ORCID Profile
0000-0002-5392-937X
Current Organisation
University of Colorado at Boulder
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Publisher: Cold Spring Harbor Laboratory
Date: 30-10-2021
DOI: 10.1101/2021.10.28.466196
Abstract: Cancer cells exhibit rewired transcriptional regulatory networks that promote tumor growth and survival. However, the processes that configure these pathological networks remain poorly understood. Through a pan-cancer epigenomic analysis, we found that primate-specific endogenous retroviruses (ERVs) are an abundant source of enhancers that show cancer-specific activity. In colorectal cancer and other epithelial tumors, oncogenic MAPK/AP1 signaling drives activation of enhancers derived from the primate-specific ERV family LTR10. Functional studies in colorectal cancer cells revealed that LTR10 elements are involved in regulating multiple genes associated with tumorigenesis, including ATG12 . Within the human population, in idual LTR10 elements show frequent structural variation resulting from a highly mutable internal tandem repeat region, which affects AP1 binding activity. Our findings reveal that ERV-derived enhancers mediate transcriptional dysregulation in response to oncogenic signaling, and shape the evolution of cancer-specific regulatory networks.
Publisher: eLife Sciences Publications, Ltd
Date: 28-06-2017
Publisher: Elsevier BV
Date: 02-2012
Publisher: Proceedings of the National Academy of Sciences
Date: 20-04-2020
Publisher: eLife Sciences Publications, Ltd
Date: 12-09-2017
DOI: 10.7554/ELIFE.27450
Abstract: Eutherians are often mistakenly termed ‘placental mammals’, but marsupials also have a placenta to mediate early embryonic development. Lactation is necessary for both infant and fetal development in eutherians and marsupials, although marsupials have a far more complex milk repertoire that facilitates morphogenesis of developmentally immature young. In this study, we demonstrate that the anatomically simple tammar placenta expresses a dynamic molecular program that is reminiscent of eutherian placentation, including both fetal and maternal signals. Further, we provide evidence that genes facilitating fetal development and nutrient transport display convergent co-option by placental and mammary gland cell types to optimize offspring success.
Location: United States of America
No related grants have been discovered for Edward Chuong.