ORCID Profile
0000-0002-4409-012X
Current Organisation
Stanford University School of Medicine
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Publisher: American Association for Cancer Research (AACR)
Date: 15-08-2019
DOI: 10.1158/0008-5472.CAN-18-3264
Abstract: These findings show that the EN1 transcription factor regulates neurogenesis-related genes and is associated with brain metastasis in triple-negative breast cancer.
Publisher: American Association for Cancer Research (AACR)
Date: 10-2017
DOI: 10.1158/2159-8290.CD-17-0222
Abstract: To investigate immune escape during breast tumor progression, we analyzed the composition of leukocytes in normal breast tissues, ductal carcinoma in situ (DCIS), and invasive ductal carcinomas (IDC). We found significant tissue and tumor subtype-specific differences in multiple cell types including T cells and neutrophils. Gene expression profiling of CD45+CD3+ T cells demonstrated a decrease in CD8+ signatures in IDCs. Immunofluorescence analysis showed fewer activated GZMB+CD8+ T cells in IDC than in DCIS, including in matched DCIS and recurrent IDC. T-cell receptor clonotype ersity was significantly higher in DCIS than in IDCs. Immune checkpoint protein TIGIT-expressing T cells were more frequent in DCIS, whereas high PD-L1 expression and lification of CD274 (encoding PD-L1) was only detected in triple-negative IDCs. Co lification of a 17q12 chemokine cluster with ERBB2 sub ided HER2+ breast tumors into immunologically and clinically distinct subtypes. Our results show coevolution of cancer cells and the immune microenvironment during tumor progression. Significance: The design of effective cancer immunotherapies requires the understanding of mechanisms underlying immune escape during tumor progression. Here we demonstrate a switch to a less active tumor immune environment during the in situ to invasive breast carcinoma transition, and identify immune regulators and genomic alterations that shape tumor evolution. Cancer Discov 7(10) 1098–115. ©2017 AACR. See related commentary by Speiser and Verdeil, p. 1062. This article is highlighted in the In This Issue feature, p. 1047
Publisher: Springer Science and Business Media LLC
Date: 14-08-2017
DOI: 10.1038/NM.4378
Location: United States of America
Location: United States of America
No related grants have been discovered for Francisco Beca.