ORCID Profile
0000-0001-8699-9019
Current Organisation
Swinburne University of Technology
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Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/0008-5472.22633196
Abstract: Neutrophils engage in multiple interactions with LLC tumor cells following microbial bioparticle treatment.
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/0008-5472.C.6599657.V1
Abstract: Abstract The inflammatory microenvironment of solid tumors creates a protumorigenic milieu that resembles chronic inflammation akin to a subverted wound healing response. Here, we investigated the effect of converting the tumor microenvironment from a chronically inflamed state to one of acute microbial inflammation by injecting microbial bioparticles directly into tumors. Intratumoral microbial bioparticle injection led to rapid and dramatic changes in the tumor immune composition, the most striking of which was a substantial increase in the presence of activated neutrophils. i In situ /i photoconversion and intravital microscopy indicated that tumor neutrophils transiently switched from sessile producers of VEGF to highly motile neutrophils that clustered to make neutrophil-rich domains in the tumor. The neutrophil clusters remodeled tumor tissue and repressed tumor growth. Single-cell transcriptional analysis of microbe-stimulated neutrophils showed a profound shift in gene expression towards heightened activation and antimicrobial effector function. Microbe-activated neutrophils also upregulated chemokines known to regulate neutrophil and CD8 sup + /sup T-cell recruitment. Microbial therapy also boosted CD8 sup + /sup T-cell function and enhanced the therapeutic benefit of checkpoint inhibitor therapy in tumor-bearing mice and provided protection in a model of tumor recurrence. These data indicate that one of the major effector mechanisms of microbial therapy is the conversion of tumor neutrophils from a wound healing to an acutely activated cytotoxic phenotype, highlighting a rationale for broader deployment of microbial therapy in the treatment of solid cancers. Significance: Intratumoral injection of microbial bioparticles stimulates neutrophil antitumor functions, suggesting pathways for optimizing efficacy of microbial therapies and paving the way for their broader utilization in the clinic. /
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/0008-5472.22633199
Abstract: Neutrophil interactions with LLC cells in unmanipulated and treated tumors.
Publisher: American Association for Cancer Research (AACR)
Date: 14-02-2023
DOI: 10.1158/0008-5472.CAN-21-4025
Abstract: Intratumoral injection of microbial bioparticles stimulates neutrophil antitumor functions, suggesting pathways for optimizing efficacy of microbial therapies and paving the way for their broader utilization in the clinic.
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/0008-5472.C.6599657
Abstract: Abstract The inflammatory microenvironment of solid tumors creates a protumorigenic milieu that resembles chronic inflammation akin to a subverted wound healing response. Here, we investigated the effect of converting the tumor microenvironment from a chronically inflamed state to one of acute microbial inflammation by injecting microbial bioparticles directly into tumors. Intratumoral microbial bioparticle injection led to rapid and dramatic changes in the tumor immune composition, the most striking of which was a substantial increase in the presence of activated neutrophils. i In situ /i photoconversion and intravital microscopy indicated that tumor neutrophils transiently switched from sessile producers of VEGF to highly motile neutrophils that clustered to make neutrophil-rich domains in the tumor. The neutrophil clusters remodeled tumor tissue and repressed tumor growth. Single-cell transcriptional analysis of microbe-stimulated neutrophils showed a profound shift in gene expression towards heightened activation and antimicrobial effector function. Microbe-activated neutrophils also upregulated chemokines known to regulate neutrophil and CD8 sup + /sup T-cell recruitment. Microbial therapy also boosted CD8 sup + /sup T-cell function and enhanced the therapeutic benefit of checkpoint inhibitor therapy in tumor-bearing mice and provided protection in a model of tumor recurrence. These data indicate that one of the major effector mechanisms of microbial therapy is the conversion of tumor neutrophils from a wound healing to an acutely activated cytotoxic phenotype, highlighting a rationale for broader deployment of microbial therapy in the treatment of solid cancers. Significance: Intratumoral injection of microbial bioparticles stimulates neutrophil antitumor functions, suggesting pathways for optimizing efficacy of microbial therapies and paving the way for their broader utilization in the clinic. /
Publisher: Oxford University Press (OUP)
Date: 18-09-2012
DOI: 10.1093/JDH/EPS030
Publisher: Trans Tech Publications, Ltd.
Date: 07-2011
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.284-286.615
Abstract: The process of new materials development traditionally employs science and engineering based inquiry in the initial phases. This paper explores how product design can help determine the feasibility of new materials for commercial application earlier and provide benefits of reduced timeframes, cost and risk factors. It discusses a case study of new materials development based on Microwave Modified Timber Technology, set in the context of an Australian Collaborative Research Centre (CRC) for Wood Innovations. The study supports benefits in early integration of product design research into new materials development processes.
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/0008-5472.22633202
Abstract: Neutrophil migration before and after microbial bioparticle treatment.
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/0008-5472.22633199.V1
Abstract: Neutrophil interactions with LLC cells in unmanipulated and treated tumors.
Publisher: Cambridge University Press (CUP)
Date: 2005
DOI: 10.1017/S0814062600000938
Abstract: In the relatively new discipline of design education we have the opportunity to frame the way that design education is formulated. The relative lack of theorists in the field of design education studies leaves unquestioned the relevance of conventional practices of design education that are premised on only tangentially relevant Art, Science and Information Technology models. There is a gap in design education development regarding how to mediate ecological concerns with techno-scientific imperatives. Environmental education researchers can influence this new field by challenging existing approaches to design education with particular attention to the ways design either contributes to or hinders the development of a sustainable society. In order to enter this discussion with environmental education researchers we identify three ecological issues faced by designers and design educators, here we pay particular attention to Industrial Design. The question for this paper is, can environmental education researchers offer advice to the design education area that may help us develop ecologically sustainable design-based programs. The newness of ecological concerns in the design research and design education areas means that we have a great deal to learn. If environmental education researchers are able to assist us with our reflections on designing curricula that in turn encourages a more ecologically aware design profession then this would be a worthwhile contribution to design practice in Australia, and indeed the world.
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/0008-5472.22633196.V1
Abstract: Neutrophils engage in multiple interactions with LLC tumor cells following microbial bioparticle treatment.
Publisher: Oxford University Press (OUP)
Date: 2006
DOI: 10.1093/JDH/EPL019
Publisher: Informa UK Limited
Date: 04-05-2015
DOI: 10.3109/17483107.2015.1042077
Abstract: The purpose of this study was to investigate of how assistive cutlery design effects perception of the user. Studies regarding the usage and development of assistive cutlery have primarily focused on the ergonomics, whereas research into the aesthetics of assistive cutlery has been minimal. A method based on Canter's "Room Inference Protocol" from the field of environmental psychology was used to evaluate the aesthetics of the assistive cutlery. A series of images were digitally composited and a survey was deployed online, with an outcome of 562 usable responses. The results demonstrated that the female model with assistive cutlery was perceived to be less attractive, less stylish and less sporty in comparison with the male model that was utilising identical pieces of assistive cutlery. The research contributes to the existing literature in the field, complimenting the study by Torrens and Smith and validating the need for greater aesthetic consideration in addition to an ergonomically acceptable response for assistive cutlery. This in turn highlights the importance of industrial design for the context and adaptations of use, rather than just a design response given to the physical manifestation of a product. Implications for Rehabilitation Reduced grip can be not only physically debilitating but also socially isolating through stigmatisation. Current assistive cutlery may be ergonomically sound, but aesthetically lacking. Large, multinational study demonstrates significant gender effect relating to the perception of women using these devices.
Publisher: MIT Press - Journals
Date: 2009
Publisher: American Association for Cancer Research (AACR)
Date: 14-04-2023
DOI: 10.1158/0008-5472.22633202.V1
Abstract: Neutrophil migration before and after microbial bioparticle treatment.
Publisher: Cambridge University Press (CUP)
Date: 07-2019
DOI: 10.1017/DSI.2019.117
Abstract: In Industrial Design, new design visualisation tools are emerging offering significant benefits to the designers. However, studies show alongside some benefits, new tools can also inhibit designers' creativity or cause time inefficiency if used in the wrong context. Thus, understanding which tools to use and when during the design process is increasingly necessary to ensure the best use of resources in design practice. Existing research on understanding the performance of design tools and the resulting frameworks for comparing tools are either specific to certain tools or highly generalised making evaluation across different design tools challenging. As such, this paper reports the creation of a more comprehensive framework of design tool characteristics to facilitate a better understanding of design tools and their uses. Demonstration of application of the framework is also given in the form of a case study on the use of Digital Sketching and its comparable tools with four practising designers. In conclusion, we show how the Design Tool Characteristics (DTCs) framework is an effective way to understand design tools, with further implications for design tool development.
Publisher: Informa UK Limited
Date: 07-2009
Publisher: Inderscience Publishers
Date: 2006
No related grants have been discovered for Simon Jackson.