ORCID Profile
0000-0003-3802-828X
Current Organisations
Leids Universitair Medisch Centrum
,
Amsterdam UMC
,
Hong Kong University of Science and Technology
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Publisher: Oxford University Press (OUP)
Date: 25-05-2017
DOI: 10.1093/IJE/DYX069
Publisher: Elsevier BV
Date: 2018
DOI: 10.1016/J.IJHEH.2017.10.001
Abstract: The protective effects of physical activity (PA) against chronic disease can be partially ascribed to its anti-inflammatory effects. On the other hand, long-term exposure to particulate matter with an aerodynamic diameter less than 2.5μm (PM To investigate the joint effects of habitual PA and long-term exposure to PM We studied 359,067 adult participants from a cohort consisting of Taiwanese residents who participated in a standard medical examination program from 2001 to 2014. Peripheral white blood cell (WBC) and differential counts were measured as indicators of systemic inflammation. Two-year average concentration of PM Compared with inactive participants, those with low, moderate or high PA levels had 0.36% [95% confidence interval (CI): 0.31%, 0.41%], 0.70% (95%CI: 0.65%, 0.76%) and 1.16% (95%CI: 1.11%, 1.22%) lower WBC counts, respectively, after adjusting for PM Habitual PA was associated with statistically significant lower markers of systemic inflammation across different levels of PM
Publisher: The Company of Biologists
Date: 2020
DOI: 10.1242/JCS.248849
Abstract: A mother's ability to produce a nutritionally-complete neonatal food source has provided a powerful evolutionary advantage to mammals. Milk production by mammary epithelial cells is adaptive, its release is exquisitely-timed and its own glandular stagnation with the permanent cessation of suckling triggers the cell death and tissue remodeling that enables female mammals to nurse successive progeny. Both chemical and mechanical signals play a role in this process. Despite this duality of input, however, much remains unknown about the nature and function of mechanical forces in this organ. Here, we characterize the force landscape in the functionally-mature gland and the capacity of luminal and basal cells to experience and exert force. We explore molecular instruments for force-sensing, in particular channel-mediated mechanotransduction, revealing increased expression of Piezo1 in mammary tissue in lactation and confirming functional expression in luminal cells. We also reveal, however, that lactation and involution proceed normally in mice with luminal-specific Piezo1 deletion. These findings support a multifaceted system of chemical and mechanical sensing in the mammary gland, and a protective redundancy that ensures continued lactational competence and offspring survival.
Publisher: Elsevier BV
Date: 07-2018
No related grants have been discovered for Alexis Lau.