ORCID Profile
0000-0002-6515-5260
Current Organisation
POSTECH
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Publisher: Elsevier
Date: 2013
Publisher: Elsevier BV
Date: 03-2012
Publisher: ACM
Date: 24-10-2011
Publisher: IEEE
Date: 20-01-2021
Publisher: Springer Science and Business Media LLC
Date: 17-09-2010
Publisher: Oxford University Press (OUP)
Date: 03-2011
DOI: 10.1530/EJE-07-0032E
Abstract: The authors apologise for errors in the results reported in their above titled article published in the European Journal of Endocrinology 2007 157 119–125 . Due to a technical error, a number of fractures were not included in the database. In the cohort of 2750 participants, a total of 487 suffered a non-vertebral fracture (not 386 as stated in the article), and the incidence was 30.0 in women and 11.8 in men per 1000 person-years, respectively. The main results were unchanged after re-analysis and no significant association was present between sex steroids and risk of non-vertebral fractures after adjustment for age in both sexes. Each 1 S.D. higher SHBG increased the risk of non-vertebral fracture by about 20% in women (HR 1.15 95% CI 1.03–1.29) and men (HR 1.18 95% CI 0.99–1.41) after adjustment for age, height, weight, smoking and physical activity. After adjustment for BMD, the increased risk was attenuated and no longer statistical significant in women (HR 1.07 95% CI 0.96–1.21) and men (HR 1.12 95% CI 0.94–1.34) respectively.
Publisher: Elsevier BV
Date: 05-2017
Publisher: Elsevier BV
Date: 05-2010
Publisher: Wiley
Date: 19-08-2013
DOI: 10.1002/JBMR.1934
Publisher: IEEE
Date: 07-2019
Publisher: ACM
Date: 30-01-2019
Publisher: Springer Science and Business Media LLC
Date: 19-08-2012
Publisher: Elsevier BV
Date: 07-2013
Publisher: IEEE
Date: 2020
Publisher: ACM
Date: 29-10-2012
Publisher: ACM
Date: 24-10-2016
Publisher: IEEE
Date: 08-2010
Publisher: Elsevier BV
Date: 09-2012
Publisher: Elsevier BV
Date: 04-2010
Publisher: Springer Science and Business Media LLC
Date: 04-01-2012
Publisher: ACM
Date: 21-10-2023
Publisher: Wiley
Date: 23-11-2010
DOI: 10.1002/JBMR.261
Publisher: IEEE
Date: 13-10-2020
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 2010
DOI: 10.2215/CJN.06160809
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2020
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2020
Publisher: Elsevier BV
Date: 09-2012
Publisher: Springer Science and Business Media LLC
Date: 21-06-2012
Publisher: Elsevier BV
Date: 08-2013
DOI: 10.1016/J.BONE.2013.04.020
Abstract: Bone remodelling accelerates and becomes unbalanced after menopause less bone is deposited than resorbed from the surface of canals traversing the cortex. The canals enlarge so the intracortical surface area enlarges. We hypothesized that cortical bone with a larger internal surface area, due to more or larger canals, is more liable to being remodelled, further enlarging the internal surface area and facilitating more remodelling and structural deterioration. For 95 monozygotic twin pairs aged 40-61 years, we measured internal cortical surface areas and structure of the distal tibia using high resolution peripheral computed tomography, and three circulating bone remodelling markers. Using principal component (PC) analyses, we identified one summary measure of intracortical and endocortical bone surface areas, cortical porosity and volumetric bone mineral density (structure PC), and one summary measure of bone remodelling markers (remodelling PC). We applied a twin regression analysis (Inference on Causation by Examination of Familial Confounding ICE FALCON) to assess consistency with a causal component in the association between a predictor (X) and an outcome (Y) by testing if the regression coefficient for the X value of the co-twin decreases after adjusting for the X value of the twin herself. With Y = remodelling PC, the regression coefficient for structure PC in the co-twin was 0.29 (p < 0.001) before, and 0.18 (p = 0.03) after, adjusting for her own structure PC (40% lower p = 0.06). With Y = structure PC, the regression coefficient for remodelling PC in the co-twin was 0.17 (p = 0.01) before, and 0.20 (p < 0.001) after, adjusting for her own remodelling PC (22% higher p = 0.7). The structure of bone, its surface area to bone matrix volume configuration, might contribute in part to its own remodelling and deterioration, but not vice versa.
Publisher: Elsevier BV
Date: 2020
Publisher: ACM
Date: 18-04-2015
Publisher: Elsevier BV
Date: 2013
Publisher: Springer Science and Business Media LLC
Date: 24-08-2011
DOI: 10.1007/S00198-010-1370-7
Abstract: The purpose of this study was to examine if the reduction in glucose post-exercise is mediated by undercarboxylated osteocalcin (unOC). Obese men were randomly assigned to do aerobic or power exercises. The change in unOC levels was correlated with the change in glucose levels post-exercise. The reduction in glucose post-acute exercise may be partly related to increased unOC. Osteocalcin (OC) in its undercarboxylated (unOC) form may contribute to the regulation of glucose homeostasis. As exercise reduces serum glucose and improves insulin sensitivity in obese in iduals and in iduals with type 2 diabetes (T2DM), we hypothesised that this benefit was partly mediated by unOC. Twenty-eight middle-aged (52.4 ± 1.2 years, mean ± SEM), obese (BMI = 32.1 ± 0.9 kg m(-2)) men were randomly assigned to do either 45 min of aerobic (cycling at 75% of VO(2peak)) or power (leg press at 75% of one repetition maximum plus jumping sequence) exercises. Blood s les were taken at baseline and up to 2 h post-exercise. At baseline, unOC was negatively correlated with glucose levels (r = -0.53, p = 0.003) and glycosylated haemoglobin (HbA1c) (r = -0.37, p = 0.035). Both aerobic and power exercises reduced serum glucose (from 7.4 ± 1.2 to 5.1 ± 0.5 mmol L(-1), p = 0.01 and 8.5 ± 1.2 to 6.0 ± 0.6 mmol L(-1), p = 0.01, respectively). Aerobic exercise significantly increased OC, unOC and high-molecular-weight adiponectin, while power exercise had a limited effect on OC and unOC. Overall, those with higher baseline glucose and HbA1c had greater reductions in glucose levels after exercise (r = -0.46, p = 0.013 and r = -0.43, p = 0.019, respectively). In a sub-group of obese people with T2DM, the percentage change in unOC levels was correlated with the percentage change in glucose levels post-exercise (r = -0.51, p = 0.038). This study reports that the reduction in serum glucose post-acute exercise (especially aerobic exercise) may be partly related to increased unOC.
Publisher: Springer Science and Business Media LLC
Date: 26-01-2017
Publisher: Elsevier BV
Date: 09-2012
Publisher: IEEE
Date: 07-2019
Publisher: Springer Berlin Heidelberg
Date: 2011
Publisher: Bioscientifica
Date: 15-04-2010
DOI: 10.1677/JOE-10-0026
Abstract: We used our genomic androgen receptor (AR) knockout (ARKO) mouse model, in which the AR is unable to bind DNA to: 1) document gender differences between males and females 2) identify the genomic (DNA-binding-dependent) AR-mediated actions in males 3) determine the contribution of genomic AR-mediated actions to these gender differences and 4) identify physiological genomic AR-mediated actions in females. At 9 weeks of age, control males had higher body, heart and kidney mass, lower spleen mass, and longer and larger bones compared to control females. Compared to control males, ARKO males had lower body and kidney mass, higher splenic mass, and reductions in cortical and trabecular bone. Deletion of the AR in ARKO males abolished the gender differences in heart and cortical bone. Compared with control females, ARKO females had normal body weight, but 14% lower heart mass and heart weight/body weight ratio. Relative kidney mass was also reduced, and relative spleen mass was increased. ARKO females had a significant reduction in cortical bone growth and changes in trabecular architecture, although with no net change in trabecular bone volume. In conclusion, we have shown that androgens acting via the genomic AR signaling pathway mediate, at least in part, the gender differences in body mass, heart, kidney, spleen, and bone, and play a physiological role in the regulation of cardiac, kidney and splenic size, cortical bone growth, and trabecular bone architecture in females.
Publisher: IEEE
Date: 07-2019
Publisher: IEEE
Date: 07-2019
Publisher: Springer Science and Business Media LLC
Date: 02-2013
Publisher: Elsevier BV
Date: 12-2011
Publisher: Wiley
Date: 30-07-2010
DOI: 10.1002/JBMR.81
Publisher: IEEE
Date: 12-2018
Publisher: Springer Science and Business Media LLC
Date: 27-07-2012
Publisher: Elsevier BV
Date: 06-2011
DOI: 10.1016/J.BONE.2011.02.023
Abstract: Study of postmortem s les of cortical bone from the trochanters of 12 Caucasian females revealed that tissue mineral density (TMD) and tissue elastic modulus correlate weakly within and between in iduals. Other material properties need to be taken into account to more fully predict variation in tissue elastic modulus. Bone is a composite material that varies in its material composition and structural organization at the macro-, micro-, and nano-scales. This hierarchical organization is essential for bone's resistance to crack initiation and propagation. We quantified the relationship between regional heterogeneity in TMD and tissue elastic modulus in cortical bone of the trochanter to determine whether TMD can be used as a predictor of tissue elastic modulus. Measurements of tissue elastic modulus and hardness were made using nanoindentation at 5 × 20 indent points spaced 100 μm apart. TMD at the same location was computed from quantitative backscattered scanning electron microscopy imaging of cortical s les from trochanters obtained at postmortem from 12 Caucasian females (mean age: 69 years range: 29 to 85 years). Within an in idual, the variance in tissue elastic modulus (CV = 18.7% range: 9 to 41.5%) was five times greater than the variance in TMD (3.6%, range: 1.8 to 5.7%). On average, only 45% of the variance in tissue elastic modulus was explained by TMD. From in idual to in idual, the proportion of the variance in tissue elastic modulus explained by TMD ranged from 0 to 64%. In 6 of 12 s les, TMD explained less than 30% of the variance in tissue elastic modulus. Results were similar for tissue hardness. Tissue mineral density is an incomplete surrogate for tissue elastic modulus. Other material properties need to be accounted for to more fully predict regional variation in tissue elastic modulus.
Publisher: Springer Science and Business Media LLC
Date: 21-04-2011
Publisher: IEEE
Date: 07-2019
Publisher: Springer International Publishing
Date: 2021
Publisher: Wiley
Date: 30-06-2010
DOI: 10.1002/JBMR.46
Publisher: Wiley
Date: 17-04-2013
DOI: 10.1002/JBMR.1827
Abstract: Most measures of femoral neck strength derived using dual-energy X-ray absorptiometry or computed tomography (CT) assume the femoral neck is a cylinder with a single cortical thickness. We hypothesized that these simplifications introduce errors in estimating strength and that detailed analyses will identify new parameters that more accurately predict femoral neck strength. High-resolution CT data were used to evaluate 457 cross-sectional slices along the femoral neck of 12 postmortem specimens. Cortical morphology was measured in each cross-section. The distribution of cortical thicknesses was evaluated to determine whether the mean or median better estimated central tendency. Finite-element models were used to calculate the stresses in each cross-section resulting from the peak hip joint forces created during a sideways fall. The relationship between cortical morphology and peak bone stress along the femoral neck was analyzed using multivariate regression analysis. In all cross-sections, cortical thicknesses were non-normally distributed and skewed toward smaller thicknesses (p < 0.0001). The central tendency of cortical thickness was best estimated by the median, not the mean. Stress increased as the median cortical thickness decreased along the femoral neck. The median, not mean, cortical thickness combined with anterior-posterior diameter best predicted peak bone stress generated during a sideways fall (R(2) = 0.66, p < 0.001). Heterogeneity in the structure of the femoral neck determines the ersity of its strength. The median cortical thickness best predicted peak femoral neck stress and is likely to be a relevant predictor of femoral neck fragility.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2020
Publisher: Springer Science and Business Media LLC
Date: 05-2010
DOI: 10.1038/NM0510-607C
Publisher: Wiley
Date: 21-06-2011
DOI: 10.1002/JBMR.360
Publisher: Wiley
Date: 30-06-2010
DOI: 10.1002/JBMR.45
No related grants have been discovered for Dongwoo Kim.