ORCID Profile
0000-0002-4842-5054
Current Organisations
Universidade Estadual de Campinas
,
South China Agricultural University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Springer Science and Business Media LLC
Date: 22-07-2019
DOI: 10.1038/S41467-019-11152-6
Abstract: Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration of acetate mediated interferon-β (IFN-β) response by increasing expression of interferon-stimulated genes in the lung. These effects were associated with reduction of viral load and pulmonary inflammation in RSV-infected mice. Type 1 IFN signaling via the IFN-1 receptor (IFNAR) was essential for acetate antiviral activity in pulmonary epithelial cell lines and for the acetate protective effect in RSV-infected mice. Activation of Gpr43 in pulmonary epithelial cells reduced virus-induced cytotoxicity and promoted antiviral effects through IFN-β response. The effect of acetate on RSV infection was abolished in Gpr43 − / − mice. Our findings reveal antiviral effects of acetate involving IFN-β in lung epithelial cells and engagement of GPR43 and IFNAR.
Publisher: Elsevier BV
Date: 02-2017
Publisher: Elsevier BV
Date: 2017
Publisher: Elsevier BV
Date: 07-2018
Publisher: Wiley
Date: 07-10-2022
Abstract: Semiconductor‐based photocatalytic solar‐to‐fuel conversion has proven an appealing strategy for achieving carbon‐neutral and green‐hydrogen production. However, almost all semiconductors exhibit unsatisfactory photocatalytic performance due to insufficient surface‐active sites, weak selectivity, and fast charge‐carrier recombination. For these reasons, cocatalyst loading has become an encouraging strategy for improving photocatalytic activity and selectivity. Owing to the scarcity, and cost of noble metal‐based cocatalysts, utilization of low‐cost noble‐metal‐free cocatalysts, such as metal carbide‐based cocatalysts, has aroused tremendous attention. This review highlights some recent crucial advances in active metal carbide‐based cocatalysts for photocatalytic solar‐to‐fuel conversion. First, the fundamentals of metal carbide‐based cocatalysts are presented, including the photocatalytic mechanism, advantages, drawbacks, and design rules. Second, three synthesis approaches of high‐active metal carbide‐based cocatalysts, namely constructing metal carbide nanostructures, epitaxial synthesis of metal carbides on nanostructured carbon, and crystal imperfection construction on metal carbides, are thoroughly addressed. Subsequently, applications of metal carbide‐based cocatalysts in photocatalytic hydrogen production, CO 2 reduction, and nitrogen reduction are further discussed. Finally, the crucial challenges and important directions of metal carbide‐based cocatalysts for photocatalytic solar‐to‐fuel conversion are proposed. This review demonstrates some new options for rationally designing and developing novel and efficient metal carbide‐based cocatalysts for highly active and selective photocatalytic solar‐to‐fuel conversion.
Publisher: Elsevier BV
Date: 2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7CY00029D
Abstract: Enhanced visible-light photocatalytic H 2 evolution over g-C 3 N 4 nanosheets modified by earth-abundant WC nanoparticles as an active noble-metal-free co-catalyst.
Publisher: Elsevier BV
Date: 06-2020
Publisher: Elsevier BV
Date: 11-2020
Publisher: Rockefeller University Press
Date: 26-12-2019
DOI: 10.1084/JEM.20190489
Abstract: Antibiotic-induced dysbiosis is a key predisposing factor for Clostridium difficile infections (CDIs), which cause intestinal disease ranging from mild diarrhea to pseudomembranous colitis. Here, we examined the impact of a microbiota-derived metabolite, short-chain fatty acid acetate, on an acute mouse model of CDI. We found that administration of acetate is remarkably beneficial in ameliorating disease. Mechanistically, we show that acetate enhances innate immune responses by acting on both neutrophils and ILC3s through its cognate receptor free fatty acid receptor 2 (FFAR2). In neutrophils, acetate-FFAR2 signaling accelerates their recruitment to the inflammatory sites, facilitates inflammasome activation, and promotes the release of IL-1β in ILC3s, acetate-FFAR2 augments expression of the IL-1 receptor, which boosts IL-22 secretion in response to IL-1β. We conclude that microbiota-derived acetate promotes host innate responses to C. difficile through coordinate action on neutrophils and ILC3s.
Publisher: Springer Science and Business Media LLC
Date: 10-10-2020
Publisher: Elsevier BV
Date: 08-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2TA06151A
Abstract: The mechanism of regulating the spin order of transition metal embedded-MXenes for boosting electrocatalytic nitrogen reduction to ammonia.
Publisher: American Chemical Society (ACS)
Date: 10-03-2017
Publisher: Wiley
Date: 05-09-2023
Abstract: This review explores the critical role of etching strategies in the evolution of structures and properties in photocatalysis, a technology offering sustainable energy solutions and environmental remediation. In the face of fossil fuel‐induced environmental issues, photocatalysis presents a promising avenue. However, enhancing photocatalytic activity remains challenging and necessitates advanced methodologies, among which etching strategies have shown great promise. Etching introduces structural vacancies, exposes active crystal facets, and fabricates nanostructures with high specific surfaces, effectively improving the light absorption and catalytic properties of photocatalysts. Despite the substantial advancements in this field, comprehensive reviews elucidating the impact of etching on photocatalysts are scarce. Thus, this review primarily focuses on the influence of various etching strategies on the structural and catalytic properties of photocatalysts. It delves into the mechanisms of morphology control, surface area enhancement, crystal structure modification, defect engineering, and surface chemistry modification through etching. The review further discusses the effect of etching on light absorption, charge separation and migration, and the adsorption and activation of reactants. It concludes by addressing the challenges and future directions of etching strategy in photocatalysis, aiming to enhance the reader’s understanding of etching modification and synthesis of photocatalysts for specific applications. This comprehensive review should aid in the development of more efficient photocatalytic materials and pave the way for breakthroughs in renewable energy technology. This article is protected by copyright. All rights reserved.
Publisher: Elsevier BV
Date: 02-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TA03048K
Abstract: The multi-functional Ni 3 C cocatalyst has been demonstrated to markedly boost the robust photocatalytic H 2 evolution g-C 3 N 4 nanosheets.
Publisher: Elsevier BV
Date: 12-2015
No related grants have been discovered for Xin Li.