection of target biomolecules in real-s les, a series of on-bead enzyme-catalyzed signal lification strategies have been developed. After careful optimization of the reaction conditions, the proposed sensors are proven to have ultra-high sensitivities to fulfill the requirement of real-s le detection.
Publisher: IEEE
Date: 05-2015
Publisher: IEEE
Date: 04-2016
Publisher: Wiley
Date: 03-02-2015
DOI: 10.1002/POLA.27529
Publisher: Elsevier BV
Date: 07-2022
Publisher: IEEE
Date: 05-2017
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2015
DOI: 10.1109/MS.2015.2
Publisher: ACM
Date: 14-05-2016
Publisher: American Association for the Advancement of Science (AAAS)
Date: 27-08-2021
Abstract: Scalable ranking approaches can map effective bio ersity and climate targets for national conservation action by 2030.
Publisher: Association for Computing Machinery (ACM)
Date: 26-02-2018
DOI: 10.1145/3183367
Abstract: Blockchain technology offers a sizable promise to rethink the way interorganizational business processes are managed because of its potential to realize execution without a central party serving as a single point of trust (and failure). To stimulate research on this promise and the limits thereof, in this article, we outline the challenges and opportunities of blockchain for business process management (BPM). We first reflect how blockchains could be used in the context of the established BPM lifecycle and second how they might become relevant beyond. We conclude our discourse with a summary of seven research directions for investigating the application of blockchain technology in the context of BPM.
Publisher: Elsevier BV
Date: 12-2019
Publisher: Cambridge University Press (CUP)
Date: 03-2009
DOI: 10.1017/S0269888909000113
Abstract: This paper develops an ontological basis for evaluating software design methods, based on the situated function–behaviour–structure framework. This framework accounts for the situatedness of designing, viewing it as a dynamic activity driven by interactions between designers and the artefacts being designed. On the basis of this framework, we derive a general evaluation schema that we apply to five software design methods. The ideas presented in this work contribute to a better understanding of design methods, and uncover opportunities for method integration and development.
Publisher: IEEE
Date: 09-2008
DOI: 10.1109/EDOC.2008.14
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2019
Publisher: Elsevier BV
Date: 08-2016
DOI: 10.1016/J.CHEMOSPHERE.2016.04.113
Abstract: Under current retrospective risk assessment framework, the total concentrations of organic pollutants in soils have been employed as the standard for over 30 years. The total concentrations reflect the overall accumulation in soils but tend to be overly conservative for assessing the ecological risks, where the bioavailability plays an important role. In this study, the bioavailability of organic pollutants in soils was evaluated using a stepwise and tiered classification method, namely the sequential ultrasonic extraction procedure (SEUP). The water-soluble and acid-soluble fractions extracted by the SEUP were the bioavailable fractions. The reliability and environmental relevance of the speciation method were examined with representative organic pollutants using the root uptake methods and the semipermeable membrane devices (SPMDs). The plant uptake amounts corrected with weight were highly correlated with the bioavailable fractions (R(2) > 0.75). The amounts of the bioavailable fractions were negatively correlated with the logKow values (R(2) ranging from 0.71 to 0.77) of the organic pollutants and the contents of soil organic matter (R(2) ranging from 0.68 to 0.96). As a refinement of the current risk assessment framework, the SUEP that has proved to be a reliable and convenient is thus highly recommended for evaluating the bioavailability of organic pollutants in soils.
Publisher: IEEE
Date: 04-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 04-2016
Publisher: IEEE
Date: 09-2007
Publisher: IEEE
Date: 06-2014
DOI: 10.1109/DSN.2014.94
Publisher: IEEE
Date: 07-2018
Publisher: IEEE
Date: 10-2016
Publisher: IEEE
Date: 09-2009
Publisher: Wiley
Date: 09-06-2021
Abstract: Developing nano‐ferroelectric materials with excellent piezoelectric performance for piezocatalysts used in water splitting is highly desired but also challenging, especially with respect to reaching large piezo‐potentials that fully align with required redox levels. Herein, heteroepitaxial strain in BaTiO 3 nanoparticles with a designed porous structure is successfully induced by engineering their surface reconstruction to dramatically enhance their piezoelectricity. The strain coherence can be maintained throughout the nanoparticle bulk, resulting in a significant increase of the BaTiO 3 tetragonality and thus its piezoelectricity. Benefiting from high piezoelectricity, the as‐synthesized blue‐colored BaTiO 3 nanoparticles possess a superb overall water‐splitting activity, with H 2 production rates of 159 μmol g −1 h −1 , which is almost 130 times higher than that of the pristine BaTiO 3 nanoparticles. Thus, this work provides a generic approach for designing highly efficient piezoelectric nanomaterials by strain engineering that can be further extended to various other perovskite oxides, including SrTiO 3 , thereby enhancing their potential for piezoelectric catalysis.
Publisher: AIP Publishing
Date: 15-12-2015
DOI: 10.1063/1.4937555
Abstract: Modulation of charge carrier density in condensed materials based on ionic/electronic interaction has attracted much attention. Here, protonic/electronic hybrid indium-zinc-oxide (IZO) transistors gated by chitosan based electrolyte were obtained. The chitosan-based electrolyte illustrates a high proton conductivity and an extremely strong proton gating behavior. The transistor illustrates good electrical performances at a low operating voltage of ∼1.0 V such as on/off ratio of ∼3 × 107, subthreshold swing of ∼65 mV/dec, threshold voltage of ∼0.3 V, and mobility of ∼7 cm2/V s. Good positive gate bias stress stabilities are obtained. Furthermore, a low voltage driven resistor-loaded inverter was built by using an IZO transistor in series with a load resistor, exhibiting a linear relationship between the voltage gain and the supplied voltage. The inverter is also used for decreasing noises of input signals. The protonic/electronic hybrid IZO transistors have potential applications in biochemical sensors and portable electronics.
Publisher: Frontiers Media SA
Date: 12-04-2019
Publisher: IEEE
Date: 12-2014
Publisher: IEEE
Date: 03-2016
Publisher: Elsevier BV
Date: 08-2013
Publisher: IEEE
Date: 06-2019
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2016
DOI: 10.1109/MIC.2016.67
Publisher: Elsevier BV
Date: 2021
Publisher: Wiley
Date: 15-07-2016
DOI: 10.1002/SPE.2427
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2015
Publisher: Springer International Publishing
Date: 2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-04-2021
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 09-2018
Publisher: Institution of Engineering and Technology (IET)
Date: 12-2020
Publisher: Elsevier BV
Date: 2021
Publisher: IEEE
Date: 12-2012
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2018
Publisher: IEEE
Date: 05-2013
Publisher: Elsevier BV
Date: 07-2006
Publisher: Institution of Engineering and Technology (IET)
Date: 03-2017
Publisher: IEEE
Date: 04-2007
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2016
DOI: 10.1109/MS.2016.81
Publisher: Elsevier BV
Date: 03-2015
DOI: 10.1016/J.JAD.2014.12.042
Abstract: Despite the high co-morbidity of depressive symptoms in patients with multiple somatic symptoms, the validity of the 9-item Patient Health Questionnaire (PHQ-9) has not yet been investigated in Chinese patients with multiple somatic symptoms. The multicenter cross-sectional study was conducted in ten outpatient departments located in four cities in China. The psychometric properties of the PHQ-9 were examined by confirmative factor analysis (CFA). Criterion validation was undertaken by comparing results with depression diagnoses obtained from the Mini International Neuropsychiatric Interview (MINI) as the gold standard. Overall, 491 patients were recruited of whom 237 had multiple somatic symptoms (SOM+ group, PHQ-15≥10). Cronbach׳s α of the PHQ-9 was 0.87, 0.87, and 0.90 for SOM+ patients, SOM- patients, and total s le respectively. All items and the total score were moderately correlated. The factor models of PHQ-9 tested by CFA yielded similar diagnostic performance when compared to sum score estimation. Multi-group confirmatory factor analysis based on unidimensional model showed similar psychometric properties over the groups with low and high somatic symptom burden. The optimal cut-off point to detect depression in Chinese outpatients was 10 for PHQ-9 (sensitivity=0.77, specificity=0.76) and 3 for PHQ-2 (sensitivity=0.77, specificity=0.74). Potential selection bias and nonresponse bias with applied s ling method. PHQ-9 (cut-off point=10) and PHQ-2 (cut-off point=3) were reliable and valid to detect major depression in Chinese patients with multiple somatic symptoms.
Publisher: Elsevier BV
Date: 05-2016
Publisher: American Association for the Advancement of Science (AAAS)
Date: 05-10-2018
Abstract: Bio ersity experiments have shown that species loss reduces ecosystem functioning in grassland. To test whether this result can be extrapolated to forests, the main contributors to terrestrial primary productivity, requires large-scale experiments. We manipulated tree species richness by planting more than 150,000 trees in plots with 1 to 16 species. Simulating multiple extinction scenarios, we found that richness strongly increased stand-level productivity. After 8 years, 16-species mixtures had accumulated over twice the amount of carbon found in average monocultures and similar amounts as those of two commercial monocultures. Species richness effects were strongly associated with functional and phylogenetic ersity. A shrub addition treatment reduced tree productivity, but this reduction was smaller at high shrub species richness. Our results encourage multispecies afforestation strategies to restore bio ersity and mitigate climate change.
Publisher: American Chemical Society (ACS)
Date: 04-08-2015
Publisher: Elsevier BV
Date: 09-2011
Publisher: Royal Society of Chemistry (RSC)
Date: 02-07-2014
DOI: 10.1039/C4RA04600E
Publisher: Elsevier BV
Date: 11-2016
DOI: 10.1016/J.CHEMOSPHERE.2016.08.038
Abstract: The current contamination status of polychlorinated biphenyls (PCBs) was studied in the agricultural soils of the Yangtze River Delta (YRD), one of the largest economic zones in China. The concentrations of PCBs ranged from <0.1 to 130 ng/g dry weight. Higher concentrations of PCBs were observed in the 0-30 cm surface layers relative to the subsurface soils. A distinct spatial distribution was observed with a declining concentration gradient from the northwest to the southeast of the region. The composition of PCBs in the soils was consistent with the Chinese commercial PCB mixtures, but different from the compositions in global background soil. Local sources including large-scale use and disposal of PCB-containing products were the main potential sources to soil. The ecological effects and human health risks associated with combined persistent organic pollutants, including PCBs, organochlorine pesticides (OCPs), phthalate esters (PAEs) and polybrominated diphenyl ethers (PBDEs), were further estimated. The four toxic organic compounds and seven physicochemical parameters together could only explain 12.7% of the variation in microbial community composition, suggesting the soil ecosystem function was not strongly influenced by the combined pollution at low concentrations. However, the potential health risks to residents via multiple pathways were notably higher for PCBs than other chemicals. The potential risks were mainly derived from PCB-126, 81, and 169.
Publisher: Elsevier BV
Date: 02-2020
DOI: 10.1016/J.NEDT.2019.104260
Abstract: Empathy is a central competence for nursing students in delivering compassionate care. Empathy training might improve the communication skills in children's nursing students. To evaluate the effectiveness of the Knowledge, Simulation, and Sharing training programme on empathy skills among children's nursing students. A controlled pre-post intervention study with a quasi-experimental design. Tertiary children's hospital in China. Children's nursing students (n = 250) in clinical internship. A Knowledge, Simulation, and Sharing (KSS) module related to empathy learning was developed and tested during a 10-month period in 2017. Nursing students were ided into an experimental group (n = 125) and control group (n = 125). Both groups received the standard internship programme. The experimental group received the KSS training. Outcome measures were: Jefferson Scale of Empathy-Health Professions Student, Clinical Communication Competence Scale and Professional Identity Scale. At the end of the internship the experimental groups had significantly higher empathy scores than the control group (114.57 versus 110.36 p = .016). The communication skills improved significantly in the experimental group after the training experimental group mean 90.22 versus control group mean 87.41 (p = .042). The professional identity scores were significantly higher in the experimental group at the end of the internship compared to the control group (mean 116.43 versus 107.68 p < .001). Subgroup analysis revealed only significant differences on professional identity outcomes between experimental and control groups on diploma level (mean 115.78 versus 107.72 p < .001) and bachelor's level (mean 120.05 versus 108.00 p < .016). The KSS training can enhance empathy and communication skills and the professional identity in children's nursing students. Further long-term effectiveness of the training needs to be tested, ideally with reported outcomes measures of children and parents.
Publisher: IEEE
Date: 09-2015
Publisher: Elsevier BV
Date: 05-2019
Publisher: IEEE
Date: 12-2020
Publisher: Springer Science and Business Media LLC
Date: 12-2019
DOI: 10.1007/S00431-019-03524-3
Abstract: This pre-post intervention study was conducted in Neonatal Intensive Care Units in two Chinese hospitals. The objective was to evaluate the effectiveness and safety of intracavitary electrocardiogram (IC-ECG)-guided peripherally inserted central catheter (PICC) placement and tip positioning in premature infants. A total of 161 premature infants who required a PICC were enrolled and ided into two groups: pre-intervention group (n = 83) from October 2017 to July 2018 and post-intervention IC-ECG group (n = 78) from August 2018 to March 2019. Nurses were trained from May 2018 to July 2018. The reposition rate in the IC-ECG group and pre-interventions group was 3.85% and 19.28%, respectively (OR 5.970 95% CI 1.666-21.395 p = 0.002). More infants achieved optimal tip position at the first attempt in the IC-ECG group than the pre-intervention group (93.59% vs 73.49% OR 0.190 95%CI 0.068-0.531 p = 0.001). The overall catheter-related complications in the pre-intervention group were 14.46% compared to 3.84% in the IC-ECG group (OR 2.962 95%CI 1.013-8.661 p = 0.040). However, no significant differences were observed between the in idual complication leakage, phlebitis and catheter-related blood stream infection.Conclusions: IC-ECG-guided peripherally inserted central catheter placement and tip positioning technology might decrease reposition rates, achieve more accurate tip positioning at the first attempt and might reduce catheter-related complications in premature infants. Further robust RCTs are needed to confirm the effectiveness of IC-ECG-guided PICC placement and tip positioning in neonates.What is Known:• Chest radiography is the gold standard for tip position confirmation of peripherally inserted central catheter placement.• Studies in adult patients have shown that electrocardiogram guidance in the placement of central venous catheters can be beneficial, while evidence in neonates is limited.What is New:• Intracavitary electrocardiogram-guided peripherally inserted central catheter placement might be superior to chest radiography in preterm infants.• Decreasing the repositioning rates and correct tip position of peripherally inserted central catheters might reduce catheter-related complications.
Publisher: IEEE
Date: 05-2017
Publisher: IEEE
Date: 09-2015
DOI: 10.1109/SRDS.2015.37
Publisher: Elsevier BV
Date: 2020
Publisher: IEEE
Date: 08-2015
Publisher: Elsevier BV
Date: 02-2007
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2021
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2021
Publisher: IEEE
Date: 09-2009
Publisher: IEEE
Date: 09-2015
Publisher: IEEE
Date: 06-2015
Publisher: American Chemical Society (ACS)
Date: 09-02-2016
Abstract: Despite recent advances in the understanding of fundamental cancer biology, cancer remains the second most common cause of death in the United States. One of the primary factors indicative of high cancer morbidity and mortality and aggressive cancer phenotypes is tumors with a low extracellular pH (pHe). Thus, the ability to measure tumor pHe in vivo using noninvasive and accurate techniques that also provide high spatiotemporal resolution has become increasingly important and is of great interest to researchers and clinicians. In an effort to develop a pH-responsive magnetic resonance imaging (MRI) contrast agent (CA) that has the potential to be used to measure tumor pHe, well-defined pH-responsive polymers, synthesized via reversible addition-fragmentation chain transfer polymerization, were attached to the surface of gadolinium-based nanoparticles (GdNPs) via a "grafting to" method after reduction of the thiocarbonylthio end groups. The successful modification of the GdNPs was verified by transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and dynamic light scattering. The performance of the pH-responsive polymer modified GdNPs was then evaluated for potential use as smart MRI CAs via monitoring the relaxivity changes with changing environmental pH. The results suggested that the pH-responsive polymers can be used to effectively modify the GdNPs surface to prepare a smart contrast agent for MRI.
Publisher: IEEE
Date: 12-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2022
Publisher: Springer International Publishing
Date: 19-12-2018
Publisher: Informa UK Limited
Date: 31-12-2018
DOI: 10.1080/09540121.2018.1563285
Abstract: Researchers and advocates have increasingly called for adolescent participation in clinical trials for new HIV prevention products, particularly adolescent girls in areas most affected by the epidemic. However, recent trials have highlighted the challenges for young women and adolescents to be able to effectively use new products that require daily dosing. This analysis provides a highly relevant context for this challenging environment by examining community members acceptability of adolescent girls' participation in clinical trials for new HIV prevention products. We conducted 41 in-depth interviews in Dar es Salaam, Tanzania and Pune, India with 22 key informants (KIs). Cultural perspectives on adolescent sexuality varied between countries, with KIs in Tanzania more readily acknowledging adolescent girls' sexual activity than KIs in India. KIs in both countries felt strongly adolescents must be well-informed about research concepts prior to participation, and emphasis should be given to preventative misconception. Despite concern in both countries that the trials might be seen as encouraging sexual behavior, KIs in Tanzania overwhelmingly supported adolescent inclusion, whereas KIs in India were more cautious. Involving adolescent girls in clinical trials for new HIV prevention products is potentially acceptable, although meaningful community engagement will be necessary.
Publisher: Elsevier BV
Date: 2014
Publisher: Springer Science and Business Media LLC
Date: 05-06-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2020
Publisher: ACM Press
Date: 2018
Publisher: Oxford University Press (OUP)
Date: 23-09-2008
DOI: 10.1093/JAC/DKN394
Abstract: Clinical studies have suggested that rates of infusion-related reactions (IRRs) may be higher with hotericin B colloidal dispersion (ABCD) versus other forms of hotericin B. However, these studies did not permit the use of pre-medications upfront, which are now commonly used. Objectives To describe the use of pre-medications and determine the rate of IRRs in the real-world setting. PRoACT, a multicentre, worldwide observational registry, captured real-world data about pre-medication practices and IRRs in patients receiving ABCD. Eligible patients were those beginning treatment with ABCD treatment was according to the site's standard treatment practice. Incidence of IRRs was collected during the first 10 days of ABCD therapy. Clinical response data were collected 12 weeks after treatment start. One hundred and seventy patients from 21 worldwide sites were included (median age 37 years 52% male). There were a total of 1230 ABCD infusions (mean dose 2.8 mg/kg/day) 90% of the infusions (1105/1230) had pre-medication. Common pre-medications included corticosteroids, antihistamines, paracetamol (acetaminophen) and metamizole. The overall IRR rate was 12% (147/1230) and was lower in infusions with pre-medication (11%) versus no pre-medication (22%), P < 0.001. Corticosteroids were associated with a decreased incidence of IRRs (P < 0.05), while paracetamol and antihistamines were not. The most common IRRs were chills (7%), fever (7%) and rigors (5%). Clearance of the fungal infection occurred in 52% of the participants. These data suggest a lower rate of IRRs with ABCD than previously reported. Pre-medication is associated with decreased IRR incidence. Corticosteroids in particular appear to decrease IRRs while paracetamol and antihistamines, though commonly used, do not.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2018
Publisher: Springer International Publishing
Date: 2017
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2015
DOI: 10.1109/MS.2015.23
Publisher: IEEE
Date: 05-2018
Publisher: Elsevier BV
Date: 12-2019
Publisher: Wiley
Date: 30-05-2019
Publisher: ACM
Date: 04-05-2015
Publisher: Tsinghua University Press
Date: 12-2013
Publisher: Elsevier BV
Date: 11-2014
Publisher: ACM
Date: 08-09-2016
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2022
Publisher: Springer Science and Business Media LLC
Date: 08-09-2018
Publisher: ACM
Date: 08-04-2019
Publisher: ACM
Date: 19-09-2012
Publisher: IEEE
Date: 11-2017
DOI: 10.1109/ESEM.2017.18
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 04-2017
Publisher: Elsevier BV
Date: 12-2015
Publisher: IEEE
Date: 05-2009
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Elsevier BV
Date: 07-2009
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Wiley
Date: 08-05-2013
DOI: 10.1002/POLB.23302
Publisher: IEEE
Date: 06-2015
DOI: 10.1109/DSN.2015.23
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2021
Publisher: Springer International Publishing
Date: 2018
Publisher: Wiley
Date: 21-07-2013
DOI: 10.1002/PSC.2533
Abstract: Anoplin is a recently discovered antimicrobial peptide (AMP) isolated from the venom sac of the spider wasp Anoplius samariensis, and it is one of the shortest α-helical AMP found naturally to date consisting of only ten amino acids. Previous results showed that anoplin exhibits potent antimicrobial activity but little hemolytic activity. In this study, we synthesized anoplin, studied its cytotoxicity in Friend virus-induced leukemia cells [murine erythroleukemia (MEL) cells], and proposed its possible mechanism. Our results showed that anoplin could inhibit the proliferation of MEL cells in a dose-dependent and time-dependent manner via disrupting the integrity of cell membrane, which indicated that anoplin exerts its cytotoxicity efficacy. In addition, the cell cycle distribution of MEL cells was arrested in the G₀/G₁ phase significantly. However, anoplin could not induce obvious apoptosis in MEL cells, as well as anoplin could not induce visible changes on morphology and quantity in the bone marrow cells isolated from normal mice. All of these results indicate that anoplin, as generally believed, is a selective AMP, a value characteristic in the design of safe therapeutic agents. The cytotoxicity of anoplin on MEL cells was mainly attributable to the plasma membrane perturbation and also to the intracellular events such as the arrest of cell cycle. Although this is an initial study that explored the activity of anoplin in vitro rather than in vivo, with the increasing resistance of conventional chemotherapy, there is no doubt that anoplin has desirable feature to be developed as a novel and selective anticancer agent.
Publisher: Elsevier BV
Date: 12-2014
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 04-2020
Publisher: Springer Science and Business Media LLC
Date: 05-03-2021
DOI: 10.1007/S11465-020-0619-X
Abstract: Typically, the achievable positioning bandwidth for piezo-actuated nanopositioners is severely limited by the first, lightly-d ed resonance. To overcome this issue, a variety of open- and closed-loop control techniques that commonly combine d ing and tracking actions, have been reported in literature. However, in almost all these cases, the achievable closed-loop bandwidth is still limited by the original open-loop resonant frequency of the respective positioning axis. Shifting this resonance to a higher frequency would undoubtedly result in a wider bandwidth. However, such a shift typically entails a major mechanical redesign of the nanopositioner. The integral resonant control (IRC) has been reported earlier to demonstrate the significant performance enhancement, robustness to parameter uncertainty, guaranteed stability and design flexibility it affords. To further exploit the IRC scheme’s capabilities, this paper presents a method of actively shifting the resonant frequency of a nanopositioner’s axis, thereby delivering a wider closed-loop positioning bandwidth when controlled with the IRC scheme. The IRC d ing control is augmented with a standard integral tracking controller to improve positioning accuracy. And both d ing and tracking control parameters are analytically optimized to result in a Butterworth Filter mimicking pole-placement—maximally flat passband response. Experiments are conducted on a nanopositioner’s axis with an open-loop resonance at 508 Hz. It is shown that by employing the active resonance shifting, the closed-loop positioning bandwidth is increased from 73 to 576 Hz. Consequently, the root-mean-square tracking errors for a 100 Hz triangular trajectory are reduced by 93%.
Publisher: Springer Science and Business Media LLC
Date: 17-10-2007
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2018
Publisher: Springer Berlin Heidelberg
Date: 2012
Publisher: Wiley
Date: 09-09-2019
Abstract: Piezocatalysis, converting mechanical vibration into chemical energy, has emerged as a promising candidate for water-splitting technology. However, the efficiency of the hydrogen production is quite limited. We herein report well-defined 10 nm BaTiO
Publisher: Springer Berlin Heidelberg
Date: 2015
Publisher: IEEE
Date: 2004
Publisher: Elsevier BV
Date: 10-1997
Publisher: Springer Berlin Heidelberg
Date: 2010
Publisher: Springer Science and Business Media LLC
Date: 19-07-2016
DOI: 10.1007/S10653-016-9853-X
Abstract: Atrazine is one of the most widely applied and persistent herbicides in the world. In view of limited information on the regional contamination of atrazine in soils in China, this study investigated the spatial distribution and environmental impacts of atrazine in agricultural soils collected from the Yangtze River Delta (YRD) as an illustrative analysis of rapidly developing regions in the country. The results showed that the concentrations of atrazine in the YRD agricultural soils ranged from <1.0 to 113 ng/g dry weight, with a mean of 5.7 ng/g, and a detection rate of 57.7 % in soils. Pesticide factory might be a major source for the elevated levels of atrazine in Zhejiang Province. The contamination of atrazine was closely associated with land use types. The concentrations and detection rates of atrazine were higher in corn fields and mulberry fields than in rice paddy fields. There was no significant difference in compositions of soil microbial phospholipids fatty acids among the areas with different atrazine levels. Positive relationship (R = 0.417, p < 0.05, n = 30) was observed between atrazine and total microbial biomass. However, other factors, such as soil type and land management practice, might have stronger influences on soil microbial communities. Human health risks via exposure to atrazine in soils were estimated according to the methods recommended by the US EPA. Atrazine by itself in all the soil s les imposed very low carcinogenic risks (<10
Publisher: IEEE
Date: 06-2014
DOI: 10.1109/DSN.2014.63
Publisher: Elsevier BV
Date: 03-2019
Publisher: Elsevier BV
Date: 2019
DOI: 10.1016/J.AUCC.2018.10.007
Abstract: The objective of this study was to review English and Chinese randomised controlled trials (RCTs) to determine the effects of family-centred care (FCC) interventions on preterm infants' and parental outcomes in the neonatal intensive care units and to conduct a meta-analysis. Systematic review and meta-analysis. Medline, CINAHL, Embase, PsycINFO, BNI, and AMED and the Chinese databases CNKI and Wanfang Data were searched in April 2017 and updated in August 2018. Only RCTs were included. Participants were preterm infants ≤37 weeks gestational age and parents. Interventions were related to FCC, and outcome measures were infant and parent clinical outcomes. Included studies were assessed for risk of bias using Cochrane Manual 5.1.0. Meta-analyses used mean differences (MDs), standardised mean differences (SMDs), or odds ratio (OR), followed by 95% confidence interval (CI). Heterogeneity was tested with Cochran's Q chi-squared test, tau-squared test, and inconsistency index (I Nineteen studies (10 from English and 9 from Chinese databases) were included meta-analysis included 15 studies (7 English and 8 Chinese RCTs). Meta-analysis showed significant improvements in weight gain (7 studies: MD, 4.57 95% CI, 2.80-6.34 P < 0.001 I FCC interventions can improve weight gain and readmission in preterm infants as well as parent satisfaction, knowledge, and skills, and possibly long-term anxiety, depression, and stress. Developing standardised outcome sets for testing family-centred care interventions is recommended.
Location: No location found
Location: United States of America
Location: United States of America
Location: United States of America
No related grants have been discovered for Li Zhu.